Nucleic Acids Structure & Function
Chromatin remodeling is essential for regulation of gene expression, DNA replication, as well as DNA repair. Here is the latest research on chromatin remodeling complexes and mechanisms underlying chromatin remodeling.
Cells are subjected to several DNA damaging events on a daily basis which results in the induction of DNA damage signaling and repair cascades to ensure genomic stability. Here is the latest research pertaining to DNA damage.
Development of gene editing techniques, including CRISPR and TALENs, has relied on mechanisms that underlie DNA repair and genome stability pathways. This feed focuses on the role of DNA repair mechanisms in gene editing and genetic engineering.
Cells are subjected to several DNA damaging events on a daily basis which results in the induction of DNA damage signaling and repair cascades to ensure genomic integrity. Here is the latest research on DNA damage signaling and repair mechanisms in primary cells.
Epitranscriptomics is a scientific field that studies epigenetic modifications on RNA. Here is the latest research pertaining to epitranscriptomics and mechanisms that underlie RNA modifications.
MicroRNAs are small non-coding RNAs that modulate gene expression at post-transcriptional level, playing a crucial role in cell differentiation and development. Discover the latest research on MicroRNAs & how they target Open Reading Frames.
MicroRNAs are small non-coding RNAs that modulate gene expression at post-transcriptional level, playing a crucial role in diseases such as prostate cancer. Discover the latest research on MicroRNAs in prostate cancer.
Nucleic acid enzymes, natural and engineered, are catalytic proteins that act on DNA and RNA. Discover the latest research on nucleic acid enzymology here.
This feed focuses on subcellular and translation regulation of RNA in Axons and how this influences Axonal Functions. Discover the latest research here.
Mitochondrial DNA mutations and resulting RNA transcripts that cause mitochondrial dysfunction are responsible for a wide spectrum of human diseases, referred to as mitochondrial diseases. Discover the latest research here.
This feed focuses on RNA Binding Proteins, which are involved in post-transcriptional processes, such as alternative splicing, RNA transport, localization and function.
Short hairpin RNA are used to interrogate gene function in model organisms. Discover the latest research in RNA hairpins in Yeast.
This feed looks at the emerging role of epigenetic modifications, such as those that occur on RNA that may affect function in various diseases. Discover the latest research on RNA Modifications in Diabetes.
The majority of human genes that encode proteins undergo alternative pre-mRNA splicing and mutations that affect splicing are more prevalent than previously thought. Discover the latest research on RNA Splicing here.
RNA Interference (RNAi) pathway is involved in post-transcriptional gene silencing, transcriptional silencing and epigenetic silencing as well as its use as a tool for forward genetics and therapeutics. Discover the latest research here.
Ribozymes are catalytic RNAs that interact with a variety of small molecule substrates and cofactors, the intracellular abundance of which are sensed by riboswitches that modulate transcription, RNA stability, or translation. Here is the latest research.
Mutations in SMCHD1 are associated with several human diseases including a severe form of muscular dystrophy. Recent studies have found this protein to be essential for X chromosome inactivation. Here is the latest research.
Targeted gene repair is a technique that can be used to change the DNA sequence at a specific site in the genome to either correct or introduce a genetic mutation. Here is the latest research on targeted gene correction.
Base editing systems, including those using a uracil DNA glycosylase inhibitor, expand the scope and efficiency of genome editing technologies. The latest research in that area can be found in this feed.
MicroRNAs are small non-coding RNAs that modulate gene expression at post-transcriptional level, playing a crucial role in cell differentiation and development. Discover the latest research on MicroRNAs in Health & Disease.
Non-coding RNAs (ncRNAs) are RNA molecules that do not code for protein, but can have functional roles in regulating gene expression at the transcriptional and post-transcriptional level. Discover the latest research on the role of ncRNAs in Health and Disease.