NCT: NCT00138879Aug 30, 2005Clinical Trial

Citrulline: A Plasmatic Marker to Assess and Monitor Small Bowel Crohn's Disease Patients

ClinicalTrials.gov

Abstract

Citrulline is an amino acid produced in the intestine and in the liver, but the liver does not contribute significantly to circulating citrulline concentrations. The intestine is thus the only organ that normally releases significant amounts of citrulline into the blood. The investigators have designed a study looking at the value of measuring plasma citrulline concentration in patients with Crohn's disease and short bowel or normal intestinal length. Measuring the plasma citrulline concentration in short bowel patients may help to distinguish between patients who need permanent parenteral feeding from patients with just transient intestinal dysfunction. It may also help the investigators in understanding the small bowel intestinal length remaining and the absorptive integrity. In patients with normal intestinal length and Crohn's disease, it may be a reliable marker of small bowel damage and could be applied to establish therapeutic improvements. It has been demonstrated to strongly correlate (inversely) with severity on intestinal biopsies. The investigators hypothesise that the plasma citrulline concentration is a marker for small bowel absorptive integrity and an appropriate surrogate for functional length of the small int...Continue Reading

Associated Papers

Nov 30, 1999·Journal of Pediatric Gastroenterology and Nutrition·L D'AntigaI Bjarnason
Jun 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P A PappasJean-Marie Saudubray
Jan 1, 1987·JPEN. Journal of Parenteral and Enteral Nutrition·A S DetskyK N Jeejeebhoy
Dec 1, 1981·The American Journal of Physiology·H G Windmueller, A E Spaeth
May 30, 2002·Transplantation Proceedings·P A PappasP Ruiz
Sep 25, 2004·Clinical Transplants·Gennaro SelvaggiAndreas Tzakis
Oct 25, 2003·International Journal of Radiation Oncology, Biology, Physics·L C H W LutgensPhilippe Lambin

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