Epigenetics & Epigenomics
This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.
Angelman syndrome is a neurogenetic imprinting disorder caused by loss of the maternally inherited UBE3A gene and is characterized by generalized epilepsy, limited expressive speech, sleep dysfunction, and movement disorders. Here is the latest research.
Beckwith-Wiedemann syndrome is an imprinting disorder characterized by overgrowth, congenital malformations and predisposition to tumors. Discover the latest research on Beckwith-Wiedemann Syndrome here.
Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.
The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.
Chromatin remodeling is essential for regulation of gene expression, DNA replication, as well as DNA repair. Here is the latest research on chromatin remodeling complexes and mechanisms underlying chromatin remodeling.
Chromatin remodeling is essential for regulation of gene expression, DNA replication, as well as DNA repair. Here is the latest research on chromatin remodeling complexes and mechanisms underlying chromatin remodeling.
DNA methylation is an epigenetic mechanism of gene regulation, and dysregulation of DNA methylation has been associated with tumorigenesis. Discover the latest research on DNA methylation here.
Targeted epigenetic interventions provide the tools to prevent nociceptive sensitization, mood-related symptoms, and other adaptations that occur in response to injury or inflammation, which will facilitate pain management and improve treatment efficacy in many chronic pain conditions. Here is the latest research on the epigenetics changes in pain.
Aging is associated with reproducible changes in DNA methylation, and this epigenetic aging signature can be used to predict biological age. Find the latest research on epigenetic clocks here.
Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.
Epitranscriptomics is a scientific field that studies epigenetic modifications on RNA. Here is the latest research pertaining to epitranscriptomics and mechanisms that underlie RNA modifications.
Epigenetic regulation of gene expression is important in determining cell fate and identity, and may be factor in altering risk or progression of cardiovascular disease. Discover the latest research on Epigenetic Regulation of Cardiovascular Disease here.
Microglial cells are instrumental in the maintenance of homeostasis in the CNS and can contribute to neurodegenerative disorders. Epigenetic mechanisms and transcriptional regulation may be potential therapeutic targets for their activation or suppression. Discover the latest research on epigenetic regulation of microglial functions here.
Epigenetic regulation involves chromatin remodeling complexes that catalyze DNA methylation changes and various types of histone modifications that can influence the expression of genes involved in neural development. Discover the latest research on the epigenetic regulation of neural development here.
Epigenetics is the study of heritable changes in gene expression that do not involve alteration of the DNA sequence. Here is the latest research.
Epigenetic changes, such as changes in histone modification patterns and noncoding RNA expression levels, have a strong influence on the aging process. Discover new insights into the role of epigenetics in aging in this feed.
Find the latest research on epigenetics and twin studies here.
While type 2 diabetes (T2D) is heritable, less than 20% of this heritability is explained by known genetic variants. This discrepancy maybe explained by epigenetic changes and epigenetic inheritance in pancreatic cells. Here is the latest research on the epigenetic control of beta cell function and failure in T2D.
Epigenetic regulation of gene expression is important in determining cell fate and identity, and is a factor in stem cell studies involving cardiomyocyte differentiation. Discover the latest research on Epigenetics in Cardiomyocyte Differentiation here.
Myotonic Dystrophy is an autosomal dominant neuromuscular disorder associated with the expansion of CTG trinucleotide repeats in the 3’ untranslated region of the myotonic dystrophy protein kinase (DMPK) gene. Here is the latest research focusing on epigenetic modifications in myotonic dystrophy.
Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.
Recent advances in epigenome engineering technologies allow now for the large-scale assessment of the functional relevance of dna methylation. Discover the latest research here.
Genomic imprinting is an epigenetically regulated process whereby genes are selectively silenced based on their parent-of-origin, leading to monoallelic expression. Discover the latest research on genomic imprinting here.
Histone deacetylases (HDACs) are key epigenetic regulators of metabolic homeostasis. Here is the latest research on HDACs in obesity.
Heterochromatin is condensed chromatin that was previously believed to be inaccessible for transcription, although this has been disproven. Heterochromatin plays a role in gene expression. Find the latest research on heterochromatin here.
Histone acetyltransferases are important chromatin modifying enzymes that catalyze acetylation of specific lysine residues in histone and nonhistone substrates to regulate gene expression. Here is the latest research.
Histone deacetylases (HDACs) are a class of chromatin modifying enzymes that remove specific acetyl groups from histones, allowing the histones to wrap DNA more tightly, thus leading to alterations in gene expression. Here is the latest research.
Histone methyltransferases, as chromatin modifiers, regulate the transcriptomic landscape in normal development as well in diseases such as cancer. Here is the latest research.
Histone modifications, including acetylation, phosphorylation, and methylation, play important roles in regulating chromatin structure and nuclear processes. They can also be passed to daughter cells as epigenetic marks. Here is the latest research on histone modification.
Histone variants substitute for canonical histones and can play important roles in development. Mutations in histone variants have been associated with tumourigenesis. Discover the latest research on Histone Variants here.
Epigenetic marks on histones can lead to gene expression via transcription or repression. Recently, it was discovered that histones marks not only play a role in gene expression but are also crucial for RNA splicing. Discover the latest research on histones and splicing here.
The 3-D organization of chromatin is an important factor in the regulation of gene expression. Find the latest research on nuclear architecture here.
Nucleosome positioning influences transcription by regulating the chromatin accessibility to transcriptional machinery and chromatin remodelling proteins. Discover the latest research on Nucleosome Positioning here.
This feed focuses on the Polycomb Group Proteins, which are protein complexes that are recruited to chromatin and are involved in the deposition of repressive histone marks, leading to gene repression.
Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.
Prader-Willi Syndrome (PWS) is a genetic disorder caused due to the absent expression of a set of genes on chromosome 15. Here is the latest research on this complex multisystem disorder.
The RNA-induced Silencing Complex mediates gene silencing through direct mRNA degradation or translational inhibition. Discover the latest research on the RNA-induced Silencing Complex here.
RNA Interference (RNAi) pathway is involved in post-transcriptional gene silencing, transcriptional silencing and epigenetic silencing as well as its use as a tool for forward genetics and therapeutics. Discover the latest research here.
Mutations in SMCHD1 are associated with several human diseases including a severe form of muscular dystrophy. Recent studies have found this protein to be essential for X chromosome inactivation. Here is the latest research.
Epigenetic modifications are carried out by proteins and protein complexes, many of which become dysregulated during diseases including cancer. Identifying structures of epigenetic machinery will shed light on proteins that govern various epigenetic processes and may aid in advancing therapeutics for certain diseases. Here is the latest research.
Uniparental Disomy occurs when one inherits two homologous chromosomes from a single parent and can lead to genetic disorders. Discover the latest research on Uniparental Disomy here.
X inactivation is a mechanism of dosage compensation via the expression of x inactive-specific transcript (XIST) and transcriptional silencing of the entire chromosome. Discover the latest research on X inactivation here.