Genomics & Medical Genomics
The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.
Artificial chromosomes are genetically engineered chromosomes derived from the DNA of a species. Discover the latest research on artificial chromosomes here.
Biodiversity refers to the variety and variability of life on Earth. Biodiversity is typically a measure of variation at the genetic, species, and ecosystem level.Discover the latest research on biodiversity data here.
Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.
CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on CRISPR-Cas applications relevant to single cell analyses. Here is the latest research.
CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.
Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). CRISPR-Cas system enables the editing of genes to create or correct mutations. Discover the latest research on CRISPR here.
CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of this system for gene editing and therapy in human diseases.
CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on mechanisms that underlie deactivation of CRISPR ribonucleases. Here is the latest research.
CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.
Genome editing technologies enable the editing of genes to create or correct mutations. Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). Here is the latest research on the use of CRISPR-Cas system in gene editing.
CRISPR-Cas system enables the editing of genes to create or correct mutations. Given that genome instability and mutation is one of the hallmarks of cancer, the CRISPR-Cas system is being explored to genetically alter and eliminate cancer cells. Here is the latest research.
CRISPR-Cas system enables the editing of genes to create or correct mutations. This technology is being investigated to combat malaria by targeting specific stretches of vector DNA and editing the genome at precise locations. Here is the latest research.
The CRISPR-Cas system is a gene editing technique that can be used for high-throughput genome-wide screens to identify modes of actions of novel antibiotics. Here is the latest research.
A variety of different high-throughput technologies can be used to identify the complete catalog of changes that characterize the molecular profile of cohorts of tumor samples. Discover the latest insights gained from cancer 'omics' in this feed.
Chromosome abnormalities can be classified as either structural or numerical. Numerical abnormalities include duplications or deletion of a pair of chromosomes, such as Down Syndrome. Structural abnormalities include missing, extra or switched parts of a chromosome. Discover the latest research on chromosomal abnormalities here.
Chromosomal deletion includes the loss of a gene sequence of DNA. The location and the genes deleted determines the significance of this abnormality. There are many identified genetic disorders that are a result from chromosomal deletion including cri du chat and Prader-Willi syndrome. Discover the latest research on chromosomal deletions here.
Chromosomal duplication is a result of extra genetic material within the area of the chromosome. The duplication may have no effect or may be expressed in the phenotype of that individual. Some duplications are thought to be of evolutionary selection. Discover the latest research on chromosomal duplication here.
Chromosomal Translocation occur when regions on two chromosomes breaks and swaps places or when a region is attached to another chromosome. Discover the latest research on Chromosomal Translocation here.
Consumer genomics is a rapidly advancing industry with the ability to gather large databases of genetic information of individual data. This information will allow people the ability to adapt their lifestyle and potentially modify disease trajectories in the future. Discover the latest research on consumer genomics here.
DNA repair is critical to prevent detrimental mutations and maintain genomic stability that can otherwise lead to disease and disability. There are a number of different mechanisms of repair including base excision repair, direct repair, nucleotide excision repair and double-strand break repair. Discover the latest research on DNA repair here.
DNA replication is initiated as specific gene sequences, called origins, that function to start DNA replication. Pre-replication complexes are assembled at these origins during the G1 phase of the cell cycle. These sequences allow for targeted activation or deactivation of replication. Discover the latest research on DNA replication origins here.
Current studies of genome-wide DNA replication profiles have focused on the dna replication timing and origin location.
CRISPR-Cas system enables the editing of genes to create or correct mutations. However, its high frequency of off-target activity is a major concern, especially for therapeutic and clinical applications. This feed focuses on methods that can detect CRISPR off-target activity.
Exon skipping is a method of RNA splicing used when a mutation occurs in the genes of exons. It is regulated largely by the use of antisense oligonucleotides that mask the mutated gene and allow the cellular machinery to skip over it. Exon skipping is being investigated as a therapeutic option for some diseases. Here is the latest research on exon skipping.
Forensic dna profiling through the use of epigenetics and DNA methylation
This feed focuses on the high throughput technologies used to dissect the genetics of behavior and their associated disorders. Discover the latest research here.
Genome editing technologies enable the editing of genes to create or correct mutations or express genes of interest. Here is the latest research on genome editing in T- cells and their application in human diseases such as adoptive T-cell immunotherapy for cancer.
Genome surgery using CRISPR genomic techniques offer the potential to correct disease-causing mutations in many neuronal disorders. Here are the latest discoveries pertaining to genome surgery and neuronal disorders.
During aging, it has been shown that genomic instability increases. This leads to mutations, cellular dysfunction, mitochondrial DNA damage, which may increase the risk for neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease and ALS. Here is the latest research on genomic instability associated with aging.
Genomic organization refers to the three-dimensional structure of chromosomes and the positioning of DNA sequence within the nuclei. Discover the latest research on genomic organization in this feed.
Recent developments in genomics and further development of advanced post-genomic technologies, it will be possible to apply a more holistic analysis to genomic analysis. Discover the latest research in Genomic Techniques.
The cause of gliomas is not known, but certain genetic mutations have been associated with the development of gliomas. Recently, the World Health Organization has proposed a new classification of gliomas based upon genetic alterations. Find the latest research research on glioma genomics here.
Glycomics, the study of glycans and glycan-binding proteins in various biological systems, is an emerging field in the postgenome and postproteomics era. Here is the latest research.
Homology-directed repair (HDR) is a double-strand break repair pathway that can be exploited to modify genomes in many organisms. Researchers are now using the CRISPR-Cas system to control the specificity of HDR genome engineering techniques. Here is the latest research.
The Human Tumor Atlas is a collaborative project that generates single-cell, multiparametric, and longitudinal maps of different cancers to investigate cancer development, metastasis, and treatments.
Metabolomics refers to the large-scale study of profiling all metabolites in biological systems in a non-targeted manner. Here is the latest research.
MicroRNAs are small non-coding RNAs that modulate gene expression at post-transcriptional level, playing a crucial role in cell differentiation and development. Discover the latest research on MicroRNAs & how they target Open Reading Frames.
Nanopore sequencing is a third generation pproach used in the sequencing of biopolymers- specifically, polynucleotides in the form of DNA or RNA. Discover the latest research on nanopore sequencing.
Neuroscience integrates data from anatomical, biological, developmental, and mathematical models to understand the nervous system. Here is the latest research on genomics in neuroscience.
Gene therapy and protein engineering strategies, guided by biological principles, are allowing ligands and receptors to be developed as next-generation therapeutics with improved safety and efficacy. Discover the latest research here.
Nuclear pore complexes are large macromolecules composed of individual proteins called nucleoporins. These complexes perforate the nuclear envelope and allow the exchange of substances between the nucleus and the cytoplasm. Here is the latest research on nuclear pore complexes.
Nucleotide excision repair is a DNA repair mechanism that is critical in the removal of a variety of DNA damages caused by UV light, chemical carcinogens causing bulky adducts, some oxidative damage and environmental mutagens. Discover the latest research on nucleotide excision repair here.
Omics' methods are used to understand the gene expression profile and proteomics of many diseases. This feed focuses on omics analyses of myocardial infarction. Here are the latest discoveries pertaining to this disease.
Viral infections have been found to be responsible for causing some cancer types in humans. The collection of the viral genome gathered from cancer genome sequencing data can help identify the origin of the cancer. Here is the latest research on oncoviral profiles.
This feed focuses on the identification of genomic, epigenetic, transcriptomic, and proteomic signatures in pancreatic cells derived from diabetic patients. Here is the latest research.
Perturb-seq has combined CRISPR gene inactivation and single-cell rna-sequencing (scRNA-seq) and is the newest addition to the geneticist's arsenal, providing scientists with study methods for functional genomics. Discover the latest research here.
Pharmacogenetics and pharmacogenomics (pgx) are rapidly growing fields that aim to elucidate the genetic basis for the interindividual differences in drug response. Here is the latest research on pharmacogenetics and pharmacogenomics.
Pharmacogenomics studies how medicine interacts with inherited genes. Here is the latest research on pharmacogenomics in cancer.
Post-transcriptional RNA modifications can be dynamic and might have functions beyond fine-tuning the structure and function of rna.
Proteogenomics is a multi-omics research field that has the aim to efficiently integrate genomics, transcriptomics and proteomics. Here is the latest research on proteogenomics.
ADAR enzymes are responsible for a-to-i rna editing, an essential post-transcriptional rna modification contributing to transcriptome and proteome diversification.
The majority of human genes that encode proteins undergo alternative pre-mRNA splicing and mutations that affect splicing are more prevalent than previously thought. Discover the latest research on RNA Splicing here.
Ribozymes are catalytic enzymes that are made entirely of ribonucleic acid. These enzymes cleave the complementary mRNA sequence and are being studied as potential therapies for some dominantly inherited diseases. Discover the latest research on ribozymes here.
Single cell sequencing (scs) can be harnessed to acquire the genomes, transcriptomes and epigenomes from individual cells. Here is the latest research on single cell sequencing.
Single cell transcriptomics enables the examination of gene expression at an individual cell level by measuring mRNA concentration of genes. Here is the latest research.
Spliceosomes are massive RNA protein macromolecules that are cellular machinery involved in the splicing and removal of the non-coding segments of DNA and the ligation of coding segments, exons. Discover the latest research on spliceosomes here.
Transcription activator-like effectors (TALEs) and TALE nucleases (TALENs) enable gene editing by targeting specific DNA sequences in the genome. Here is the latest research.
Tau aggregation is an important characteristic in some neurodegenerative disorders, including Alzheimer’s Disease. Discover the latest research using genomics to understand Tau aggregation.
Telomere dysfunction in response to critical telomere shortening induces dna damage checkpoints that lead to cell cycle arrest and/or cell death.
Telomere elongation by telomerase counteracts the telomere shortening due to the incomplete replication of chromosome ends by dna polymerase.
The HIV genome is composed of two identical single-stranded RNA molecules. It contains nine genes encoding fifteen structural and regulatory viral proteins. Find the latest research on the HIV genome here.
Transposable elements (tes) have profound effects on the structure, function and evolution of their host genomes.
Base editing systems, including those using a uracil DNA glycosylase inhibitor, expand the scope and efficiency of genome editing technologies. The latest research in that area can be found in this feed.
This feed focuses on the virology of CRISPR and its use in developing CRISPR-Cas systems. Discover the latest research here.
Yeast is a unicellular eukaryote that is utilized and manipulated in biological research to examine biological processes that underlie DNA replication, cell growth, and division, among numerous others. This feed focuses on yeast as a model organism.
Zinc-finger nucleases are engineered restriction enzymes that enable gene editing by targeting specific DNA sequences in the genome. Here is the latest research.
mtDNA transcription generates the necessary RNAs that encode several protein subunits involved in the oxidative phosphorylation process. Here is the latest research.