Enzymes & Catalytic Processes
ATP synthases are enzymes located in the inner mitochondrial membrane that catalyze the synthesis of ATP during cellular respiration. Discover the latest research on ATP synthases here.
This feed focuses on biomimetrics, synthetic biology and bio- and tissue-engineering approaches used for modeling human diseases.
This feed focuses on broad characteristics of the CRISPR system and the proteins associated with it.
Biosyntheic transformtions are multi-step, enzyme-catalyzed processes where substrates are converted into more complex products in living organisms. Simple compounds are modified, converted into other compounds, or joined together to form macromolecules. Discover the latest research on biosynthetic transformations here.
This feed focuses on structure and function of coenzymes in catalytic reactions, including cellular redox systems.
This feed focuses on cytochromes, including cytochrome C and the cytochromes P450 (CYP) enzyme system, and their involvement in the activation and inactivation of drugs.
The electron transport chain (ETC) facilitates the transfer of electrons through redox while transferring protons across the membrane into the intermembrane space. This feed focuses on the structure and mechanism of the ETC as well as mitochondrial disorders caused by defects in the oxidative phosphorylation pathway.
This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.
This feed focuses on axonal transport pathways and the role of lysosomes and axon cargo transport in maintaining homeostasis in neurons.
This feed focuses on the C9orf72 protein and its possible role in lysosome function and implication in frontotemporal dementia and amyotrophic lateral sclerosis
Cytochrome P450 (CYP450) are a family of enzymes involved in two major processes, such as the synthesis of fatty acids, steroids, and biles acids, and the metabolism of toxins and drugs. Discover the latest research on the Mechanisms of CYP450 enzymes here.
This feed focuses on the role of metalloproteins in metabolic processes, including the role of iron-sulfur (Fe-S) proteins in cellular respiration as well as DNA and RNA metabolism.
Nucleic acid enzymes, natural and engineered, are catalytic proteins that act on DNA and RNA. Discover the latest research on nucleic acid enzymology here.
Oxygenation is a chemical production that introduces oxygen atom into an organic compound. Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound. In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases. Cytochrome P450 (CYP) enzymes are expressed mainly in the liver and are active in mono-oxygenation and hydroxylation of various xenobiotics, including drugs and alcohols, as well as that of endogenous compounds such as steroids, bile acids, prostaglandins, leukotrienes and biogenic amines. Here is the latest research.
Poly(ADP-Ribose) Polymerase (PARP) is an enzyme with several functions, including cell differentiation, proliferation, and DNA damage repair. Here is the latest research on PARP.
Fumarate Reductase is an enzyme that uses fumarate and quinol as substrates to generate succinate and quinone and has several biological functions, including a role in anaerobic respiration. Here is the latest research.
Ribozymes are catalytic RNAs that interact with a variety of small molecule substrates and cofactors, the intracellular abundance of which are sensed by riboswitches that modulate transcription, RNA stability, or translation. Here is the latest research.
Vitamin K-dependent carboxylases generate gamma-carboxyglutamic acids with malonate moieties by modifying glutamate residues in vitamin K-dependent proteins. This feed focuses on cellular mechanisms regulated by vitamin K-dependent carboxylases.