This feed focuses on biomimetrics, synthetic biology and bio- and tissue-engineering approaches used for modeling human diseases.
Total artificial hearts (TAH) and ventricular assist devices (VADs) provide cardiac support for patients with end-stage heart disease and have significantly improved the survival of these patients. Discover the latest research on Artificial Heart and Ventricular Assist Devices here.
Advances in biomaterial engineering have permitted the development of sophisticated drug-releasing materials with a biomimetic 3D support that allow a better control of the microenvironment of transplanted cells. Here is the latest research.
Brain organoids are three-dimensional cell culture models derived from human pluripotent stem cells. Since they resemble the embryonic brain, they can be used to help study brain biology, early brain development, and brain diseases. Discover the latest research on brain organoids in disease modeling here.
Over 1700 different mutations in the CFTR genes have been shown to cause cystic fibrosis. Here is the latest research on structural therapy for CFTR mutants.
CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of this system for gene editing and therapy in human diseases.
Genome editing technologies enable the editing of genes to create or correct mutations. Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). Here is the latest research on the use of CRISPR-Cas system in gene editing.
CRISPR-Cas system enables the editing of genes to create or correct mutations. This technology is being investigated to combat malaria by targeting specific stretches of vector DNA and editing the genome at precise locations. Here is the latest research.
Cardiac organoids are 3D organ-like structures that can be derived from patients with cardiovascular diseases and are important disease models for drug discovery. Discover the latest research on Cardiac Organoids here.
Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.
Cerebral organoids are an emerging cutting-edge technology to model human brain development and neurodevelopmental disorders. Here is the latest research.
Diabetes causes microvascular changes known as Diabetic Vasculopathy. This feed focuses on how organoid model systems can be used to study these vascular changes.
Enteroids are organoids derived from the small intestine. Discover the latest research on enteroids here.
Gene therapy is emerging as a potential strategy for the treatment of cardiovascular diseases, such as peripheral arterial disease, ischemic heart disease, restenosis after angioplasty, vascular bypass graft occlusion and transplant-associated coronary artery disease. Discover the latest research on gene therapy for cardiovascular diseases here.
Genetic engineering is a process that alters the genetic structure of an organism by removing or introducing DNA. This technique is being tested to program cells. Discover the latest research on genetic engineering to program cells here.
Genome editing is a powerful tool to study specific mutations or genes involved in the development and progression of cardiovascular disease. Discover the latest research on Genome Editing in Cardiovascular Disease here.
Genome surgery using CRISPR genomic techniques offer the potential to correct disease-causing mutations in many neuronal disorders. Here are the latest discoveries pertaining to genome surgery and neuronal disorders.
Homology-directed repair (HDR) is a double-strand break repair pathway that can be exploited to modify genomes in many organisms. Researchers are now using the CRISPR-Cas system to control the specificity of HDR genome engineering techniques. Here is the latest research.
Mammalian cells & synthetic biology describes the recent advancements in mammalian synthetic biology where new technologies and tools are developed to programm and probe mammalian cell behaviours that can lead to potential therapeutic applications. Discover the latest research on mammalian cells and synthetic biology here.
Microphysiological systems (mps), also known as organs-on-a-chip, are a class of microfluidic platforms that recreate properties of tissue microenvironments.
Nanoparticles enable the delivery of substances, including nucleic acids and chemotherapeutic drugs, to a targeted region while sparing healthy tissues, thus overcoming adverse systemic effects of gene therapy or drug delivery. Here is the latest research on nanoparticle delivery.
Nanopore sequencing is a third generation pproach used in the sequencing of biopolymers- specifically, polynucleotides in the form of DNA or RNA. Discover the latest research on nanopore sequencing.
Blood-brain barrier protects the central nervous system from conventional therapeutics. This feed focuses on the development and use of nanomedicine for neurological diseases.
Neuroregeneration is the growth or repair of neural cells and tissues following damage or injury. Discover the latest research on neuroregeneration here.
Organoids are three-dimensional structures derived from adult or embryonic stem cells, tissues, or tumors, that enable the mimicry of in vivo architecture in tissue culture. Here is the latest research on organoids.
Cerebral organoids derived from induced pluripotent stem (IPS) cells have illuminated early developmental events altered by disease processes, and may be a promising avenue for future therapies in neurodegenerative disorders. Here is the latest research on organoids and neurodegeneration.
Organoids are 3D organ-like structures that can be derived from patient tumor cells to model disease. Discover the latest research here.
Oxygen tension is determined by the balance between net oxygen entering the system and the consumption of oxygen by cells, which can be affected by cell density and type. For instance, hepatocytes consume higher levels of oxygen compared to endothelial cells. Here is the latest research on oxygen tension in liver models.
Using biocompatible and biodegradable peptides in nanomedicine for atherosclerosis provides targeting and therapeutic functionality that can assist in overcoming delivery barriers of traditional drugs and makes them attractive for in vivo use. Here is the latest research.
DNA origami uses a long custom single-stranded DNA scaffold to allow template assembly of numerous short oligonucleotides. Filamentous bacteriophages and related phagemids are excellent sources of scaffolds. Here is the latest research on DNA origami and phagemids.
Plant synthetic biology is an emerging field that aims to engineer genetic circuits to function in plants. Discover the latest research pertaining to plant synthetic biology in this feed.
Single-cell RNA sequencing of the adult human kidney transcriptome can provide molecular information about cell-specific responses to environmental variables and disease states. This information can provide a dataset to benchmark human kidney organoids. Discover the latest research on adult kidney organoids at single cell resolution here.
Recent advance in cellular tissue-engineered skin constructs have refined the applications already commercially available, in particular, by the use of genetically modified cells to enhance their properties on the treatment of wounds and to ease the application of epidermis using sprayed keratinocytes. Here is the latest research on skin constructs.
This feed focuses on the latest research pertaining to mechanisms that facilitate reduction-oxidation biocatalysis only using light energy as a source. Here is the latest research.
This feed describes latest advances in spinal cord regeneration research and potential nerve regeneration treatments after spinal cord injuries.
Tissue engineering is an interdisciplinary field that aims to create, repair, and/or replace tissues and organs by using biomaterial scaffolds, growth factors, stem cells, and genetic engineering. Discover the latest research on tissue engineering here.
Tissue engineering aims to create, repair, and/or replace tissues and organs by using biomaterial scaffolds, growth factors, stem cells, and genetic engineering. Here is the latest research on biomaterial scaffolds that can be used for tissue therapy.
Development of autologous tissue-engineered vascular constructs using vascular smooth muscle cells derived from human induced pluripotent stem cells holds great potential in treating patients with vascular disease. Here is the latest research.
Yeast is a unicellular eukaryote that is utilized and manipulated in biological research to examine biological processes that underlie DNA replication, cell growth, and division, among numerous others. This feed focuses on yeast as a model organism.