Morphogenesis & Embryology
Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis
Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.
Three major axes, anteroposterior, dorsoventral, and left-right axes, patterned during embryogenesis determine the overall body plan of an organism. Discover the latest research on axis formation here.
BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.
Caspases, the family of cysteine proteases are involved in programmed cell death, but their role in metabolic diseases, inflammation and immunity has been of interested. Discover the latest research on caspases in metabolic diseases here.
Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.
Cell fate specification is determined by complex signal transduction pathways including Notch and the Sonic hedgehog signaling pathway. Here is the latest research on regulation of cell fate determination.
Chondrogenesis is the earliest phase of skeletal development, involving mesenchymal cell recruitment and migration, condensation of progenitors, and chondrocyte differentiation, and maturation and resulting in the formation of cartilage and bone during endochondral ossification. Here is the latest research.
Collective cell migration is the coordinated movement of cells, which organize tissues during morphogenesis, repair and some cancers. Here is the latest research.
Cyclins and cylin-dependent kinases (CDKs) are two classes of regulatory molecules that determine a cell’s progression through cell cycle. Here is the latest research.
Cytoskeletal motors of the dynein, kinesin and myosin superfamilies maintain and adapt subcellular organelle organization to meet functional demands and support the vesicular transport of material between organelles. Here is the latest research on cytoskeletal and motor biophysics.
The cytoskeleton is a dynamic network of interlinking protein filaments that extends from the plasma membrane to the nucleus. Here is the latest research.
A dynamic cytoskeleton is critical for the generation of cell polarity. This feed focuses on cell polarity and the cytoskeleton, including actin and microtubular cytoskeletal organization.
Embryogenesis is the process by which the embryo forms and develops. It starts with the fertilization of the egg cell (ovum) by a sperm cell, (spermatozoon). Once fertilized, the ovum is referred to as a zygote, a single diploid cell. The zygote undergoes mitotic divisions with no significant growth (a process known as cleavage) and cellular differentiation, leading to development of a multicellular embryo
During organogenesis, the endoderm of vertebrates produces tissue within the lungs, thyroid, and pancreas
Fertilization occurs when eggs and spermatozoa fuse to generate a zygote. Discover the latest research on Fertilization here.
The fibroblast growth factor signaling pathway is an evolutionary conserved signaling cascade that regulates several basic biologic processes, including tissue development, angiogenesis, and tissue regeneration. Here is the latest research.
Gastrulation is a phase early in the embryonic development of most animals, during which the single-layered blastula is reorganized into a multilayered structure known as the gastrula. Before gastrulation, the embryo is a continuous epithelial sheet of cells; by the end of gastrulation, the embryo has begun differentiation to establish distinct cell lineages, set up the basic axes of the body, and internalized one or more cell types including the prospective gut
Gonadogenesis, the process of forming an ovary or a testis from a bipotential gonad, is critical to the development of sexually reproducing adults
Mammalian cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of mammalian cell cycle and growth.
Morphogens are signaling factors that direct cell fate and tissue development at a distance from their source. They are involved in the establishment of positional information that is essential for pattern formation. Here is the latest research.
Regeneration in humans is the regrowth of tissues or organs in response to injury or damage. Discover the latest research on organ neuroregeneration here.
Plant cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of Plant cell cycle and growth.
This feed focuses on the Polycomb Group Proteins, which are protein complexes that are recruited to chromatin and are involved in the deposition of repressive histone marks, leading to gene repression.
The Sonic Hedgehog signaling pathway regulates developmental processes including cell patterning and differentiation and plays a role in tissue repair and regeneration. Here is the latest research on this complex signal transduction pathway.
Retinal development in vertebrae is a complex molecular process that is regulated by several signal transduction pathways, including the Sonic hedgehog signaling pathway. Here is the latest research.
Wnt signal transduction pathway is regulated by several molecules and is critical for embryonic development, cell proliferation, differentiation, and tissue patterning. Here is the latest research on Wnt signaling.
Wound healing is a complex biologic process that involves the integration of inflammation, mitosis, angiogenesis, synthesis, and remodeling of the extracellular matrix. Here is the latest research.