Autoimmunity & Autoimmune Diseases
Acute disseminated encephalomyelitis (ADEM) is a rare inflammatory demyelinating disease of the central nervous system. Discover the latest research on acute disseminated encephalomyelitis here.
Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.
Adult-onset Still's disease (AOSD) is a form of Still's disease, a rare systemic autoinflammatory disease characterized by the classic triad of persistent high spiking fevers, joint pain, and a distinctive salmon-colored bumpy rash. Discover the latest research on AOSD here.
Anti-N-Methyl-D-Aspartate (NMDA) receptor encephalitis is a form of of brain inflammation due to antibodies against NMDA receptors. Discover the latest research on anti-NMDA receptor encephalitis here.
Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.
Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.
In autoimmune diseases, the immune system responds and attacks self-antigens and damages or impairs the function of the tissues. The treatment for autoimmune diseases often involves immunosuppressive agents, but newer treatments are being investigated. Discover the latest research on autoimmune disease therapy here.
Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.
Autoimmune hemolytic anemia (AIHA) occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst (lyse), leading to an insufficient number of oxygen-carrying red blood cells in the circulation. Discover the latest research on AIHA here.
Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.
Autoimmune lymphoproliferative syndrome (ALPS) is a rare genetic disorder of abnormal lymphocyte survival caused by defective Fas mediated apoptosis. Discover the latest research on ALPS here.
This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.
Autoimmune polyendocrinopathies, also called polyglandular autoimmune syndromes (PGASs), or polyendocrine autoimmune syndromes(PASs), are a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine organ, although non-endocrine organs can be affected. Discover the latest research on autoimmune polyendocrinopathies here.
Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.
Bullous pemphigoid is a chronic and relatively benign subepidermal blistering disease usually of the elderly and without histopathologic acantholysis. Discover the latest research on bullous pemphigoid here.
Chorea is a movement disorder characterized by brief, involuntary, irregular contractions. The contractions appear to flow across adjacent muscles. Chorea may be due to neurodegenerative disorders, structural brain damage, or autoimmune diseases. Find the latest research on chorea here.
Churg-Strauss syndrome, also known as eosinophilic granulomatosis with polyangiitis (EGPA) or allergic granulomatosis, is an extremely rare autoimmune condition that causes inflammation of small and medium-sized blood vessels (vasculitis) in persons with a history of airway allergic hypersensitivity (atopy). Discover the latest research on Churg-Strauss syndrome here.
A healthy and balanced diet is essential for controlling diseases such as multiple scelrosis. Here are the latest discoveries pertaining to diet and this disease.
Encephalitis is a condition of inflammation of the brain parenchyma, occurs as a result of infectious or autoimmune causes, and can lead to encephalopathy, seizures, focal neurological deficits, neurological disability, and death. Here is the latest research.
Experimental autoimmune encephalomyelitis is a commonly used animal model for autoimmune central nervous system diseases, most notably multiple sclerosis. Here is the latest research on experimental autoimmune encephalomyelitis.
Food allergies result from an immune response to food molecules and are classified as either IgE-mediated, non-IgE-mediated or both. Discover the latest research on Food Allergy Pathogenesis here.
Genome-wide association studies have revealed pathways linked to autoimmune disorders and their pathogenesis. Discover the latest research on the Genetics of Autoimmunity here.
Giant cell arteritis is a systemic autoimmune disorder that typically affects medium and large arteries, usually leading to occlusive granulomatous vasculitis with transmural infiltrate containing multinucleated giant cells. Discover the latest research on giant cell arteritis here.
Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis (WG), is a long-term systemic disorder that involves the formation of granulomas and inflammation of blood vessels.Discover the latest research on GPA here.
Graves disease is common form of hyperthyroidism with a diffuse hyperplastic goiter. It is an autoimmune disorder that produces antibodies against thyroid stimulating hormone receptor. These autoantibodies activate the TSH receptor, thereby stimulating the thyroid gland and hypersecretion of thyroid hormones.Discover the latest research on Graves disease here.
Hematopoiesis is the process by which a limited number of hematopoietic stem cells maintain a functioning blood and immune system. Aging of these stem cells leads to several functional changes, including alterations affecting self-renewal and differentiation. Here is the latest research.
IgA glomerulonephritis is a chronic form of glomerulonephritis characterized by deposits of predominantly Iimmunoglobin A in the mesangial area. Discover the latest research on IgA glomerulonephritis here.
Immune tolerance happens when the immune system is not responsive to a substance or organism and does not elicit an immune response. This is a normal physiological response for some antigens, especially when detecting self from non-self. This has been a potential area of therapy for some disorders. Here is the latest research on immune tolerance.
This feed focuses on the role of mutations in immune genes leading to Type 1 Diabetes, an autoimmune disease.
Immunoglobulin G4-related disease is a spectrum of systemic autoimmune diseases in which immunoglobulin G4 plays a pathophysiologic role. It can affect multiple organs in highly variable presentations, characterized by inflammatory lesions composed of IgG4-positive plasma cells, further infiltrated by T helper cells when linked to progressive fibrosis and eventual organ damage. Discover the latest research on immunoglobulin G4-related disease here.
Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.
Juvenile arthritis is any form of chronic arthritis or chronic arthritis-related conditions which affects individuals under the age of 16. Discover the latest research juvenile arthritis.
Lupus vasculitis is a complication of systemic lupus erythematosus in which the autoimmune response causes the deposition of immune complexes within the blood vessels. Discover the latest research on lupus vasculitis here.
Membranoproliferative glomerulonephritis is type of Chronic glomerulonephritis characterized histologically by proliferation of mesangial cells, increase in the mesangial extracellular matrix, and a thickening of the glomerular capillary walls. Discover the latest research on membranoproliferative glomerulonephritis here.
Microscopic polyangiitis is a primary systemic vasculitis of small- and some medium-sized vessels. It is characterized by a tropism for kidneys and lungs, positive association with anti-neutrophil cytoplasmic antibodies (ANCA), and a paucity of immunoglobulin deposits in vessel walls. Discover the latest research on microscopic polyangiitis here.
Multiple Sclerosis is a demyelinating autoimmune disease of the CNS, resulting in symptoms including optic neuritis and motor weakness. Discover the latest research on Multiple Sclerosis here.
Multiple Sclerosis (MS) is a demyelinating autoimmune disease of the CNS, resulting in symptoms including optic neuritis and motor weakness. Here is the latest research on pathology of this complex neurodegenerative disease.
Myocarditis is an acute or chronic inflammatory disease of the myocardium which can be viral, postinfectious immune or primarily organ-specific autoimmune. Discover the latest research on myocarditis here.
Sjogren's syndrome is a chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. Discover the latest research on Sjogren's syndrome here.
Stiff person syndrome is a rare neurological disorder characterised by muscular rigidity and superimposed spasms of the trunk and limbs. Discover the latest research on stiff person syndrome here.
Systemic autoimmunity is a complex disease process that results from a loss of immunological tolerance, characterized by the inability of the immune system to discriminate self from non-self. Discover the latest research on Systemic Autoimmunity here.
Systemic lupus erythematosus is an autoimmune disorder which can affect and damage any organ system in the body. It has a diverse range of immunological manifestations and is more prominent in young women, with the exact etiology still unknown. Here is the latest research on systemic lupus erythematosus.
Currently treatments for autoimmune diseases are anti-inflammatory and immunosuppressive, although recent advances in regulatory T cell therapy have shown promise as a potential therapeutic strategy. Discover the latest research on Therapies for Autoimmunity here.
Transverse myelitis is inflammation of the entire width of the spinal cord. It presents as motor, sensory, or autonomic dysfunction. The cause is not known, but it has been associated with various infections, immune disorders, and demyelination. Find the latest research on transverse myelitis here.
Type 1 diabetes is a chronic disease characterized by progressive immune-mediated destruction of insulin-producing beta cells in pancreatic islets. Here is the latest research.
The brains of individuals with type 1 diabetes display signs of accelerated aging. Furthermore, epidemiological data indicates that a significant portion of the diabetic population exhibits brain changes that are hallmarks of Alzheimer’s disease and vascular dementia. Here is the latest research.
Insulin-producing cells derived from human embryonic stem cells or induced pluripotent stem cells have for long been a promising, but elusive treatment far from clinical translation into type 1 diabetes therapy. Here is the latest research.