Chemical Biology of the Cell
AFM in situ DNA describes in situ analysis (or study) of DNA using atomic force microscopy. Discover the latest research on AFM in situ DNA here.
Bacterial protein structures can expedite the development of novel antibiotics. Here is the latest research on bacterial proteins and the resolution of their structures.
Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.
Cholesterol is essential for a variety of cellular processes, including cell growth and division, and it plays an important role in various signaling pathways. Here is the latest research on cholesterol synthesis and the role of cholesterol in cell signaling.
This feed focuses on cytochromes, including cytochrome C and the cytochromes P450 (CYP) enzyme system, and their involvement in the activation and inactivation of drugs.
Gangliosides are sialic acid-containing glycosphingolipids concentrated on cell surfaces and found in abundance in the nervous system. Gangliosides have several functions, including a role in cholesterol absorption. Here is the latest research.
Glycation refers to the covalent binding of a sugar molecule to a protein or lipid. Advanced glycation end proteins (AGEs) have been implicated in several diseases including neurogenerative diseases, diabetes, and atherosclerosis. Here is the latest research on glycation and AGEs.
Glycolipids are amphitropic compounds with one or more monosaccharide residues glycosidically linked to a lipid. Discover the latest research on glycolipids here.
Intrinsically disordered proteins exhibit biological activity even though they lack a well-defined 3D structure in solution. Here is the latest research on their role in cells.
Lipid metabolism refers to the synthesis and degradation of lipids in cells and is a complex process essential for fat storage and construction of cellular membranes. Discover the latest research on lipid and membrane metabolism here.
Lipid droplets are cellular organelles that store neutral lipids enclosed in a phospholipid monolayer. They are at the centre of lipid and energy homeostasis, and several metabolic diseases including obesity and diabetes. Here is the latest research on lipid droplet biology.
Lipid metabolism is important in several cellular processes and functions including signal transduction. Disorders of lipid metabolism can occur impairing normal function. Here is the latest research on lipid metabolism and lipid disorders.
Lipidomics is a branch of metabolomics that comprehensively analyses lipids in biological systems to determine the molecules with which they interact and their function within the cell. Here is the latest research.
The cellular membrane is composed of diverse lipid molecules that help maintain membrane integrity and homeostasis. Discover the latest research on Lipids & Membrane Homeostasis
This feed focuses on axonal transport pathways and the role of lysosomes and axon cargo transport in maintaining homeostasis in neurons.
This feed focuses on the C9orf72 protein and its possible role in lysosome function and implication in frontotemporal dementia and amyotrophic lateral sclerosis
Cytochrome P450 (CYP450) are a family of enzymes involved in two major processes, such as the synthesis of fatty acids, steroids, and biles acids, and the metabolism of toxins and drugs. Discover the latest research on the Mechanisms of CYP450 enzymes here.
This feed focuses on biochemical techniques used for isolating and purifying membrane proteins from cells. Discover the latest research on Membrane Protein Extraction here.
Membrane proteins are found on cellular and intracellular membranes, and play important roles such as signal transduction, transport and enzymatic functions. Discover the latest research on the structure and function of membrane proteins here.
This feed focuses on Membrane Transport proteins and their dysfunction which can lead to heart disease. Discover the latest research on Membrane Transport in Heart Failure.
The intestinal microbiome is responsible for metabolism of bile acids and generation of the bile acid pool. Discover the latest research on Microbes: Cholesterol & Bile Acid.
This feed focuses on the role of the mitochondria and cholesterol on neurodevelopmental disorders (ND).
Mitochondria can sense ecm composition changes, and changes in mitochondrial functioning modify the ecm. Discover the latest research on how mitochondrial changes affect diabetic nephropathy.
There is emerging evidence that mitochondria are involved in post-translational modifications and may be involved in metabolic diseases. Discover the latest research on mitochondria protein regulation.
Cellular respiration occurs in the mitochondria and an important hub for metabolic processes that is dysregulated in cancer. Discover the latest research here.
Mitochondrial metabolism links energy production to other essential cellular processes such as signaling, cellular differentiation, and apoptosis. Discover the latest research here.
This feed focuses on the role of mitochondrial networks and energy metabolism in muscle cells. Discover the latest research here.
N-glycan synthesis is the process where a N-glycan consisting of a large number of monosaccharides that are linked to a nitrogen, is produced. In eukaryotes, N-linked glycans are derived from a core 14-sugar unit assembled in the cytoplasm and endoplasmic reticulum (ER). First, two N-acetyl glucosamine residues are attached to dolichol monophosphate, a lipid, on the external side of the ER membrane. Five mannose residues are then added to this structure. At this point, the partially finished core glycan is flipped across the ER membrane, so that it is now located within the reticular lumen. Assembly then continues within the ER, with the addition of four more mannose residues. Finally, three glucose residues are added to this structure. Following full assembly, the glycan is transferred en bloc by the glycosyltransferase oligosaccharyltransferase to a nascent peptide chain, within the reticular lumen. This core structure of N-linked glycans, thus, consists of 14 residues (3 glucose, 9 mannose, and 2 N-acetylglucosamine). Discover the latest research on N-glycan synthesis here.
Orangellar TRP channels are transient receptor potential (TRP) channels mediate Ca2+ flux and voltage changes across membranes in response to environmental and cellular signals. Discover the latest research on organellar TRP channels here.
Oxygenation is a chemical production that introduces oxygen atom into an organic compound. Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound. In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases. Cytochrome P450 (CYP) enzymes are expressed mainly in the liver and are active in mono-oxygenation and hydroxylation of various xenobiotics, including drugs and alcohols, as well as that of endogenous compounds such as steroids, bile acids, prostaglandins, leukotrienes and biogenic amines. Here is the latest research.
Phosphorylation is the attachment of a phosphoryl group, which is often provided by ATP, to a protein by a specific type of enzyme called kinase. Discover the latest research on phosphorylation here.
Ubiquitin is a small regulatory protein that is attached to proteins as a post-translational modification in a process known as ubiquitination to regulate protein turnover, location, or activity. Here is the latest research on the ubiquitin system.
tRNA modifications are partial or minor changes on tRNA that result in different version of the original tRNA. Discover the latest research on tRNA modification here.