The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes.
This feed focuses on the role of the aging process on developing diabetes.
Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.
An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.
The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.
Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.
Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.
Autophagy is a lysosomal pathway that involves degradation of proteins and functions in normal growth and pathological conditions, through a series of complex networks. The catabolic process involves delivery of proteins and organelles to the lysosome. Here is the latest research on autophagy networks.
Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.
This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.
Examining the genomics, transcriptomics, proteomics, and metabolomics of the human thymus gland at the single cell level will help build a single cell atlas of this gland, which would give a unique ID card for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the thymus gland during development and aging. Discover the latest research on the cell atlas of the human thymus here.
Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of neurodegenerative and cardiovascular diseases. This feed focuses on the role of this protein in cerebrovasculature and cerebrovascular dysfunction.
While abilities like vocabulary resist aging, other abilities such as memory, decision-making, and reasoning, gradually decline. Here is the latest research on decision-making and cognitive aging.
This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.
Aging is associated with reproducible changes in DNA methylation, and this epigenetic aging signature can be used to predict biological age. Find the latest research on epigenetic clocks here.
Epigenetic changes, such as changes in histone modification patterns and noncoding RNA expression levels, have a strong influence on the aging process. Discover new insights into the role of epigenetics in aging in this feed.
The evolution of aging involves many different processes including the biology of senescence and has been seen in different animal models including drosophila. The mechanisms underlying the biology of aging and being explored. Discover the latest research on the evolution of aging here.
Forkheadbox-O (FoxO) family of transcription factors are downstream of insulin signaling and are involved in longevity and aging. Discover the latest research on FoxO Signaling in Aging here.
This feed focuses on the genetics and epigenetics of aging. Discover the latest research here.
During aging, it has been shown that genomic instability increases. This leads to mutations, cellular dysfunction, mitochondrial DNA damage, which may increase the risk for neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease and ALS. Here is the latest research on genomic instability associated with aging.
Gut microbiota composition has been implicated in neuroinflammatory responses, as well as brain aging and brain-aging related diseases like amyloid neuropathies. Here is the latest research.
Hematopoiesis is the process by which a limited number of hematopoietic stem cells maintain a functioning blood and immune system. Aging of these stem cells leads to several functional changes, including alterations affecting self-renewal and differentiation. Here is the latest research.
Hutchinson-gilford progeria syndrome is a very rare premature aging disorder that affects children, clinically mimicking physiological aging at a young age. The disease incidence is estimated at 1 in 18 million. Discover the latest research on Hutchinson-gilford progeria syndrome here.
Mapping the human immune system spatially, within and between tissues, will provide the basis for studying mechanisms of tissue residency and the effects of aging. Find new research on analysis of the immune system by multiple approaches here.
Slow, low-grade inflammation occurs during aging, however the mechanisms that are involved are still largely unclear. Pro-inflammatory biomarkers have been associated with cognitive decline and neurodegeneration. Here is the latest research on inflammation during aging.
This membrane trafficking pathway is important in the degradation of proteins and organelles and involves the formation of double membrane autophagosomes that are transported to the lysosome. Here is the latest research on membrane trafficking in autophagy.
This feed focuses on the impact of insulin resistance, caloric restriction, cytokine signaling, and metabolism on dementia and neurodegenerative diseases. Here is the latest research in this domain.
Aging leads to the loss of cellular homeostasis, a decline in physiological function and an increase on pathological substrates. Some of these substrates may include metabolites that may accumulate in tissues and disrupt normal functioning. Discover the latest research on metabolite signals in aging here.
Autophagy is thus a key determinant for mitochondrial health and proper cell function. In addition to autophagy's significance in mitochondrial integrity, several lines of evidence suggest that mitochondria can also substantially influence the autophagic process.
This feed focuses on genetic aspects of neurodegeneration and aging, with emphasis on the role of protein aggregates in neurodegenerative diseases including Alzhiemer’s. Here is the latest research.
Nutrient sensing pathways such as insulin-like growth factor and TOR signaling are being explored for their involvement in aging. Healthy dietary modifications have been shown to slow the progression of aging. Discover the latest research on nutrient-sensing pathways and aging here.
Nutrition improves health and well-being and is one of the important determining factors in successful aging. The mechanism by which nutrition plays a roll in aging is still being unveiled. Discover the latest research on nutrition and aging here.
PARP inhibitors are a novel type of therapeutic agent being investigated for the treatment of some cancer types, particularly targeting tumors that are deficient in the homologous recombination DNA repair pathway. They have shown promise in BRCA mutations in breast cancer. Discover the latest research on PARP inhibitors here.
Poly(ADP-Ribose) Polymerase (PARP) is an enzyme with several functions, including cell differentiation, proliferation, and DNA damage repair. Here is the latest research on PARP.
Proteostasis enables the maintenance of protein homeostasis via modulation of protein translation, enhancement of chaperone capacity and the prompt clearance of misfolded proteins. It is affected in several neurodegenerative diseases. Here is the latest research.
The redox theory of aging is that aging is a decline in plasticity of genome-exposome interaction that occurs as a consequence of execution of differentiation and exposure memory systems. This includes compromised mitochondrial and bioenergetic flexibility, impaired food utilization and metabolic homeostasis, decreased barrier and defense capabilities and loss of reproductive fidelity and fecundity. This theory accounts for hallmarks of aging, including failure to maintain oxidative or xenobiotic defenses, mitochondrial integrity, proteostasis, barrier structures, DNA repair, telomeres, immune function, metabolic regulation and regenerative capacity.
This feed focuses on genetic, epigenetic, and transcriptomic processes pertaining to retinal development and aging. Here is the latest research.
Selective autophagy has been found to be a critical mediator for cellular homeostasis involved with the turnover of proteins, protein aggregates, organelles and pathogens. It has been characterized by distinct cargo receptors that undergo specific mechanisms for degradation. Here is the latest research on selective autophagy.
Diabetes has been found to induce premature senescence of endothelial retinal cells. An increase in senescence-associated cytokines has been found in patients with diabetic retinopathy. Understanding the mechanism and preventing this from occurring is of great importance. Here is the latest research on senescence and diabetic retinopathy.
Senotherapeutics, which selectively kill senescent cells (senolytics) or to suppress the senescence-associated secretory phenotype (SASP) that drives sterile inflammation associated with ageing (senomorphics), have been implicated to be novel strategy for aging intervention applicable to promote healthy aging and to prevent or treat age-related diseases
Autophagy is an important process in degradation of proteins and organelles, survival during nutrient starvation and cellular remodelling. It is regulated by a complex network of signaling cascades. Discover the latest research on signal regulation of autophagy initiation here.
Sirtuins, a family of highly conserved NAD+-dependent lysine-specific deacetylases has recently been suggested to have a critical impact in the direction and regulation of many metabolic pathways as well as energy sensing in mammals. Discover the latest research on sirtuins in metabolic regulation here.
Aging tissues experience a progressive decline in homeostatic and regenerative capacities, which has been attributed to degenerative changes in tissue-specific stem cells, stem cell niches and systemic cues that regulate stem cell activity. Understanding the molecular pathways involved in this age-dependent deterioration of stem cell function will be critical for developing new therapies for diseases of aging that target the specific causes of age-related functional decline.
Telomere shortening is associated with cellular senescence and accelerated aging. Discover the latest research on Telomeres & Aging here.
Vascular Dementia refers to the decline in thinking ability caused by cerebrovascular diseases. Discover the latest research on aspects underlying vascular dementia here.