Neurodegeneration & Neurodegenerative Diseases


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  • Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.
    ALS
    Fast Growing

    Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

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  • ALS shares with a considerable proportion of FTD cases the same neuropathological substrate, namely, inclusions of abnormally phosphorylated protein tdp-43 (ptdp-43). Here are the latest discoveries pertaining to ptdp-43 and these diseases.
    ALS & FTD: TDP-43
    Fast Growing

    ALS shares with a considerable proportion of FTD cases the same neuropathological substrate, namely, inclusions of abnormally phosphorylated protein tdp-43 (ptdp-43). Here are the latest discoveries pertaining to ptdp-43 and these diseases.

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  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.
    ALS - Pathogenic Mechanisms
    Influential

    Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

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  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating phenotypes associated with this genetically heterogeneous disorder.
    ALS - Phenotypes

    Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating phenotypes associated with this genetically heterogeneous disorder.

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  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.
    ALS: Genetics

    Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

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  • Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here are the latest discoveries pertaining to this disease.
    ALS: Prions

    Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here are the latest discoveries pertaining to this disease.

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  • Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research.
    ALS: Stress Granules

    Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research.

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  • Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS therapies here.
    ALS: Therapies
    Fast Growing

    Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS therapies here.

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  • Transposon silencing is a form of transcriptional gene silencing. These gene silencing mechanisms are impaired in Amyotrophic lateral sclerosis (ALS). Here are the latest discoveries pertaining to transposon silencing and this disease.
    ALS: Transposon de-silencing

    Transposon silencing is a form of transcriptional gene silencing. These gene silencing mechanisms are impaired in Amyotrophic lateral sclerosis (ALS). Here are the latest discoveries pertaining to transposon silencing and this disease.

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  • Age-related dementia (Alzheimer's disease) results from the destructive impact of the pulse on cerebral vasculature. Evidence is reviewed that the neuropathology of the dementia is caused by the breakdown of small cerebral vessels (silent microbleeds), that the microbleeds result from pulse-induced damage to the cerebral vessels, and that pulse becomes increasingly destructive with age, because of the age-related stiffening of the aorta and great arteries, which causes an increase in the intensity of the pressure pulse. Discover the latest research on age-related dementia here.
    Age-related Dementia
    Fast Growing

    Age-related dementia (Alzheimer's disease) results from the destructive impact of the pulse on cerebral vasculature. Evidence is reviewed that the neuropathology of the dementia is caused by the breakdown of small cerebral vessels (silent microbleeds), that the microbleeds result from pulse-induced damage to the cerebral vessels, and that pulse becomes increasingly destructive with age, because of the age-related stiffening of the aorta and great arteries, which causes an increase in the intensity of the pressure pulse. Discover the latest research on age-related dementia here.

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  • This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.
    Aging Epidemiology
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    This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

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  • This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.
    Aging Genetics
    Fast Growing

    This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

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  • Alexander disease is a rare neurological disorder caused by mutations in the astrocyte-specific intermediate filament protein glial fibrillary acidic protein (GFAP). Here is the latest research.
    Alexander Disease
    Fast Growing

    Alexander disease is a rare neurological disorder caused by mutations in the astrocyte-specific intermediate filament protein glial fibrillary acidic protein (GFAP). Here is the latest research.

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  • Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.
    Alpha-Synuclein Aggregation

    Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

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  • Alpha-synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. They have also been detected in several other neurodegenerative diseases, known as synucleopathies. Here is the latest research on alpha-synuclein antibody therapeutics.
    Alpha-Synuclein Antibody Therapeutics
    Going Viral

    Alpha-synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. They have also been detected in several other neurodegenerative diseases, known as synucleopathies. Here is the latest research on alpha-synuclein antibody therapeutics.

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  • α-Synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. Here is the latest research on α-Synuclein structure and function.
    Alpha-Synuclein Structure and Function
    Fast Growing

    α-Synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. Here is the latest research on α-Synuclein structure and function.

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  • Alstrom syndrome is a rare disorder characterized by early obesity, loss of central vision, diabetes mellitus, hearing loss, and short stature. Here is the latest research.
    Alstrom Syndrome

    Alstrom syndrome is a rare disorder characterized by early obesity, loss of central vision, diabetes mellitus, hearing loss, and short stature. Here is the latest research.

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  • Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's Disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's Disease here.
    Alzheimer's Disease: APOE
    Fast Growing

    Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's Disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's Disease here.

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  • Amyloid precursor protein proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques. Here is the latest research.
    Alzheimer's Disease: APP
    Fast Growing

    Amyloid precursor protein proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques. Here is the latest research.

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  • Alzheimer's disease (AD) is a chronic neurodegenerative disease associated with accumulation of amyloid plaques, which are comprised of amyloid beta. Here is the latest research in this field.
    Alzheimer's Disease: Abeta

    Alzheimer's disease (AD) is a chronic neurodegenerative disease associated with accumulation of amyloid plaques, which are comprised of amyloid beta. Here is the latest research in this field.

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  • Alzheimer's disease is a chronic neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.
    Alzheimer's Disease: Animal models

    Alzheimer's disease is a chronic neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

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  • Alzheimer's disease is a chronic neurodegenerative disease. This feed focuses on early markers, as well as environmental, pharmacological, and drug-response biomarkers associated with this disease.
    Alzheimer's Disease: Early Markers

    Alzheimer's disease is a chronic neurodegenerative disease. This feed focuses on early markers, as well as environmental, pharmacological, and drug-response biomarkers associated with this disease.

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  • The feed focuses on the role of dysfunctional endosomal trafficking in Alzheimer’s Disease and the potential for targeting the endosome as a therapeutic target.
    Alzheimer's Disease: Endosomes

    The feed focuses on the role of dysfunctional endosomal trafficking in Alzheimer’s Disease and the potential for targeting the endosome as a therapeutic target.

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  • Genes and microglia are associated with the risk of developing and the progression of conditions such as Alzheimer's Disease (AD). Here are the latest discoveries pertaining to this disease.
    Alzheimer's Disease: Genes&Microglia

    Genes and microglia are associated with the risk of developing and the progression of conditions such as Alzheimer's Disease (AD). Here are the latest discoveries pertaining to this disease.

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  • Alzheimer's disease is a chronic neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations here.
    Alzheimer's Disease: Genetics

    Alzheimer's disease is a chronic neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations here.

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  • Variants within membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease by recent genome-wide association studies. Here is the latest research.
    Alzheimer's Disease: MS4A

    Variants within membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease by recent genome-wide association studies. Here is the latest research.

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  • Alzheimer's disease (AD) is a chronic neurodegenerative disease. Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.
    Alzheimer's Disease: Neuroimaging

    Alzheimer's disease (AD) is a chronic neurodegenerative disease. Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

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  • RNA regulation involves several mechanisms that are used by cells to decreases or increase the production of RNA. Issues with RNA regulation are associated with Alzheimer's Disease (AD). Here are the latest discoveries pertaining to RNA regulation and this disease.
    Alzheimer's Disease: RNA Regulation
    Fast Growing

    RNA regulation involves several mechanisms that are used by cells to decreases or increase the production of RNA. Issues with RNA regulation are associated with Alzheimer's Disease (AD). Here are the latest discoveries pertaining to RNA regulation and this disease.

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  • RNA sequencing is used to reveal the presence and quantity of RNA in a given sample. In this feed, RNA sequencing investigates the genetic and molecular mechanisms related to the pathophysiology of Alzheimer's disease (AD). Here are the latest discoveries pertaining to RNA sequencing and this disease.
    Alzheimer's Disease: RNA Sequencing
    Fast Growing

    RNA sequencing is used to reveal the presence and quantity of RNA in a given sample. In this feed, RNA sequencing investigates the genetic and molecular mechanisms related to the pathophysiology of Alzheimer's disease (AD). Here are the latest discoveries pertaining to RNA sequencing and this disease.

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  • Alzheimer's disease is a chronic neurodegenerative disease. This feed focuses on the underlying role of Tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's.
    Alzheimer's Disease: Tau & TDP-43

    Alzheimer's disease is a chronic neurodegenerative disease. This feed focuses on the underlying role of Tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's.

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  • Transcription involves copying (transcribing) the gene's DNA sequence into RNA. Impaired transcription is associated with the pathogenesis and progression of conditions such as Alzheimer's disease (AD). Here are the latest discoveries pertaining to transcription and this disease.
    Alzheimer's Disease: Transcription

    Transcription involves copying (transcribing) the gene's DNA sequence into RNA. Impaired transcription is associated with the pathogenesis and progression of conditions such as Alzheimer's disease (AD). Here are the latest discoveries pertaining to transcription and this disease.

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  • Amyloid beta is neurotoxic and a major component of plaques in Alzheimer’s disease. Accumulation induces neurotoxic effects including oxidative damage and mitochondrial dysfunction. Breakdown of amyloid is important to prevent the development of Alzheimer’s disease. Here is the latest research on amyloid beta deposition and degradation.
    Amyloid Beta Deposition & Degradation

    Amyloid beta is neurotoxic and a major component of plaques in Alzheimer’s disease. Accumulation induces neurotoxic effects including oxidative damage and mitochondrial dysfunction. Breakdown of amyloid is important to prevent the development of Alzheimer’s disease. Here is the latest research on amyloid beta deposition and degradation.

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  • Familial Amyloid Neuropathies (FAP) are a rare group of autosomal dominant diseases in which nerves are compromised due to protein aggregation or fibril formation of transthyretin, apolipoprotein A1, or gelsolin proteins, resulting in nervous system dysfunction. Here is the latest research.
    Amyloidogenesis-associated Polyneuropathy

    Familial Amyloid Neuropathies (FAP) are a rare group of autosomal dominant diseases in which nerves are compromised due to protein aggregation or fibril formation of transthyretin, apolipoprotein A1, or gelsolin proteins, resulting in nervous system dysfunction. Here is the latest research.

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  • This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.
    Antisense Oligonucleotide - Therapies For ALS

    This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

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  • This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.
    Antisense Oligonucleotides: ND

    This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

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  • Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.
    Aphasia
    Fast Growing

    Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.

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  • Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.
    ApoE Phenotypes
    Fast Growing

    Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

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  • The relationship between astrocytes and amyloid has been suggested in some neurological diseases such as Alzheimer’s disease. Neuronal damage stimulates the activation of reactive astrocytes, which may the source of amyloid that forms in Alzheimer’s. Here is the latest research on astrocytes and amyloid.
    Astrocytes & Amyloid

    The relationship between astrocytes and amyloid has been suggested in some neurological diseases such as Alzheimer’s disease. Neuronal damage stimulates the activation of reactive astrocytes, which may the source of amyloid that forms in Alzheimer’s. Here is the latest research on astrocytes and amyloid.

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  • Astrocytes are abundant within the central nervous system and their dysfunction has been thought to be an important contributor to some neurodegenerative diseases, in particular Huntington’s disease. Damage to these cells may make neurons more susceptible to degeneration. Here is the latest research on astrocytes and Huntington’s disease.
    Astrocytes & Huntington’s Disease

    Astrocytes are abundant within the central nervous system and their dysfunction has been thought to be an important contributor to some neurodegenerative diseases, in particular Huntington’s disease. Damage to these cells may make neurons more susceptible to degeneration. Here is the latest research on astrocytes and Huntington’s disease.

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  • Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.
    Astrocytes and Neurodegeneration

    Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

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  • Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.
    Astrocytes in Repair & Regeneration
    Fast Growing

    Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

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  • Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.
    Ataxia
    Fast Growing

    Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

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  • Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.
    Ataxia telangiectasia
    Fast Growing

    Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

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  • The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.
    Autophagy & Aging: Inhibitors
    Influential

    The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.

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  • Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in cancer and Parkinson’s.
    Autophagy: Cancer & Parkinson

    Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in cancer and Parkinson’s.

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  • Axonal Neuropathy refers to disease or dysfunction of nerves caused as a result of damage or degeneration of axons. Here is the latest research.
    Axonal Neuropathies

    Axonal Neuropathy refers to disease or dysfunction of nerves caused as a result of damage or degeneration of axons. Here is the latest research.

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  • Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.
    Basal Ganglia
    Fast Growing

    Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

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  • Batten Disease is a group of nervous system disorders known as neuronal ceroid lipfuscinosis. This feed focuses on neurobiological and neuropathological aspects of this disease. Discover more here.
    Batten Disease

    Batten Disease is a group of nervous system disorders known as neuronal ceroid lipfuscinosis. This feed focuses on neurobiological and neuropathological aspects of this disease. Discover more here.

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  • Cytokines can affect the central nervous system through crossing the blood brain barrier and entering the CSF and interstitial fluid spaces. Some cytokines are able to cross through transport systems and can affect tissues within the CNS, whereas others are unable to cross. Here is the latest research on the blood brain barrier and cytokines.
    Blood Brain Barrier & Cytokines

    Cytokines can affect the central nervous system through crossing the blood brain barrier and entering the CSF and interstitial fluid spaces. Some cytokines are able to cross through transport systems and can affect tissues within the CNS, whereas others are unable to cross. Here is the latest research on the blood brain barrier and cytokines.

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  • The BBB is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the BBB and changes in permeability allows pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research on BBB regulation in health and disease.
    Blood Brain Barrier Regulation in Health & Disease
    Fast Growing

    The BBB is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the BBB and changes in permeability allows pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research on BBB regulation in health and disease.

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  • Bovine spongiform encephalopathy is a neurodegenerative disease belonging to the transmissible spongiform encephalopathies, a group of diseases including sheep scrapie and human Creutzfeldt-Jakob disease. Here is the latest research.
    Bovine Spongiform Encephalopathy

    Bovine spongiform encephalopathy is a neurodegenerative disease belonging to the transmissible spongiform encephalopathies, a group of diseases including sheep scrapie and human Creutzfeldt-Jakob disease. Here is the latest research.

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  • Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.
    Brain Aging
    Fast Growing

    Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

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  • Brain organoids are used to represent an in vitro model of the human brain. These brain organoids are derived from three-dimensional human pluripotent stem cells and can be used to help study brain biology, early brain development and different brain diseases. Discover the latest research on brain organoids in disease modeling here.
    Brain Organoids in Disease Modeling
    Fast Growing

    Brain organoids are used to represent an in vitro model of the human brain. These brain organoids are derived from three-dimensional human pluripotent stem cells and can be used to help study brain biology, early brain development and different brain diseases. Discover the latest research on brain organoids in disease modeling here.

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  • A brain-computer interface, also known as a brain-machine interface, is a bi-directional communication pathway between an external device and a wired brain. Here is the latest research on this topic.
    Brain-Computer Interface
    Fast Growing

    A brain-computer interface, also known as a brain-machine interface, is a bi-directional communication pathway between an external device and a wired brain. Here is the latest research on this topic.

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  • The CNS contains lymphatic vessels in the meninges that connect and drain the CSF into the peripheral lymphatic system. Impaired functioning of the CNS lymphatic system can be dangerous with the accumulation of toxic substances such as amyloid protein that is part of Alzheimer’s disease pathogenesis. Here is the latest research on the CNS lymphatics.
    CNS Lymphatics

    The CNS contains lymphatic vessels in the meninges that connect and drain the CSF into the peripheral lymphatic system. Impaired functioning of the CNS lymphatic system can be dangerous with the accumulation of toxic substances such as amyloid protein that is part of Alzheimer’s disease pathogenesis. Here is the latest research on the CNS lymphatics.

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  • Canavan disease is an autosomal recessive degenerative disorder that causes progressive damage to nerve cells in the brain, and is one of the most common degenerative cerebral diseases of infancy. Discover the latest research on Canavan disease here.
    Canavan Disease
    Fast Growing

    Canavan disease is an autosomal recessive degenerative disorder that causes progressive damage to nerve cells in the brain, and is one of the most common degenerative cerebral diseases of infancy. Discover the latest research on Canavan disease here.

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  • This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.
    Cell Aging
    Fast Growing

    This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

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  • Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research.
    Central Pontine Myelinolysis

    Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research.

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  • Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of neurodegenerative and cardiovascular diseases. This feed focuses on the role of this protein in cerebrovasculature and cerebrovascular dysfunction.
    Cerebrovasculature & ApoE
    Fast Growing

    Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of neurodegenerative and cardiovascular diseases. This feed focuses on the role of this protein in cerebrovasculature and cerebrovascular dysfunction.

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  • Charcot-Marie-Tooth (CMT) disease is a hereditary motor and sensory neuropathy characterized by loss of muscle and touch sensation. Discover the latest research on CMT here.
    Charcot-Marie-Tooth Disease (CMT)

    Charcot-Marie-Tooth (CMT) disease is a hereditary motor and sensory neuropathy characterized by loss of muscle and touch sensation. Discover the latest research on CMT here.

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  • The inflammatory response is activated when demyelination occurs. Accumulation of excess myelin debris triggers cholesterol crystal formation. Cholesterol deposits in the CNS can overwhelm phagocytes resulting in impaired tissue regeneration. Here is the latest research on cholesterol synthesis in inflammation and remyelination.
    Cholesterol Synthesis in Inflammation & Remyelination
    Influential

    The inflammatory response is activated when demyelination occurs. Accumulation of excess myelin debris triggers cholesterol crystal formation. Cholesterol deposits in the CNS can overwhelm phagocytes resulting in impaired tissue regeneration. Here is the latest research on cholesterol synthesis in inflammation and remyelination.

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  • Cockayne syndrome is a rare multisystem autosomal recessive disorder characterized by severe photosensitive genodermatosis that is associated with premature aging caused by defects in the UV-induced DNA damage repair system. Here is the latest research.
    Cockayne Syndrome

    Cockayne syndrome is a rare multisystem autosomal recessive disorder characterized by severe photosensitive genodermatosis that is associated with premature aging caused by defects in the UV-induced DNA damage repair system. Here is the latest research.

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  • This feed focuses on the role of environmental and genetic factors including environmental policies, disease susceptibility, and socioeconomic status on cognitive decline. Here is the latest research.
    Cognitive Decline: Environmental And Genetic Factors

    This feed focuses on the role of environmental and genetic factors including environmental policies, disease susceptibility, and socioeconomic status on cognitive decline. Here is the latest research.

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  • This feed focuses on complex memory functions, including remote memory, recognition memory, and spatial cognition. Here is the latest research.
    Complex Memory Functions
    Fast Growing

    This feed focuses on complex memory functions, including remote memory, recognition memory, and spatial cognition. Here is the latest research.

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  • Corpus Callosum Agenesis Neuronopathy is a neurodegenerative disorder characterized by severe progressive sensorimotor neuropathy beginning in infancy. Here is the latest research.
    Corpus Callosum Agenesis Neuronopathy

    Corpus Callosum Agenesis Neuronopathy is a neurodegenerative disorder characterized by severe progressive sensorimotor neuropathy beginning in infancy. Here is the latest research.

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  • There exist several mechanisms and neural circuits in the cortex that enable organisms to move from one place to another. Discover the latest research on cortical control of locomotion here.
    Cortical Control of Locomotion
    Influential

    There exist several mechanisms and neural circuits in the cortex that enable organisms to move from one place to another. Discover the latest research on cortical control of locomotion here.

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  • Corticobasal Degeneration (CBD)is a rare, neurodegenerative disease of the cerebral cortex and the basal ganglia, characterized by movement disorders. Discover the latest research on CBD here.
    Corticobasal Degeneration
    Fast Growing

    Corticobasal Degeneration (CBD)is a rare, neurodegenerative disease of the cerebral cortex and the basal ganglia, characterized by movement disorders. Discover the latest research on CBD here.

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  • Creutzfeldt-Jakob Disease is a fatal neurodegenerative disease caused due to aggregation and accumulation of misfolded prion proteins. Here are the latest discoveries pertaining to this disease.
    Creutzfeldt-Jakob Disease
    Influential

    Creutzfeldt-Jakob Disease is a fatal neurodegenerative disease caused due to aggregation and accumulation of misfolded prion proteins. Here are the latest discoveries pertaining to this disease.

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  • While abilities like vocabulary resist aging, other abilities such as memory, decision-making, and reasoning, gradually decline. Here is the latest research on decision-making and cognitive aging.
    Decision Making & Cognitive Aging
    Fast Growing

    While abilities like vocabulary resist aging, other abilities such as memory, decision-making, and reasoning, gradually decline. Here is the latest research on decision-making and cognitive aging.

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  • This feed focuses on the impact of insulin resistance, caloric restriction, cytokine singling, and metabolism on dementia and neurodegenerative diseases. Here is the latest research in this domain.
    Dementia & Neurodegenerative Diseases
    Fast Growing

    This feed focuses on the impact of insulin resistance, caloric restriction, cytokine singling, and metabolism on dementia and neurodegenerative diseases. Here is the latest research in this domain.

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  • Demyelinating diseases result in damage to the myelin sheath that surrounds nerves in the brain and spinal cord and can result in neurological conditions such as multiple sclerosis. Here is the latest research on demyelinating disorders of the central nervous system.
    Demyelinating Disorders of the CNS
    Fast Growing

    Demyelinating diseases result in damage to the myelin sheath that surrounds nerves in the brain and spinal cord and can result in neurological conditions such as multiple sclerosis. Here is the latest research on demyelinating disorders of the central nervous system.

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  • A healthy and balanced diet is essential for controlling diseases such as multiple scelrosis. Here are the latest discoveries pertaining to diet and this disease.
    Diet and Multiple Sclerosis
    Influential

    A healthy and balanced diet is essential for controlling diseases such as multiple scelrosis. Here are the latest discoveries pertaining to diet and this disease.

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  • Diffuse Neurofibrillary Tangles with Calcification (DNTC) is a rare form of presenile dementia. Here is the latest research.
    Diffuse Neurofibrillary Tangles with Calcification
    Influential

    Diffuse Neurofibrillary Tangles with Calcification (DNTC) is a rare form of presenile dementia. Here is the latest research.

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  • Embryonic neural stem cells can be used to investigate the effect of different toxins and molecules on the proliferation and differentiation of these cells. Discover the latest research of embryonic neural stem cells here.
    Embryonic Neural Stem Cells
    Fast Growing

    Embryonic neural stem cells can be used to investigate the effect of different toxins and molecules on the proliferation and differentiation of these cells. Discover the latest research of embryonic neural stem cells here.

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  • Environmental factors play a role in neurological diseases and in particular their contribution in astrocyte proinflammation is of interest. The activation of astrocytes may be involved in neuroinflammation and implicated in neurodegenerative diseases. Here is the latest research on environment and astrocyte proinflammation.
    Environment & Astrocyte Proinflammation

    Environmental factors play a role in neurological diseases and in particular their contribution in astrocyte proinflammation is of interest. The activation of astrocytes may be involved in neuroinflammation and implicated in neurodegenerative diseases. Here is the latest research on environment and astrocyte proinflammation.

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  • Microglial cells are instrumental in the maintenance of homeostasis in the CNS and can contribute to neurodegenerative disorders. Epigenetic mechanisms and transcriptional regulation may be potential therapeutic targets for their activation or suppression. Discover the latest research on epigenetic regulation of microglial functions here.
    Epigenetic Regulation of Microglia Functions

    Microglial cells are instrumental in the maintenance of homeostasis in the CNS and can contribute to neurodegenerative disorders. Epigenetic mechanisms and transcriptional regulation may be potential therapeutic targets for their activation or suppression. Discover the latest research on epigenetic regulation of microglial functions here.

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  • Myotonic Dystrophy is an autosomal dominant neuromuscular disorder associated with the expansion of CTG trinucleotide repeats in the 3’ untranslated region of the myotonic dystrophy protein kinase (DMPK) gene. Here is the latest research focusing on epigenetic modifications in myotonic dystrophy.
    Epigenetics of Myotonic Dystrophy

    Myotonic Dystrophy is an autosomal dominant neuromuscular disorder associated with the expansion of CTG trinucleotide repeats in the 3’ untranslated region of the myotonic dystrophy protein kinase (DMPK) gene. Here is the latest research focusing on epigenetic modifications in myotonic dystrophy.

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  • Familial Amyloid Neuropathies (FAP) are a rare group of autosomal dominant diseases in which nerves are compromised due to protein aggregation or fibril formation of transthyretin, apolipoprotein A1, or gelsolin proteins, resulting in nervous system dysfunction. Here is the latest research.
    Familial Amyloid Neuropathies

    Familial Amyloid Neuropathies (FAP) are a rare group of autosomal dominant diseases in which nerves are compromised due to protein aggregation or fibril formation of transthyretin, apolipoprotein A1, or gelsolin proteins, resulting in nervous system dysfunction. Here is the latest research.

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  • Fragile X-associated tremor/ataxia syndrome (FXTAS) is caused by the expansion of CGG triple repeat in the FMR1 gene and characterized by movement problems and cognitive impairment. Here is the latest research.
    Fragile X-associated tremor/ataxia syndrome

    Fragile X-associated tremor/ataxia syndrome (FXTAS) is caused by the expansion of CGG triple repeat in the FMR1 gene and characterized by movement problems and cognitive impairment. Here is the latest research.

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  • Friedreich's ataxia is a rare autosomal recessive disease caused by defects in FXN gene and characterized by progressive damage of the nervous system and movement problems. Here is the latest research.
    Friedreich's Ataxia

    Friedreich's ataxia is a rare autosomal recessive disease caused by defects in FXN gene and characterized by progressive damage of the nervous system and movement problems. Here is the latest research.

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  • Frontotemporal dementia (FTD) refers to disorders caused by progressive neuronal loss in the frontal and temporal lobes of the brain. Here is the latest research on FTD and FTD-associated disorders.
    Frontotemporal Dementia
    Fast Growing

    Frontotemporal dementia (FTD) refers to disorders caused by progressive neuronal loss in the frontal and temporal lobes of the brain. Here is the latest research on FTD and FTD-associated disorders.

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  • Frontotemporal lobar degeneration or frontotemporal dementia refers to a group of uncommon disorders that occur as a result of progressive nerve cell loss in the frontal and temporal lobes of the brain. Here is the latest research.
    Frontotemporal Lobar Degeneration
    Fast Growing

    Frontotemporal lobar degeneration or frontotemporal dementia refers to a group of uncommon disorders that occur as a result of progressive nerve cell loss in the frontal and temporal lobes of the brain. Here is the latest research.

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  • GRIP1 is a glutamate receptor interacting protein 1 and myeloid cells consists of granulocytes and monocytes, before they have differentiated and are derived from hematopoietic stem cells. The interaction between GRIP1 and myeloid cells in inflammation is in the early stages. Here is the latest research on GRIP1 and myeloid cells in inflammation.
    GRIP1 in Myeloid Cells in Neuroinflammation

    GRIP1 is a glutamate receptor interacting protein 1 and myeloid cells consists of granulocytes and monocytes, before they have differentiated and are derived from hematopoietic stem cells. The interaction between GRIP1 and myeloid cells in inflammation is in the early stages. Here is the latest research on GRIP1 and myeloid cells in inflammation.

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  • Galectins proteins bind to sugar molecules and mediate the cellular response to endocytic vesicles. It is believed that some galectin proteins are involved in microglia activation induced by α-synuclein. Here is the latest research on galectins and alpha-synuclein.
    Galectins & Alpha-Synuclein

    Galectins proteins bind to sugar molecules and mediate the cellular response to endocytic vesicles. It is believed that some galectin proteins are involved in microglia activation induced by α-synuclein. Here is the latest research on galectins and alpha-synuclein.

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  • Gene therapy is a powerful tool that can potentially be used for treating neurodegenerative diseases such as amyotrophic lateral sclerosis, spinal muscular atrophy, Parkinson's disease and Alzheimer's disease. Here is the latest research.
    Gene Therapies for Neurodegenerative Diseases

    Gene therapy is a powerful tool that can potentially be used for treating neurodegenerative diseases such as amyotrophic lateral sclerosis, spinal muscular atrophy, Parkinson's disease and Alzheimer's disease. Here is the latest research.

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  • Gene-environment interaction is when two different genotypes respond to environmental variation in different ways.Genes and environment interact to form an individual's personality. Abnormal or extreme behaviour could thus be explained by hereditary factors in combination with poor environmental conditions.
    Gene-Environment Interaction & Behaviour

    Gene-environment interaction is when two different genotypes respond to environmental variation in different ways.Genes and environment interact to form an individual's personality. Abnormal or extreme behaviour could thus be explained by hereditary factors in combination with poor environmental conditions.

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  • Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.
    Genetic Screens in iPSC-Derived Brain Cells
    Fast Growing

    Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

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  • Genome surgery using CRISPR genomic techniques offer the potential to correct disease-causing mutations in many neuronal disorders. Here are the latest discoveries pertaining to genome surgery and neuronal disorders.
    Genome Surgery & Neuronal Disorders
    Fast Growing

    Genome surgery using CRISPR genomic techniques offer the potential to correct disease-causing mutations in many neuronal disorders. Here are the latest discoveries pertaining to genome surgery and neuronal disorders.

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  • Gerstmann-Straussler-Scheinker disease is a rare neurodegenerative disorder caused by prions and characterized by symptoms associated with prion-associated diseases. Here is the latest research.
    Gerstmann-Straussler-Scheinker Disease

    Gerstmann-Straussler-Scheinker disease is a rare neurodegenerative disorder caused by prions and characterized by symptoms associated with prion-associated diseases. Here is the latest research.

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  • The glymphatic system is a CSF-mediated waste clearance pathway that is formed by astroglial cells. The removal of potentially harmful substances such as amyloid protein is important to prevent toxic levels accumulate in the brain. Discover the latest research on glymphatics here.
    Glymphatics
    Influential

    The glymphatic system is a CSF-mediated waste clearance pathway that is formed by astroglial cells. The removal of potentially harmful substances such as amyloid protein is important to prevent toxic levels accumulate in the brain. Discover the latest research on glymphatics here.

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  • Gut microbiota composition has been implicated in neuroinflammatory responses, as well as brain aging and brain-aging related diseases like amyloid neuropathies. Here is the latest research.
    Gut Microbiota And Brain In Aging
    Fast Growing

    Gut microbiota composition has been implicated in neuroinflammatory responses, as well as brain aging and brain-aging related diseases like amyloid neuropathies. Here is the latest research.

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  • Gut microbiota has been implicated in neurodevelopment, neuroinflammatory responses, and neurological disorders. Here is the latest research on the role of gut microbiota in movement disorders.
    Gut Microbiota in Movement Disorders

    Gut microbiota has been implicated in neurodevelopment, neuroinflammatory responses, and neurological disorders. Here is the latest research on the role of gut microbiota in movement disorders.

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  • Hallervorden-Spatz disease, also known as pantothenate kinase-associated neurodegeneration, is a rare neurodegenerative disease associated with iron accumulation in the brain. Here is the latest research.
    Hallervorden-Spatz Disease

    Hallervorden-Spatz disease, also known as pantothenate kinase-associated neurodegeneration, is a rare neurodegenerative disease associated with iron accumulation in the brain. Here is the latest research.

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  • The formation of blood cells, hematopoiesis, has been exploited for the potential use as a therapy in Alzheimer’s disease. Decreased levels of lymphocytes and proteins involved in stem cell recruitment are found in early stages of Alzheimer’s disease. Here is the latest research on hematopoiesis and Alzheimer’s disease.
    Hematopoiesis & Alzheimer's Disease
    Fast Growing

    The formation of blood cells, hematopoiesis, has been exploited for the potential use as a therapy in Alzheimer’s disease. Decreased levels of lymphocytes and proteins involved in stem cell recruitment are found in early stages of Alzheimer’s disease. Here is the latest research on hematopoiesis and Alzheimer’s disease.

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  • Hematopoiesis is the process by which a limited number of hematopoietic stem cells maintain a functioning blood and immune system. Aging of these stem cells leads to several functional changes, including alterations affecting self-renewal and differentiation. Here is the latest research.
    Hematopoiesis In Aging
    Influential

    Hematopoiesis is the process by which a limited number of hematopoietic stem cells maintain a functioning blood and immune system. Aging of these stem cells leads to several functional changes, including alterations affecting self-renewal and differentiation. Here is the latest research.

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  • Hereditary demyelinating diseases of the central nervous systems are caused primarily due to inherited genetic conditions. Examples include Alexander, Canavan, and Pelizaeus-Merzbacher diseases. Here is the latest research.
    Hereditary Demyelinating Diseases Of The CNS
    Fast Growing

    Hereditary demyelinating diseases of the central nervous systems are caused primarily due to inherited genetic conditions. Examples include Alexander, Canavan, and Pelizaeus-Merzbacher diseases. Here is the latest research.

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  • Hereditary optic atrophy is a mitochondrially inherited disease that results in bilateral subacute loss of central vision due to degeneration of retinal ganglion cells and the optic nerve. Here is the latest research.
    Hereditary Optic Atrophy
    Influential

    Hereditary optic atrophy is a mitochondrially inherited disease that results in bilateral subacute loss of central vision due to degeneration of retinal ganglion cells and the optic nerve. Here is the latest research.

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  • Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.
    Hereditary Sensory Autonomic Neuropathy
    Fast Growing

    Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

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  • Hereditary spastic paraplegia is a neurodegenerative disorder characterized by spastic paraplegia, cognitive impairment, peripheral neuropathy, and progressive spasticity of lower limbs. Here is a latest research.
    Hereditary Spastic Paraplegia
    Fast Growing

    Hereditary spastic paraplegia is a neurodegenerative disorder characterized by spastic paraplegia, cognitive impairment, peripheral neuropathy, and progressive spasticity of lower limbs. Here is a latest research.

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  • Huntington disease is a hereditary neurodegenerative disease characterized by poor coordination and involuntary body movements. Discover the latest research on Huntington disease here.
    Huntington Disease

    Huntington disease is a hereditary neurodegenerative disease characterized by poor coordination and involuntary body movements. Discover the latest research on Huntington disease here.

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  • Huntington’s disease (HD) is a hereditary neurodegenerative disease caused by mutations in the HTT gene which encodes the huntingtin protein. HD is characterized by poor coordination and involuntary body movements. Here is the latest research on the structure and function of huntingtin.
    Huntington’s Disease - HTT Structure & Function
    Fast Growing

    Huntington’s disease (HD) is a hereditary neurodegenerative disease caused by mutations in the HTT gene which encodes the huntingtin protein. HD is characterized by poor coordination and involuntary body movements. Here is the latest research on the structure and function of huntingtin.

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  • Huntington’s disease (HD) is a hereditary neurodegenerative disease caused by mutations in the HTT gene which encodes the huntingtin protein. HD is characterized by poor coordination and involuntary body movements. Here is the latest research on the structure and function of huntingtin.
    Huntington’s Disease Genetics

    Huntington’s disease (HD) is a hereditary neurodegenerative disease caused by mutations in the HTT gene which encodes the huntingtin protein. HD is characterized by poor coordination and involuntary body movements. Here is the latest research on the structure and function of huntingtin.

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  • Huntington’s disease is a hereditary neurodegenerative disease characterized by poor coordination and involuntary body movements. Here is the latest research on Huntington’s disease therapeutics.
    Huntington’s Disease Therapeutics

    Huntington’s disease is a hereditary neurodegenerative disease characterized by poor coordination and involuntary body movements. Here is the latest research on Huntington’s disease therapeutics.

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  • The innate immune system is a first line of defense against infection. Pathological states can occur if there is over activation of the innate immune system, particularly in the. The excessive activation of these cells can lead to inflammation and neurodegenerative diseases. Here is the latest research on innate immunity and neurodegeneration.
    Innate Immunity: Neurodegeneration

    The innate immune system is a first line of defense against infection. Pathological states can occur if there is over activation of the innate immune system, particularly in the. The excessive activation of these cells can lead to inflammation and neurodegenerative diseases. Here is the latest research on innate immunity and neurodegeneration.

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  • Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects movement. Drug Inosine is proposed to slow progression of this disease. Here is the latest research on Inosine in PD.
    Inosine: Parkinson's Disease

    Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects movement. Drug Inosine is proposed to slow progression of this disease. Here is the latest research on Inosine in PD.

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  • Fatal familial insomnia is a familial prion disease linked to a mutation of the prion protein gene. Here is the latest research on this rare genetic degenerative brain disorder.
    Insomnia Familial Fatal
    Fast Growing

    Fatal familial insomnia is a familial prion disease linked to a mutation of the prion protein gene. Here is the latest research on this rare genetic degenerative brain disorder.

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  • Interactomics is the intersection of bioinformatics and biology concerned with investigating the interaction and the consequences of these interactions between proteins in a cell. Here is the latest research on interactomic data in neurodegeneration.
    Interactomics in Neurodegeneration
    Fast Growing

    Interactomics is the intersection of bioinformatics and biology concerned with investigating the interaction and the consequences of these interactions between proteins in a cell. Here is the latest research on interactomic data in neurodegeneration.

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  • Interneurons are found throughout central nervous system and create important networks of connections between other sensory and motor neurons. The use of stem cells to artificially create interneurons enables the study and understanding of the role of the interneurons throughout the CNS. Here is the latest research on interneurons and stem cells.
    Interneurons & Stem Cells

    Interneurons are found throughout central nervous system and create important networks of connections between other sensory and motor neurons. The use of stem cells to artificially create interneurons enables the study and understanding of the role of the interneurons throughout the CNS. Here is the latest research on interneurons and stem cells.

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  • Kennedy Disease, also known as X-linked bulbospinal muscular atrophy, is a progressive neuromuscular disorder caused by mutations in the androgen receptor gene and characterize by wasting of proximal and bulbar muscles. Here is the latest research.
    Kennedy Disease
    Fast Growing

    Kennedy Disease, also known as X-linked bulbospinal muscular atrophy, is a progressive neuromuscular disorder caused by mutations in the androgen receptor gene and characterize by wasting of proximal and bulbar muscles. Here is the latest research.

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  • Mutations in the LRRK2 gene are a risk-factor for developing Parkinson’s disease. However, LRRK2 has been shown to function as a central regulator of vesicular trafficking, infection, immunity, and inflammation. Here is the latest research on the role of this kinase on immunity during infection.
    LRRK2 & Immunity During Infection

    Mutations in the LRRK2 gene are a risk-factor for developing Parkinson’s disease. However, LRRK2 has been shown to function as a central regulator of vesicular trafficking, infection, immunity, and inflammation. Here is the latest research on the role of this kinase on immunity during infection.

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  • Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease. Increased kinase activity of certain LRRK2 mutants is thought to underlie dopaminergic neuron damage. Thus, LRRK2 inhibitors offer the potential to target an underlying cause of the disease. Here is the latest research.
    LRRK2 Inhibitors

    Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease. Increased kinase activity of certain LRRK2 mutants is thought to underlie dopaminergic neuron damage. Thus, LRRK2 inhibitors offer the potential to target an underlying cause of the disease. Here is the latest research.

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  • Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.
    LRRK2 and Microtubules

    Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.

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  • Lafora disease is an inherited neurodegenerative disorder characterized by the presence of abnormal glycogen inclusions, called Lafora bodies, in neurons and other tissues. Here is the latest research on this fatal, autosomal recessive disorder.
    Lafora Disease
    Going Viral

    Lafora disease is an inherited neurodegenerative disorder characterized by the presence of abnormal glycogen inclusions, called Lafora bodies, in neurons and other tissues. Here is the latest research on this fatal, autosomal recessive disorder.

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  • Lewy Body Disease, associated with abnormal deposits of proteins like alpha-synuclein in the brain, causes a decline in mental abilities. Here is the latest on this progressive neurological disorder.
    Lewy Body Disease
    Fast Growing

    Lewy Body Disease, associated with abnormal deposits of proteins like alpha-synuclein in the brain, causes a decline in mental abilities. Here is the latest on this progressive neurological disorder.

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  • Lichtheim's disease or subacute combined degeneration of spinal cord is a degenerative disease associated with deficiencies in vitamin B12, vitamin E, and copper. Here is a latest research.
    Lichtheim's Disease

    Lichtheim's disease or subacute combined degeneration of spinal cord is a degenerative disease associated with deficiencies in vitamin B12, vitamin E, and copper. Here is a latest research.

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  • The feed focuses on therapeutic interventions used to treat Multiple Sclerosis.
    MS: Therapies

    The feed focuses on therapeutic interventions used to treat Multiple Sclerosis.

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  • The mechanism of axonal degeneration is still poorly understood, but studies in animal models have suggested some cellular and molecular mechanisms responsible. The degeneration of axons in the CNS has been found to be characteristic of many neurodegenerative diseases. Discover the latest research on the mechanisms of axon degeneration here.
    Mechanisms of Axon Degeneration
    Fast Growing

    The mechanism of axonal degeneration is still poorly understood, but studies in animal models have suggested some cellular and molecular mechanisms responsible. The degeneration of axons in the CNS has been found to be characteristic of many neurodegenerative diseases. Discover the latest research on the mechanisms of axon degeneration here.

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  • Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Whilst some key players seem to have been identified so far, the mechanisms that underlie prion propagation to the brain are still not fully understood. Here is the latest research pertaining to mechanisms of prion propagation.
    Mechanisms of Prion Propagation

    Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Whilst some key players seem to have been identified so far, the mechanisms that underlie prion propagation to the brain are still not fully understood. Here is the latest research pertaining to mechanisms of prion propagation.

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  • Mesenchymal stem cells are multipotent cells that are a readily available source of stem cells from bone marrow, adipose tissue and umbilical cord blood. They have shown promise for the therapeutic potential in neurological diseases. Discover the latest research on mesenchymal stem cells and neurological diseases here.
    Mesenchymal Stem Cell & Neurological Diseases
    Fast Growing

    Mesenchymal stem cells are multipotent cells that are a readily available source of stem cells from bone marrow, adipose tissue and umbilical cord blood. They have shown promise for the therapeutic potential in neurological diseases. Discover the latest research on mesenchymal stem cells and neurological diseases here.

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  • The gut microbiota shares a symbiotic relationship with the human host. Dysbiosis is linked with several neurological pathologies including Parkinson’s disease (PD). Here is the latest research on the modulation of PD by the gut microbiota.
    Microbiome Modulation in Parkinson's Disease
    Fast Growing

    The gut microbiota shares a symbiotic relationship with the human host. Dysbiosis is linked with several neurological pathologies including Parkinson’s disease (PD). Here is the latest research on the modulation of PD by the gut microbiota.

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  • Multiple sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system which is characterized by inflammatory demyelination and neurodegeneration. Here is the latest research on the influence of the human microbiome on this dymyelinating disorder.
    Microbiome and MS
    Fast Growing

    Multiple sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system which is characterized by inflammatory demyelination and neurodegeneration. Here is the latest research on the influence of the human microbiome on this dymyelinating disorder.

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  • Microglia are resident macrophages of the CNS. They play a role in scavenging the CNS for plaques, phagocytosis, and extracellular signaling. Here is the latest research on their role in CNS diseases.
    Microglia And CNS Diseases

    Microglia are resident macrophages of the CNS. They play a role in scavenging the CNS for plaques, phagocytosis, and extracellular signaling. Here is the latest research on their role in CNS diseases.

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  • Microglia are immune cells of the central nervous system and are thought to play a role in the repair of neurons following injury. The mechanism by which microglia are involved is still under investigation. Discover the latest research on microglia in neural tissue regeneration here.
    Microglia in Neural Tissue Regeneration
    Fast Growing

    Microglia are immune cells of the central nervous system and are thought to play a role in the repair of neurons following injury. The mechanism by which microglia are involved is still under investigation. Discover the latest research on microglia in neural tissue regeneration here.

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  • Microglia are the resident macrophages of the central nervous system. Microglia-derived inflammatory neurotoxins play a principal role in the pathogenesis of several neurodegenerative disorders. Here is the latest research on the role of microglia in health and disease.
    Microglia: Health and Disease

    Microglia are the resident macrophages of the central nervous system. Microglia-derived inflammatory neurotoxins play a principal role in the pathogenesis of several neurodegenerative disorders. Here is the latest research on the role of microglia in health and disease.

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  • Protein misfolding is the primary cause of several neurodegenerative disease, including Alzheimer’s and Parkinson’s disease. Here is the latest research.
    Misfolded Proteins: ND

    Protein misfolding is the primary cause of several neurodegenerative disease, including Alzheimer’s and Parkinson’s disease. Here is the latest research.

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  • Misfolding and aggregation of proteins can lead to several diseases. For instance, misfolding of prion or tau proteins are associated with several neurodegenerative diseases. Here is the latest research on diseases caused by protein misfolding and aggregation.
    Misfolding & Aggregation Diseases

    Misfolding and aggregation of proteins can lead to several diseases. For instance, misfolding of prion or tau proteins are associated with several neurodegenerative diseases. Here is the latest research on diseases caused by protein misfolding and aggregation.

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  • This feed focuses on the role of the mitochondria and cholesterol on neurodevelopmental disorders (ND).
    Mitochondria & Cholesterol in ND

    This feed focuses on the role of the mitochondria and cholesterol on neurodevelopmental disorders (ND).

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  • Mutations in RNA-binding proteins, including TARDBP, have been found in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This feed focuses on molecular mechanisms that underlie ALS and FTD.
    Molecular Mechanisms of Disease in ALS & FTD

    Mutations in RNA-binding proteins, including TARDBP, have been found in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This feed focuses on molecular mechanisms that underlie ALS and FTD.

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  • Prion diseases are fatal neurodegenerative and infectious disorders characterized by structural transition of the host-encoded cellular prion protein into the aberrantly folded pathologic isoform of the protein. Here is the latest research on molecular diagnostic strategies for prion diseases.
    Molecular diagnostic strategies in prion disease

    Prion diseases are fatal neurodegenerative and infectious disorders characterized by structural transition of the host-encoded cellular prion protein into the aberrantly folded pathologic isoform of the protein. Here is the latest research on molecular diagnostic strategies for prion diseases.

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  • The motor cortex is associated with planning, control, and execution of voluntary movements. This feed focuses on bi-directional communication pathways between an external device and the motor cortex.
    Motor Cortex & Brain-Machine Interfaces
    Fast Growing

    The motor cortex is associated with planning, control, and execution of voluntary movements. This feed focuses on bi-directional communication pathways between an external device and the motor cortex.

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  • Multiple Sclerosis is a demyelinating autoimmune disease of the CNS, resulting in symptoms including optic neuritis and motor weakness. Discover the latest research on Multiple Sclerosis here.
    Multiple Sclerosis

    Multiple Sclerosis is a demyelinating autoimmune disease of the CNS, resulting in symptoms including optic neuritis and motor weakness. Discover the latest research on Multiple Sclerosis here.

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  • Multiple sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system which is characterized by inflammatory demyelination and neurodegeneration. Here is the latest research MS and aging.
    Multiple Sclerosis and Aging
    Going Viral

    Multiple sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system which is characterized by inflammatory demyelination and neurodegeneration. Here is the latest research MS and aging.

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  • Multiple Sclerosis (MS) is a demyelinating autoimmune disease of the CNS, resulting in symptoms including optic neuritis and motor weakness. Here is the latest research on development and application of methods for diagnosis of MS.
    Multiple Sclerosis: Diagnostic Methods

    Multiple Sclerosis (MS) is a demyelinating autoimmune disease of the CNS, resulting in symptoms including optic neuritis and motor weakness. Here is the latest research on development and application of methods for diagnosis of MS.

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  • Magnetic resonance imaging has been used to diagnose and monitor the disease progression in multiple sclerosis. MRI has improved the management of MS patients and provided information on the level of atrophy in the brain and the severity of the disease. Discover the latest research on multiple sclerosis imaging here.
    Multiple Sclerosis: Imaging

    Magnetic resonance imaging has been used to diagnose and monitor the disease progression in multiple sclerosis. MRI has improved the management of MS patients and provided information on the level of atrophy in the brain and the severity of the disease. Discover the latest research on multiple sclerosis imaging here.

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  • Multiple Sclerosis (MS) is a demyelinating autoimmune disease of the CNS, resulting in symptoms including optic neuritis and motor weakness. Here is the latest research on pathology of this complex neurodegenerative disease.
    Multiple Sclerosis: Pathology

    Multiple Sclerosis (MS) is a demyelinating autoimmune disease of the CNS, resulting in symptoms including optic neuritis and motor weakness. Here is the latest research on pathology of this complex neurodegenerative disease.

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  • Multiple System Atrophy (MSA) is a rare neurodegenerative disorder which affects the body’s autonomic functions, including breathing and muscle control. Discover the latest research on MSA here.
    Multiple System Atrophy

    Multiple System Atrophy (MSA) is a rare neurodegenerative disorder which affects the body’s autonomic functions, including breathing and muscle control. Discover the latest research on MSA here.

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  • Myelin surrounds axons and is important for efficient axonal function. Formation of myelin is regulated by many signaling pathways. Degeneration is a target for many diseases, particularly in multiple sclerosis and regeneration is associated with oligodendrocyte progenitor cells. Here is the latest research on myelin formation and repair.
    Myelin Formation & Repair
    Influential

    Myelin surrounds axons and is important for efficient axonal function. Formation of myelin is regulated by many signaling pathways. Degeneration is a target for many diseases, particularly in multiple sclerosis and regeneration is associated with oligodendrocyte progenitor cells. Here is the latest research on myelin formation and repair.

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  • Myeloid cells in the CNS are innate immune cells that are essential for brain development and maintenance. Here is the latest research on myeloid cells, including microglia, in neuroinflammation.
    Myeloid Cells And Neuroinflammation
    Fast Growing

    Myeloid cells in the CNS are innate immune cells that are essential for brain development and maintenance. Here is the latest research on myeloid cells, including microglia, in neuroinflammation.

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  • Myoclonic cerebellar dyssynergia is a rare neurodegenerative disorder characterized by myoclonus, cognitive impairment, epilepsy, and ataxia. Here is the latest research.
    Myoclonic Cerebellar Dyssynergia

    Myoclonic cerebellar dyssynergia is a rare neurodegenerative disorder characterized by myoclonus, cognitive impairment, epilepsy, and ataxia. Here is the latest research.

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  • Myotonia congenita is a disorder that causes sustained tensing of skeletal muscles, preventing them from relaxing. This feed focuses on mechanisms that underlie this condition and therapeutic strategies used for its treatment.
    Myotonia Congenita
    Fast Growing

    Myotonia congenita is a disorder that causes sustained tensing of skeletal muscles, preventing them from relaxing. This feed focuses on mechanisms that underlie this condition and therapeutic strategies used for its treatment.

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  • Myotonic Dystrophy is an autosomal dominant neuromuscular disorder associated with the expansion of CTG trinucleotide repeats in the 3’ untranslated region of the myotonic dystrophy protein kinase (DMPK) gene. Here is the latest research.
    Myotonic Dystrophy

    Myotonic Dystrophy is an autosomal dominant neuromuscular disorder associated with the expansion of CTG trinucleotide repeats in the 3’ untranslated region of the myotonic dystrophy protein kinase (DMPK) gene. Here is the latest research.

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  • Neural stem cells are self-renewing, multipotent cells that are present in both the embryonic and adult brain. Several factors, including metabolism, have been shown to regulate proliferation, differentiation, and quiescence of neural stem cells. Here is the latest research.
    Neural Stem Cell Regulation
    Fast Growing

    Neural stem cells are self-renewing, multipotent cells that are present in both the embryonic and adult brain. Several factors, including metabolism, have been shown to regulate proliferation, differentiation, and quiescence of neural stem cells. Here is the latest research.

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  • Neuroacanthocytosis is a heterogeneous group of hereditary syndromes characterized by the association of neurological abnormalities with acanthocytosis. Discover the latest research on neuroacanthocytosis here.
    Neuroacanthocytosis

    Neuroacanthocytosis is a heterogeneous group of hereditary syndromes characterized by the association of neurological abnormalities with acanthocytosis. Discover the latest research on neuroacanthocytosis here.

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  • This feed focuses on genetic aspects of neurodegeneration and aging, with emphasis on the role of protein aggregates in neurodegenerative diseases including Alzhiemer’s. Here is the latest research.
    Neurodegeneration And Aging

    This feed focuses on genetic aspects of neurodegeneration and aging, with emphasis on the role of protein aggregates in neurodegenerative diseases including Alzhiemer’s. Here is the latest research.

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  • This feed focuses on the role of the endolysosome, an organelle involved in protein degradation. Defects in the endolysosome may cause neurodegenerative diseases, such as Alzheimer’s Disease.
    Neurodegeneration: Endolysosome

    This feed focuses on the role of the endolysosome, an organelle involved in protein degradation. Defects in the endolysosome may cause neurodegenerative diseases, such as Alzheimer’s Disease.

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  • Neurodegeneration is the progressive loss of structure or function of neurons, including neuronal death, and leads to several diseases, including Alzheimer’s and Parkinson’s. This feed focuses on the genetic alterations that underlie neurodegeneration.
    Neurodegeneration: Genetics
    Fast Growing

    Neurodegeneration is the progressive loss of structure or function of neurons, including neuronal death, and leads to several diseases, including Alzheimer’s and Parkinson’s. This feed focuses on the genetic alterations that underlie neurodegeneration.

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  • microRNAs (miRNAs) are key regulatory RNAs that control modulate gene expression in various biological processes and neurodegenerative disorders. Here are the latest discoveries pertaining to miRNAs and neurodegeneration.
    Neurodegeneration: MicroRNA

    microRNAs (miRNAs) are key regulatory RNAs that control modulate gene expression in various biological processes and neurodegenerative disorders. Here are the latest discoveries pertaining to miRNAs and neurodegeneration.

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  • TDP43 is is implicated in several neurodegenerative disorders including Alzheimer's disease, amyotrophic lateral sclerosis and frontotemporal lobe dementia. It has also been shown to regulate microglial phagocytosis. Here is the latest research on the role of TDP43 and microglia in neurodegeneration.
    Neurodegeneration: Microglia & TDP-43
    Fast Growing

    TDP43 is is implicated in several neurodegenerative disorders including Alzheimer's disease, amyotrophic lateral sclerosis and frontotemporal lobe dementia. It has also been shown to regulate microglial phagocytosis. Here is the latest research on the role of TDP43 and microglia in neurodegeneration.

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  • Progranulin is a secreted growth factor involved in inflammation, wound healing, cancer, and for its neurotrophic properties. Along with lipids (fats), these molcules are associated with neurodegenerative processes. Here are the latest discoveries pertaining to these molecules and neurodegeneration.
    Neurodegeneration: Progranulin & Lipids

    Progranulin is a secreted growth factor involved in inflammation, wound healing, cancer, and for its neurotrophic properties. Along with lipids (fats), these molcules are associated with neurodegenerative processes. Here are the latest discoveries pertaining to these molecules and neurodegeneration.

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  • Neurofibromatosis is a genetic disorder that causes tumors to form in the central nervous system. While these tumors are typically benign, they can become malignant. Other complications of neurofibromatosis include hearing loss, learning impairment, vision loss, etc. Here is the latest research.
    Neurofibromatosis
    Fast Growing

    Neurofibromatosis is a genetic disorder that causes tumors to form in the central nervous system. While these tumors are typically benign, they can become malignant. Other complications of neurofibromatosis include hearing loss, learning impairment, vision loss, etc. Here is the latest research.

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  • Neurofibromatosis 1 (NF1), also known as von Recklinghausen disease, is an autosomal dominant condition caused by mutations in the NF1 gene. Here is the latest research.
    Neurofibromatosis 1
    Fast Growing

    Neurofibromatosis 1 (NF1), also known as von Recklinghausen disease, is an autosomal dominant condition caused by mutations in the NF1 gene. Here is the latest research.

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  • Neuroinflammation is a defensive response, characterized by the activation of proinflammatory molecules including microglia and astrocytes. The response has been implicated in brain injuries, acute and chronic neurological and neurodegenerative disorders such as Alzheimer’s disease. Here is the latest research on neuroinflammation.
    Neuroinflammation

    Neuroinflammation is a defensive response, characterized by the activation of proinflammatory molecules including microglia and astrocytes. The response has been implicated in brain injuries, acute and chronic neurological and neurodegenerative disorders such as Alzheimer’s disease. Here is the latest research on neuroinflammation.

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  • Neuromodulation refers to a physiological process in which a neuron uses chemical(s) to regulate a variety of neuronal populations. Discover the latest research on neuromodulation here.
    Neuromodulation
    Fast Growing

    Neuromodulation refers to a physiological process in which a neuron uses chemical(s) to regulate a variety of neuronal populations. Discover the latest research on neuromodulation here.

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  • This feed focuses on neuronal and network dysfunction in neurodegenerative disorders and the effects of tauopathies on synapses and memory.
    Neuronal and Network Dysfunction In Neurodegeneration

    This feed focuses on neuronal and network dysfunction in neurodegenerative disorders and the effects of tauopathies on synapses and memory.

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  • Multiple sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system which is characterized by inflammatory demyelination and neurodegeneration. Here is the latest research on neuroprotective mechanisms in MS.
    Neuroprotection in MS
    Fast Growing

    Multiple sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system which is characterized by inflammatory demyelination and neurodegeneration. Here is the latest research on neuroprotective mechanisms in MS.

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  • Neuroregeneration is the growth or repair of neural cells and tissues following damage or injury. Discover the latest research on neuroregeneration here.
    Neuroregeneration
    Fast Growing

    Neuroregeneration is the growth or repair of neural cells and tissues following damage or injury. Discover the latest research on neuroregeneration here.

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  • Nutrition improves health and well-being and is one of the important determining factors in successful aging. The mechanism by which nutrition plays a roll in aging is still being unveiled. Discover the latest research on nutrition and aging here.
    Nutrition & Aging
    Fast Growing

    Nutrition improves health and well-being and is one of the important determining factors in successful aging. The mechanism by which nutrition plays a roll in aging is still being unveiled. Discover the latest research on nutrition and aging here.

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  • Olivopontocerebellar atrophy (OPCA) refers to neurodegeneration of the inferior olivary nucleus, pons, and the cerebellum, and is characterized by cerebellar ataxia and other neurological problems. Here is the latest research.
    Olivopontocerebellar Atrophy

    Olivopontocerebellar atrophy (OPCA) refers to neurodegeneration of the inferior olivary nucleus, pons, and the cerebellum, and is characterized by cerebellar ataxia and other neurological problems. Here is the latest research.

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  • Opsoclonus-Myoclonus Syndrome (OMS) is a rare inflammatory neurological disorder characterized by ocular, sleep, and behavioural disorders, as well as ataxia. Here is the latest research on OMS.
    Opsoclonus-Myoclonus Syndrome

    Opsoclonus-Myoclonus Syndrome (OMS) is a rare inflammatory neurological disorder characterized by ocular, sleep, and behavioural disorders, as well as ataxia. Here is the latest research on OMS.

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  • Neurodegeneration is the progressive loss of neural structures and functions, including neuronal death. This feed focuses on dynamics of neuronal organelles in neurodegenerative diseases.
    Organelles in Neurodegeneration

    Neurodegeneration is the progressive loss of neural structures and functions, including neuronal death. This feed focuses on dynamics of neuronal organelles in neurodegenerative diseases.

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  • Recently, cerebral organoids derived from induced pluripotent stem (ips) cells have illuminated early developmental events altered by disease processes, and may be a promising avenue for future therapies in neurodegenerative disorders. Here is the latest research on Organoids & Neurodegeneration.
    Organoids & Neurodegeneration
    Fast Growing

    Recently, cerebral organoids derived from induced pluripotent stem (ips) cells have illuminated early developmental events altered by disease processes, and may be a promising avenue for future therapies in neurodegenerative disorders. Here is the latest research on Organoids & Neurodegeneration.

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  • P2Y12 is a G-coupled receptor that is known for its role in platelet activation. However, the expression and involvement in the CNS and microglial activation and renewal is less known. Discover the latest research on P2Y12 and microglial self-renewal here.
    P2Y12 & Microglial Self-Renewal
    Fast Growing

    P2Y12 is a G-coupled receptor that is known for its role in platelet activation. However, the expression and involvement in the CNS and microglial activation and renewal is less known. Discover the latest research on P2Y12 and microglial self-renewal here.

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  • Induced pluripotent stem cells (iPSCs) may be obtained by direct reprogramming of different somatic cells to a pluripotent state by forced expression of a handful of transcription factors. This feed focuses on the generation of neurons of the paraventricular nucleus of the hypothalamus from iPSCs.
    PVN Neurons from iPSCs
    Fast Growing

    Induced pluripotent stem cells (iPSCs) may be obtained by direct reprogramming of different somatic cells to a pluripotent state by forced expression of a handful of transcription factors. This feed focuses on the generation of neurons of the paraventricular nucleus of the hypothalamus from iPSCs.

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  • Paraneoplastic disorders of the nervous system are syndromes that affect diverse organs systems (including endocrine, neurologic, dermatologic systems, etc.) that occur in association with systemic cancer. Here is the latest research.
    Paraneoplastic Syndromes of the Nervous System
    Going Viral

    Paraneoplastic disorders of the nervous system are syndromes that affect diverse organs systems (including endocrine, neurologic, dermatologic systems, etc.) that occur in association with systemic cancer. Here is the latest research.

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  • Parkinson's Disease is a progressive neurodegenerative disorder characterized by loss of muscle control, including trembling of the limbs and impaired balance. Here is the latest research.
    Parkinson's Disease

    Parkinson's Disease is a progressive neurodegenerative disorder characterized by loss of muscle control, including trembling of the limbs and impaired balance. Here is the latest research.

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  • Alpha-synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. Here is the latest research.
    Parkinson's Disease: Alpha-Synuclein

    Alpha-synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. Here is the latest research.

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  • Parkinson’s disease is a progressive neurodegenerative disorder that affects movement. This feed focuses on animal models used for Parkinson's disease research.
    Parkinson's Disease: Animal Models

    Parkinson’s disease is a progressive neurodegenerative disorder that affects movement. This feed focuses on animal models used for Parkinson's disease research.

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  • Parkinson’s disease is a progressive neurodegenerative disorder that affects movement. This feed focuses on genomic and drug-response biomarkers in Parkinson’s disease.
    Parkinson's Disease: Biomarkers

    Parkinson’s disease is a progressive neurodegenerative disorder that affects movement. This feed focuses on genomic and drug-response biomarkers in Parkinson’s disease.

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  • Parkinson’s disease (PD) is a neurodegenerative disorder that affects movement. This feed focuses on therapeutic aspects, diagnostic tools including medical imaging, and clinical trials in PD.
    Parkinson's Disease: Diagnostics and Clinical Trials
    Fast Growing

    Parkinson’s disease (PD) is a neurodegenerative disorder that affects movement. This feed focuses on therapeutic aspects, diagnostic tools including medical imaging, and clinical trials in PD.

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  • Parkinson’s disease is a progressive neurodegenerative disorder that affects movement. This feed focuses on genetic screening approaches and genetic predispositions in Parkinson’s disease.
    Parkinson's Disease: Genetics

    Parkinson’s disease is a progressive neurodegenerative disorder that affects movement. This feed focuses on genetic screening approaches and genetic predispositions in Parkinson’s disease.

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  • Parkinson’s disease (PD) is a neurodegenerative disorder that affects movement. This feed focuses on leucine-rich repeat kinase 2 (LRRK2) which is the most prominent genetic contributor to PD.
    Parkinson's Disease: LRRK2

    Parkinson’s disease (PD) is a neurodegenerative disorder that affects movement. This feed focuses on leucine-rich repeat kinase 2 (LRRK2) which is the most prominent genetic contributor to PD.

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  • This feed focuses on different types of light therapies and methods, including optogenetics and low-level laser applications.
    Photobiomodulation & Neuromodulation
    Fast Growing

    This feed focuses on different types of light therapies and methods, including optogenetics and low-level laser applications.

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  • Plexopathies are disorder that affects networks of nerves, blood vessels, or lymph vessels. Symptoms of this disorder include loss of motor control, pain, and sensory deficits. Here is the latest research.
    Plexopathies

    Plexopathies are disorder that affects networks of nerves, blood vessels, or lymph vessels. Symptoms of this disorder include loss of motor control, pain, and sensory deficits. Here is the latest research.

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  • Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research.
    Pontocerebellar hypoplasia
    Influential

    Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research.

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  • Postpoliomyelitis syndrome is characterized by a sudden or progressive loss of muscle strength, muscle atrophy, muscle pain, fatigue, intolerance to cold, after a period of at least 15 years from the acute polio virus infection, a period of neurological and functional stability. Here is the latest research.
    Postpoliomyelitis Syndrome
    Fast Growing

    Postpoliomyelitis syndrome is characterized by a sudden or progressive loss of muscle strength, muscle atrophy, muscle pain, fatigue, intolerance to cold, after a period of at least 15 years from the acute polio virus infection, a period of neurological and functional stability. Here is the latest research.

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  • Prion diseases or transmissible spongiform encephalopathies are rare progressive neurogenerative diseases caused by misfolded prion proteins. Here is the latest research in this domain.
    Prion Disease

    Prion diseases or transmissible spongiform encephalopathies are rare progressive neurogenerative diseases caused by misfolded prion proteins. Here is the latest research in this domain.

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  • The Prion Disease: Cholesterol feed describes the role cholesterol plays in the conversion and transmission of prion. Discover the latest research on the role of cholesterol in prion disease here.
    Prion Disease: Cholesterol

    The Prion Disease: Cholesterol feed describes the role cholesterol plays in the conversion and transmission of prion. Discover the latest research on the role of cholesterol in prion disease here.

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  • Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion proteins, as an important biomarker of prion disease, are responsible for the transmissible spongiform encephalopathies. Here is the latest research investigating biomarkers in prion diseases.
    Prion Diseases: Biomarkers

    Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion proteins, as an important biomarker of prion disease, are responsible for the transmissible spongiform encephalopathies. Here is the latest research investigating biomarkers in prion diseases.

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  • Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Distinct prion strains are associated with different prion protein conformations and glycosylation patterns and associate with disease progression and severity. Here is the latest research on strain diversity and neurotoxicity in prion diseases.
    Prion Diseases: strain diversity and neurotoxicity

    Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Distinct prion strains are associated with different prion protein conformations and glycosylation patterns and associate with disease progression and severity. Here is the latest research on strain diversity and neurotoxicity in prion diseases.

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  • Prion diseases are fatal, transmissible, neurodegenerative diseases caused by the misfolding of the prion protein (prp). Here is the latest research on prion diseases.
    Prion Neurodegeneration

    Prion diseases are fatal, transmissible, neurodegenerative diseases caused by the misfolding of the prion protein (prp). Here is the latest research on prion diseases.

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  • Progressive Multifocal Leukoencephalopathy (PML) occurs due to JC virus infection. While most adults are infected, PML emerges in individuals with weakened immune systems. Here is the latest on PML.
    Progressive Multifocal Leukoencephalopathy (PML)
    Fast Growing

    Progressive Multifocal Leukoencephalopathy (PML) occurs due to JC virus infection. While most adults are infected, PML emerges in individuals with weakened immune systems. Here is the latest on PML.

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  • Progressive Supranuclear Palsy (PSP) is a rare neurodegenerative disorder that affects movement, gait, balance, and speech. Discover the latest research on PSP here.
    Progressive Supranuclear Palsy

    Progressive Supranuclear Palsy (PSP) is a rare neurodegenerative disorder that affects movement, gait, balance, and speech. Discover the latest research on PSP here.

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  • This feed focuses on the contribution of aging-associated proteotoxicity to inflammation and neurodegenerative disorders, including Alzheimer’s and dementia. Discover the latest research here.
    Proteotoxicity to Inflammation & Dementia

    This feed focuses on the contribution of aging-associated proteotoxicity to inflammation and neurodegenerative disorders, including Alzheimer’s and dementia. Discover the latest research here.

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  • Tau mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) are associated with changes in alternative RNA splicing. Here is the latest research on RNA & Tau in Frontotemporal Dementia.
    RNA & Tau in Frontotemporal Dementia

    Tau mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) are associated with changes in alternative RNA splicing. Here is the latest research on RNA & Tau in Frontotemporal Dementia.

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  • Reactive oxygen species (ROS) are reactive chemicals containing oxygen. They generated as a byproduct of oxidative energy metabolism and play a role in regulating several intracellular signaling pathways. Here is the latest research on ROS metabolism and signaling.
    ROS: Metabolism & Signaling
    Fast Growing

    Reactive oxygen species (ROS) are reactive chemicals containing oxygen. They generated as a byproduct of oxidative energy metabolism and play a role in regulating several intracellular signaling pathways. Here is the latest research on ROS metabolism and signaling.

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  • Refsum disease is an autosomal recessive disorder of lipid metabolism characterized by adult-onset retinitis pigmentosa, anosmia, sensory neuropathy, ataxia, and an accumulation of phytanic acid in plasma and tissues. Here is the latest research on this peroxisomal disorder.
    Refsum Disease

    Refsum disease is an autosomal recessive disorder of lipid metabolism characterized by adult-onset retinitis pigmentosa, anosmia, sensory neuropathy, ataxia, and an accumulation of phytanic acid in plasma and tissues. Here is the latest research on this peroxisomal disorder.

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  • Risk factors for neurodegeneration include trauma, lifestyle, and allelic variants of disease-associated genes with incomplete penetrance. Here is the latest research.
    Risk Factors for Neurodegeneration

    Risk factors for neurodegeneration include trauma, lifestyle, and allelic variants of disease-associated genes with incomplete penetrance. Here is the latest research.

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  • Scrapie is one of the several transmissible spongiform encephalopathies that affect the nervous system of sheep and goats. Here is the latest research on this fatal degenerative disease.
    Scrapie

    Scrapie is one of the several transmissible spongiform encephalopathies that affect the nervous system of sheep and goats. Here is the latest research on this fatal degenerative disease.

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  • Secondary Parkinson disease refers to a group of disorders that present similarly to Parkinson disease but have different etiology. Secondary Parkinson disease is caused due to the blockade of or interference in dopamine’s action in the basal ganglia. Here is the latest research.
    Secondary Parkinson disease
    Influential

    Secondary Parkinson disease refers to a group of disorders that present similarly to Parkinson disease but have different etiology. Secondary Parkinson disease is caused due to the blockade of or interference in dopamine’s action in the basal ganglia. Here is the latest research.

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  • There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration
    Sexual Dimorphism in Neurodegeneration

    There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

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  • Shy-Drager Syndrome is a progressive disorder of the central and sympathetic nervous systems characterized by symptoms of autonomic nervous system failure, impaired speech, difficulties breathing and swallowing, and anhidrosis. Here is the latest research.
    Shy-Drager Syndrome

    Shy-Drager Syndrome is a progressive disorder of the central and sympathetic nervous systems characterized by symptoms of autonomic nervous system failure, impaired speech, difficulties breathing and swallowing, and anhidrosis. Here is the latest research.

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  • Single-cell RNA sequencing is a technique that is used to study an isolated selection of single-cells and obtaining their transcripts which are then used to generate sequence libraries. These can then be used to assess the diversity in the brain and understand neurological diseases. Here is the latest research on single-cell RNA in the brain.
    Single-Cell RNA Sequencing: Brain
    Fast Growing

    Single-cell RNA sequencing is a technique that is used to study an isolated selection of single-cells and obtaining their transcripts which are then used to generate sequence libraries. These can then be used to assess the diversity in the brain and understand neurological diseases. Here is the latest research on single-cell RNA in the brain.

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  • Spinal cord injuries are serious and can cause temporary or permanent changes including loss of muscle function, sensation, or autonomic functions. Here is the latest research.
    Spinal Cord Injuries
    Fast Growing

    Spinal cord injuries are serious and can cause temporary or permanent changes including loss of muscle function, sensation, or autonomic functions. Here is the latest research.

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  • This feed describes the advancement in spinal cord regeneration research and potential nerve regeneration treatments after spinal cord injuries.
    Spinal Cord injury: Regeneration
    Fast Growing

    This feed describes the advancement in spinal cord regeneration research and potential nerve regeneration treatments after spinal cord injuries.

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  • Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by genetic defects in SMN1 gene, which encodes survival motor neuron 1 (SMN1) protein. SMA is characterized by loss of lower motor neurons and progressive muscle wasting. Here is the latest research on this rare condition.
    Spinal Muscular Atrophy

    Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by genetic defects in SMN1 gene, which encodes survival motor neuron 1 (SMN1) protein. SMA is characterized by loss of lower motor neurons and progressive muscle wasting. Here is the latest research on this rare condition.

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  • Spinocerebellar ataxias (SCA) are hereditary and characterized by cerebellar degeneration, which affects muscle coordination and balance. Discover the latest research on SCA and related ataxias here.
    Spinocerebellar & Related Ataxias
    Fast Growing

    Spinocerebellar ataxias (SCA) are hereditary and characterized by cerebellar degeneration, which affects muscle coordination and balance. Discover the latest research on SCA and related ataxias here.

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  • microRNAs (miRNAs) are key regulatory RNAs that control modulate gene expression in various biological processes and human diseases such as Spinocerebellar Ataxia. Here are the latest discoveries pertaining to miRNAs and this disease.
    Spinocerebellar Ataxia: miRNAs

    microRNAs (miRNAs) are key regulatory RNAs that control modulate gene expression in various biological processes and human diseases such as Spinocerebellar Ataxia. Here are the latest discoveries pertaining to miRNAs and this disease.

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  • The use of stem cells is being explored as a treatment option for neuroimmune disorders. The immune system has been demonstrated to have negative impacts on cognitive function and neurogenesis and is a potential target for therapeutic intervention. Discover the latest research on stem cells and neuroimmunology.
    Stem Cells & Neuroimmunology
    Fast Growing

    The use of stem cells is being explored as a treatment option for neuroimmune disorders. The immune system has been demonstrated to have negative impacts on cognitive function and neurogenesis and is a potential target for therapeutic intervention. Discover the latest research on stem cells and neuroimmunology.

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  • Stem cells have the potential to develop into many different types of cells in the body and may be useful as a therapy for several diseases including neurodegenerative diseases. Discover the latest research on stem cells and neurodegenerative diseases here.
    Stem Cells in Neurodegenerative Diseases
    Fast Growing

    Stem cells have the potential to develop into many different types of cells in the body and may be useful as a therapy for several diseases including neurodegenerative diseases. Discover the latest research on stem cells and neurodegenerative diseases here.

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  • Striatonigral degeneration is a neurological disorder resulting from a disrupted connection between the striatum and substantia nigra, which enable balance and movement. Here is the latest research.
    Striatonigral Degeneration

    Striatonigral degeneration is a neurological disorder resulting from a disrupted connection between the striatum and substantia nigra, which enable balance and movement. Here is the latest research.

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  • As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at a much more rapid rate. In MS it has been shown that there is a reduction in synaptic density, which is a potential area to target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.
    Synapse Loss as Therapeutic Target in MS

    As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at a much more rapid rate. In MS it has been shown that there is a reduction in synaptic density, which is a potential area to target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

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  • Synaptic alterations are emerging as critical determinants of neurodegeneration. Here is the latest research on alterations of synaptic transmission and plasticity in neurodegeneration and neurodegerative disorders.
    Synaptic Transmission in Neurodegeneration
    Fast Growing

    Synaptic alterations are emerging as critical determinants of neurodegeneration. Here is the latest research on alterations of synaptic transmission and plasticity in neurodegeneration and neurodegerative disorders.

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  • Synucleinopathies are neurodegenerative diseases characterized by accumulation of alpha-synuclein protein aggregates in neurons and glial cells. Discover the latest research on synucleinopathies here.
    Synucleinopathies

    Synucleinopathies are neurodegenerative diseases characterized by accumulation of alpha-synuclein protein aggregates in neurons and glial cells. Discover the latest research on synucleinopathies here.

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  • Tau and alpha-synuclein are proteins that form aggregates which characterize various neurodegenerative disorders including Parkinson’s disease. This feed focuses on the reaction of T lymphocytes in response to tau and alpha-synuclein.
    T Cell Reactivity to Tau & Alpha-Synuclein in PD

    Tau and alpha-synuclein are proteins that form aggregates which characterize various neurodegenerative disorders including Parkinson’s disease. This feed focuses on the reaction of T lymphocytes in response to tau and alpha-synuclein.

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  • TAR DNA binding protein (TDP43) is a DNA and RNA binding protein that is implicated in several neurodegenerative disorders known as “TDP43 proteinopathies" including Alzheimer's disease, amyotrophic lateral sclerosis and frontotemporal lobe dementia. Here is the latest research.
    TDP-43 Proteinopathies

    TAR DNA binding protein (TDP43) is a DNA and RNA binding protein that is implicated in several neurodegenerative disorders known as “TDP43 proteinopathies" including Alzheimer's disease, amyotrophic lateral sclerosis and frontotemporal lobe dementia. Here is the latest research.

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  • Tau Aggregation is an important characteristic in some neurodegenerative disorders, including Alzheimer’s Disease. Discover the latest research using genomics to understand Tau Aggregation.
    Tau Aggregation: Genomics

    Tau Aggregation is an important characteristic in some neurodegenerative disorders, including Alzheimer’s Disease. Discover the latest research using genomics to understand Tau Aggregation.

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  • Tau vaccination and administration of anti-tau antibodies can prevent pathology and cognitive impairment in transgenic mouse models of tauopathy, suggesting that therapies which increase anti-tau antibodies might slow the development and/or progression of tauopathies including Alzheimer's disease. Here is the latest research.
    Tau Antibody Therapy in Neurodegenerative Diseases
    Influential

    Tau vaccination and administration of anti-tau antibodies can prevent pathology and cognitive impairment in transgenic mouse models of tauopathy, suggesting that therapies which increase anti-tau antibodies might slow the development and/or progression of tauopathies including Alzheimer's disease. Here is the latest research.

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  • Tau toxicity has been implicated in the emergence of synaptic dysfunction in Alzheimer's disease. Here is the latest research on Tau Toxicity in the Synapses.
    Tau Toxicity in the Synapses

    Tau toxicity has been implicated in the emergence of synaptic dysfunction in Alzheimer's disease. Here is the latest research on Tau Toxicity in the Synapses.

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  • Tauopathies are neurodegenerative disorders caused due to misfolding and aggregation of the tau protein in neurofibrillary tangles in the brain. Discover the latest research on tauopathies here.
    Tauopathies

    Tauopathies are neurodegenerative disorders caused due to misfolding and aggregation of the tau protein in neurofibrillary tangles in the brain. Discover the latest research on tauopathies here.

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  • Tauopathies are neurodegenerative disorders that are caused due to the accumulation of abnormal tau proteins in neurons and/or the glia. Here is the latest research on tauopathy biochemistry.
    Tauopathy Biochemistry
    Influential

    Tauopathies are neurodegenerative disorders that are caused due to the accumulation of abnormal tau proteins in neurons and/or the glia. Here is the latest research on tauopathy biochemistry.

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  • Neurodegeneration is the progressive loss of structure or function of neurons, including neuronal death, and leads to several diseases, including Alzheimer’s and Parkinson’s. This feed focuses on therapeutic targets for neurodegenerative disorders.
    Therapeutic Targets For Neurodegeneration

    Neurodegeneration is the progressive loss of structure or function of neurons, including neuronal death, and leads to several diseases, including Alzheimer’s and Parkinson’s. This feed focuses on therapeutic targets for neurodegenerative disorders.

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  • Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.
    Torsion Dystonia

    Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

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  • Tourette Syndrome is a neuropsychiatric disorder characterized by multiple motor and vocal tics and often associated with neurobehavioral comorbidities, such as obsessive-compulsive disorder. Here is the latest research on this childhood-onset neurodevelopmental disorder.
    Tourette Syndrome
    Going Viral

    Tourette Syndrome is a neuropsychiatric disorder characterized by multiple motor and vocal tics and often associated with neurobehavioral comorbidities, such as obsessive-compulsive disorder. Here is the latest research on this childhood-onset neurodevelopmental disorder.

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  • Traumatic Encephalopathy is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.
    Traumatic Encephalopathy

    Traumatic Encephalopathy is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.

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  • Triplet Repeat Disorders are genetic disorders that occur as a result of expansion of trinucleotide repeats in certain genes. Examples include Huntington’s disease, certain types of spinocerebellar ataxia, and Fragile X syndrome, among others. Here is the latest research.
    Triplet Repeat Disorders

    Triplet Repeat Disorders are genetic disorders that occur as a result of expansion of trinucleotide repeats in certain genes. Examples include Huntington’s disease, certain types of spinocerebellar ataxia, and Fragile X syndrome, among others. Here is the latest research.

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  • Tuberous Sclerosis (TSC) is an autosomal dominant genetic disorder caused by mutations in TSC1 or TSC2 tumor suppressor genes and characterized by the development of benign hamartomas in multiple organs. Here is the latest research.
    Tuberous Sclerosis

    Tuberous Sclerosis (TSC) is an autosomal dominant genetic disorder caused by mutations in TSC1 or TSC2 tumor suppressor genes and characterized by the development of benign hamartomas in multiple organs. Here is the latest research.

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  • Type 2 Neurofibromatosis are rare inherited autosomal dominant diseases caused by the NF2 gene. It is characterized by the growth of noncancerous tumors in the nervous system, specifically along the auditory nerve. Symptoms include hearing loss, tinnitus, and balance problems. Here is the latest research on Type 2 Neurofibromatosis.
    Type 2 Neurofibromatosis

    Type 2 Neurofibromatosis are rare inherited autosomal dominant diseases caused by the NF2 gene. It is characterized by the growth of noncancerous tumors in the nervous system, specifically along the auditory nerve. Symptoms include hearing loss, tinnitus, and balance problems. Here is the latest research on Type 2 Neurofibromatosis.

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  • Unverricht-Lundborg Syndrome is a type of progressive myoclonus epilepsy characterized by involuntary muscle jerking/twitching, seizures, muscle rigidity, and convulsions. Discover the latest research on this rare inherited form of epilepsy here.
    Unverricht-Lundborg Syndrome

    Unverricht-Lundborg Syndrome is a type of progressive myoclonus epilepsy characterized by involuntary muscle jerking/twitching, seizures, muscle rigidity, and convulsions. Discover the latest research on this rare inherited form of epilepsy here.

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  • Vascular Dementia refers to the decline in thinking ability caused by cerebrovascular diseases. Discover the latest research on aspects underlying vascular dementia here.
    Vascular Dementia
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    Vascular Dementia refers to the decline in thinking ability caused by cerebrovascular diseases. Discover the latest research on aspects underlying vascular dementia here.

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  • Wallerian Degeneration refers to active degeneration of part of the axon distal to the injury in response to nerve fiber damage. Here is the latest research on aspects underlying this degeneration
    Wallerian Degeneration

    Wallerian Degeneration refers to active degeneration of part of the axon distal to the injury in response to nerve fiber damage. Here is the latest research on aspects underlying this degeneration

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  • Wilson’s disease is an autosomal recessive disorder caused by mutation in the ATP7B gene and is characterized by copper build-up in the body. Discover the latest research on Wilson’s disease here.
    Wilson Disease

    Wilson’s disease is an autosomal recessive disorder caused by mutation in the ATP7B gene and is characterized by copper build-up in the body. Discover the latest research on Wilson’s disease here.

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  • Neurodegeneration is the progressive loss of structure or function of neurons, including neuronal death. Several diseases, including Alzheimer’s and Parkinson’s disease, occur as a result of neurodegeneration. This feed focuses on the utility of induced pluripotent stem cells in neurodegenerative disorders.
    iPSC & Neurodegeneration
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    Neurodegeneration is the progressive loss of structure or function of neurons, including neuronal death. Several diseases, including Alzheimer’s and Parkinson’s disease, occur as a result of neurodegeneration. This feed focuses on the utility of induced pluripotent stem cells in neurodegenerative disorders.

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  • Induced pluripotent stem cell (iPSCs) models can be generated to study mechanisms involved in neurodegeneration. The iPSCs can be selectively differentiated into specific neurons such as dopaminergic neurons that are susceptible to neurodegeneration. Discover the latest research on iPSC models in neurodegeneration here.
    iPSC Models in Neurodegeneration

    Induced pluripotent stem cell (iPSCs) models can be generated to study mechanisms involved in neurodegeneration. The iPSCs can be selectively differentiated into specific neurons such as dopaminergic neurons that are susceptible to neurodegeneration. Discover the latest research on iPSC models in neurodegeneration here.

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  • Induced pluripotent stem cell-derived microglia have recently been developed and provide unlimited access to patient-derived material. These cells can be used to model and investigate mechanism that underlie neurodegenerative diseases. Here is the latest research.
    iPSC-derived Microglia in Neurodegeneraton
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    Induced pluripotent stem cell-derived microglia have recently been developed and provide unlimited access to patient-derived material. These cells can be used to model and investigate mechanism that underlie neurodegenerative diseases. Here is the latest research.

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