This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.
The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.
Antipsychotic-induced weight gain (aiwg) is a common adverse effect of this treatment, particularly with second-generation antipsychotics, and it is a major health problem around the world. Here are the latest discoveries pertaining to AIWG.
G-protein-coupled receptors (GPCRs), the largest family of integral membrane proteins, participate in the regulation of many physiological functions and are the targets of approximately 30% of currently marketed drugs. Here is the latest research.
Glial cells within the brain, particularly astrocytes and microglia, support synaptic transmission and neuron-glial circuit through the secretion of signaling molecules. The network of communication between glial cells and neurons is highly complex yet organized. Here is the latest research on glia and synaptic circuits.
The hypothalamus has received significant attention in this regard given its ability to influence feeding behavior, yet organisms rely on a much broader diversity and distribution of neuronal networks to regulate both energy intake and expenditure. Here is the latest research on the hypothalamus and feeding.
This feed focuses on the molecular organization of synapses between two nerve cells, synaptic signal transduction, and synaptic vesicles. Here is the latest research on organization of synapses.
Myelin surrounds axons and is important for efficient axonal function. Formation of myelin is regulated by many signaling pathways. Degeneration is a target for many diseases, particularly in multiple sclerosis and regeneration is associated with oligodendrocyte progenitor cells. Here is the latest research on myelin formation and repair.
The NDMA receptor is an ionotropic receptor that is activated when glutamate or glycine binds to it, initiating several downstream signaling cascades. NDMA receptor signaling is thought to be implicated in different pathologies, including depression. Here is the latest research on NDMA receptor signaling.
Calcium plays an important role in neuronal signalling, acting as a secondary messenger, depolarization of neuronal membrane and synaptic vesicle activity and release of neurotransmitters. Here is the latest research on neuronal calcium signalling.
Stress can cause an imbalance within neural circuitry subserving cognition, decision making, anxiety, and mood that can increase or decrease expression of those behaviors and behavioral states. Find the latest research on the neuronal circuitry of stress here.
Gated ion channels are found throughout the body and may be gated by such factors including voltage or ligands. These channels are fundamental for signalling in neurons and contribute to several physiological processes. Discover the latest research on neuronal signalling of gated ion channels.
The binding of neurotropic factors activates tyrosine kinase receptors in both central and peripheral neurons. This signals the correct location, morphology, and integration of neurons into the vast neural network. Discover the latest research of neuronal tyrosine kinase receptors here.
There are >50 peptides released by neurons that function as neuromodulators, neurotransmitters, neurohormones, and hormones. Here is the latest research on the systemic function of neuropeptides in the body.
Neurotransmitter receptors are a group of proteins on the surface of postsynaptic membranes, which become activated or inhibited with the binding of neurotransmitters. The binding can result in a cascade of signalling events. Discover the latest research on neurotransmitter receptor signalling here.
Neurotransmitters are released from synaptic vesicles in presynaptic neurons in response to neural activity, diffuse across the synaptic cleft, and bind specific receptors in order to bring about changes in postsynaptic neurons. Here is the latest research.
Serotonin and dopamine are neurotransmitters involved in feeding and eating disorders. Here are the latest discoveries pertaining to neurotransmitters in feeding.
Glioblastoma is a malignant brain tumor with mutations in various signaling pathways involved in tumorigenic processes. Developing therapeutic agents against these signaling pathways are ongoing. Discover the latest research on signaling pathways in glioblastoma.
Neural stem cells play a critical role in the production of neuronal cells in neurogenesis is of great importance. Of interest is the role signalling mechanisms in adult neurogenesis. Discover the latest research on signalling in adult neurogenesis.
Synapses are essential for neuronal function. Synaptic loss and alterations are associated with sensory, motor, and cognitive impairments, and have been implicated in several neurodegenerative diseases. Here is the latest research on synaptic biochemistry.
Visual Neuroscience describes the visual system of the human body and the brain's visual cortex. Here are the latest discoveries pertaining to vision neuroscience.