Cell Growth & Cell Cycle
Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.
Key regulators of cell cycle, including cyclins, cyclin dependent kinase inhibitors, DNA replication factors, are controlled by proteolysis. Discover the latest research on cell cycle control and proteolysis.
Computational modeling and the theory of nonlinear dynamical systems allow one to not simply describe the events of the cell cycle, but also to understand why these events occur. Discover the latest research on cell cycle modeling here.
Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.
Centromere identity must be maintained through multiple generations. A new study reveals a Constitutive Centromere-Associated Network (CCAN)-dependent retention of CENP-A, a key epigenetic mark for centromeres, in centromeres during DNA replication and a replication-dependent error correction to eliminate ectopic CENP-A in chromosome arms. Discover the latest research on centromere in DNA replication here.
The centromere is a specialized DNA sequence of a chromosome that links a pair of sister chromatids. During prophase, specialized regions of the centromeres known as kinetochores attach chromosomes to spindle fibers. Here is the latest research on centromeres and the kinetochore.
Collective cell migration is the coordinated movement of cells, which organize tissues during morphogenesis, repair and some cancers. Here is the latest research.
Cyclins and cylin-dependent kinases (CDKs) are two classes of regulatory molecules that determine a cell’s progression through cell cycle. Here is the latest research.
Embryogenesis is the process by which the embryo forms and develops. It starts with the fertilization of the egg cell (ovum) by a sperm cell, (spermatozoon). Once fertilized, the ovum is referred to as a zygote, a single diploid cell. The zygote undergoes mitotic divisions with no significant growth (a process known as cleavage) and cellular differentiation, leading to development of a multicellular embryo
During organogenesis, the endoderm of vertebrates produces tissue within the lungs, thyroid, and pancreas
Gastrulation is a phase early in the embryonic development of most animals, during which the single-layered blastula is reorganized into a multilayered structure known as the gastrula. Before gastrulation, the embryo is a continuous epithelial sheet of cells; by the end of gastrulation, the embryo has begun differentiation to establish distinct cell lineages, set up the basic axes of the body, and internalized one or more cell types including the prospective gut
Gonadogenesis, the process of forming an ovary or a testis from a bipotential gonad, is critical to the development of sexually reproducing adults
The Hippo pathway regulates diverse cellular phenotypes such as organ size, angiogenesis, tissue regeneration and self-renewal. YAP and TAZ important transcriptional coactivators downstream of hippo signaling. Discover the latest research on Hippo Pathway-YAP/TAZ here.
The Human Tumor Atlas is a collaborative project that generates single-cell, multiparametric, and longitudinal maps of different cancers to investigate cancer development, metastasis, and treatments.
Mammalian cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of mammalian cell cycle and growth.
Cytokinesis is the highly regulated process that physically separates daughter and mother cells in late mitosis. The mitotic-exit network (MEN), the signalling pathway that drives mitotic exit, directly regulates cytokinesis. Discover the latest research on mitotic-exit networks with cytokinesis here.
Morphogens are signaling factors that direct cell fate and tissue development at a distance from their source. They are involved in the establishment of positional information that is essential for pattern formation. Here is the latest research.
Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in Parkinson’s disease.
Plant cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of Plant cell cycle and growth.
Phosphorylation-dependent changes orchestrate almost every step of cell division, from entry into mitosis to cytokinesis. These changes are mediated by several different protein kinases, including the Aurora and Cyclin-dependent kinases. Here is the latest research examining the role of protein kinases in mitosis.
Specialized telomeric proteins, as well as DNA repair and checkpoint proteins with a dual role in telomere maintenance and DNA damage signaling/repair, protect telomere ends from degradation. Here is the latest research on telomeres and cell cycle checkpoints.
The addition of ubiquitin to a protein substrate via a multistep process is referred to as ubiquitination, which can have a variety of different effects on the protein including flagging the protein for degradation, altering its location or activity, or altering protein-protein interactions. Dysreguation of this pathway has been implicated in multiple disease processes.