NCT: NCT03410524Jan 25, 2018Clinical Trial

Evaluation of Oral Simethicone With Low Volume Polyethylene Glycol Bowel Preparation During Colonoscopy

ClinicalTrials.gov
Mohit Rishi

Abstract

An adequate bowel preparation has been well established to lead to a successful colonoscopy. Research has consistently demonstrated inadequate bowel preparation with lower adenoma detection rates. Over the years, endoscopy centers have changed the constituents of bowel preparation in light of new research. In 2006, 3 medical organizations recommended the use of polyethylene glycol (PEG) solution for bowel preparation. Initially, a 4 liter PEG solution was commonly used using a split dose regimen for bowel prep. However, many patients found that this large volume gave them side effects including bloating and cramping. Other studies showed that a low volume PEG solution with oral bisacodyl fared equally in terms of adequacy of bowel preparation. With the institution of lower volume PEG preparation our offices noted improved patient toleration, satisfaction, and clinical outcomes. However, multiple endoscopists have noticed an increased in intraluminal bubbles and foam with the low volume preparation. This can impair proper visualization of the bowel wall even with an adequate bowel preparation. The current standard of practice includes irrigation, lavage, and suctioning using a simethicone infused saline during the colonoscopy. I...Continue Reading

Associated Papers

Jan 21, 2016·World Journal of Gastrointestinal Endoscopy·Nicole M Harrison, Michael C Hjelkrem
Jun 26, 2009·World Journal of Gastroenterology : WJG·Sasinee TongprasertSasivimol Rattanasiri
May 1, 1994·Journal of Applied Toxicology : JAT·L BrecevićF Strajnar
Mar 1, 1994·Diseases of the Colon and Rectum·W J AdamsD W King
Jan 20, 2016·The American Journal of Gastroenterology·Robin ParmarAlan N Barkun
Aug 2, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Fabrizio ParentePier Alberto Testoni

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