Neuromuscular Diseases


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  • Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.
    ALS

    Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

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  • ALS shares with a considerable proportion of FTD cases the same neuropathological substrate, namely, inclusions of abnormally phosphorylated protein tdp-43 (ptdp-43). Here are the latest discoveries pertaining to ptdp-43 and these diseases.
    ALS & FTD: TDP-43

    ALS shares with a considerable proportion of FTD cases the same neuropathological substrate, namely, inclusions of abnormally phosphorylated protein tdp-43 (ptdp-43). Here are the latest discoveries pertaining to ptdp-43 and these diseases.

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  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.
    ALS - Pathogenic Mechanisms

    Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

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  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating phenotypes associated with this genetically heterogeneous disorder.
    ALS - Phenotypes

    Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating phenotypes associated with this genetically heterogeneous disorder.

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  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.
    ALS: Genetics
    Going Viral

    Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

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  • Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here are the latest discoveries pertaining to this disease.
    ALS: Prions

    Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here are the latest discoveries pertaining to this disease.

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  • Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research.
    ALS: Stress Granules

    Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research.

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  • Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS therapies here.
    ALS: Therapies

    Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS therapies here.

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  • Transposon silencing is a form of transcriptional gene silencing. These gene silencing mechanisms are impaired in Amyotrophic lateral sclerosis (ALS). Here are the latest discoveries pertaining to transposon silencing and this disease.
    ALS: Transposon de-silencing
    Fast Growing

    Transposon silencing is a form of transcriptional gene silencing. These gene silencing mechanisms are impaired in Amyotrophic lateral sclerosis (ALS). Here are the latest discoveries pertaining to transposon silencing and this disease.

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  • This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.
    Antisense Oligonucleotide - Therapies For ALS
    Going Viral

    This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

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  • Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.
    Chronic Fatigue Syndrome
    Fast Growing

    Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

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  • Myotonic Dystrophy is an autosomal dominant neuromuscular disorder associated with the expansion of CTG trinucleotide repeats in the 3’ untranslated region of the myotonic dystrophy protein kinase (DMPK) gene. Here is the latest research focusing on epigenetic modifications in myotonic dystrophy.
    Epigenetics of Myotonic Dystrophy

    Myotonic Dystrophy is an autosomal dominant neuromuscular disorder associated with the expansion of CTG trinucleotide repeats in the 3’ untranslated region of the myotonic dystrophy protein kinase (DMPK) gene. Here is the latest research focusing on epigenetic modifications in myotonic dystrophy.

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  • Gene therapy is a powerful tool that can potentially be used for treating neurodegenerative diseases such as amyotrophic lateral sclerosis, spinal muscular atrophy, Parkinson's disease and Alzheimer's disease. Here is the latest research.
    Gene Therapies for Neurodegenerative Diseases

    Gene therapy is a powerful tool that can potentially be used for treating neurodegenerative diseases such as amyotrophic lateral sclerosis, spinal muscular atrophy, Parkinson's disease and Alzheimer's disease. Here is the latest research.

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  • Gene therapy uses genes to treat or prevent diseases such as muscle diseases. Here are the latest discoveries pertaining to gene therapy and muscle diseases.
    Gene Therapy of Muscle Diseases
    Fast Growing

    Gene therapy uses genes to treat or prevent diseases such as muscle diseases. Here are the latest discoveries pertaining to gene therapy and muscle diseases.

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  • Kennedy Disease, also known as X-linked bulbospinal muscular atrophy, is a progressive neuromuscular disorder caused by mutations in the androgen receptor gene and characterize by wasting of proximal and bulbar muscles. Here is the latest research.
    Kennedy Disease

    Kennedy Disease, also known as X-linked bulbospinal muscular atrophy, is a progressive neuromuscular disorder caused by mutations in the androgen receptor gene and characterize by wasting of proximal and bulbar muscles. Here is the latest research.

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  • Mutations in RNA-binding proteins, including TARDBP, have been found in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This feed focuses on molecular mechanisms that underlie ALS and FTD.
    Molecular Mechanisms of Disease in ALS & FTD

    Mutations in RNA-binding proteins, including TARDBP, have been found in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This feed focuses on molecular mechanisms that underlie ALS and FTD.

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  • The motor cortex is associated with planning, control, and execution of voluntary movements. This feed focuses on bi-directional communication pathways between an external device and the motor cortex.
    Motor Cortex & Brain-Machine Interfaces

    The motor cortex is associated with planning, control, and execution of voluntary movements. This feed focuses on bi-directional communication pathways between an external device and the motor cortex.

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  • Motor neuron diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy are progressive neurodegenerative diseases that result in the death of motor neurons. Discover the latest research on motor neuron disease here.
    Motor Neuron Disease

    Motor neuron diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy are progressive neurodegenerative diseases that result in the death of motor neurons. Discover the latest research on motor neuron disease here.

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  • Muscular dystrophy refers to a range of muscle diseases caused by defects in muscle proteins, leading to death of the muscle cells, with loss of muscle tissue, and weakness. Here are the latest discoveries pertaining to this disease.
    Muscular Dystrophy

    Muscular dystrophy refers to a range of muscle diseases caused by defects in muscle proteins, leading to death of the muscle cells, with loss of muscle tissue, and weakness. Here are the latest discoveries pertaining to this disease.

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  • Myopathies are genetic or acquired disorders of skeletal muscle that lead to varying degrees of weakness, atrophy, and exercise intolerance. Here are the latest discoveries pertaining to this disease.
    Myopathies
    Influential

    Myopathies are genetic or acquired disorders of skeletal muscle that lead to varying degrees of weakness, atrophy, and exercise intolerance. Here are the latest discoveries pertaining to this disease.

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  • Myotonic Dystrophy is an autosomal dominant neuromuscular disorder associated with the expansion of CTG trinucleotide repeats in the 3’ untranslated region of the myotonic dystrophy protein kinase (DMPK) gene. Here is the latest research.
    Myotonic Dystrophy

    Myotonic Dystrophy is an autosomal dominant neuromuscular disorder associated with the expansion of CTG trinucleotide repeats in the 3’ untranslated region of the myotonic dystrophy protein kinase (DMPK) gene. Here is the latest research.

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  • Neuromuscular disorders result in impaired functioning of the muscles. Discover the latest research on these disorders, including ALS, and the underlying genetic aspects here.
    Neuromuscular Disorders

    Neuromuscular disorders result in impaired functioning of the muscles. Discover the latest research on these disorders, including ALS, and the underlying genetic aspects here.

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  • This feed focuses on experimental systems, including cell and tissue-based therapies, as well as genomic and proteomic approaches, used to study neuromuscular disorders in vitro.
    Neuromuscular Disorders: In Vitro

    This feed focuses on experimental systems, including cell and tissue-based therapies, as well as genomic and proteomic approaches, used to study neuromuscular disorders in vitro.

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  • Diseases of the neuromuscular junction cause skeletal muscle fatigue and include inherited and acquired disorders that affect presynaptic, intrasynaptic or postsynaptic components. Discover the latest research on neuromuscular junction diseases here.
    Neuromuscular Junction Diseases

    Diseases of the neuromuscular junction cause skeletal muscle fatigue and include inherited and acquired disorders that affect presynaptic, intrasynaptic or postsynaptic components. Discover the latest research on neuromuscular junction diseases here.

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  • Peripheral nervous system diseases cover a wide spectrum of disease affecting the peripheral nerves, with the most common being diabetic neuropathy. Discover the latest research on peripheral nervous system diseases here.
    Peripheral Nervous System Diseases

    Peripheral nervous system diseases cover a wide spectrum of disease affecting the peripheral nerves, with the most common being diabetic neuropathy. Discover the latest research on peripheral nervous system diseases here.

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  • Postpoliomyelitis syndrome is characterized by a sudden or progressive loss of muscle strength, muscle atrophy, muscle pain, fatigue, intolerance to cold, after a period of at least 15 years from the acute polio virus infection, a period of neurological and functional stability. Here is the latest research.
    Postpoliomyelitis Syndrome
    Fast Growing

    Postpoliomyelitis syndrome is characterized by a sudden or progressive loss of muscle strength, muscle atrophy, muscle pain, fatigue, intolerance to cold, after a period of at least 15 years from the acute polio virus infection, a period of neurological and functional stability. Here is the latest research.

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  • Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by genetic defects in SMN1 gene, which encodes survival motor neuron 1 (SMN1) protein. SMA is characterized by loss of lower motor neurons and progressive muscle wasting. Here is the latest research on this rare condition.
    Spinal Muscular Atrophy

    Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by genetic defects in SMN1 gene, which encodes survival motor neuron 1 (SMN1) protein. SMA is characterized by loss of lower motor neurons and progressive muscle wasting. Here is the latest research on this rare condition.

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  • Stiff person syndrome is a rare neurological disorder characterised by muscular rigidity and superimposed spasms of the trunk and limbs. Discover the latest research on stiff person syndrome here.
    Stiff-Person Syndrome
    Influential

    Stiff person syndrome is a rare neurological disorder characterised by muscular rigidity and superimposed spasms of the trunk and limbs. Discover the latest research on stiff person syndrome here.

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