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Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Refsum disease is an autosomal recessive disorder of lipid metabolism characterized by adult-onset retinitis pigmentosa, anosmia, sensory neuropathy, ataxia, and an accumulation of phytanic acid in plasma and tissues. Here is the latest research on this peroxisomal disorder.

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

CRISPR-Cas system enables the editing of genes to create or correct mutations. This technology is being investigated to combat malaria by targeting specific stretches of vector DNA and editing the genome at precise locations. Here is the latest research.

Computed axial tomography (CT or CAT) is a non-invasive imaging technique that uses X-rays to take slices of the particular region of interest. This data is sent to a computer where a 2D image is generated. CT of the brain can be helpful in understanding pathological processes of some diseases. Discover the latest research of CT of the brain here.

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

TDP-43 is implicated in several neurodegenerative disorders including Alzheimer's disease, amyotrophic lateral sclerosis and frontotemporal lobe dementia. It has also been shown to regulate microglial phagocytosis. Here is the latest research on the role of TDP-43 and microglia in neurodegeneration.

Congenital, Lipomatous, Overgrowth, Vascular Malformations, Epidermal Nevi and Spinal/Skeletal Anomalies and/or Scoliosis (CLOVES) syndrome is a rare genetic disorder caused by mutations in the PIK3CA gene. Symptoms include blood vessel abnormalities, small tissue tumors, skin legions and spinal abnormalities. Here is the latest research on CLOVES syndrome.

DDX3X syndrome is caused by a spontaneous mutation at conception that primarily affects females due to its location on the X-chromosome. DDX3X syndrome has been linked to intellectual disabilities, seizures, autism, low muscle tone, brain abnormalities, and slower physical developments. Here is the latest research.

Prion diseases are fatal neurodegenerative and infectious disorders characterized by structural transition of the host-encoded cellular prion protein into the aberrantly folded pathologic isoform of the protein. Here is the latest research on diagnostic strategies for prion diseases.

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent preprints published on COVID-19.

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Fumarate Reductase is an enzyme that uses fumarate and quinol as substrates to generate succinate and quinone and has several biological functions, including a role in anaerobic respiration. Here is the latest research.

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Vitamin K-dependent carboxylases generate gamma-carboxyglutamic acids with malonate moieties by modifying glutamate residues in vitamin K-dependent proteins. This feed focuses on cellular mechanisms regulated by vitamin K-dependent carboxylases.

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Adult polyglucosan body disease (APBD) is a rare autosomal recessive disease characterized by defects in the glycogen brancher enzyme 1 (GBE1) gene. Discover the latest research on APBD here.

Mutations, single nucleotide variants and large genomic rearrangements, in non-coding regions of the genome can have severe consequences such as disruption of transcription factor binding sites and functions of non-coding RNAs and can impact tumor development and progression. Here is the latest research.

Hereditary breast and ovarian cancer due to mutations in the brca1 and brca2 genes is the most common cause of hereditary forms of both breast and ovarian cancer. Here are the latest discoveries pertaining to these cancers.

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Forkheadbox-O (FoxO) family of transcription factors are downstream of insulin signaling and are involved in longevity and aging. Discover the latest research on FoxO Signaling in Aging here.

Oxygen tension is determined by the balance between net oxygen entering the system and the consumption of oxygen by cells, which can be affected by cell density and type. For instance, hepatocytes consume higher levels of oxygen compared to endothelial cells. Here is the latest research on oxygen tension in liver models.

Pearson syndrome is a rare disease that affects the bone marrow and pancreas. It is caused by a mutation in the mitochondrial DNA. Symptoms include pancreatic insufficiency, anemia, neutropenia, and thrombocytopenia which can lead to feeling weak, tired, and bruising more easily. Here is the latest research on Pearson Syndrome.

This feed focuses on subcellular and translation regulation of RNA in Axons and how this influences Axonal Functions. Discover the latest research here.

When demyelination occurs an inflammatory response is activated. Accumulation of excess myelin debris triggers cholesterol crystal formation, and cholesterol deposits in the CNS can overwhelm phagocytes, resulting in impaired tissue regeneration. Here is the latest research on cholesterol synthesis in inflammation and remyelination.

Hebbian theory is a neuroscientific theory claiming that an increase in synaptic efficacy arises from a presynaptic cell's repeated and persistent stimulation of a postsynaptic cell. Find the latest research on Hebbian theory here.

The Sonic Hedgehog signaling pathway regulates developmental processes including cell patterning and differentiation and plays a role in tissue repair and regeneration. Here is the latest research on this complex signal transduction pathway.

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Misfolded prion proteins characterize a number of fatal neurodegenerative diseases. Distinct prion strains are associated with different prion protein conformations and glycosylation patterns and associate with disease progression and severity. Here is the latest research on strain diversity and neurotoxicity in prion diseases.

Histone deacetylases (HDACs) are key epigenetic regulators of metabolic homeostasis. Here is the latest research on HDACs in obesity.

Factors associated with COVID-19 patient admissions to Intensive Care Units and with death include older age, comorbid conditions, obesity. Ethnic minority backgrounds and genetics, as well as economic inequalities are also likely to play a role in disease outcomes. A variety of COVID-19 risk factors are explored in the publications followed in this feed.

Understanding the innate and acquired immune response to SARS-CoV-2 is essential for development of COVID-19 therapeutic treatment and design of prophylactic vaccines. This feed surfaces immunological studies, including studies into the cytokine storm that has been observed in severely ill patients.

COVID-19 patients frequently have neurological symptoms, which are probably caused by the virus invading the central nervous system. Symptoms range from a loss of smell and taste to serious complications such as encephalitis, many of which are associated with poor prognosis. This feed follows the latest developments and research into the neurological complications associated with COVID-19.

COVID-19 represents a particular challenge to people with serious chronic medical conditions such as diabetes, hypertension, cardiovascular disease, and chronic lung disease. Research into the intersection between comorbidities and COVID-19 is focusing on risks and treatment outcomes for these patients.

This feed represents a collection of systematic literature reviews available for COVID-19 and coronaviruses. These reviews use systematic methods to collect and critically assess secondary data available for a specific research question, providing a synthesis of qualitative or quantitative findings.

The research highlighted in this feed investigates the immunopathology seen in severely ill COVID-19 patients, which often resembles the cytokine storm syndrome: uncontrolled immune activation generates excessive release of cytokines, resulting in hyperinflammation and multi-organ disease.

Deciphering and comparing the proteins of different coronaviruses forms a basis for understanding SARS-CoV-2 evolution and virus-receptor interactions. This feed follows studies analyzing the structures of coronavirus proteins, thereby revealing potential drug target sites.

A growing number of complications associated with COVID-19 has been identified. This feed focuses primarily on cardiovascular and respiratory manifestations in severely ill patients.

The SARS-CoV-2 virus enters the human host cell via the receptor ACE2 and uses the serine protease TMPRSS2 for S protein priming. The ACE2 usage has been shown to be crucial for transmissibility of other coronaviruses. Much research into the COVID-19 pandemic focuses on understanding the complex process of virus entry.

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

The entry of coronaviruses into susceptible host cells is mediated by the viral S (Spike) glycoprotein. This feed covers latest findings about this complex process and the ongoing research efforts into finding therapeutics that can target the viral Spike protein and hence disrupt virus-cell fusion.

Epidemiological studies play a crucial role in understanding and managing the progression of COVID-19. Research followed in this feed includes studies of transmission dynamics and the change of the basic reproductive number (R) as new pubic health measures take effect.

Growing evidence shows that COVID-19 can result in serious complications affecting the cardiovascular system, including dysrhythmias, myocarditis, acute myocardial infarction, and heart failure. This feed follows studies investigating the effects of SARS-CoV-2 infection on the heart.

COVID-19 patients typically present with high fever and a persistent cough. This feed focuses on clinical diagnosis, including RT-PCR testing for the presence of SARS-CoV-2 and radiographic assessment of lungs.

Models that predict the course of the COVID-19 epidemic have been crucial in developing public health policies and continue to be used to plan effective control strategies. This feed surfaces papers reporting new models and modeling methods applied to COVID-19 data.

The provision of Personal Protective Equipment for hospital staff and other workers providing essential services has been a key challenge in the early stages of the COVID-19 pandemic. Research into the protection offered by PPE, as well as best-practice guidelines for PPE use, is covered in this feed.

While most COVID-19 infections cause only mild to moderate symptoms, severely affected patients, such as those presenting with pneumonia, ARDS or septic shock, require hospitalization. This feed focuses on clinical management of patients using oxygen therapy, ventilation, and other treatment strategies, and covers some medical case reports.

Artificial intelligence (AI) offers a powerful new tool that could potentially be instrumental in controling and managing the SARS-CoV-2 virus. The papers in this feed report on the applications of AI to the current pandemic, which may be able to predict the location of the next outbreak, or facilitate new drug design.

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent preprints published on COVID-19.

Astrocytes are abundant within the central nervous system and their dysfunction has been thought to be an important contributor to some neurodegenerative diseases, in particular Huntington’s disease. Damage to these cells may make neurons more susceptible to degeneration. Here is the latest research on astrocytes and Huntington’s disease.

Brain organoids are three-dimensional in vitro cellular models of the brain that can recapitulate many processes such as the neurodevelopment. In addition, these organoids can be combined with other cell types, such as neurons and astrocytes to study their interactions in assembloids. Disease processes can also be modeled by induced pluripotent stem cell-derived organoids and assembloids from patients with neurodegenerative disorders. Discover the latest research on the models here.

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Some neurodegenerative disorders are believed to be due to RNA-induced cellular toxicity caused by the expansion of nucleotide-repeat sequences in DNA. Discover the latest research on RNA-mediated toxicity in neurodegeneration here.

Tauopathies are neurodegenerative disorders caused due to misfolding and aggregation of the tau protein in neurofibrillary tangles in the brain. This feed focuses on the structural basis of protein pathology in tauopathies. Here is the latest research.

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Parkinson's disease (PD) is a neurodegenerative disorder caused by the progressive loss of dopaminergic neurons. Some PD-genes may be associated with astrocyte dysfunction. Discover the latest research on astrocytes in Parkinson's disease here.

Tau proteins include six highly soluble protein isoforms produced by alternative splicing from the gene MAPT (microtubule-associated protein tau). Combating tau-associated pathologies is a key focus of neurodegeneration research. Here is the latest research on tau and neurodegeneration.

Parkinson's disease is a progressive, neurodegenerative disorder that affects both motor and cognitive function. The etiology of the disease is mostly unknown, but it probably involves both environmental and genetic. This feed focuses on profiling and defining Parkinson’s disease using biological and computational methods.

While a link has been established between RNA, RNA-binding proteins, and motor proteins, mechanisms underlying RNA trafficking are still unclear. Furthermore, interactions between cargo and motor proteins are dysregulated in microsatellite repeat expansion diseases, including Huntington’s disease. Here is the latest research focusing on RNA trafficking and neurodegeneration.

Neurodegenerative diseases may be caused in part by triggers from peripheral body systems or inflammation mediated by brain cells other than neurons. Understanding these peripheral factors is necessary for designing treatments. Additionally, genetic tools allowing for delivery of transgenes past the blood-brain barrier are important for treatments of any CNS diseases. Discover the latest research on neurodegenerative disorders, their peripheral causes, and viral vectors for CNS delivery here.

Neurodegenerative disorders and obesity appear to have common pathologies including neuroinflammation. Targeting common pathways may prove to be a useful treatment strategy for neurodegenerative disease. Discover the latest research on neurodegenerative disorders and obesity here.

Neurodegeneration is the progressive loss of structure or function of neurons, including neuronal death, and leads to several diseases, including Alzheimer’s and Parkinson’s. This feed focuses on the genetics and pathology of neurodegenerative diseases.

The innate immune response is an important regulator of the downstream immune response, and it is becoming increasingly evident that immune dysfunction has impacts on the pathogenesis of multiple disease states, including neurodegeneration. Additionally, mutations in several genes involved in the innate immune response have been associated with neurodegeneration. Discover the latest research on innate immunity and neurodegeneration here.

Triggering receptor expressed on myeloid cells 2 (TREM2) is an important gene implicated in neurodegenerative disorders like Alzheimer's Disease, Parkinson's Disease, and Frontotemporal Lobar Degeneration. Discover the latest research studying the molecular mechanisms of TREM2 in neurodegeneration here.

Aberrant T cell activity is known to mediate considerable damage in a variety of disease states, and the immune system has been recognized to contribute to the development of neurodegenerative disorders. It is therefore important to identify the characteristics of T cells involved in the pathogenesis of neurodegenerative diseases. Discover the latest research on T cells and neurodegeneration here.

Patients with neurodegenerative diseases often have an altered composition of the gut microbiome. Novel reports suggest that there is an extensive crosstalk between the gut microbiome and the brain, and this may influence neurodegeneration. Discover the latest research on how the gut microbiome influences neurodegeneration here.

Extracellular vesicles found in human biological fluids may provide insight into the protein profiles of human neurons in various diseases, including Parkinson's disease. Here is the latest research on extracellular vesicles and Parkinson's disease.

The Neurodegeneration Challenge Network aims to provide funding for and to bring together researchers studying neurodegenerative diseases. Find the latest research from the NDCN grantees here.

Microglial proliferation and activation, as well as its concentration around amyloid plaques, is a prominent feature of Alzheimer’s disease. Here is the latest research on microglia and Alzheimer’s disease.

Asthma is a condition in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath. Discover the latest preprints here.

Cognitive neuroscience is the study of biological processes that underlie cognition and addresses the role of neural circuits in regulating cognitive activities. Here are the latest preprints on cognitive neuroscience.

Human immunodeficiency virus (HIV) is a retroviral infection that can lead to acquired immunodeficiency syndrome (AIDS). HIV can be effectively controlled through antiviral drugs to prevent progression to AIDS. Discover the latest preprints on HIV here.

Parkinson’s disease is a progressive neurodegenerative disorder that affects movement. This feed focuses on genetic screening approaches and genetic predispositions in Parkinson’s disease.

Computation neuroscience employs models, statistics, simulations, and theoretical analyses to understand mechanisms that govern neural functions. Here are the latest preprints in this domain.

This feed focuses on Type 2 Diabetes, a disease where the body doesn’t produce or respond to insulin anymore, leading to abnormal glucose levels in the blood.

Cancer genomics employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest preprints here.

The Human Tumor Atlas is a collaborative project that uses detailed maps of a variety of cancers to investigate cancer development, metastasis, and treatments. Discover the latest preprints from the Human Tumor Atlas here.

Genome editing technologies enable the editing of genes to create or correct mutations. Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). Here are the latest preprints on the use of CRISPR-Cas system in gene editing.

MAPK pathway is a complex signaling pathway that regulates transcription, translation, cell cycle, and proliferation. Targeting this pathway has long been considered a promising strategy for cancer therapy. Here is the latest research on this pathway.

Cancer immunotherapy is an important field of research that is looking at controlling cancer and tumor growth by activating the individuals own immune system. Recent studies have utilized chimeric antigen receptor t-cell therapy, immune checkpoint inhibitors and neoantigen vaccines. Discover the latest preprints on cancer immunotherapy here.

Tissue engineering is an interdisciplinary field that aims to create, repair, and/or replace tissues and organs by using biomaterial scaffolds, growth factors, stem cells, and genetic engineering. Discover the latest preprints on tissue engineering here.

Chromatin remodeling is essential for regulation of gene expression, DNA replication, as well as DNA repair. Here is the latest research on chromatin remodeling complexes and mechanisms underlying chromatin remodeling.

Epigenetics is the study of heritable changes in gene expression that do not involve alteration of the DNA sequence. Here are the latest preprints in epigenetics.

RNA Interference (RNAi) pathway is involved in post-transcriptional gene silencing, transcriptional silencing and epigenetic silencing as well as its use as a tool for forward genetics and therapeutics. Discover the latest preprints on RNAi here.

Here are the latest preprints on physiological and in silico networks and circuits implicated in the nervous system.

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

This feed focuses on preprints of projection neurons in the brain which are responsible for synthesis and release of the neurotransmitter dopamine.

Development of gene editing techniques, including CRISPR and TALENs, has relied on mechanisms that underlie DNA repair and genome stability pathways. This feed focuses on the role of DNA repair mechanisms in gene editing and genetic engineering.

Genome editing technologies enable the editing of genes to create or correct mutations. Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). Here is the latest research on the use of CRISPR-Cas system in gene editing.

Proteogenomics is a multi-omics research field that has the aim to efficiently integrate genomics, transcriptomics and proteomics. Here is the latest research on proteogenomics.

Nanoparticles enable the delivery of substances, including nucleic acids and chemotherapeutic drugs, to a targeted region while sparing healthy tissues, thus overcoming adverse systemic effects of gene therapy or drug delivery. Here is the latest research on nanoparticle delivery.

Fluorescence in situ hybridization (FISH) is one of the major techniques used to detect of chromosomal aberrations. Here is the latest research.

Cerebral organoids derived from induced pluripotent stem (IPS) cells have illuminated early developmental events altered by disease processes, and may be a promising avenue for future therapies in neurodegenerative disorders. Here is the latest research on organoids and neurodegeneration.

Differences in genetic backgrounds pose a limitation to studying and inferring genetic mechanisms of diseases. These limitations can be overcome using induced pluripotent stem cell-derived isogenic models of diseases. Here is the latest research.

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Protein function prediction methods are techniques that bioinformatics researchers use to assign biological or biochemical roles to proteins. Discover the latest research on protein function prediction here.

Glycomics, the study of glycans and glycan-binding proteins in various biological systems, is an emerging field in the postgenome and postproteomics era. Here is the latest research.

Circulating free DNA (cfDNA) are degraded DNA fragments released to the blood plasma. cfDNA has been shown to be a useful biomarker for a multitude of ailments other than cancer and fetal medicine. Here is the latest research on Circulating free DNA (cfDNA) sequencing.

Cancer immunotherapy is an important field of research that is looking at controlling cancer and tumor growth by activating the individuals own immune system. Recent studies have utilized chimeric antigen receptor t-cell therapy, immune checkpoint inhibitors and neoantigen vaccines. Discover the latest research on cancer immunotherapy here.

Tissue engineering aims to create, repair, and/or replace tissues and organs by using biomaterial scaffolds, growth factors, stem cells, and genetic engineering. Here is the latest research on biomaterial scaffolds that can be used for tissue therapy.

Adult stem cells have been extensively studied for tissue repair and regeneration. Discover the latest research on stem cell tissue repair here.

Non-coding RNAs (ncRNAs) are RNA molecules that do not code for protein, but can have functional roles in regulating gene expression at the transcriptional and post-transcriptional level. Discover the latest research on the role of ncRNAs in Health and Disease.

Metabolomics refers to the large-scale study of profiling all metabolites in biological systems in a non-targeted manner. Here is the latest research.

This feed focuses on novel advances in medical devices used to manage type I diabetes, such as an artificial pancreas and insulin pumps.

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression through inhibition of protein translation or by degradation of specific transcripts. miRNAs can regulate cardiovascular health, and be potential biomarkers or targets in cardiovascular disease. Discover the latest research on miRNAs in Cardiovascular Biology here.

Genome surgery using CRISPR genomic techniques offer the potential to correct disease-causing mutations in many neuronal disorders. Here are the latest discoveries pertaining to genome surgery and neuronal disorders.

National Institute of Allergy and Infectious Diseases (NIAID) goal is to perform leading research to understand, treat, and prevent infectious, immunologic, and allergic diseases. Follow this feed to stay updated on research from this group.

The KEMRI-Wellcome Institute - Researcher Network was formed through a partnership between Kenya Medical Research Institute formed a partnership with the Welcome Trust and the University of Oxford. Their major research themes are Clinical Research, Population health, Health Systems, Genomics and infectious disease transmission and Vaccines. Follow this feed to stay up to date on work published by this institute.

The International Cancer Genomics Consortium (ICGC) was established to investigate the genomic changes present in many forms of cancer. Follow this feed to stay up to date on research from this institute.

Institut Curie - Centre de Recherche covers multiple areas of research: the biology of radiations, cell signaling and Cancer, second Development biology, Cancer, Genetics and Epigenetics, third integrative tumor biology, immunology and environment, and fourth multiscale Physics-Biology-Chemistry and Cancer. Follow this feed to stay updated on research from this group.

The National Human Genome Research Institute (NHGRI) supports research focusing on genomics related human health and disease. To stay updated on research published by NHGRI follow this feed.

The International Cancer Genome Consortium (ICGC) was founded with the goal of mapping the genome of 25,000 primary untreated cancers. The ICGC has also pushed for the global sharing of genomic data to facilitate cancer research. Find the latest research from the ICGC here.

The Eli and Edythe L. Broad Institute of MIT and Harvard was launched to gain a better understanding of human health and disease through genomics. Find the latest research from the Broad Institute here.

Institute for Stem Cell Biology and Regenerative Medicine, at Stanford University was established in 2002 with the goal of discovering how the stem cells are created regulated, how they differentiate, and ultimately translate this knowledge into new medical therapies. Follow this feed to stay up to date on research published by the members of this institute.

The Neurodegeneration Challenge Network aims to provide funding for and to bring together researchers studying neurodegenerative diseases. Find the latest research from the NDCN grantees here.

European Bioinformatics Institute focuses both on data resource development and investigator-driven research in the field of bioinformatics. Follow this feed to stay up to date on research by this institute.

Find the latest research from the Stanford Medicine Department of Genetics here.

The Chan-Zuckerberg Biohub aims to support the fundamental research and develop the technologies that will enable physicians to cure, prevent, or manage all diseases in our childrens' lifetimes. The CZ Biohub brings together researchers from UC Berkeley, Stanford, and UCSF. Find the latest research from the CZ Biohub researcher network here.

The London School of Hygiene and Tropical Medicine involves cross-disciplinary research groups including laboratory, clinical, population and social sciences, all working to address major public and global health challenges. Their research contributes to health policy and practice in the UK and around the world. Follow this feed to stay up to date on work published by this institute.

Dana-Farber Cancer Institute focuses on advancing cancer tratment through supporting clinical trials and translational research. Follow this feed to stay up to date on research from this institute.

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.

The Collaboration for AIDS Vaccine Discovery (CAVD) focuses on designing a variety of novel HIV vaccine candidates and advancing the most promising candidates to clinical trials. Follow this feed to stay up to date on this important research from the CAVD.

The European Molecular Biology Laboratory (EMBL) research institution focusing on the fundamental understanding of basic biological processes in model organisms. Follow this feed to stay updated on research from the members of this institute.

The Immunological Genome Project (ImmGen) aims to build a gene expression database for murine immune cells. This will allow for the computational reconstruction of genetic regulatory networks across the immune system. Follow the latest research from ImmGen researchers here.

Tetralogy of Fallot is a congenital heart defect with an unknown cause which is typically treated by open heart surgery in the first year of life. Symptoms include bluish skin colour, heart murmur, and finger clubbing. Here is the latest research.

Cystic fibrosis is an autosomal recessive disease, which is the result of a genetic defect in the cystic fibrosis transmembrane conductance regulator (cftr) gene. Here is the latest research on this disease

Li-Fraumeni syndrome in an inherited predisposition to a range of cancers due to a mutation in the tumor suppressor gene TP53. The diagnosis is made if cancer occurs at a young age and there is also a family history of sarcoma or cancer at a young age. Find the latest research on Li-Fraumeni syndrome here.

Fragile X syndrome is caused by an expanded CGG repeat (> 200 repeats) in the 5' untranslated portion of the fragile mental retardation 1 gene (FMR1) within the X chromosome, leading to deficiency of fragile X mental retardation protein (FMRP). It is characterized by cognitive impairment, hyperactivity, seizures, language delay, and enlargement of the ears, head, and testes. Discover the latest research on Fragile X syndrome here.

Neurofibromatosis 1 (NF1), also known as von Recklinghausen disease, is an autosomal dominant condition caused by mutations in the NF1 gene. Here is the latest research.

Cockayne syndrome is a rare multisystem autosomal recessive disorder characterized by severe photosensitive genodermatosis that is associated with premature aging caused by defects in the UV-induced DNA damage repair system. Follow the latest research with this feed.

Castleman disease is a rare disorder that involves an overgrowth of cells in the lymph nodes. Unicentric Castleman disease affects one lymph node, usually in the chest or abdomen. Multicentric Castleman disease affects multiple lymph nodes, commonly located in the neck, collarbone, underarm and groin areas. Discover the latest research on Castleman disease here.

Creutzfeldt-Jakob Disease is a fatal neurodegenerative disease caused by aggregation and accumulation of misfolded prion proteins. Here are the latest discoveries pertaining to this disease.

Multiple myeloma is a cancer of the plasma cells, which normally is involved in antibody production. Discover the latest research on Multiple myeloma here.

Glioblastoma Multiforme (GBM) is a tumor that develops from astrocytes and oligodendrocytes. Here is the latest research on mechanisms that underlie GBM and associated therapeutic approaches.

Hodgkin disease or Hodgkin's lymphoma is a type of lymphoma that affects the lymph system. Here is the latest research on Hodgkin disease.

Rett syndrome is a severe neurological disorder caused by mutations in the X-linked gene methyl-CpG-binding protein 2 (MECP2). Discover the latest research on Rett syndrome here.

Retinitis pigmentosa is a hereditary, progressive degeneration of the retina due to death of rod photoreceptors initially and subsequent death of cone photoreceptors. It is characterized by deposition of pigment in the retina. Discover the latest research on retinitis pigmentosa here.

Huntington's disease is a hereditary neurodegenerative disease characterized by poor coordination and involuntary body movements. Discover the latest research on Huntington's disease here.

Turner syndrome is a syndrome of defective gonadal development in phenotypic females associated with the karyotype 45,X (or 45,XO). Patients generally are of short stature with undifferentiated gonads (streak gonads), sexual infantilism, hypogonadism, webbing of the neck, cubitus valgus, elevated gonadotropins, decreased estradiol level in blood, and congenital heart defects. Discover the latest research on Turner syndrome here.

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

Progressive Supranuclear Palsy (PSP) is a rare neurodegenerative disorder that affects movement, gait, balance, and speech. Discover the latest research on PSP here.

Prader-Willi Syndrome (PWS) is a rare genetic disorder caused by missing or non-working genes on chromosome 15. In infancy, symptoms include hypotonia, feeding difficulties, and delayed development; later on, affected children develop an extreme appetite, typically resulting in obesity. Here is the latest research on this complex multisystem disorder.

Marfan syndrome is an autosomal dominant disorder of connective tissue with abnormal features in the heart, the eye, and the skeleton. It is associated with mutations in the gene encoding fibrillin, a major element of extracellular microfibrils of connective tissue. Discover the latest research on Marfan syndrome here.

The Proceedings of the National Academy of Sciences (PNAS) is a peer-reviewed multidisciplinary scientific journal. Here are the latest research papers from PNAS.

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Science Magazine is a peer-reviewed academic journal of the American Association for the Advancement of Science. Find the latest research from Science here.

Nature is the world's leading multidisciplinary science journal. Discover the latest research from Nature here.

Discover the latest reviews in immunology research in this collection of the top immunology review journals.

Discover the latest cardiology research in this collection of the top cardiology journals.

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.

Discover the latest genomics research in this collection of the top open access genomics journals.

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Discover the latest research from the prestigious journals: Nature, Cell, and Science.

Discover the latest general biology research in this collection of the top biology journals.

Discover the latest respiratory research published by the journals from the American Thoracic Society.

Discover the latest infectious disease research in this collection of the top infectious disease journals.

Discover the latest diabetes research published by the journals from the American Diabetes Association.

Discover the latest reviews in neuroscience research in this collection of the top neuroscience review journals.

The Lancet is a peer-reviewed general medical journal published by Elsevier. Discover the latest research from the Lancet here.

Discover the latest medical research in this collection of the top medical journals.

PLOS Medicine is a peer-reviewed journal covering medical sciences and published by the Public Library of Science. Discover the latest research from PLOS Medicine here.

PLOS Biology is a peer-reviewed journal covering in the field of biology and published by the Public Library of Science. Find the latest research from PLOS Biology here.

Misfolded prion proteins characterize a number of fatal neurodegenerative diseases. Distinct prion strains are associated with different prion protein conformations and glycosylation patterns and associate with disease progression and severity. Here is the latest research on strain diversity and neurotoxicity in prion diseases.

Kennedy Disease, also known as X-linked bulbospinal muscular atrophy, is a progressive neuromuscular disorder caused by mutations in the androgen receptor gene and characterized by wasting of proximal and bulbar muscles. Follow the research into Kennedy Disease with this feed.

LRRK2 has been shown to function as a central regulator of vesicular trafficking, infection, immunity, and inflammation. Mutations in the LRRK2 gene are a risk-factor for developing Parkinson’s disease. Here is the latest research on the role of this kinase on immunity during infection.

Vascular Endothelial Growth Factor B (VEGF-B) is growth factor related to VEGFA, but is not typically involved in blood vessel growth. Discover the latest research on VEGF-B & Angiogenesis here.

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease. Increased kinase activity of certain LRRK2 mutants is thought to underlie dopaminergic neuron damage. Thus, LRRK2 inhibitors offer the potential to target an underlying cause of the disease. Here is the latest research.

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Adult polyglucosan body disease (APBD) is a rare autosomal recessive disease characterized by defects in the glycogen brancher enzyme 1 (GBE1) gene. Discover the latest research on APBD here.

KAT6A Syndrome is a rare genetic disorder characterized by mutations in the lysine acetyltransferase 6A (KAT6A). Patients with KAT6A syndrome have a large range of symptoms, including neurodevelopmental delays and heart defects. Discover the latest research on KAT6A Syndrome here.

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Some key proteins have been identified, but the mechanisms that underlie prion propagation in the brain are still not fully understood. This feed follows the latest research into mechanisms of prion propagation.

Tau vaccination and administration of anti-tau antibodies can prevent pathology and cognitive impairment in transgenic mouse models of tauopathy, suggesting that therapies which increase anti-tau antibodies might slow the development and/or progression of tauopathies including Alzheimer's disease. Here is the latest research.

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Astrocytes are abundant within the central nervous system and their dysfunction has been thought to be an important contributor to some neurodegenerative diseases, in particular Huntington’s disease. Damage to these cells may make neurons more susceptible to degeneration. Here is the latest research on astrocytes and Huntington’s disease.

α-Synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. Here is the latest research on α-synuclein structure and function.

Amyloid beta is a peptide that is a major component of plaques in Alzheimer’s disease (AD). Accumulation induces neurotoxic effects including oxidative damage and mitochondrial dysfunction. Amyliod plaques are being studied as a drug target in the treatment of AD. Here is the latest research on amyloid beta deposition and degradation.

Creutzfeldt-Jakob Disease is a fatal neurodegenerative disease caused by aggregation and accumulation of misfolded prion proteins. Here are the latest discoveries pertaining to this disease.

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here is the latest research on ALS and prions.

Tauopathies are neurodegenerative disorders caused due to misfolding and aggregation of the tau protein in neurofibrillary tangles in the brain. This feed focuses on the structural basis of protein pathology in tauopathies. Here is the latest research.

Mutations in RNA-binding proteins, including TARDBP, have been found in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This feed focuses on molecular mechanisms that underlie ALS and FTD.