This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.
Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.
Cell signaling is a vital mechanism for communication within cells and outside with the environment. Several different signaling pathways have been found and advanced imaging techniques are being developed to visualize the molecules involved in these signaling pathways. Find the latest research in advanced imaging of cellular signaling here.
Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.
Caveolins are small proteins with a hairpin loop conformation that are located in the plasma membrane of various cell types where they bind cholesterol and interact with receptors essential for several signal transduction pathways. Here is the latest research.
Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.
Cytokines are proteins that are released by a subset of immune cells and play a role in intercellular communication, cell proliferation, differentiation, and survival. Discover the latest research on the influence of cytokine signaling on transcription here.
Dynamin GTPases are proteins that are responsible for endocytosis in cells, as well as division of organelles, cytokinesis, and pathogen resistance. Discover the latest research on dynamin GTPases here.
Extracellular vesicles are cell-derived structures containing complex cargo, including proteins and nucleic acids, that originate from endosomal systems or the plasma membrane. Here is the latest research on technologies for the analysis of extracellular vesicles.
The fibroblast growth factor signaling pathway is an evolutionary conserved signaling cascade that regulates several basic biologic processes, including tissue development, angiogenesis, and tissue regeneration. Here is the latest research.
Forkheadbox-O (FoxO) family of transcription factors are downstream of insulin signaling and are involved in longevity and aging. Discover the latest research on FoxO Signaling in Aging here.
G-protein-coupled receptors (GPCRs), the largest family of integral membrane proteins, participate in the regulation of many physiological functions and are the targets of approximately 30% of currently marketed drugs. Here is the latest research.
GFRAL is a receptor for growth differentiation factor 15 (GDF15). These proteins play a role in regulating inflammatory pathways, as well as cell repair, apoptosis, and cell growth. Here is the latest research on GFRAL/GDF15-mediated signal transduction.
GLP-1 signaling pathway has been well studied for its role in regulating glucose homeostasis, as well as its beneficial effects in energy and nutrient metabolism. Discover the latest research on this signaling pathway here.
GPCRs are membrane receptors implicated in the pathophysiology of various diseases. Several GPCRs, including GLP-1 receptor, glucagon receptor, and adiponectin receptor, are also involved in metabolic regulation and homeostasis. Here is the latest research.
G-protein coupled receptors (GPCRs) are membrane receptors implicated in the pathophysiology of various diseases, including neurodegenerative disorders, infectious diseases, and cancer. Here is the latest research on GPCR signaling pathway.
Gap junctions are specialized intercellular communication channels that transfer molecules between neighboring cells and thereby alter intracellular signaling and metabolism. Here is the latest research on the influence of gap junctions on intercellular signaling.
The JAK/STAT signaling pathways is important for various processes including immunity, cell division, cell death, and tumor formation. Recent data has implicated this pathway in metabolic diseases including type 2 diabetes and obesity. Here is the latest research.
Lipids are water-insoluble molecules that make up the cell membrane and play an essential role in functioning as second messengers, hormones, and in signal transduction. Here is the latest research on lipid signaling in human diseases.
MAPK pathway is a complex signaling pathway that regulates transcription, translation, cell cycle, and proliferation. Targeting this pathway has long been considered a promising strategy for cancer therapy. Here is the latest research on this pathway.
Morphogens are signaling factors that direct cell fate and tissue development at a distance from their source. They are involved in the establishment of positional information that is essential for pattern formation. Here is the latest research.
Nrf2 facilitates the recruitment of inflammatory cells, regulates expression of anti-inflammatory genes through the antioxidant response element, and plays a role in regulation of the inflammasome. Here is the latest research on Nrf2 signaling in inflammation.
This feed focuses on the family of Protein Kinase C (PKC), which are serine/threonine kinases. These kinases depend on calcium, phospholipids and diacylglycerols for activity.
This feed focuses on post-translational modifications (PTMs) that occur on transcription factors, which may affect transcriptional processes.
Phosphoproteomics refers to the identification and quantification of phosphorylated proteins in the proteome. This approach provides a high-throughput method of examining the state of intracellular phosphorylation. Here is the latest research on phosphoproteomics.
The redox theory of aging is that aging is a decline in plasticity of genome-exposome interaction that occurs as a consequence of execution of differentiation and exposure memory systems. This includes compromised mitochondrial and bioenergetic flexibility, impaired food utilization and metabolic homeostasis, decreased barrier and defense capabilities and loss of reproductive fidelity and fecundity. This theory accounts for hallmarks of aging, including failure to maintain oxidative or xenobiotic defenses, mitochondrial integrity, proteostasis, barrier structures, DNA repair, telomeres, immune function, metabolic regulation and regenerative capacity.
Reactive oxygen species (ROS) are reactive chemicals containing oxygen which may have complex roles in promoting the development of neurodegenerative diseases. They are generated as a byproduct of oxidative energy metabolism and play a role in regulating several intracellular signaling pathways. Here is the latest research on ROS metabolism and signaling in neurodegeneration.
Autophagy is an important process in degradation of proteins and organelles, survival during nutrient starvation and cellular remodelling. It is regulated by a complex network of signaling cascades. Discover the latest research on signal regulation of autophagy initiation here.
Expression of genes are thought to be involved in signaling pathways, which are important for cell growth, metabolism, apoptosis and more. It is thought that gene expression plays a part in the signaling pathways that implicates the biological effects of the cell. Here is the latest research on signal transduction and the control of gene expression.
The Sonic Hedgehog signaling pathway regulates developmental processes including cell patterning and differentiation and plays a role in tissue repair and regeneration. Here is the latest research on this complex signal transduction pathway.
T lymphocyte proliferation and differentiation are controlled by signaling pathways initiated by the T cell antigen receptor. Discover the latest research here on how key serine-threonine kinases and their substrates mediate T cell signaling and coordinate T cell metabolism to meet the metabolic demands of participating in an immune response
Ubiquitin is a small regulatory protein that is attached to proteins as a post-translational modification in a process known as ubiquitination to regulate protein turnover, location, or activity. Here is the latest research on the ubiquitin system.
Wnt signal transduction pathway is regulated by several molecules and is critical for embryonic development, cell proliferation, differentiation, and tissue patterning. Here is the latest research on Wnt signaling.
Wound healing involves many cells including, platelets, neutrophils, macrophages and fibroblasts. These molecules release cytokines such as interleukins, tumor necrosis factor alpha and growth factors that largely manage the inflammatory phase of healing and promote the recruitment of additional cells. Here is the latest research on wound healing cells and signals.