When demyelination occurs an inflammatory response is activated. Accumulation of excess myelin debris triggers cholesterol crystal formation, and cholesterol deposits in the CNS can overwhelm phagocytes, resulting in impaired tissue regeneration. Here is the latest research on cholesterol synthesis in inflammation and remyelination.
Granule cells present in the dentate gyrus of the hippocampus and are essential for memory functioning. These cells release granule molecules that are important factors for information processing and synaptic plasticity. Here is the latest research on granule cell in hippocampal processing.
Hebbian theory is a neuroscientific theory claiming that an increase in synaptic efficacy arises from a presynaptic cell's repeated and persistent stimulation of a postsynaptic cell. Find the latest research on Hebbian theory here.
Myelin plasticity, as another form of activity-dependent plasticity, is relevant not only to nervous system development but also to complex information processing tasks that involve coupling and synchrony among different brain rhythms. Several cellular, molecular, and epigenetic mechanisms have been investigated as contributors to myelin plasticity. Find the latest research on myelin plasticity here.
Neuroinflammation is a complex process that has been noted in multiple neurological disease states such as brain injuries, infectious disease, and neurodegenerative disorders. Microglia and other cell types are activated and initiate a pro inflammatory response. Here is the latest research on neuroinflammation.
Neuronal plasticity is the brain’s ability to change its structure and function in response to internal or external factors. Here is the latest research on mechanisms that influence this process.
Prepulse inhibition (ppi) of the startle response is an index used to evaluate how the pre-attention system works. Here are the latest discoveries pertaining to PPI.
Netrin-1 is a protein that is secreted and thought to be involved in cell plasticity, cell migration, axonal growth, and synaptic plasticity. Studies have shown an upregulation of Netrin-1 following ischemic stroke or brain injury, promoting synaptic plasticity and axonal regeneration. Here is the latest research on synaptic plasticity and Netrin-1.
Neurons project from the ventral hippocampus and are important for working memory, spatial memory and connection to other regions of the cortex. Projections from the hippocampus to the amygdala are involved in emotional processing such as reward and fear. Here is the latest research on ventral hippocampal circuits.