NCT: NCT01414777Aug 11, 2011Clinical Trial

Intravenous Ondansetron to Attenuate the Hypotensive, Bradycardic Response to Spinal Anesthesia in Healthy Parturients

ClinicalTrials.gov

Abstract

The investigators hypothesize that given prophylactically, intravenous ondansetron will attenuate the drop in blood pressure and heart rate frequently seen after spinal anesthesia. Eighty-six American Society of Anesthesiologists (ASA) physical status I or II in preoperative patient assessment, parturients age of 18 to 45 years scheduled to undergo elective caesarean section will be enrolled. Patients will be randomized to 2 groups: the ondansetron group, receiving 8 mg intravenous ondansetron diluted in 10 mL of saline; or the placebo group, who were administered 10 mL of saline given 5 minutes prior to performing the spinal anesthetic. Investigational Pharmacy will randomize and dispense study drug. Baseline measurements of vital signs will be taken. Otherwise standard management will then be used: Patients must be NPO for 8 hours Pulse oximetry, EKG monitoring, noninvasive blood pressure at a minimum of every 3 minutes, more frequently if decided by the provider. Standard lumbar puncture in a sitting position the L3-L4 or L4-L5 Whitacre pencil-point, 25 gauge Injectate: 2 mL of 0.75% hyperbaric bupivacaine, 100 mcg preservative free morphine, 20 mcg fentanyl Immediately after completing the subarachnoid injection, patien...Continue Reading

Associated Papers

Dec 6, 2005·European Journal of Clinical Pharmacology·Charlotte AskerBengt Källén
Apr 30, 2003·Anesthesiology·Jason A Campagna, Christopher Carter
Aug 19, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Carlos M Villalón, David Centurión
May 26, 2007·Anesthesiology·Jill M MhyreNorah N Naughton
Jan 25, 2002·Postgraduate Medical Journal·N K Kuşcu, F Koyuncu
Jun 5, 2001·Anesthesiology·S S Liu, S B McDonald
Feb 1, 1990·The American Journal of Physiology·R VeelkenG F DiBona
Sep 1, 1995·British Journal of Anaesthesia·R JacksonJ Thorburn
Jan 1, 1989·European Journal of Cancer & Clinical Oncology·M L TuckerK Capel-Edwards
May 1, 1996·American Journal of Obstetrics and Gynecology·C A SullivanJ C Morrison
Mar 11, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Robert M Martinek
Jan 24, 2007·Anesthesia and Analgesia·Sahar M Siddik-SayyidAnis S Baraka
Sep 16, 2003·Clinical Obstetrics and Gynecology·Joy L Hawkins
Jan 1, 1994·International Anesthesiology Clinics·C C Rout, D A Rocke
May 1, 1994·Obstetrics and Gynecology·S M Kinsella, G Lohmann
Aug 26, 2004·BJOG : an International Journal of Obstetrics and Gynaecology·Adrienne EinarsonGideon Koren

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