Nucleus: Structure & Function
Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.
Chromatin remodeling is essential for regulation of gene expression, DNA replication, as well as DNA repair. Here is the latest research on chromatin remodeling complexes and mechanisms underlying chromatin remodeling.
Nuclear bodies are membrane-less subnuclear organelles capable of affecting numerous nuclear functions from gene expression to rRNA biogenesis. They consist of the nucleoli, Cajal bodies, nuclear speckles, polycomb bodies, and paraspeckles. Discover the latest research on Biogenesis and Function of Nuclear Bodies here.
The nuclear envelope provides barrier between the nucleus and cytoplasm. It plays a key role in transport function and nuclear growth, organization, and integrity. Discover the latest research on nuclear envelope dynamics here.
Nuclear import and export of RNA is a complex process involving several enzymes and receptors that recognize and bind to nuclear localization signals or nuclear export signals. Here is the latest research.
The nuclear pore is a large complex of proteins that allow macromolecules to cross from the nucleus to the cytoplasm and vice versa. Discover the latest research on the structure and function of the nuclear pore here.
Nuclear transport refers to the import and export of large molecules into and out of the nucleus. This process is controlled by the nuclear pore complexes, where cargo bearing a nuclear localization or export signal is transported via nuclear transport receptors. Find the latest research on nuclear transport here.
The nucleolus is the site of ribosome biogenesis, making ribosomal subunits from proteins and ribosomal RNA. Discover the latest research on nucleolar dynamics here.
DNA replication requires a concerted effort of numerous proteins and replication units to organize the densely packed DNA within the nucleus and is a highly regulated process. Discover the latest research on Organization of DNA Replication here.
This feed focuses on the Polycomb Group Proteins, which are protein complexes that are recruited to chromatin and are involved in the deposition of repressive histone marks, leading to gene repression.
Mutations in SMCHD1 are associated with several human diseases including a severe form of muscular dystrophy. Recent studies have found this protein to be essential for X chromosome inactivation. Here is the latest research.
DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.
The cancer stem cell theory proposes that, in tumors, there exist a sub-population of cells that possess characteristics of normal stem cells, specifically the ability to self-renew, and that these cells proliferate and sustain the cancer. Here is the latest research on stem and cancer cells.
The double helix structure of DNA is important for its biological function. Discover the latest research on the Structure and Function of DNA here.
Centromeres specify the kinetochore formation sites on individual chromosomes, and are epigenetically marked by the assembly of nucleosomes containing the centromere-specific histone h3 variant, CENPA. Discover the latest research on Structure of Centromere Chromatin here.
Epigenetic modifications are carried out by proteins and protein complexes, many of which become dysregulated during diseases including cancer. Identifying structures of epigenetic machinery will shed light on proteins that govern various epigenetic processes and may aid in advancing therapeutics for certain diseases. Here is the latest research.