Metabolism & Metabolic Diseases
Baterial metabolism is how bacteria obtain the energy and nutrients they need to live and reproduce.The study of bacterial metabolism focuses on the chemical diversity of substrate oxidations and dissimilation reactions (reactions by which substrate molecules are broken down), which normally function in bacteria to generate energy. Also within the scope of bacterial metabolism is the study of the uptake and utilization of the inorganic or organic compounds required for growth and maintenance of a cellular steady state (assimilation reactions). Discover the latest research on bacterial metabolism here.
Glycosylation disorders are typically associated with disruptions of early steps in glycan biosynthesis pathways. This feed focuses on the latest research on mechanisms and pathways underlying glycosylation disorders.
Phospholipids are the major component of cell membranes. This feed focuses on the role of gut microorganisms in phospholipid metabolism.
This feed focuses on small molecules produced by the human microbiota. Several small molecules representing each of the major metabolic classes have been identified and implicated in several biological processes including modulation of the immune system and antibiosis. Here is the latest research.
Lipid metabolism refers to the synthesis and degradation of lipids in cells and is a complex process essential for fat storage and construction of cellular membranes. Discover the latest research on lipid and membrane metabolism here.
Lipid droplets are cellular organelles that store neutral lipids enclosed in a phospholipid monolayer. They are at the centre of lipid and energy homeostasis, and several metabolic diseases including obesity and diabetes. Here is the latest research on lipid droplet biology.
Lipid metabolism is important in several cellular processes and functions including signal transduction. Disorders of lipid metabolism can occur impairing normal function. Here is the latest research on lipid metabolism and lipid disorders.
Lipidomics is a branch of metabolomics that comprehensively analyses lipids in biological systems to determine the molecules with which they interact and their function within the cell. Here is the latest research.
Lysosomal storage diseases and related disorders are a heterogeneous group of rare diseases caused by genetic mutations that result in deficiencies of specific lysosomal enzymes. Here is the latest research on lysosomal storage diseases.
This feed focuses on proteomics, transcriptomics, and metabolomics in the human microbiota, as well as on metabolic pathways and reactions that underlie physiological and biochemical properties of the cell. Here is the latest research on metabolic networks in the microbiome.
Metabolomics refers to the large-scale study of profiling all metabolites in biological systems in a non-targeted manner. Here is the latest research.
This feed focuses on the role of metalloproteins in metabolic processes, including the role of iron-sulfur (Fe-S) proteins in cellular respiration as well as DNA and RNA metabolism.
The intestinal microbiome is responsible for metabolism of bile acids and generation of the bile acid pool. Discover the latest research on Microbes: Cholesterol & Bile Acid.
Glycans are sugars that can be attached to biological molecules through glycosylation. This feed focuses on the influence of microbial glycans on the immune system and in human diseases.
The human microbiota is composed of all microorganisms that reside inside and on the human body. This feed focuses on the collective genomes of all these microorganisms. Here is the latest research.
Mitochondrial metabolism links energy production to other essential cellular processes such as signaling, cellular differentiation, and apoptosis. Discover the latest research here.
Oxidative stress plays a critical role in the development of many diseases including microvascular and cardiovascular complications in diabetes. Here is the latest research on the role of oxidative stress in diabetes.
Phenylketonuria (PKU) is an autosomal recessive disorder characterized by abnormalities in amino acid metabolism caused as a result of deficiency in phenylalanine hydroxylase, an enzyme that converts phenylalanine to tyrosine. Here is the latest research.
Polyglucosan Body Disease affects the nervous system and is characterized by peripheral neuropathy and spasticity. Discover the latest research on this disease here.
Prader-Willi Syndrome (PWS) is a rare genetic disorder caused by missing or non-working genes on chromosome 15. In infancy, symptoms include hypotonia, feeding difficulties, and delayed development; later on, affected children develop an extreme appetite, typically resulting in obesity. Here is the latest research on this complex multisystem disorder.
Reactive oxygen species (ROS) are reactive chemicals containing oxygen which may have complex roles in promoting the development of neurodegenerative diseases. They are generated as a byproduct of oxidative energy metabolism and play a role in regulating several intracellular signaling pathways. Here is the latest research on ROS metabolism and signaling in neurodegeneration.
The feed focuses on the role of defective mitochondria and their early role in promoting retinal degeneration.