Amyotrophic Lateral Sclerosis (ALS) is associated with the death of neurons that control voluntary muscles. This feed followes the latest research into therapies for this progressive neurodegenerative disease.
Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.
Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.
Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.
Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.
Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.
Biosensor development and applications describe recent progress in biosensor development and their applications in the field of antibiotics and metabolic engineering. Discover the latest research on biosensor development and applications in this feed.
The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.
The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.
Brain organoids are three-dimensional cell culture models derived from human pluripotent stem cells. Since they resemble the embryonic brain, they can be used to help study brain biology, early brain development, and brain diseases. Discover the latest research on brain organoids in disease modeling here.
A brain-computer interface, also known as a brain-machine interface, is a bi-directional communication pathway between an external device and a wired brain. Here is the latest research on this topic.
Cancer immunotherapy is an important field of research that is looking at controlling cancer and tumor growth by activating the individuals own immune system. Recent studies have utilized chimeric antigen receptor t-cell therapy, immune checkpoint inhibitors and neoantigen vaccines. Discover the latest research on cancer immunotherapy here.
Cochlear implants replace damaged parts of the inner ear. Implants may involve or include invasive eeg electrodes, deep brain stimulator, motor cortex stimulator, responsive neurostimulation, osteo-integrated hearing aid, middle ear implant, cochlear implant, auditory brainstem implant, vagal nerve stimulator and spinal cord stimulator. Discover the latest research on cochlear implants here.
This feed focuses on novel advances in medical devices used to manage type I diabetes, such as an artificial pancreas and insulin pumps.
Electrocardiogram (ECG) can be used in combination with deep learning techniques for biosignal analysis as a means for computer guided diagnosis. Here is the latest research on ECG and deep learning.
The recent ebola outbreak in west Africa has stressed the need for advances in research to develop a vaccine against this deadly virus. Much progress has been made in pre-clinical and clinical studies and future vaccines for the ebola virus look promising. Here is the latest research on ebola vaccines.
Embryonic neural stem cells can be used to investigate the effect of different toxins and molecules on the proliferation and differentiation of these cells. Discover the latest research of embryonic neural stem cells here.
The development to make HIV vaccines for both the prevention and treatment of HIV infection is ongoing. Some individuals with HIV infection produce antibodies which suppress the virus and allow the patients to remain asymptomatic, suggesting that a vaccine may be achievable. Find the latest research on HIV vaccines here.
Immunotherapy in cancer is used to help the immune system fight against invading cancer cells. It is used to slow the progression of the disease and prevent metastasis while enhancing the immune response. There are different types, including monoclonal antibodies and checkpoint inhibitors. Here is the latest research on immune therapies in cancer.
Immuno-oncology (or cancer immunotherapy) is the artificial stimulation of the immune system to treat cancer, improving on the immune system's natural ability to fight cancer. It exploits the fact that cancer cells often have tumor antigens, molecules on their surface that can be detected by the antibody proteins of the immune system, binding to them. The tumor antigens are often proteins or other macromolecules. Normal antibodies bind to external pathogens, but the modified immunotherapy antibodies bind to the tumor antigens marking and identifying the cancer cells for the immune system to inhibit or kill. Discover the latest research on immuno-oncology here.
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects movement. The drug Inosine is proposed to slow progression of this disease. Here is the latest research on Inosine in PD.
Interneurons are found throughout the central nervous system and create important networks of connections between other sensory and motor neurons. This feed covers the use of stem cells to artificially create interneurons and insights gained into the role of interneurons throughout the CNS.
Engineered lactobacilli have successfully been tested as delivery vectors in various disease models, including models of colitis and food and mouth disease. Here is the latest research on the application of lactobacilli for health.
Research for development of a malaria vaccine is currently underway to find an effective modality to control and eliminate the transmission of malaria. To date, no vaccine has been found to be efficacious in fighting against malaria. Here is the latest research on malaria vaccines.
Membrane and voltage-sensing domains describes the voltage-sensing domains of transmembrane proteins found in the cellular wall. Discover the latest research on membrane and voltage-sensing domains here.
Mesenchymal stem cells are multipotent cells that are a readily available source of stem cells from bone marrow, adipose tissue, and umbilical cord blood. They have shown promise for therapeutic use in neurological diseases. Discover the latest research on mesenchymal stem cells and neurological diseases here.
Treatment of metastatic cancers depends on the type of cancer and the severity of the disease. The regime often includes medications such as chemotherapy or hormone therapy, but may also include immunotherapy, radiation therapy, surgery or a combination. Discover the latest research on metastatic cancer treatments here.
Microglia are immune cells of the central nervous system and are thought to play a role in the repair of neurons following injury. The mechanism by which microglia are involved is still under investigation. Discover the latest research on microglia in neural tissue regeneration here.
The motor cortex is associated with planning, control, and execution of voluntary movements. This feed focuses on bi-directional communication pathways between an external device and the motor cortex.
Myelin surrounds axons and is important for efficient axonal function. Formation of myelin is regulated by many signaling pathways. Degeneration can result in multiple diseases such as multiple sclerosis, and regeneration is associated with oligodendrocyte progenitor cells. Here is the latest research on myelin formation and repair.
Nanoparticles enable the delivery of substances, including nucleic acids and chemotherapeutic drugs, to a targeted region while sparing healthy tissues, thus overcoming adverse systemic effects of gene therapy or drug delivery. Here is the latest research on nanoparticle delivery.
Neural stem cells are self-renewing, multipotent cells that are present in both the embryonic and adult brain. Several factors, including metabolism, have been shown to regulate proliferation, differentiation, and quiescence of neural stem cells. Here is the latest research.
Neurodegeneration is the progressive loss of structure or function of neurons, including neuronal death, and leads to several diseases, including Alzheimer’s and Parkinson’s. This feed focuses on therapeutic targets for neurodegenerative disorders.
Neurodegeneration is the progressive loss of structure or function of neurons, including neuronal death. Several diseases, including Alzheimer’s and Parkinson’s disease, occur as a result of neurodegeneration. This feed focuses on the utility of induced pluripotent stem cells in neurodegenerative disorders.
Neuromodulation alters nerve activity by delivering electrical or pharmaceutical agents directly to a target area. This feed focuses on different types of light therapies and methods, including optogenetics and low-level laser applications.
Induced pluripotent stem cells (iPSCs) may be obtained by direct reprogramming of different somatic cells to a pluripotent state by forced expression of a handful of transcription factors. This feed focuses on the generation and application of neurons differentiated from/to iPSCs.
Neuroregeneration is the growth or repair of neural cells and tissues following damage or injury. Discover the latest research on neuroregeneration here.
Several methods have been utilized to isolate and characterize individual antibodies from the human repertoire and each of these methods has been applied to the generation of broadly neutralizing HIV antibodies. Discover the latest research on neutralizing HIV antibodies.
Cerebral organoids derived from induced pluripotent stem (IPS) cells have illuminated early developmental events altered by disease processes, and may be a promising avenue for future therapies in neurodegenerative disorders. Here is the latest research on organoids and neurodegeneration.
P2Y12 is a G-protein-coupled receptor known for its role in platelet activation. However, its role in the CNS and involvement in microglial activation and renewal is less well understood. Discover the latest research on P2Y12 and microglial self-renewal here.
Pluripotent stem cells (PSCs) are progenitor cells that can give rise to three basic layers of the body, thus potentially allowing the production of any cells or tissues needed by the body for repair. Here is the latest research on the PSCs in development and disease.
Quantum dots have unique optical and electrical properties with great potential for new applications. Here is the latest research focusing on the synthesis of quantum dots and their applications in biomedicine.
This feed describes latest advances in spinal cord regeneration research and potential nerve regeneration treatments after spinal cord injuries.
Patients with Type I diabetes lack insulin-producing cells. Stem cell therapies can potentially generate insulin-producing cells for transplantation. Discover the latest research here.
Adult stem cells have been extensively studied for tissue repair and regeneration. Discover the latest research on stem cell tissue repair here.
The use of stem cells is being explored as a treatment option for neuroimmune disorders, including Multiple Sclerosis. The immune system has been demonstrated to have negative impacts on cognitive function and neurogenesis and is a potential target for therapeutic intervention. Discover the latest research on stem cells and neuroimmunology.
Stem cells have the potential to develop into many different types of cells in the body and may be useful as a therapy for several diseases including neurodegenerative diseases. Discover the latest research on stem cells and neurodegenerative diseases here.
Stem cell neuronal differentiation provides an excellent cellular model with which to examine the impact of neurodevelopmental disorders. Discover the latest research on Stem Cells in neurodevelopment disorders here.
Autophagy is an important pathway for breaking down proteins and damaged organelles and may play an important role in reducing cardiovascular diseases. Discover the latest research on Targeting Autophagy in Cardiovascular Disease here.
Treatment options for anorexia nervosa are limited. Diet and psychotherapy including family based therapy and cognitive behavioural therapy are two commonly used treatments while pharmacotherapies have limited benefits. Discover the latest research on treatment for anorexia nervosa here.
Tissue engineering aims to create, repair, and/or replace tissues and organs by using biomaterial scaffolds, growth factors, stem cells, and genetic engineering. Here is the latest research on biomaterial scaffolds that can be used for tissue therapy.
This feed focuses on Viral Oncology Therapies, which exploits the ability of genetically engineered viruses to infect and kill cancer cells. Discover the latest research on Viral Oncology Therapies here.
Vitamin K-dependent carboxylases generate gamma-carboxyglutamic acids with malonate moieties by modifying glutamate residues in vitamin K-dependent proteins. This feed focuses on cellular mechanisms regulated by vitamin K-dependent carboxylases.
Yeast is a unicellular eukaryote that is utilized and manipulated in biological research to examine biological processes that underlie DNA replication, cell growth, and division, among numerous others. This feed focuses on yeast as a model organism.
The challenges in developing a safe and effective Zika virus vaccine include limiting side effects such as Guillain-Barré syndrome, a potential consequence of Zika virus infection. Discover the latest research on Zika vaccines here.
Differences in genetic backgrounds pose a limitation to studying and inferring genetic mechanisms of diseases. These limitations can be overcome using induced pluripotent stem cell-derived isogenic models of diseases. Here is the latest research.
Induced pluripotent stem cell (iPSCs) models can be generated to study mechanisms involved in neurodegeneration. The iPSCs can be selectively differentiated into specific neurons such as dopaminergic neurons that are susceptible to neurodegeneration. Discover the latest research on iPSC models in neurodegeneration here.
Induced pluripotent stem cell-derived microglia have recently been developed and provide unlimited access to patient-derived material. These cells can be used to model and investigate the mechanism that underlie neurodegenerative diseases. This feed follows the latest research in this area using iPSC-derived microglia.