Computational & Bioinformatic Methods
Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.
RNA sequencing is used to reveal the presence and quantity of RNA in a given sample. In this feed, RNA sequencing investigates the genetic and molecular mechanisms related to the pathophysiology of Alzheimer's disease (AD). Here are the latest discoveries pertaining to RNA sequencing and this disease.
The open source software R / Bioconductor is used for statistical analysis and visualization, with continual generation of new analysis packages and updates. Find the latest research on programming and Bioconductor here.
Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.
CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on CRISPR-Cas applications relevant to single cell analyses. Here is the latest research.
Cancer genomics employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research here.
Several sequencing approaches are employed to understand and examine tumor development and progression. These include whole genome as well as RNA sequencing. Here is the latest research on cancer sequencing.
Chromatin Immunoprecipitation followed by sequencing (ChIP-seq) is a genome-wide technique used to map histone marks and protein binding (ie transcription factors) on chromatin. This can reveal insight into the regulation and dynamics of gene expression. Discover the latest research on ChIP-seq here.
Inter/Intra-Species: Comparative Sequencing describes the sequencing techniques that compare between and within species genomes. Discover the latest research on comparative sequencing of inter/intra-species here.
Computational benchmarking studies aim to rigorously compare the performance of different bioinformatic methods using well-characterized datasets. Discover the latest research on Benchmarking Computational Methods here.
Computational pathology is an approach to diagnosis that incorporates multiple sources of data (e.g., pathology, radiology, clinical, molecular and lab operations); uses mathematical models to generate diagnostic inferences; and presents clinically actionable knowledge to customers. This vision goes beyond an informatics-centric view and leverages the core competency of pathology and the ability to effectively communicate clinically actionable knowledge. Discover the latest research on computational pahtology here.
Consumer genomics is a rapidly advancing industry with the ability to gather large databases of genetic information of individual data. This information will allow people the ability to adapt their lifestyle and potentially modify disease trajectories in the future. Discover the latest research on consumer genomics here.
Investigating human cellular proteins through a combination of highly multiplexed imaging and proteomic analyses can help characterize all human cells at the proteomic level. Discover the latest research on deep visual proteomics here.
CRISPR-Cas system enables the editing of genes to create or correct mutations. However, its high frequency of off-target activity is a major concern, especially for therapeutic and clinical applications. This feed focuses on methods that can detect CRISPR off-target activity.
This feed describes how digital interventions, which are digital and mobile technologies used to support health system needs, can complement and improve pharmacotherapy in disease management. Discover the latest research on drug and digtial intervention here,
Expression Quantitative Trait Loci (eQTL) analysis is the identification of specific or groups of genetic variants that affect gene expression levels within the cell. Discover the latest research on Expression Quantitative Trait Loci Analysis here.
Forensic dna profiling through the use of epigenetics and DNA methylation
Genome annotation is the process of identifying genes and assigning function to each gene in a genome sequence. It provides the means to elucidate biological function from sequence. Here is the latest research.
Recent developments in genomics and further development of advanced post-genomic technologies, it will be possible to apply a more holistic analysis to genomic analysis. Discover the latest research in Genomic Techniques.
Glycomics, the study of glycans and glycan-binding proteins in various biological systems, is an emerging field in the postgenome and postproteomics era. Here is the latest research.
Recent advances in next-generation sequencing have enabled faster and more accurate haplotyping methods to detect variants across a chromosome. Discover the latest research on Haplotyping here.
Mapping the human liver by combining transcriptomics, spatial organization, and cell-cell interactions will facilitate the study of liver disease and the development of novel therapeutics. This feed includes new research on analysis of the human liver.
Metabolic, protein-protein, and gene regulatory networks composed of physical and biochemical interactions between macromolecules are the three main types of interactome networks. Here is the latest research on these networks in cancer.
Interactomics is the intersection of bioinformatics and biology concerned with investigating the interaction and the consequences of these interactions between proteins in a cell. Here is the latest research on interactomic data in neurodegeneration.
Lipidomics is a branch of metabolomics that comprehensively analyses lipids in biological systems to determine the molecules with which they interact and their function within the cell. Here is the latest research.
The transcriptome and proteome of the human male testis is being mapped to better understand its molecular functioning and disease pathology. Using methods such as mass spectrometry, FISH, and RNA sequencing, the human testis can be mapped successfully. Discover the latest research on mapping the transcriptome and proteome of the human testis here.
Metabolomics refers to the large-scale study of profiling all metabolites in biological systems in a non-targeted manner. Here is the latest research.
Prion diseases are fatal neurodegenerative and infectious disorders characterized by structural transition of the host-encoded cellular prion protein into the aberrantly folded pathologic isoform of the protein. Here is the latest research on molecular diagnostic strategies for prion diseases.
Here is the latest research on scientific methods, processes, algorithms, and systems pertaining to the nervous system.
Neuroscience integrates data from anatomical, biological, developmental, and mathematical models to understand the nervous system. Here is the latest research on genomics in neuroscience.
Omics are used to understand the gene expression profile and proteomics of many diseases. This feed focuses on the omics of myocardial infarction and heart failure. Here are the latest discoveries pertaining to this disease.
Perturb-seq has combined CRISPR gene inactivation and single-cell rna-sequencing (scRNA-seq) and is the newest addition to the geneticist's arsenal, providing scientists with study methods for functional genomics. Discover the latest research here.
Pharmacogenetics and pharmacogenomics (pgx) are rapidly growing fields that aim to elucidate the genetic basis for the interindividual differences in drug response. Here is the latest research on pharmacogenetics and pharmacogenomics.
Protein function prediction methods are techniques that bioinformatics researchers use to assign biological or biochemical roles to proteins. Discover the latest research on protein function prediction here.
Proteogenomics is a multi-omics research field that has the aim to efficiently integrate genomics, transcriptomics and proteomics. Here is the latest research on proteogenomics.
Serotonin is a multifaceted neurotransmitter with various functions, including reward and learning. Discover the latest research on the computational landscape of serotonin here.
Single cell sequencing (scs) can be harnessed to acquire the genomes, transcriptomes and epigenomes from individual cells. Here is the latest research on single cell sequencing.
Single cell transcriptomics enables the examination of gene expression at an individual cell level by measuring mRNA concentration of genes. Here is the latest research.
Single-cell RNA sequencing is a technique that is used to study an isolated selection of single-cells and obtaining their transcripts which are then used to generate sequence libraries. These can then be used to assess the diversity in the brain and understand neurological diseases. Here is the latest research on single-cell RNA in the brain.
Single-cell technologies are used to help scientists profile gene and protein expression levels in a variety of diseases including cancer. Here is the latest research on single-cell tumor analysis.
Structural variations, such as insertions, deletions, inversions, and duplications, are a common feature in human genomes, and a number of studies have reported that such variations are associated with human diseases. Here is the latest research focusing on structural variation detection.
Structure-based drug design (sbdd) combines the power of many scientific disciplines, such as x-ray crystallography, nuclear magnetic resonance, medicinal chemistry, molecular modeling, biology, enzymology and biochemistry, in a functional paradigm of drug development. Here is the latest research on sbdd.
Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.
Tau Aggregation is an important characteristic in some neurodegenerative disorders, including Alzheimer’s Disease. Discover the latest research using genomics to understand Tau Aggregation.
Despite advances in DNA sequencing technology, assembly of complex genomes remains a major challenge, particularly for genomes sequenced using short reads, which yield highly fragmented assemblies. Here is the latest research on de novo genome assembly.