Cancer Genetics & Genomics
Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.
Cancer genomics employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research here.
Several sequencing approaches are employed to understand and examine tumor development and progression. These include whole genome as well as RNA sequencing. Here is the latest research on cancer sequencing.
Childhood vascular tumors are formed from cells related to blood vessels or lymph vessels. Here is the latest research on the genetics of childhood vascular tumors.
Cancer cells produce circulating tumor DNA (ctDNA) which can be found in the blood stream using novel high-throughput sequencing technologies. Here is the latest research on ctDNA.
The cause of gliomas is not known, but certain genetic mutations have been associated with the development of gliomas. Recently, the World Health Organization has proposed a new classification of gliomas based upon genetic alterations. Find the latest research research on glioma genomics here.
Metabolic, protein-protein, and gene regulatory networks composed of physical and biochemical interactions between macromolecules are the three main types of interactome networks. Here is the latest research on these networks in cancer.
Long non-coding RNA (lncRNA) are regulatory RNAs exceeding 200 nucleotides in length. LncRNAs are implicated in regulation of gene transcription, post-transcriptional regulation, as well as epigenetic epigenetic regulation. Here is the latest research on lncRNAs and cancer.
Mutations, single nucleotide variants and large genomic rearrangements, in non-coding regions of the genome can have severe consequences such as disruption of transcription factor binding sites and functions of non-coding RNAs and can impact tumor development and progression. Here is the latest research.
Viral infections have been found to be responsible for causing some cancer types in humans. The collection of the viral genome gathered from cancer genome sequencing data can help identify the origin of the cancer. Here is the latest research on oncoviral profiles.