Neglected Tropical Diseases
African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.
Buruli ulcer is a progressive disease of subcutaneous tissues caused by mycobacterium ulcerans. Here is the latest research.
Chagas disease, also known as American trypanosomiasis, is a tropical parasitic disease caused by the protist Trypanosoma cruzi. It is spread mostly by insects known as Triatominae, or "kissing bugs". The symptoms change over the course of the infection. In the early stage, symptoms are typically either not present or mild, and may include fever, swollen lymph nodes, headaches, or local swelling at the site of the bite. After 8–12 weeks, individuals enter the chronic phase of disease and in 60–70% it never produces further symptoms.The other 30–40% of people develop further symptoms 10–30 years after the initial infection, including enlargement of the ventricles of the heart in 20–30%, leading to heart failure. An enlarged esophagus or an enlarged colon may also occur in 10% of people. Discover the latest research on Chagas disease here.
Chikungunya fever is a viral disease transmitted to humans by the bite of chikungunya virus infected aedes mosquitoes. Discover the latest research on chikungunya here.
Clonorchiasis is a food foodborne parasitic infection caused by the trematode Clonorchis sinensis and presents as liver disease. Find the latest research on clonorchiasis here.
Cysticercosis in humans results from infestation with the larval stage of the parasite cysticercus cellulosae of the tapeworm taenia solium. Discover the latest research on cysticercosis here.
Dengue Virus, a mosquito transmitted pathogen, is the causative agent of dengue fever, the most important arboviral disease of humans, which affects an estimated 50-100 million people annually. Discover the latest research here.
Echinococcosis or hydatid disease in humans is a zoonotic infection caused by the larval stages of cestode species of the genus echinococcus. Discover the latest research on Echinococcosis here.
Fascioliasis is a zoonotic parasitic disease caused by fasciola hepatica and fasciola gigantica that primarily affects ruminants. Discover the latest research on Fascioliasis here.
Filariasis is a parasitic infection caused by various nematodes of the Filarioidea superfamily. Different worms present as different infections depending on the the location of thhe infection: lymphatic filariasis (caused by Wuchereria bancrofti, Brugia malayi, and Brugia timori) is an infection of the lymphatic system, subcutaneous filariasis (caused by Loa loa, Mansonella streptocerca, and Onchocerca volvulus) is an infection of the skin, and serous cavity filariasis (Mansonella perstans and Mansonella ozzardi) is an abdominal infection. Find the latest research on filariasis here.
Infectious Disease Sequencing is a emerging field due to low-cost massively parallel sequencing and allows researchers to monitor outbreaks of infectious pathogens. Discover the latest research on Infectious Disease Sequencing here.
Pyroptosis is a form of necrotic and inflammatory programmed cell death induced by inflammatory caspases, one of which is activated by Inflammasome, a multiprotein oligomer responsible for the activation of inflammatory responses. Discover the latest research on inflammasome and pyroptosis here.
Leishmaniasis is a parasitic infection caused by Leishmania species and transmitted though the bite of phlebotomine sand flies. It is considered to be a neglected tropical disease. Leishmaniasis is often categorized as cutaneous (presenting with skin sores, mucocutaneous (presenting with skin and mucosal lesions), and visceral (affecting multiple organs). Find the latest research on leishmaniasis here.
Leprosy, also known as Hansen's disease (HD), is a long-term infection by the bacteria Mycobacterium leprae or Mycobacterium lepromatosis. Infection can lead to damage of the nerves, respiratory tract, skin, and eyes. This damage may result in a lack of ability to feel pain, which can lead to the loss of parts of extremities from repeated injuries or infection due to unnoticed wounds. Discover the latest research on leprosy here.
Mycetoma is a tropical disease that is caused by bacteria or fungi, and leads to subcutaneous inflammation. Discover the latest research on Mycetoma here.
Onchocerciasis, also known as river blindness, is a disease caused by infection with the parasitic worm Onchocerca volvulus. Symptoms include severe itching, bumps under the skin, and blindness. It is the second-most common cause of blindness due to infection, after trachoma. Discover the latest research on onchocerciasis here.
Rabies is a lethal viral diseased caused by the Rabies virus. Symptoms include fever and hydrophobia. Discover the latest research on Rabies here.
Scabies is a parasitic skin disease specific to humans caused by a microscopic mite, sarcoptes scabiei var. Discover the latest research on scabies here.
Schistosomiasis is a parasitic infection that affects 200 million people and is directly responsible for an annual death of 20,000 patients. Here is the latest research.
Trachoma, caused by ocular infection with Chlamydia trachomatis, remains the leading infectious cause of blindness. Here is the latest research.