Membranes: Structure & Function
Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.
Lipids are essential in many biological functions, including membrane structure, energy storage, and cell signaling. Find the latest research on the cell biology of lipids here.
Dynamin GTPases are proteins that are responsible for endocytosis in cells, as well as division of organelles, cytokinesis, and pathogen resistance. Discover the latest research on dynamin GTPases here.
Several protein complexes are present on the ER membrane that facilitates the protein translocation across and into the ER where folding can occur. Discover the latest research on ER Membrane: Protein Translocation here.
Adsorptive and receptor-mediated endocytosis via clathrin-coated vesicles provides the major and best-characterized portal for uptake of multiple molecules and particles into cells. Via clathrin-dependent endocytosis, cells receive nutrients, regulate receptors and other plasma membrane constituents, take up antigens, and remove senescent, excess, and potentially harmful substances from the extracellular fluid. Discover the latest research on endocytic system here.
Dynamin GTPases are proteins that are responsible for endocytosis in cells, as well as division of organelles, cytokinesis, and pathogen resistance. Discover the latest research on dynamin GTPases here.
Extracellular vesicles are cell-derived structures containing complex cargo, including proteins and nucleic acids, that originate from endosomal systems or the plasma membrane. Here is the latest research on technologies for the analysis of extracellular vesicles.
Extracellular vesicles are implicated in propagating toxic amyloid proteins in neurodegenerative disorders. Here is the latest research on extracellular vesicles including exosomes in the CNS.
Glycosylphosphatidylinositol (GPI) is a glycolipid anchor for several cell-surface proteins that play a role in various biological processes, including signal transduction, prion disease pathogenesis, and immune response. Here is the latest research.
GTPases, including small ras sub-families and large dynamin are regulators of intracellular trafficking. They are implicated in vesicular transport and important for the communication within cells. Discover the latest search on GTPases in intracellular trafficking here.
Gap junctions are specialized intercellular communication channels that transfer molecules between neighboring cells and thereby alter intracellular signaling and metabolism. Here is the latest research on the influence of gap junctions on intercellular signaling.
Interfacial lipids are key regulators of membrane-protein association and play a role in stabilizing membrane proteins. Here is the latest research.
Ion channels are pore-forming proteins that allow the passage of ions from one side of the membrane to the other and are at the heart of many biological processes including nerve activity and muscle contraction. Discover the latest research on ion channels here.
The cellular membrane is composed of diverse lipid molecules that help maintain membrane integrity and homeostasis. Discover the latest research on Lipids & Membrane Homeostasis
Membrane Biophysics describes the study of membrane using various biophysical techiniques such as imaging, computational modeling, etc. Discover the latest research on membrane biophysics.
This feed focuses on biochemical techniques used for isolating and purifying membrane proteins from cells. Discover the latest research on Membrane Protein Extraction here.
Membrane proteins are found on cellular and intracellular membranes, and play important roles such as signal transduction, transport and enzymatic functions. Discover the latest research on the structure and function of membrane proteins here.
Membrane trafficking is the process through which macromolecules and other cargo are distributed throughout cell, released from the cell, or taken into the cell from extracellular space. Here is the latest research on mechanisms that regulate membrane trafficking.
This membrane trafficking pathway is important in the degradation of proteins and organelles and involves the formation of double membrane autophagosomes that are transported to the lysosome. Here is the latest research on membrane trafficking in autophagy.
This feed focuses on Membrane Transport proteins and their dysfunction which can lead to heart disease. Discover the latest research on Membrane Transport in Heart Failure.
Phosphoinositides are a subset of membrane phospholipids with wide-ranging effects in cell function.
Localization of proteins is critical for ensuring the correct location for physiological functioning. If an error occurs, diseases such as cardiovascular, neurodegenerative disorders and cancers can present. Therapies are being explored to target this mislocalization. Here is the latest research on protein localization in disease and therapy.
SNAP receptor proteins mediate plasma membrane fusion, or the fusion of a vesicle with its target membrane. This is a key process in intracellular trafficking, synaptic transmission, and exocytosis.
Ion channels and pumps are central to a number of cell functions, including membrane excitability and synaptic transmission. With sophisticated imaging, these channels and pumps have been characterized as selective for the ions, sodium, potassium chloride and calcium. Here is the latest research on selection ion transport in channels and pumps.
G-protein-coupled receptors (GPCRs), the largest family of integral membrane proteins, participate in the regulation of many physiological functions and are the targets of approximately 30% of currently marketed drugs. Here is the latest research on structures of these receptors.
Voltage-sensing domains of transmembrane proteins describes the domain responsible for detecting changes in membrane potential. Discover the latest research on voltage-sensing domains here.