Diabetes & Acquired Metabolic Diseases
This feed focuses on the role of the aging process on developing diabetes.
This feed focuses on mechanisms that underlie cellular plasticity as a treatment for diabetes and other degenerative diseases.
Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.
Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.
Asprosin is a fasting-induced hormone produced in the white adipose tissue to stimulate the hepatic release of glucose into the bloodstream. Discover the latest research on this protein hormone here.
Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.
Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.
This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.
Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.
COVID-19 (short for “Coronavirus Disease 2019") is the disease caused by the novel coronavirus, SARS-CoV-2. Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. COVID-19 represents a particular challenge to people with serious chronic medical conditions such as diabetes. To keep our community as informed as possible, the American Diabetes Association is partnering with the Chan Zuckerberg Initiative's Meta to highlight the latest research developments at the intersection of COVID-19 and diabetes.
This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.
Glucagon-like peptide 1 (GLP-1) plays a role in glucose metabolism, energy homeostasis, and inflammation suppression. GLP-1 receptor signaling has been shown to impact cardiovascular function. This feed focuses on the role of GLP-1 and GLP-1 receptor agonists on cardiovascular biology.
Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.
Caspases, the family of cysteine proteases are involved in programmed cell death, but their role in metabolic diseases, inflammation and immunity has been of interested. Discover the latest research on caspases in metabolic diseases here.
Circadian rhythms are essential for regulation of physiological and biochemical processes and its disruptions are associated with deleterious metabolic outcomes and diseases. Here is the latest research on circadian clocks and type 2 diabetes.
Clinical lipidology focuses on diagnosis, pathophysiology, and clinical management of lipid and lipoprotein disorders. Here is the latest research.
This feed focuses on the complications of diabetes, including diabetic nephropathy, ketoacidosis, cardiomyopathy, and neuropathy.
Epidemiological data indicate that a significant portion of the diabetic population exhibits brain changes that are hallmarks of Alzheimer’s disease and vascular dementia. However, direct biological links remain incompletely understood. Here is the latest research in this area.
Epidemiological evidence suggests that the diabetic population has a significantly higher risk of developing cancer. However, biological links between these diseases remain elusive. Discover the latest research on diabetes and cancer here.
Immune Checkpoint Inhibitors are novel treatments for cancer, but their use has been associated with increased risk of developing type I diabetes. Discover the latest research here.
This feed focuses on novel advances in medical devices used to manage type I diabetes, such as an artificial pancreas and insulin pumps.
This feed focuses on Diabetic Kidney Disease, where microvascular defects associated with diabetes leads to kidney function decline. Discover the latest research here.
Diabetes causes microvascular changes known as Diabetic Vasculopathy. This feed focuses on how organoid model systems can be used to study these vascular changes.
This feed focuses on the dyslipidemia, a disorder in lipid metabolism that leads to abnormal levels of lipids in patients with diabetes.
This feed focuses on morbidity aspects, disease management, prevalence studies, and distribution patterns and determinants in the diabetic population. Here is the latest epidemiological research.
While type 2 diabetes (T2D) is heritable, less than 20% of this heritability is explained by known genetic variants. This discrepancy maybe explained by epigenetic changes and epigenetic inheritance in pancreatic cells. Here is the latest research on the epigenetic control of beta cell function and failure in T2D.
GLP-1 signaling pathway has been well studied for its role in regulating glucose homeostasis, as well as its beneficial effects in energy and nutrient metabolism. Discover the latest research on this signaling pathway here.
GPCRs are membrane receptors implicated in the pathophysiology of various diseases. Several GPCRs, including GLP-1 receptor, glucagon receptor, and adiponectin receptor, are also involved in metabolic regulation and homeostasis. Here is the latest research.
Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.
This feed focuses on genetic factors that predisposes diabetic patients to cardiovascular (CV) disease. Discover the latest research here.
There exist several gender differences in mechanisms that underlie glucose homeostasis. These include the sex-specific effects of testosterone and estrogen and the prevalence and incidence of diabetes, among others. Here is the latest research.
Glycation refers to the covalent binding of a sugar molecule to a protein or lipid. Advanced glycation end proteins (AGEs) have been implicated in several diseases including neurogenerative diseases, diabetes, and atherosclerosis. Here is the latest research on glycation and AGEs.
Glycolipids are amphitropic compounds with one or more monosaccharide residues glycosidically linked to a lipid. Discover the latest research on glycolipids here.
The feed focuses on the emerging role of Gut Microbiota, also known as the gastrointestinal microbiome, in Type 2 Diabetes. Deficiency in gut microbiota has been linked to type 2 diabetes.
Histone deacetylases (HDACs) are key epigenetic regulators of metabolic homeostasis. Here is the latest research on HDACs in obesity.
Hepatokines are liver-derived proteins that regulate glucose and lipid metabolism. This feed focuses on the role of hepatokines in cardiovascular disease and diabetes.
This feed focuses on the role of mutations in immune genes leading to Type 1 Diabetes, an autoimmune disease.
Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.
The JAK/STAT signaling pathways is important for various processes including immunity, cell division, cell death, and tumor formation. Recent data has implicated this pathway in metabolic diseases including type 2 diabetes and obesity. Here is the latest research.
High blood glucose levels can damage the glomerulus and lead to thickening of the glomerular basement membrane, over time resulting in kidney deterioration and failure. At present, there is no cure. Here is the latest research on kidney diseases in individuals with type 2 diabetes.
Metabolic flux analysis is an important method for the quantitative estimation of intracellular metabolic flows through metabolic pathways and the elucidation of cellular physiology. Here is the latest research.
Metabolic pathways have been used as drug targets in the development of therapeutic compounds. Change of metabolic pathways can render the loss of therapeutic effects, a mechanism that is commonly found in drug resistance. Discover the latest research on metabolic pathways and drug resistance here.
Metabolic syndrome is characterized by obesity, insulin resistance, dyslipidemia and hypertension. It significantly increases the risk for cardiovascular and disease and type 2 diabetes. Increasing prevalence has been associated with the increasing rates of obesity worldwide. Here is the latest research on the metabolic syndrome.
The constellation of dyslipidemia (hypertriglyceridemia and low levels of high-density lipoprotein cholesterol), elevated blood pressure, impaired glucose tolerance, and central obesity is now classified as metabolic syndrome, also called syndrome X. It is considered to be a precursor of cardiovascular disease. Discover the latest research on metabolic syndrome and cardiovascular disease here.
Metabolic syndrome is a complex disorder characterized by a cluster of metabolic abnormalities including hypertension, obesity, type 2 diabetes, and dyslipidemia. Here is the latest research on metabolic syndrome and type 2 diabetes mellitus.
This feed focuses on the role of metalloproteins in metabolic processes, including the role of iron-sulfur (Fe-S) proteins in cellular respiration as well as DNA and RNA metabolism.
Mitochondria can sense ecm composition changes, and changes in mitochondrial functioning modify the ecm. Discover the latest research on how mitochondrial changes affect diabetic nephropathy.
This feed focuses on Non-Alcoholic Fatty Liver Disease (NAFLD) in diabetic patients, which can lead to increased medical complications, such as cirrhosis.
Nutrition can be used to prevent and manage chronic conditions by combining dietary interventions with personalized factors such as genetic background or metabolic profile. This feed focuses on dietary modifications for the management of diabetes.
Obesity is becoming a major health concern and epidemic worldwide. It is regarded as a systemic, low-grade inflammatory state and has been linked to several diseases, one of major importance is cardiovascular diseases. Here is the latest research on obesity and cardiovascular diseases.
This feed focuses on the potential role of omega-3 fatty acid supplementation in patients with diabetes, such as reducing cardiovascular disease.
Oxidative stress plays a critical role in the development of many diseases including microvascular and cardiovascular complications in diabetes. Here is the latest research on the role of oxidative stress in diabetes.
This feed focuses on the identification of genomic, epigenetic, transcriptomic, and proteomic signatures in pancreatic cells derived from diabetic patients. Here is the latest research.
Patients with prediabetes syndrome have abnormally high blood glucose levels, thereby increasing the risk of developing diabetes and vascular complications. Discover the latest research here.
Proinsulin, a prohormone precursor to insulin, is produced in beta cells of pancreatic islets. Here is the latest research on proinsulin in type 2 diabetes.
This feed looks at the emerging role of epigenetic modifications, such as those that occur on RNA that may affect function in various diseases. Discover the latest research on RNA Modifications in Diabetes.
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are novel anti-diabetic drugs that lowers blood glucose. This feed focuses on the role of SGLT2i in diabetes and reducing heart failure.
Diabetes has been found to induce premature senescence of endothelial retinal cells. An increase in senescence-associated cytokines has been found in patients with diabetic retinopathy. Understanding the mechanism and preventing this from occurring is of great importance. Here is the latest research on senescence and diabetic retinopathy.
Sirtuins, a family of highly conserved NAD+-dependent lysine-specific deacetylases has recently been suggested to have a critical impact in the direction and regulation of many metabolic pathways as well as energy sensing in mammals. Discover the latest research on sirtuins in metabolic regulation here.
Patients with Type I diabetes lack insulin-producing cells. Stem cell therapies can potentially generate insulin-producing cells for transplantation. Discover the latest research here.
Type 1 diabetes is a chronic disease characterized by progressive immune-mediated destruction of insulin-producing beta cells in pancreatic islets. Here is the latest research.
The brains of individuals with type 1 diabetes display signs of accelerated aging. Furthermore, epidemiological data indicates that a significant portion of the diabetic population exhibits brain changes that are hallmarks of Alzheimer’s disease and vascular dementia. Here is the latest research.
This feed focuses on Type 2 Diabetes, a disease where the body doesn’t produce or respond to insulin anymore, leading to abnormal glucose levels in the blood.
Insulin-producing cells derived from human embryonic stem cells or induced pluripotent stem cells have for long been a promising, but elusive treatment far from clinical translation into type 1 diabetes therapy. Here is the latest research.