Immunologic Deficiency Syndromes

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Chronic Granulomatous Disease is an inherited immunodeficiency disorder that is characterized by recurrent infections and granuloma formation. Discover the latest research on Chronic Granulomatous Disease here.

Common variable immunodeficiency is a primary immunodeficiency disease characterized by hypogammaglobulinemia and lack of antibody production. Here is the latest research.

Deltaretroviruses such as human T-lymphotropic virus type 1 and bovine leukemia virus induce a persistent infection that remains generally asymptomatic but can also lead to leukemia or lymphoma. Here is the latest research on Deltaretroviruses infections.


HIV/AIDS is a global pandemic with Sub-Saharan Africa being the most affected region. In 2017, almost 37 million people were infected with HIV and almost 1 million deaths occurred due to AIDS. Find the latest research on HIV/AIDS here.

HIV co-infection worsens the histological course of other viral infections, such as HCV by increasing and accelerating the risk of cirrhosis or leading to rare but lethal fibrosing cholestatic hepatitis. Discover the latest research on HIV co-infection.

While good nutrition is important for all individuals, it is especially an important issue for those infected HIV for several reasons. HIV infection impacts metabolic, cardiovascular, and psychological functioning and nutrition is key in managing these changes. Find the latest research on HIV and nutrition here.

The development to make HIV vaccines for both the prevention and treatment of HIV infection is ongoing. Some individuals with HIV infection produce antibodies which suppress the virus and allow the patients to remain asymptomatic, suggesting that a vaccine may be achievable. Find the latest research on HIV vaccines here.

HIV-1 reverse transcriptase is among the earliest HIV proteins identified and is involved in viral replication. More than half of investigational long-acting antivirals target hiv-1 reverse transcriptase and/or integrase (hiv-1 in). Discover the latest research here.

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.

This feed focuses on emerging cell and gene therapies, such as HIV vaccines, for treating patients living with HIV/AIDS. Discover the latest research here.

HIV can affect the body's ability to produce hormones and maintain their normal levels. Some drugs that are used to treat HIV-related conditions can also affect hormone levels. Discover the latest research on hormones and HIV here.

Hyper-IgM syndrome is a heterogeneous group of disorders characterized by normal or elevated serum IgM levels associated with absent or decreased IgG, IgA and IgE. Here is the latest research.

IgA deficiency, the most common primary immunodeficiency, is a very heterogeneous clinical disorder which may be associated with a variety of infections, allergies, autoimmune disorders, gastrointestinal diseases, and genetic disorders. Here is the latest research.


IgG deficiency is an immunodeficiency disorder characterized by a decrease in immunoglobulin G. Individuals with this disorder have a higher likelihood of getting infections. Here are the latest discoveries pertaining to this.

Kaposi's Sarcoma is the most common malignancy associated with human immunodeficiency virus-1 (HIV-1) infection, characterized by abnormal skin growth and can result in significant morbidity.

Lymphopenia has been associated with autoimmune pathology and it has been suggested that lymphopenia-induced proliferation of naive T cells may be responsible for the development of immune pathology. Here is the latest research.


Several methods have been utilized to isolate and characterize individual antibodies from the human repertoire and each of these methods has been applied to the generation of broadly neutralizing HIV antibodies. Discover the latest research on neutralizing HIV antibodies.

The HIV genome is composed of two identical single-stranded RNA molecules. It contains nine genes encoding fifteen structural and regulatory viral proteins. Find the latest research on the HIV genome here.

X-linked severe combined immunodeficiency is caused by mutations in the common cytokine-receptor gamma chain, resulting in disruption of development of T lymphocytes and natural-killer cells. Here is the latest research.