Neurodevelopment

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research.

A common feature of autism spectrum disorder (ASD) is the impairment of motor control and learning, consistent with perturbation in cerebellar function. Find the latest research on ASD and motor learning here.

The absence of effective treatments for autism are due to the high clinical and genetic heterogeneity between affected individuals, restricted knowledge of the underlying pathophysiological mechanisms, and the lack of reliable diagnostic biomarkers. Identification of more homogenous biological subgroups is therefore essential for the development of novel treatments based on the molecular mechanisms underpinning autism and autism spectrum disorders. Find the latest research on autism treatment targets here.

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Cerebral organoids are an emerging cutting-edge technology to model human brain development and neurodevelopmental disorders. Here is the latest research.

Congenital brain malformations are a major cause of morbidity and mortality in pediatric patients younger than 2 years. Discover the latest research on congenital brain malformations here.

Double Cortex (DCX) Related Disorders are X-linked inherited disorders that manifest as lissencephaly in males and subcortical band heterotopia in females. Discover the latest research on DCX-Related Disorders here.

Imaging of the brain through different stages of development provides insight on brain structure, function, and plasticity. Insights gained from studying how the brain develops in healthy individuals and in disease can improve understanding and treatment for those with developmental deficits. Follow this feed to stay up to date on developmental neuroimaging.

Epigenetic regulation involves chromatin remodeling complexes that catalyze DNA methylation changes and various types of histone modifications that can influence the expression of genes involved in neural development. Discover the latest research on the epigenetic regulation of neural development here.

Synapses are crucial for the transmission of information within neural circuits. These specialized intercellular junctions are the basis for the formation of complex networks. Formation of these synapses involve numerous steps that are essential for transmission of information. Here is the latest research on formation of synapses and circuits.

The genetic landscape of an individual can have drastic effects on brain development and brain developmental disorders. Discover the latest research here.

Glial cells play an essential role in maintaining brain homeostasis, forming myelin, and providing support and protection for neurons. Follow new research into glia cell differentiation with this feed.

Hippocampal neurogenesis is the formation of new neurons from neural progenitor cells in the dentate gyrus. This is important for behavioural responses, learning and memory. Here is the latest research on hippocampal neurogenesis.

This feed focuses on the role of the mitochondria and cholesterol on neurodevelopmental disorders (ND).

Myelin surrounds axons and is important for efficient axonal function. Formation of myelin is regulated by many signaling pathways. Degeneration is a target for many diseases, particularly in multiple sclerosis and regeneration is associated with oligodendrocyte progenitor cells. Here is the latest research on myelin formation and repair.

Here is the latest research on structures and gene circuits in the nervous system of model organism C. Elegans.

Neural stem cells are self-renewing, multipotent cells that are present in both the embryonic and adult brain. Several factors, including metabolism, have been shown to regulate proliferation, differentiation, and quiescence of neural stem cells. Here is the latest research.

This feed focuses on neuroblastoma in Zebrafish, as well as MYCN and ALK oncogenes which are highly expressed in neuroblastoma. Here is the latest research.

This feed focuses on mechanisms that underlie the evolution of axonal guidance pathways, neurogenesis, and synaptic connectivity. Here is the latest research.

Neuronal identity is important for defining the end result of stem cell differentiation through neuronal developmentor for regenerative medicine. This could involved transcription factors used to drive induce pluripotent stem cells towards the neuronal lineage. Discover the latest research on Neuronal Identity here.

Neuronal plasticity is the brain’s ability to change its structure and function in response to internal or external factors. Here is the latest research on mechanisms that influence this process.

Neuronal remodeling is a critical step in the development of the mature nervous system and important in the refinement to respond to developmental and environmental influences. Disruption of this process can lead to neuropsychiatric diseases. Here is the latest research on neuronal remodeling.

Single-cell RNA sequencing is a technique that is used to study an isolated selection of single-cells and obtaining their transcripts which are then used to generate sequence libraries. These can then be used to assess the diversity in the brain and understand neurological diseases. Here is the latest research on single-cell RNA in the brain.

The Sonic Hedgehog signaling pathway regulates developmental processes including cell patterning and differentiation and plays a role in tissue repair and regeneration. Here is the latest research on this complex signal transduction pathway.