Protein Structure & Function
α-Synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. Here is the latest research on α-synuclein structure and function.
Bacterial protein structures can expedite the development of novel antibiotics. Here is the latest research on bacterial proteins and the resolution of their structures.
Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.
Chaperones are proteins that play an essential role in protein folding, stability, assembly, and degradation. Their depletion or dysfunction has been implicated in protein folding disorders. Here is the latest research.
Cholesterol is essential for a variety of cellular processes, including cell growth and division, and it plays an important role in various signaling pathways. Here is the latest research on cholesterol synthesis and the role of cholesterol in cell signaling.
Cryogenic electron microscopy (Cryo-EM) allows the determination of biological macromolecules and their assemblies at a near-atomic resolution. Here is the latest research.
This feed focuses on endoplasmic reticulum biochemistry, and includes ER stress and the unfolded protein response.
Glycosylphosphatidylinositol (GPI) is a glycolipid anchor for several cell-surface proteins that play a role in various biological processes, including signal transduction, prion disease pathogenesis, and immune response. Here is the latest research.
Gangliosides are sialic acid-containing glycosphingolipids concentrated on cell surfaces and found in abundance in the nervous system. Here is the latest research.
This feed focuses on biological and bioinformatical technologies including high-throughput screening assays that that aim to identify metabolic proteins. Here is the latest research.
Imaging mass spectrometry enables the visualization and assessment of the spatial distribution of molecules, including biomarkers and metabolites, based on their molecular mass. Here is the latest research.
Intrinsically disordered proteins exhibit biological activity even though they lack a well-defined 3D structure in solution. Here is the latest research on their role in cells.
Misfolding and aggregation of proteins can lead to several diseases. For instance, misfolding of prion or tau proteins are associated with several neurodegenerative diseases. Here is the latest research on diseases caused by protein misfolding and aggregation.
Molecular dynamics refers to a computer simulation method that enables the study of physical movements of molecules and atoms. Here is the latest research on molecular dynamics simulation of proteins.
Protein misfolding is the primary cause of several neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease. This feed follows studies investigating protein misfolding in neurodegeneration.
Recent advances in de novo design of proteins has resulted in a burst of new protein structures and assemblies, providing insights into protein functions and opening up avenues for therapeutic intervention in human diseases. This feed follows the latest research in this new area.
Proteolysis refers to the breakdown of proteins into amino acids or shorter polypeptides. Discover the latest research on mechanism that underlie proteolysis here.
Proteostasis enables the maintenance of protein homeostasis via modulation of protein translation, enhancement of chaperone capacity and the prompt clearance of misfolded proteins. It is affected in several neurodegenerative diseases. Here is the latest research.
This feed focuses on proteotoxicity, which plays an important role in aging-associated inflammation of the CNS and is a major hallmark of different neurodegenerative disorders. Discover the latest research on proteotoxicity in inflammation and neurodegeneration here.
Ribosomes synthesize and, sometimes in association with chaperone proteins, fold amino acid polypeptides into active 3D proteins. Here is the latest research on ribosomes and protein folding.
Tauopathies are neurodegenerative disorders that are caused due to the accumulation of abnormal tau proteins in neurons and/or the glia. Here is the latest research on tauopathy biochemistry.
tRNA modifications are partial or minor changes on tRNA that result in different version of the original tRNA. Discover the latest research on tRNA modification here.
α-Synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. Here is the latest research on α-Synuclein structure and function.