Regulation of Gene Expression


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  • Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.
    Alternative splicing

    Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

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  • Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.
    Archaeal RNA Polymerase
    Going Viral

    Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

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  • Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.
    CREs: Gene & Cell Therapy

    Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

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  • CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on CRISPR-Cas applications relevant to single cell analyses. Here is the latest research.
    CRISPR & Single Cell Analyses
    Fast Growing

    CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on CRISPR-Cas applications relevant to single cell analyses. Here is the latest research.

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  • CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.
    CRISPR & Staphylococcus
    Fast Growing

    CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

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  • Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). CRISPR-Cas system enables the editing of genes to create or correct mutations. Discover the latest research on CRISPR here.
    CRISPR (general)
    Fast Growing

    Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). CRISPR-Cas system enables the editing of genes to create or correct mutations. Discover the latest research on CRISPR here.

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  • CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of this system for gene editing and therapy in human diseases.
    CRISPR Genome Editing & Therapy
    Fast Growing

    CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of this system for gene editing and therapy in human diseases.

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  • CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on mechanisms that underlie deactivation of CRISPR ribonucleases. Here is the latest research.
    CRISPR Ribonucleases Deactivation
    Fast Growing

    CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on mechanisms that underlie deactivation of CRISPR ribonucleases. Here is the latest research.

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  • CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.
    CRISPR Screens in Drug Resistance

    CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

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  • This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that affect virus-host interactions. Here is the latest research.
    CRISPR Screens in Virology
    Fast Growing

    This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that affect virus-host interactions. Here is the latest research.

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  • Genome editing technologies enable the editing of genes to create or correct mutations. Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). Here is the latest research on the use of CRISPR-Cas system in gene editing.
    CRISPR for Genome Editing
    Fast Growing

    Genome editing technologies enable the editing of genes to create or correct mutations. Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). Here is the latest research on the use of CRISPR-Cas system in gene editing.

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  • CRISPR-Cas system enables the editing of genes to create or correct mutations. Given that genome instability and mutation is one of the hallmarks of cancer, the CRISPR-Cas system is being explored to genetically alter and eliminate cancer cells. Here is the latest research.
    CRISPR in Cancer

    CRISPR-Cas system enables the editing of genes to create or correct mutations. Given that genome instability and mutation is one of the hallmarks of cancer, the CRISPR-Cas system is being explored to genetically alter and eliminate cancer cells. Here is the latest research.

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  • The CRISPR-Cas system is a gene editing technique that can be used for high-throughput genome-wide screens to identify modes of actions of novel antibiotics. Here is the latest research.
    CRISPRi Screens for Antibiotics
    Fast Growing

    The CRISPR-Cas system is a gene editing technique that can be used for high-throughput genome-wide screens to identify modes of actions of novel antibiotics. Here is the latest research.

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  • Chromatin remodeling is essential for regulation of gene expression, DNA replication, as well as DNA repair. Here is the latest research on chromatin remodeling complexes and mechanisms underlying chromatin remodeling.
    Chromatin Remodeling
    Fast Growing

    Chromatin remodeling is essential for regulation of gene expression, DNA replication, as well as DNA repair. Here is the latest research on chromatin remodeling complexes and mechanisms underlying chromatin remodeling.

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  • Cis-regulatory elements are DNA regions that regulate the transcription of neighbouring genes. Trans-regulatory elements are genomic loci that regulate the expression of distant genes by encoding transcription factors. Here is the latest research on CREs and TREs.
    Cis- & Trans-Regulatory Elements
    Fast Growing

    Cis-regulatory elements are DNA regions that regulate the transcription of neighbouring genes. Trans-regulatory elements are genomic loci that regulate the expression of distant genes by encoding transcription factors. Here is the latest research on CREs and TREs.

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  • CpG sites are genomic loci where cytosine is followed by a guanine along its 5’ to 3’ direction. CpG sites are common in CpG islands and its methylation has been implicated in cancer, aging, and gene silencing. Here is the latest research.
    CpG Sites

    CpG sites are genomic loci where cytosine is followed by a guanine along its 5’ to 3’ direction. CpG sites are common in CpG islands and its methylation has been implicated in cancer, aging, and gene silencing. Here is the latest research.

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  • CRISPR-Cas system enables the editing of genes to create or correct mutations. This technology is being investigated to combat malaria by targeting specific stretches of vector DNA and editing the genome at precise locations. Here is the latest research.
    Crispr In Malaria

    CRISPR-Cas system enables the editing of genes to create or correct mutations. This technology is being investigated to combat malaria by targeting specific stretches of vector DNA and editing the genome at precise locations. Here is the latest research.

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  • Cytokines are proteins that are released by a subset of immune cells and play a role in intercellular communication, cell proliferation, differentiation, and survival. Discover the latest research on the influence of cytokine signaling on transcription here.
    Cytokine Signaling & Transcription

    Cytokines are proteins that are released by a subset of immune cells and play a role in intercellular communication, cell proliferation, differentiation, and survival. Discover the latest research on the influence of cytokine signaling on transcription here.

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  • DNA helicases are motor enzymes that move along the DNA phosphodiester backbone separating two DNA strands using energy derived from ATP hydrolysis. They are essential for several cellular processes including DNA replication and transcription. Here is the latest research.
    DNA Helicases

    DNA helicases are motor enzymes that move along the DNA phosphodiester backbone separating two DNA strands using energy derived from ATP hydrolysis. They are essential for several cellular processes including DNA replication and transcription. Here is the latest research.

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  • DNA supercoiling is the over- or under-winding of a DNA strand. It is essential for several biological processes including DNA compacting, DNA metabolism, and likely gene expression. Here is the latest research.
    DNA Supercoiling
    Going Viral

    DNA supercoiling is the over- or under-winding of a DNA strand. It is essential for several biological processes including DNA compacting, DNA metabolism, and likely gene expression. Here is the latest research.

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  • Genome editing technologies enable the editing of genes to create or correct mutations, thus have immense therapeutic potential. However, editing efficiency is limited by the delivery of editing machinery. Here is the latest research pertaining to the delivery of editing machinery.
    Delivery of Editing Machinery
    Going Viral

    Genome editing technologies enable the editing of genes to create or correct mutations, thus have immense therapeutic potential. However, editing efficiency is limited by the delivery of editing machinery. Here is the latest research pertaining to the delivery of editing machinery.

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  • CRISPR-Cas system enables the editing of genes to create or correct mutations. However, its high frequency of off-target activity is a major concern, especially for therapeutic and clinical applications. This feed focuses on methods that can detect CRISPR off-target activity.
    Detecting CRISPR Off-Targets

    CRISPR-Cas system enables the editing of genes to create or correct mutations. However, its high frequency of off-target activity is a major concern, especially for therapeutic and clinical applications. This feed focuses on methods that can detect CRISPR off-target activity.

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  • Epitranscriptomics is a scientific field that studies epigenetic modifications on RNA. Here is the latest research pertaining to epitranscriptomics and mechanisms that underlie RNA modifications.
    Epigenetic Modifications of RNA

    Epitranscriptomics is a scientific field that studies epigenetic modifications on RNA. Here is the latest research pertaining to epitranscriptomics and mechanisms that underlie RNA modifications.

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  • Epigenetics is the study of heritable changes in gene expression that do not involve alteration of the DNA sequence. Here is the latest research.
    Epigenetics

    Epigenetics is the study of heritable changes in gene expression that do not involve alteration of the DNA sequence. Here is the latest research.

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  • Eukaryotic RNA polymerase I (RNAP I) is an enzyme responsible for transcribing ribosomal RNA (not 5S rRNA), which accounts for over 50% of total RNA in a cell. Here is the latest research.
    Eukaryotic RNA Polymerase I

    Eukaryotic RNA polymerase I (RNAP I) is an enzyme responsible for transcribing ribosomal RNA (not 5S rRNA), which accounts for over 50% of total RNA in a cell. Here is the latest research.

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  • RNA polymerase II (RNAP II) is a 550 kDa multiprotein complex composed of 12 subunits. Here is the latest research on RNAP II and its role it regulating transcription and transcription-coupled recombination repair.
    Eukaryotic RNA Polymerase II

    RNA polymerase II (RNAP II) is a 550 kDa multiprotein complex composed of 12 subunits. Here is the latest research on RNAP II and its role it regulating transcription and transcription-coupled recombination repair.

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  • Eukaryotic RNA polymerase III (RNAP III) is a multisubunit enzyme responsible for transcribing tRNA, 5S rRNA, and several small RNAs. Here is the latest research.
    Eukaryotic RNA Polymerase III

    Eukaryotic RNA polymerase III (RNAP III) is a multisubunit enzyme responsible for transcribing tRNA, 5S rRNA, and several small RNAs. Here is the latest research.

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  • Gene regulatory networks are comprised of molecular regulators that interact with each other and other factors in a cell to regulate and modulate gene expression. Here is the latest research.
    Gene Regulatory Networks

    Gene regulatory networks are comprised of molecular regulators that interact with each other and other factors in a cell to regulate and modulate gene expression. Here is the latest research.

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  • Understanding the genetic regulation of cardiac development and function is crucial in generating future therapeutics for cardiovascular diseases. Discover the latest research on Genetic Regulation of Heart Development & Function here.
    Genetic Regulation of Heart Development & Function

    Understanding the genetic regulation of cardiac development and function is crucial in generating future therapeutics for cardiovascular diseases. Discover the latest research on Genetic Regulation of Heart Development & Function here.

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  • Genome editing technologies enable the editing of genes to create or correct mutations or express genes of interest. Here is the latest research on genome editing in T- cells and their application in human diseases such as adoptive T-cell immunotherapy for cancer.
    Genome Editing & T-Cells

    Genome editing technologies enable the editing of genes to create or correct mutations or express genes of interest. Here is the latest research on genome editing in T- cells and their application in human diseases such as adoptive T-cell immunotherapy for cancer.

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  • Histone deacetylases (HDACs) are key epigenetic regulators of metabolic homeostasis. Here is the latest research on HDACs in obesity.
    HDACs in Obesity
    Fast Growing

    Histone deacetylases (HDACs) are key epigenetic regulators of metabolic homeostasis. Here is the latest research on HDACs in obesity.

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  • Epigenetic marks on histones can lead to gene expression via transcription or repression. Recently, it was discovered that histones marks not only play a role in gene expression but are also crucial for RNA splicing. Discover the latest research on histones and splicing here.
    Histones and Splicing
    Influential

    Epigenetic marks on histones can lead to gene expression via transcription or repression. Recently, it was discovered that histones marks not only play a role in gene expression but are also crucial for RNA splicing. Discover the latest research on histones and splicing here.

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  • MicroRNAs are small non-coding RNAs that modulate gene expression at post-transcriptional level, playing a crucial role in cell differentiation and development. Discover the latest research on MicroRNAs & how they target Open Reading Frames.
    MicroRNAs & Open Reading Frames

    MicroRNAs are small non-coding RNAs that modulate gene expression at post-transcriptional level, playing a crucial role in cell differentiation and development. Discover the latest research on MicroRNAs & how they target Open Reading Frames.

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  • Transcription is the first step in gene expression. This feed focuses on mechanisms that underlie transcription in microorganisms. Here is the latest research.
    Microbial Transcription

    Transcription is the first step in gene expression. This feed focuses on mechanisms that underlie transcription in microorganisms. Here is the latest research.

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  • Nuclear import and export of RNA is a complex process involving several enzymes and receptors that recognize and bind to nuclear localization signals or nuclear export signals. Here is the latest research.
    Nuclear Export & Import of RNA
    Influential

    Nuclear import and export of RNA is a complex process involving several enzymes and receptors that recognize and bind to nuclear localization signals or nuclear export signals. Here is the latest research.

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  • Piwi-interacting RNAs (piRNAs) are a subset of small RNAs predominantly expressed in the germlines of various species and have key regulatory functions. Here is the latest research.
    PIWI-interacting RNAs
    Influential

    Piwi-interacting RNAs (piRNAs) are a subset of small RNAs predominantly expressed in the germlines of various species and have key regulatory functions. Here is the latest research.

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  • This feed focuses on post-translational modifications (PTMs) that occur on transcription factors, which may affect transcriptional processes.
    PTMs of Transcription Factors

    This feed focuses on post-translational modifications (PTMs) that occur on transcription factors, which may affect transcriptional processes.

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  • Polyadenylation is the addition of a stretch of adenine bases to messenger RNA and other RNAs. Given that this processes is essential for the production of mature mRNA for translation, polyadenylation can regulate gene expression. Here is the latest research.
    Polyadenylation

    Polyadenylation is the addition of a stretch of adenine bases to messenger RNA and other RNAs. Given that this processes is essential for the production of mature mRNA for translation, polyadenylation can regulate gene expression. Here is the latest research.

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  • This feed focuses on the Polycomb Group Proteins, which are protein complexes that are recruited to chromatin and are involved in the deposition of repressive histone marks, leading to gene repression.
    Polycomb Group Proteins

    This feed focuses on the Polycomb Group Proteins, which are protein complexes that are recruited to chromatin and are involved in the deposition of repressive histone marks, leading to gene repression.

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  • RNA helicases are motor enzymes that unwind RNA and are essential for several RNA metabolism processes including ribosome biogenesis, translation initiation, and pre-mRNA splicing. Defects in RNA helicases are associated with cancers, infectious diseases, as well as neurodegenerative disorders. Here is the latest research.
    RNA Helicases
    Fast Growing

    RNA helicases are motor enzymes that unwind RNA and are essential for several RNA metabolism processes including ribosome biogenesis, translation initiation, and pre-mRNA splicing. Defects in RNA helicases are associated with cancers, infectious diseases, as well as neurodegenerative disorders. Here is the latest research.

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  • This feed focuses on genetic, epigenetic, and transcriptomic processes pertaining to retinal development and aging.
    Retinal Development: Genetics

    This feed focuses on genetic, epigenetic, and transcriptomic processes pertaining to retinal development and aging.

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  • Sirtuins, a family of highly conserved NAD+-dependent lysine-specific deacetylases has recently been suggested to have a critical impact in the direction and regulation of many metabolic pathways as well as energy sensing in mammals. Discover the latest research on sirtuins in metabolic regulation here.
    Sirtuins in Metabolic Regulation

    Sirtuins, a family of highly conserved NAD+-dependent lysine-specific deacetylases has recently been suggested to have a critical impact in the direction and regulation of many metabolic pathways as well as energy sensing in mammals. Discover the latest research on sirtuins in metabolic regulation here.

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  • Transcription activator-like effectors (TALEs) and TALE nucleases (TALENs) enable gene editing by targeting specific DNA sequences in the genome. Here is the latest research.
    TALEs and TALENs
    Fast Growing

    Transcription activator-like effectors (TALEs) and TALE nucleases (TALENs) enable gene editing by targeting specific DNA sequences in the genome. Here is the latest research.

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  • Base editing systems, including those using a uracil DNA glycosylase inhibitor, expand the scope and efficiency of genome editing technologies. The latest research in that area can be found in this feed.
    Uracil & Genome Editing

    Base editing systems, including those using a uracil DNA glycosylase inhibitor, expand the scope and efficiency of genome editing technologies. The latest research in that area can be found in this feed.

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  • Wnt signal transduction pathway is regulated by several molecules and is critical for embryonic development, cell proliferation, differentiation, and tissue patterning. Here is the latest research on Wnt signaling.
    Wnt Signaling

    Wnt signal transduction pathway is regulated by several molecules and is critical for embryonic development, cell proliferation, differentiation, and tissue patterning. Here is the latest research on Wnt signaling.

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  • Zinc finger transcription factors are composed of a zinc finger binding domain and a transcription factor effector domain. They are a powerful tool to probe the determinants of chromatin accessibility and remodeling within endogenous chromosomal loci. Here is the latest research.
    Zinc-Finger Transcription Factors
    Fast Growing

    Zinc finger transcription factors are composed of a zinc finger binding domain and a transcription factor effector domain. They are a powerful tool to probe the determinants of chromatin accessibility and remodeling within endogenous chromosomal loci. Here is the latest research.

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  • Different mRNAs have different levels of stability. mRNA degradation is a complex process involving several degradation pathways, many of which utilize similar enzymes. Here is the latest research focusing on mRNA degradation.
    mRNA Degradation

    Different mRNAs have different levels of stability. mRNA degradation is a complex process involving several degradation pathways, many of which utilize similar enzymes. Here is the latest research focusing on mRNA degradation.

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  • mRNA capping, the addition of a 5’ 7-methylguanosine cap to messenger RNA, is an evolutionarily conserved process. Here is the latest research on mRNA capping enzymes and the importance of mRNA capping on biological processes.
    mRNA capping

    mRNA capping, the addition of a 5’ 7-methylguanosine cap to messenger RNA, is an evolutionarily conserved process. Here is the latest research on mRNA capping enzymes and the importance of mRNA capping on biological processes.

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  • Non-coding RNAs (ncRNAs) are RNA molecules that do not code for protein, but can have functional roles in regulating gene expression at the transcriptional and post-transcriptional level. Discover the latest research on the role of ncRNAs in Health and Disease.
    ncRNAs in Health and Disease

    Non-coding RNAs (ncRNAs) are RNA molecules that do not code for protein, but can have functional roles in regulating gene expression at the transcriptional and post-transcriptional level. Discover the latest research on the role of ncRNAs in Health and Disease.

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  • Small interfering RNA (siRNA) are double-stranded RNA molecules that operate in the RNA interference pathway. Here is the latest research on silencing of genes in the central nervous system using siRNAs.
    siRNA CNS Silencing

    Small interfering RNA (siRNA) are double-stranded RNA molecules that operate in the RNA interference pathway. Here is the latest research on silencing of genes in the central nervous system using siRNAs.

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  • Aminoacyl-tRNA synthetases, also known as tRNA-ligases, are enzymes that attaches the appropriate amino acid onto its transfer RNA. Mutations in these enzymes have been linked to several diseases including Charcot-Marie-Tooth and cancer. Here is the latest research.
    tRNA synthetases
    Fast Growing

    Aminoacyl-tRNA synthetases, also known as tRNA-ligases, are enzymes that attaches the appropriate amino acid onto its transfer RNA. Mutations in these enzymes have been linked to several diseases including Charcot-Marie-Tooth and cancer. Here is the latest research.

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