Gene Targeting & Editing
Acute myeloid leukaemia (AML) is a common hematological type of cancer. As the population ages, there has been a rise in the frequency of AML. RNA expression has been used to see if there are different genetic profiles that exist within AML and whether these may underpin the variations in survival rates. Here is the latest research on AML and RNA.
The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.
The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.
Over 1700 different mutations in the CFTR genes have been shown to cause cystic fibrosis. Here is the latest research on structural therapy for CFTR mutants.
CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on mechanisms that underlie deactivation of CRISPR ribonucleases. Here is the latest research.
CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.
Genome editing technologies enable the editing of genes to create or correct mutations. Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). Here is the latest research on the use of CRISPR-Cas system in gene editing.
CRISPR-Cas system enables the editing of genes to create or correct mutations. Given that genome instability and mutation is one of the hallmarks of cancer, the CRISPR-Cas system is being explored to genetically alter and eliminate cancer cells. Here is the latest research.
CRISPR-Cas system enables the editing of genes to create or correct mutations. This technology is being investigated to combat malaria by targeting specific stretches of vector DNA and editing the genome at precise locations. Here is the latest research.
The CRISPR-Cas system is a gene editing technique that can be used for high-throughput genome-wide screens to identify modes of actions of novel antibiotics. Here is the latest research.
Development of gene editing techniques, including CRISPR and TALENs, has relied on mechanisms that underlie DNA repair and genome stability pathways. This feed focuses on the role of DNA repair mechanisms in gene editing and genetic engineering.
Genetic circuits are essential for many biological processes including oscillation (e.g. the cell cycle), cell differentiation, patterning of multicellular tissues, and cellular response to environmental signals. Here is the latest research on editing these genetic circuits.
Gene therapy is emerging as a potential strategy for the treatment of cardiovascular diseases, such as peripheral arterial disease, ischemic heart disease, restenosis after angioplasty, vascular bypass graft occlusion and transplant-associated coronary artery disease. Discover the latest research on gene therapy for cardiovascular diseases here.
Genetic epidemiology examines the role of genetic factors in determining health and disease in populations and the interaction between these genetic factors with environmental factors. Here is the latest research on the genetic epidemiology of complex multifactorial diseases like cancer.
Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.
The genetic aspects of the endocrine system, including hormones and hormone metabolism is the focus of this feed. Here is the latest research on genetics and metabolic hormones.
This feed focuses on genetic factors that predisposes diabetic patients to cardiovascular (CV) disease. Discover the latest research here.
Anorexia Nervosa is a psychiatric disease that can be severely debilitating and life-threatening. Genetic associations have discovered abnormalities on chromosome 12. Other genetic risk factors are being investigated to discern if there are other genetic and familial links. Here is the latest research pertaining to this disease.
Genome editing technologies enable the editing of genes to create or correct mutations or express genes of interest. Here is the latest research on genome editing in T- cells and their application in human diseases such as adoptive T-cell immunotherapy for cancer.
Genome editing is a powerful tool to study specific mutations or genes involved in the development and progression of cardiovascular disease. Discover the latest research on Genome Editing in Cardiovascular Disease here.
Genome surgery using CRISPR genomic techniques offer the potential to correct disease-causing mutations in many neuronal disorders. Here are the latest discoveries pertaining to genome surgery and neuronal disorders.
Recent developments in genomics and further development of advanced post-genomic technologies, it will be possible to apply a more holistic analysis to genomic analysis. Discover the latest research in Genomic Techniques.
Homology-directed repair (HDR) is a double-strand break repair pathway that can be exploited to modify genomes in many organisms. Researchers are now using the CRISPR-Cas system to control the specificity of HDR genome engineering techniques. Here is the latest research.
Parkinson’s disease is a progressive neurodegenerative disorder that affects movement. This feed focuses on genetic screening approaches and genetic predispositions in Parkinson’s disease.
Mutations in SMCHD1 are associated with several human diseases including a severe form of muscular dystrophy. Recent studies have found this protein to be essential for X chromosome inactivation. Here is the latest research.
Transcription activator-like effectors (TALEs) and TALE nucleases (TALENs) enable gene editing by targeting specific DNA sequences in the genome. Here is the latest research.
Targeted gene repair is a technique that can be used to change the DNA sequence at a specific site in the genome to either correct or introduce a genetic mutation. Here is the latest research on targeted gene correction.
Transposons can replicate and spread through the host’s genome and therefore be used as a genetic tool for analysis of gene function. Discover the latest research on the use of transposons for gene editing here.
Base editing systems, including those using a uracil DNA glycosylase inhibitor, expand the scope and efficiency of genome editing technologies. The latest research in that area can be found in this feed.
This feed focuses on the virology of CRISPR and its use in developing CRISPR-Cas systems. Discover the latest research here.
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression through inhibition of protein translation or by degradation of specific transcripts. miRNAs can regulate cardiovascular health, and be potential biomarkers or targets in cardiovascular disease. Discover the latest research on miRNAs in Cardiovascular Biology here.