NCT: NCT04380935May 8, 2020Clinical Trial

Effectiveness and Safety of Convalescent Plasma Therapy on COVID-19 Patients With Acute Respiratory Distress Syndrome

ClinicalTrials.gov
Andri Maruli Tua Lubis

Abstract

Corona virus disease 2019 (COVID-19) has been declared as a Pandemic by the World Health Organization (WHO). According to WHO report on March 31st 2020, globally COVID-19 have infected over 750,000 people and caused over 36,000 deaths with case fatality rate of 4.85%. In Indonesia, COVID-19 have infected 1,414 people and caused 122 deaths with case fatality rate of 8.63%. In severe cases, COVID-19 causes complications, such as acute respiratory distress syndrome (ARDS), sepsis, septic shock, and multi-organ dysfunction syndrome (MODS), where age and comorbid illnesses as a major factor to these complications. Up to this point there are several promising therapies for COVID-19 but is not yet recommended and in need of further research. The use of convalescent plasma has been approved by the US Food and Drug Administration (FDA) through the scheme of emergency investigational new drug (eIND). This method has been used as the treatment in several outbreak or plague cases over the years, such as the flu epidemic in 1918, polio, measles, mumps, SARS (severe acute respiratory syndrome), EVD (Ebola virus disease) and MERS (middle-eastern respiratory syndrome) and this treatment shows better outcome. Several case report on the use of c...Continue Reading

Associated Papers

Mar 4, 2020·JAMA : the Journal of the American Medical Association·Barnaby Edward YoungSingapore 2019 Novel Coronavirus Outbreak Research Team
Mar 13, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chuan QinDai-Shi Tian
Jul 2, 2019·BMJ Open Respiratory Research·Mark J D GriffithsSimon V Baudouin
Mar 29, 2020·JAMA : the Journal of the American Medical Association·John D Roback, Jeannette Guarner
Feb 23, 2020·The Lancet. Respiratory Medicine·Zhe XuFu-Sheng Wang
Dec 24, 2004·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y ChengG Cheng
Mar 29, 2020·JAMA : the Journal of the American Medical Association·Chenguang ShenLei Liu
Jul 10, 2018·Journal of Translational Internal Medicine·Gautam RawalRaj Kumar
Sep 10, 2015·American Journal of Respiratory and Critical Care Medicine·Elisabeth D RivielloRobert A Fowler
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanChina Medical Treatment Expert Group for Covid-19
Mar 29, 2020·BMJ : British Medical Journal·Janice Hopkins Tanne
Jan 7, 2016·The New England Journal of Medicine·Johan van GriensvenEbola-Tx Consortium
Jul 17, 2012·JAMA : the Journal of the American Medical Association·V Marco RanieriArthur S Slutsky

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