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The Mannose-Binding Lectin Complement Pathway is activated when mannose-binding lectin binds to mannose found on the surface of pathogens. Subsequent complement activation is similar to the classical complement pathway, but without the need for antigen-antibody complexes. Discover the latest research here.
Meta's top-ranked research topics
Acute hemorrhagic leukoencephalitis is a rare form of acute disseminated encephalomyelitis characterized by acute inflammation in the brain and spinal cord that causes demyelination and bleeding. It is often fatal, although treatment with immunosuppressives and plasma exchange can be helpful. Find the latest research on acute hemorrhagic leukoencephalitis here.
Spotlight on Single Cell Atlases
Popular feeds about the Human Cell Atlas and other single-cell research
The novel CUT&Tag technique has the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.
Examining the spatial arrangement of cell types in the retina and performing single cell analyses on these cell types will integrate information on the biology of these cells and development of disease. Discover the latest research pertaining to the Cell Atlas of the Neural Retina here.
Mapping bone marrow hematopoiesis by combining transcriptomics and imaging techniques will facilitate the study of hematopoietic disease and the development of novel therapeutics. This feed includes new research on analysis of the bone marrow hematopoiesis by multiple approaches.
The open source software R / Bioconductor is used for statistical analysis and visualization, with continual generation of new analysis packages and updates. Find the latest research on Programming: Bioconductor Software Packages here.
Immediate access to unpublished research
Hypoxia is a condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level. Hypoxia may be classified as either generalized, affecting the whole body, or local, affecting a region of the body. Discover the latest preprints here.
G-protein-coupled receptors (GPCRs), the largest family of integral membrane proteins, participate in the regulation of many physiological functions and are the targets of approximately 30% of currently marketed drugs. Here are the latest preprints on GPCRs.
Methods & Applications
A selection of feeds about state-of-the-art technologies
Nanoparticles enable the delivery of substances, including nucleic acids and chemotherapeutic drugs, to a targeted region while sparing healthy tissues, thus overcoming adverse systemic effects of gene therapy or drug delivery. Here is the latest research on nanoparticle delivery.
Publications from different research communities
The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.
The Collaboration for AIDS Vaccine Discovery (CAVD) focuses on designing a variety of novel HIV vaccine candidates and advancing the most promising candidates to clinical trials. Follow this feed to stay up to date on this important research from the CAVD.
National Institute of Allergy and Infectious Diseases (NIAID) goal is to perform leading research to understand, treat, and prevent infectious, immunologic, and allergic diseases. Follow this feed to stay updated on research from this group.
Institut Curie - Centre de Recherche covers multiple areas of research: the biology of radiations, cell signaling and Cancer, second Development biology, Cancer, Genetics and Epigenetics, third integrative tumor biology, immunology and environment, and fourth multiscale Physics-Biology-Chemistry and Cancer. Follow this feed to stay updated on research from this group.
Spotlight on Oxygen Sensing
Feeds in the 2019 Nobel Prize research area
Oxygenation is a chemical production that introduces oxygen atom into an organic compound. Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound. In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases. Cytochrome P450 (CYP) enzymes are expressed mainly in the liver and are active in mono-oxygenation and hydroxylation of various xenobiotics, including drugs and alcohols, as well as that of endogenous compounds such as steroids, bile acids, prostaglandins, leukotrienes and biogenic amines. Here is the latest research.
Reactive oxygen species (ROS) are reactive chemicals containing oxygen. They generated as a byproduct of oxidative energy metabolism and play a role in regulating several intracellular signaling pathways. Here is the latest research on ROS metabolism and signaling.
Journal tables of content
In the News
Science making headlines
GRIP1 is a glutamate receptor interacting protein 1 and myeloid cells consists of granulocytes and monocytes, before they have differentiated and are derived from hematopoietic stem cells. The interaction between GRIP1 and myeloid cells in inflammation is in the early stages. Here is the latest research on GRIP1 and myeloid cells in inflammation.
Localization of proteins is critical for ensuring the correct location for physiological functioning. If an error occurs, diseases such as cardiovascular, neurodegenerative disorders and cancers can present. Therapies are being explored to target this mislocalization. Here is the latest research on protein localization in disease and therapy.