Stem Cell Biology & Therapy
Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.
Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.
In autoimmune diseases, the immune system responds and attacks self-antigens and damages or impairs the function of the tissues. The treatment for autoimmune diseases often involves immunosuppressive agents, but newer treatments are being investigated. Discover the latest research on autoimmune disease therapy here.
Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.
Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.
mRNA-based technology is being studied as a potential technology that could be used to reprogram cell fate. This technique provides the potential to generate safe reprogrammed cells that can be used for clinical applications. Here is the latest research on cell fate conversion by mRNA.
Chromatin regulators affect gene expression by influencing the access of proteins such as transcription factors to DNA. Here is the latest research on the role of chromatin regulating proteins on cellular differentiation.
Cilia produce different signaling molecules including ciliary neurotrophic factor that modulate the expression of many processes throughout the body. Exploiting the signaling pathway may be a therapeutic strategy for promoting the growth of different cell types. Here is the latest research on ciliary signaling and growth.
Cis-regulatory elements are regions DNA that regulate the transcription of neighbouring genes. Trans-regulatory elements are genomic loci that regulate the expression of distant genes. Here is the latest research on CREs and TREs.
Human craniofacial stem cells are recently discovered sources of putative mesenchymal stem cells that hold great promise for autogenic or allogenic cell therapy and tissue engineering. Here is the latest research.
DPP4 has the potential to truncate proteins. DPP4-mediated truncation of certain chemokines, interleukins, and colony stimulating factors have recently been linked to regulation of hematopoietic stem/progenitor cells. Given its role in tumor biology, it is also used as a marker for various cancers. Here is the latest research.
Embryonic neural stem cells can be used to investigate the effect of different toxins and molecules on the proliferation and differentiation of these cells. Discover the latest research of embryonic neural stem cells here.
Exocrine glands are a specific type of gland which contains ducts that secrete a specialized substance to a surface, such as the salivary glands, respiratory and gastrointestinal glands. Diseases can affect the exocrine glands and impair their normal functioning. Discover the latest research on exocrine glands here.
Genetic engineering is a process that alters the genetic structure of an organism by removing or introducing DNA. This technique is being tested to program cells. Discover the latest research on genetic engineering to program cells here.
Hematopoietic stem cell (HCT) transplants have been used as treatment options for some types of cancer including lymphoma and leukemia as well as some immunodeficiency illnesses and congenital abnormalities. Currently research is underway into the potential use of HCTs in genetic disorders. Here is the latest research on HCT transplantation.
The formation of blood cells, hematopoiesis, has been exploited for the potential use as a therapy in Alzheimer’s disease. Decreased levels of lymphocytes and proteins involved in stem cell recruitment are found in early stages of Alzheimer’s disease. Here is the latest research on hematopoiesis and Alzheimer’s disease.
Hematopoiesis is the process by which a limited number of hematopoietic stem cells maintain a functioning blood and immune system. Aging of these stem cells leads to several functional changes, including alterations affecting self-renewal and differentiation. Here is the latest research.
Induced pluripotent stem cells (iPSCs) may be obtained by direct reprogramming of different somatic cells to a pluripotent state by forced expression of a handful of transcription factors, These cells have similar properties to those of embryonic stem cells (escs) but bypass the ethical concerns of embryo destruction and can be exploited for both research and clinical applications.Discover the latest research on iPSC here.
Interneurons are found throughout central nervous system and create important networks of connections between other sensory and motor neurons. The use of stem cells to artificially create interneurons enables the study and understanding of the role of the interneurons throughout the CNS. Here is the latest research on interneurons and stem cells.
Intestinal epithelium has self-renewal capacity that Is driven by intestinal stem cells. The rapidly cycling p stem cells help renew and regulate proper intestinal epithelial functioning. Here is the latest research on intestinal stem cells.
Liver stem cells are fast to growth and differentiate, which is a key factor in liver regeneration. They could potentially provide a limitless source of cells that are being examined for a variety of clinical applications. Discover the latest research on liver stem cells here.
Lung epithelial progenitor cells are controlled by many different signaling molecules and are key in the regeneration of proper lung function. The use of manipulating endogenous lung stem cells to treat lung disorders is an exciting and novel area of research. Discover the latest research on lung epithelial progenitor cells here.
Scleroderma is a chronic autoimmune disease that leads to hardening of connective tissues in the body. Lung fibrosis and disease is one of the leading causes of deaths in patients with scleroderma. Here is the latest research.
Hematopoietic stem cells reside in the bone marrow and give rise to lymphoid and myeloid stem cells, which differentiate into various cell types. This feed focuses on factors and mechanisms that underlie differentiation of lymphoid stem cells.
Mesenchymal stem cells are multipotent stem cells isolated from bone marrow with the capacity to differentiate into a variety of cell types and are being investigated for a number of potential therapeutic applications. Discover the latest research on mesenchymal stem cells here.
Mesenchymal stem cells are multipotent cells that are a readily available source of stem cells from bone marrow, adipose tissue and umbilical cord blood. They have shown promise for the therapeutic potential in neurological diseases. Discover the latest research on mesenchymal stem cells and neurological diseases here.
Establishing cardiomyocytes derived from human induced pluripotent stem cells has great potential as a cell source for therapeutic applications, such as regenerative medicine. Discover the latest research on Molecular Drivers of Cardiomyocyte Maturation here.
Muscle stem cells are comprised of a population of stem and progenitor cells that are important for maintaining muscle homeostasis. Muscle regeneration is important in preparing and adapting following exercise, injury and in muscular disease. Discover the latest research on muscle stem cells here.
Chronic Myeloid Leukemia (CML) is a stem cell cancer that arises due to the fusion and constitutive expression of BCR-ABL1 in hematopoietic stem cells, which give rise to both myeloid and lymphoid cell lineages. CML is characterized by increased and unregulated proliferation of myeloid cells. Here is the latest research.
Neural stem cells are self-renewing, multipotent cells that are present in both the embryonic and adult brain. Several factors, including metabolism, have been shown to regulate proliferation, differentiation, and quiescence of neural stem cells. Here is the latest research.
Neurodegeneration is the progressive loss of structure or function of neurons, including neuronal death. Several diseases, including Alzheimer’s and Parkinson’s disease, occur as a result of neurodegeneration. This feed focuses on the utility of induced pluripotent stem cells in neurodegenerative disorders.
Neuroregeneration is the growth or repair of neural cells and tissues following damage or injury. Discover the latest research on neuroregeneration here.
Regeneration in humans is the regrowth of tissues or organs in response to injury or damage. Discover the latest research on organ neuroregeneration here.
Organoids are three-dimensional structures derived from adult or embryonic stem cells, tissues, or tumors, that enable the mimicry of in vivo architecture in tissue culture. Here is the latest research on organoids.
Peripheral blood stem cells (PBSCs) have become increasingly popular for use as an alternative to bone marrow for allogeneic transplantation. Here is the latest research.
Pluripotent stem cells (PSCs) are progenitor cells that can give rise to three basic layers of the body, thus potentially allowing the production of any cells or tissues needed by the body for repair. Here is the latest research on the PSCs in development and disease.
Induced pluripotent stem cells (iPSCs) may be obtained by direct reprogramming of different somatic cells to a pluripotent state by forced expression of a handful of transcription factors. This feed focuses on the generation of neurons of the paraventricular nucleus of the hypothalamus from iPSCs.
To form the complex network of the CNS, there is a synchronous flow of proliferation, migration and differentiation of neuronal cells. When errors in these processes occur, it is thought to be a contributing factor to cognitive deficits and neurodevelopmental disorders. Here is the latest research on proliferation and neurodevelopmental disorders.
Prostate stem cells are important for the development, maturation and function of the prostate. They can give rise to three types of prostate epithelial cells and have been implicated in both benign prostate hyperplasia and prostate cancer. Here is the latest research on prostate stem cells.
Single cell sequencing (scs) can be harnessed to acquire the genomes, transcriptomes and epigenomes from individual cells. Here is the latest research on single cell sequencing.
The cancer stem cell theory proposes that, in tumors, there exist a sub-population of cells that possess characteristics of normal stem cells, specifically the ability to self-renew, and that these cells proliferate and sustain the cancer. Here is the latest research on stem and cancer cells.
Stem cell niches are dynamic microenvironments that balance stem cell activity to maintain tissue homeostasis and repair throughout the lifetime of an organism. Here is the latest research.
Patients with Type I diabetes lack insulin-producing cells. Stem cell therapies can potentially generate insulin-producing cells for transplantation. Discover the latest research here.
Adult stem cells have been extensively studied for tissue repair and regeneration. Discover the latest research on stem cell tissue repair here.
The use of stem cells is being explored as a treatment option for neuroimmune disorders. The immune system has been demonstrated to have negative impacts on cognitive function and neurogenesis and is a potential target for therapeutic intervention. Discover the latest research on stem cells and neuroimmunology.
Stem cells have the therapeutic potential for cardiac repair and regeneration after myocardial infarction. Discover the latest research in Stem Cells In Cardiac Repair here.
Stem cells have the potential to develop into many different types of cells in the body and may be useful as a therapy for several diseases including neurodegenerative diseases. Discover the latest research on stem cells and neurodegenerative diseases here.
Stem cell neuronal differentiation provides an excellent cellular model with which to examine the impact of neurodevelopmental disorders. Discover the latest research on Stem Cells in neurodevelopment disorders here.
Development of autologous tissue-engineered vascular constructs using vascular smooth muscle cells derived from human induced pluripotent stem cells holds great potential in treating patients with vascular disease. Here is the latest research.
Wound healing involves many cells including, platelets, neutrophils, macrophages and fibroblasts. These molecules release cytokines such as interleukins, tumor necrosis factor alpha and growth factors that largely manage the inflammatory phase of healing and promote the recruitment of additional cells. Here is the latest research on wound healing cells and signals.
Differences in genetic backgrounds pose a limitation to studying and inferring genetic mechanisms of diseases. These limitations can be overcome using induced pluripotent stem cell-derived isogenic models of diseases. Here is the latest research.
Induced pluripotent stem cell (iPSCs) models can be generated to study mechanisms involved in neurodegeneration. The iPSCs can be selectively differentiated into specific neurons such as dopaminergic neurons that are susceptible to neurodegeneration. Discover the latest research on iPSC models in neurodegeneration here.
Induced pluripotent stem cell-derived microglia have recently been developed and provide unlimited access to patient-derived material. These cells can be used to model and investigate mechanism that underlie neurodegenerative diseases. Here is the latest research.
Insulin-producing cells derived from human embryonic stem cells or induced pluripotent stem cells have for long been a promising, but elusive treatment far from clinical translation into type 1 diabetes therapy. Here is the latest research.
Long non-coding RNAs (lncRNA) are a class of RNAs that exceed 200 nucleotides in length and cannot be translated into proteins. LncRNAs have been shown to regulate several cellular processes and signaling pathways. Here is the latest research on their role in stem cells and cancer.