Antibody engineering technologies are constantly advancing to improve the clinical effectiveness of monoclonal and bispecific antibodies. Discover the latest research on Antibody Engineering here.
Immunometabolism involves not only the way metabolites are digested by the immune system, but the way in which they can alter the pathway of the immune system. These responses occur in day-to-day healthy cell functioning, but can result in diseases, such as autoimmune disorders. Discover the latest research on cellular immunometabolism here.
Co-operation of immune cells in both innate and adaptive immunity is essential in mounting an appropriate immune effector cell response. Discover the latest research on Co-operation of Effector Responses here.
Cross-priming is the process whereby professional APC, mainly dendritic cells, prime t-cells by presenting antigens processed from proteins of other cells such as tumor cells or virus-infected cells. Discover the latest research on cross-priming here.
Follicular t helper cells are an important subset of helper t-cells which help to the formation of germinal centers and b-cells differentiation. Discover the latest research on follicular t helper cells here.
Immune complexes are formed by the binding of antibodies to soluble antigens eliciting an immune response and are prevalent in autoimmune diseases. Discover the latest research on Immune Complexes here.
Abnormal immune system maturation is influenced by microbial stimulation and is believed to be a driving force behind the increase in allergies among children. Discover the latest research on Immune Maturation here.
Immune microenvironments can influence cellular functions and signaling pathways, including those of tumor cells and their response to immunotherapies. Discover the latest research on Immune Microenvironments here.
Mapping the human immune system spatially, within and between tissues, will provide the basis for studying mechanisms of tissue residency and the effects of aging. This feed follos new studies profiling the immune system, including at different developmental stages.
Immunological surveillance occurs when T-cells detect and destroy virally infected or neoplastically transformed cells in the body. Discover the latest research on immunologic surveillance here.
Immunosenescence is defined as changes in the innate and adaptive immune response associated with increased age. Discover the latest research on immunosenescence here.
Inflammation has been implicated in initiation and progression of tumors, as well as elimination of cancerous cells. Here is the latest research on the role of inflammation in cancer.
Leukocyte trafficking from blood into tissue is a fundamental process in immune surveillance and the immune response to stimuli. Discover the latest research on Leukocyte Trafficking here.
The precise localization and structure of lymphoid organ development allows for an orchestrated immune response to an array of potential pathogens. Discover the latest research on Lymphoid Organ Development here.
Natural Killer (NK) cells are critical for the containment of viral replication, particularly during early infection. Some viruses such as HIV and influenza have developed mechanisms to evade NK detection and infect the host. Here is the latest research on NK cells and viral immunity.
Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.
The use of stem cells is being explored as a treatment option for neuroimmune disorders, including Multiple Sclerosis. The immune system has been demonstrated to have negative impacts on cognitive function and neurogenesis and is a potential target for therapeutic intervention. Discover the latest research on stem cells and neuroimmunology.
Treg cells are critical for the maintenance of immune homeostasis and suppression of naturally occurring self-reactive t cells. Discover the latest research on treg cells here.
The tumor immune microenvironment (TIME) is composed of hetereogenous immune cells that have infiltrated the tumor, and is a central target of cancer immunotherapies. Characterization of the TIME is key to predicting response and development of immunotherapy. Discover the latest research here.