Drug Development & Biopharmaceutics
Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.
Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.
Anthrax toxin, comprising protective antigen, lethal factor, and oedema factor, is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in humans and animals. Here is the latest research on Anthrax.
Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.
Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.
Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.
Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.
An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.
Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.
Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.
Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.
Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.
Beta-lactamase inhibitors are a class of antibiotics that inhibit beta-lactamases, a family of enzymes involved in bacterial resistance to beta-lactam antibiotics. Here is the latest research.
Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.
Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.
Cephalosporins are a class of beta-lactam antibiotics used for prophylaxis and treatment of infections caused by bacteria susceptible to these antibiotics, including gram-positive bacteria Staphylococcus and Streptococcus. More recent generations of this drug class also exhibits some activity against gram-negative bacteria. Here is the latest research.
Biomaterial-based delivery systems based on micro- and nanoparticles that encapsulate plasmid DNA represent the most promising strategy for DNA vaccine delivery. Microparticulate delivery systems allow for passive targeting to antigen presenting cells through size exclusion and can allow for sustained presentation of DNA to cells through degradation and release of encapsulated vaccines. In contrast, nanoparticle encapsulation leads to increased internalization, overall greater transfection efficiency, and the ability to increase uptake across mucosal surfaces. Discover the latest research on DNA vaccine delivery here
This feed describes how digital interventions, which are digital and mobile technologies used to support health system needs, can complement and improve pharmacotherapy in disease management. Discover the latest research on drug and digtial intervention here,
This feed describes how bioconjugation, a covalent linking between the drug molecule and a biomolecule, can alter (facilitate or impede) drug delivery in living organisms. Discover the latest research on bioconjugation in drug delivery here
Drug efflux transporters, such as P-glycoprotein (Pgp), multidrug resistance proteins (MRPs) or organic anion transporting polypeptides (OATPs), transport drug molecules out of the cells. Discover the latest research on drug efflux transporters here.
Drug persistance is the duration of time from initiation to discontinuation of therapy.Discover the latest research on drug persistence here,
Drug-induced diseases (DID) also called as iatrogenic diseases. Most of these DIDs are largely preventable, if strict vigilance and proper periodic clinical and diagnostic monitoring are undertaken
The recent ebola outbreak in west Africa has stressed the need for advances in research to develop a vaccine against this deadly virus. Much progress has been made in pre-clinical and clinical studies and future vaccines for the ebola virus look promising. Here is the latest research on ebola vaccines.
Eectrospinning a versatile and the most preferred technique for the fabrication of nanofibers has revolutionized by opening unlimited avenues in biomedical fields. Electrospinning is being used for fabricating nanofibers for various biomedical and dental applications such as tooth regeneration, wound healing and prevention of dental caries. Discover the latest research on electrospinning and nanofibers here.
Glycopeptide antibiotics are drugs composed of a glycosylated cyclic or polycyclic non-ribosomal peptides. Examples invoice vancomycin, teicoplanin, bleomycin, etc. Here is the latest research on glycopeptide antibiotics.
Glycylcycline are a class of antibiotics derived from tetracycline to overcome mechanisms of tetracycline resistance. Discover the latest research on these antibiotics in this feed.
The development to make HIV vaccines for both the prevention and treatment of HIV infection is ongoing. Some individuals with HIV infection produce antibodies which suppress the virus and allow the patients to remain asymptomatic, suggesting that a vaccine may be achievable. Find the latest research on HIV vaccines here.
The influenza virus is a common viral infection that can rapidly evolve and render previous vaccines ineffective. There are two types of FDA approved drug treatments for the influenza virus, neuraminidase inhibitors and M2-inhibitors. Discover the latest research on influenza drug therapy here.
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects movement. The drug Inosine is proposed to slow progression of this disease. Here is the latest research on Inosine in PD.
Leprostatics are anti-infective agents that inhibit the growth of Mycobacterium leprae, the bacteria that causes leprosy. Here is the latest research on leprostatics.
Research for development of a malaria vaccine is currently underway to find an effective modality to control and eliminate the transmission of malaria. To date, no vaccine has been found to be efficacious in fighting against malaria. Here is the latest research on malaria vaccines.
Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.
Nanoparticles enable the delivery of substances, including nucleic acids and chemotherapeutic drugs, to a targeted region while sparing healthy tissues, thus overcoming adverse systemic effects of gene therapy or drug delivery. Here is the latest research on nanoparticle delivery.
Blood-brain barrier protects the central nervous system from conventional therapeutics. This feed focuses on the development and use of nanomedicine for neurological diseases.
Opioids work on opioid receptors to relieve pain and other medical symptoms. Here is the latest research on the therapeutic role of opioids and opioid receptors in pain management.
Oxazolidinones are a class of synthetic antibiotics that inhibit the ribosomal 50S subunit of bacteria, thus preventing the formation of the 70S initiation complex essential for bacterial reproduction. Discover the latest research on this class of antibiotics in this feed.
Protacs, which induce selective degradation of their target protein via the ubiquitin-proteasome system, are useful for the down-regulation of various proteins, including disease-related proteins and epigenetic proteins. Here is the latest research on protacs.
Penicillin is a group of antibiotics that can be administered intravenously or intramuscularly to treat bacterial infections caused by staphylococci and streptococci. While they are still widely used today, many bacteria have developed resistance to penicillin. Here is the latest research on penicillins.
Pharmacogenetics and pharmacogenomics (pgx) are rapidly growing fields that aim to elucidate the genetic basis for the interindividual differences in drug response. Here is the latest research on pharmacogenetics and pharmacogenomics.
Polypharmacologic drug screening is the screening of pharmaceutical agents that act on multiple targets or disease pathways. Discover the latest research on polypharmacologic drug screening here,
Psychoactive drugs are psychotherapeutic drugs used to modify emotions and behavior in the treatment of psychiatric illnesses. Here is the latest research on psychoactive drugs and the pathways they modulate.
Quinolones are a class of broad-spectrum antibiotics used against a wide range of bacteria. Examples include lomefloxacin, ofloxacin, and norfloxacin. Discover the latest research on quinolones and their derivatives in this feed.
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are novel anti-diabetic drugs that lowers blood glucose. This feed focuses on the role of SGLT2i in diabetes and reducing heart failure.
Selectins are a class of lectin molecule expressed on endothelial cells that permit leukocyte rolling and eventual extravasation. Targeting selectins may prove useful in modifying inflammation and for drug delivery to the endothelium.
Structure-based drug design (sbdd) combines the power of many scientific disciplines, such as x-ray crystallography, nuclear magnetic resonance, medicinal chemistry, molecular modeling, biology, enzymology and biochemistry, in a functional paradigm of drug development. Here is the latest research on sbdd.
Sulfonamide is a functional group found as the base of several classes of drugs. Sulfonamides can act as synthetic antimicrobial agents, anti-diabetics, diuretics, anticonvulsants, etc. Here is the latest research.
Tetracycline is an oral antibiotic used to treat a number of infections including cholera, plague, malaria, and syphilis. It is also the first line of treatment for several diseases including Rickettsia and Lyme disease. Here is the latest research.
Vitamin K-dependent carboxylases generate gamma-carboxyglutamic acids with malonate moieties by modifying glutamate residues in vitamin K-dependent proteins. This feed focuses on cellular mechanisms regulated by vitamin K-dependent carboxylases.
The challenges in developing a safe and effective Zika virus vaccine include limiting side effects such as Guillain-Barré syndrome, a potential consequence of Zika virus infection. Discover the latest research on Zika vaccines here.