Infections of the CNS
Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here are the latest discoveries pertaining to this disease.
Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.
Bovine spongiform encephalopathy is a neurodegenerative disease belonging to the transmissible spongiform encephalopathies, a group of diseases including sheep scrapie and human Creutzfeldt-Jakob disease. Here is the latest research.
Brain abscess is an accumulation of pus caused by inflammation and infected materials in the brain. Symptoms include fever, headache, seizures and other neurological problems. Discover the latest research on brain abscess today.
The CNS contains lymphatic vessels in the meninges that connect and drain the CSF into the peripheral lymphatic system. Impaired functioning of the CNS lymphatic system can be dangerous with the accumulation of toxic substances such as amyloid protein that is part of Alzheimer’s disease pathogenesis. Here is the latest research on the CNS lymphatics.
Central nervous system bacterial infections are medical emergencies and include bacterial meningitis and spinal epidural abscess. Treatment with antibiotics can reduce morbidity and mortality. Discover the latest research on central nervous system bacterial infections here.
Central nervous system fungal infections are rare and typically occur in immunocompromised patients, such as those with HIV infection or transplant recipients. Discover the latest research on central nervous system fungal infections here.
Central nervous system parasitic infections can occur when parasites invade the blood-brain barrier and can also occur in immunocompromised patients. Toxoplasma gondii is a parasite that can lead to encephalitis and other neurological symptoms. Discover the latest research central nervous system parasitic infections here.
Central nervous system viral diseases can cause inflammation leading to encephalitis, meningitis, or myelitis. These infections can be diagnosed by spinal tap. Discover the latest research on central nervous system viral diseases here.
Creutzfeldt-Jakob Disease is a fatal neurodegenerative disease caused due to aggregation and accumulation of misfolded prion proteins. Here are the latest discoveries pertaining to this disease.
Encephalitis is a condition of inflammation of the brain parenchyma, occurs as a result of infectious or autoimmune causes, and can lead to encephalopathy, seizures, focal neurological deficits, neurological disability, and death. Here is the latest research.
Encephalomyelitis is characterized by inflammation of the brain or spinal cord. This includes acute disseminated encephalomyelitis, which can be caused by viral infection and characterized by damage to the myelin sheath. Discover the latest research on encephalomyelitis here.
Epidural abscess is an accumulation of pus in the lining between the spine and the membrane lining. This can be caused by bacterial and other microbes. Discover the latest research on epidural abscess here.
Fungal meningitis is a serious disease caused by a fungal infection of the central nervous system mostly in individuals with immune system deficiencies. Here is the latest research.
Gerstmann-Straussler-Scheinker disease is a rare neurodegenerative disorder caused by prions and characterized by symptoms associated with prion-associated diseases. Here is the latest research.
Fatal familial insomnia is a familial prion disease linked to a mutation of the prion protein gene. Here is the latest research on this rare genetic degenerative brain disorder.
Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Whilst some key players seem to have been identified so far, the mechanisms that underlie prion propagation to the brain are still not fully understood. Here is the latest research pertaining to mechanisms of prion propagation.
Meningococcal myelitis is characterized by inflammation and myelin damage to the meninges and spinal cord. Discover the latest research on meningococcal myelitis here.
Meningoencephalitis, also known as herpes meningoencephalitis, is a medical condition that simultaneously resembles both meningitis, which is an infection or inflammation of the meninges, and encephalitis, which is an infection or inflammation of the brain. Discover the latest research on meningoencephalitis here.
Prion diseases are fatal neurodegenerative and infectious disorders characterized by structural transition of the host-encoded cellular prion protein into the aberrantly folded pathologic isoform of the protein. Here is the latest research on molecular diagnostic strategies for prion diseases.
Poliomyelitis, also known as polio, is a viral disease that can rarely lead to paralysis. This disease is nearly eradicated due to vaccination. Discover the latest research on Poliomyelitis here.
Postpoliomyelitis syndrome is characterized by a sudden or progressive loss of muscle strength, muscle atrophy, muscle pain, fatigue, intolerance to cold, after a period of at least 15 years from the acute polio virus infection, a period of neurological and functional stability. Here is the latest research.
Prion diseases or transmissible spongiform encephalopathies are rare progressive neurogenerative diseases caused by misfolded prion proteins. Here is the latest research in this domain.
Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion proteins, as an important biomarker of prion disease, are responsible for the transmissible spongiform encephalopathies. Here is the latest research investigating biomarkers in prion diseases.
Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Distinct prion strains are associated with different prion protein conformations and glycosylation patterns and associate with disease progression and severity. Here is the latest research on strain diversity and neurotoxicity in prion diseases.
Prion diseases are fatal, transmissible, neurodegenerative diseases caused by the misfolding of the prion protein (prp). Here is the latest research on prion diseases.
Progressive Multifocal Leukoencephalopathy (PML) occurs due to JC virus infection. While most adults are infected, PML emerges in individuals with weakened immune systems. Here is the latest on PML.
Pseudorabies is caused by the pseudorabies virus, also known as Suid herpesvirus 1. This disease is found in swine and other economically important animals. Discover the latest research on pseudorabies here.
Viral meningitis in adults results in mild cognitive impairment in a significant proportion of patients that is not identified by clinical examination or cognitive screening tests. Here is the latest research.