Pulmonary Vascular Diseases
Over 1700 different mutations in the CFTR genes have been shown to cause cystic fibrosis. Here is the latest research on structural therapy for CFTR mutants.
Chronic obstructive pulmonary disease (copd) is a progressive respiratory disease associated with increasing morbidity and mortality worldwide.
Chronic thromboembolic pulmonary hypertension refers to high blood pressure in arteries of the lung. The underlying cause include blood clots and related scarring. Discover the latest research on this disease here.
Cystic fibrosis is an autosomal recessive disease, which is the result of a genetic defect in the cystic fibrosis transmembrane conductance regulator (cftr) gene. Here is the latest research on this disease
Embolic diseases can result in serious complications, depending where the emboli travels and organs that it affects. Thromboembolisms arise from pieces of a blood clot breaking free. Treatment and prevention involves anticoagulants for the different types of embolic diseases. Here is the latest research on embolic diseases.
Endothelin receptors are G-protein coupled receptors that mediate smooth muscle contraction or relaxation which in turn regulate blood pressure. Discover the latest research on endothelins and their receptors here.
Hereditary hemorrhagic telangiectasia (HHT), or Osler-Weber-Rendu disease, is a genetic disorder characterized by abnormal blood vessel formation. Because it can affect blood vessels in various organs, HHT can cause bleeding in various organs and symptoms can manifest as nosebleeds, skin and mouth lesions, and digestive tract problems. Follow the latest research on HHT here.
Pulmonary arterial hypertension refers to the high blood pressure in the arteries that go from the heart ot the lungs. Here is the latest research.
Cor pulmonale, also known as pulmonary heart disease, refers to the enlargement and failure of the right ventricle of the heart caused as a result of high blood pressure in the lungs or increased vascular resistance. Here is the latest research.
Pulmonary hypertension results in increased pulmonary arterial pressures and pulmonary vascular resistance, commonly from cardiac and respiratory diseases. As a result of the structural and functional changes, right heart failure can occur, leading to premature death. Here is the latest research on pulmonary hypertension.
Pulmonary vein stenosis is the stenosis of one or more of the pulmonary veins that returns blood from the lung to the left atrium. Discover the latest research on this rare cardiovascular disorder here.
Pulmonary veno-occlusive disease is a form of pulmonary hypertension characterized by pulmonary venule remodeling. Here is the latest research on this disease.
Tetralogy of Fallot is a congenital heart defect with an unknown cause which is typically treated by open heart surgery in the first year of life. Symptoms include bluish skin colour, heart murmur, and finger clubbing. Here is the latest research.
Soluble guanylate cyclase (sGC) stimulators and activators have been developed to treat patients with pulmonary hypertension and heart failure, respectively. Recently these sGC modulators have been explored for the treatment of fibrosis. Discover the latest research on sGC modulators here.