α-Synuclein Structure and Function

α-Synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. Here is the latest research on α-Synuclein structure and function.

May 26, 2020
Open Access

The HSP110/HSP70 disaggregation system generates spreading-competent toxic α-synuclein species

The EMBO Journal
Jessica TittelmeierCarmen Nussbaum-Krammer
May 7, 2020
Review
Open Access

Glucocerebrosidase Defects as a Major Risk Factor for Parkinson's Disease

Frontiers in Aging Neuroscience
Micol AvenaliSilvia Cerri
July 19, 2020
Open Access

Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models

Journal of Neuroinflammation
Michiyo IbaEliezer Masliah
May 7, 2020
Open Access

Long-range Regulation of Partially Folded Amyloidogenic Peptides

Scientific Reports
Shayon BhattacharyaDamien Thompson
May 6, 2020
Open Access

A myosin-7B-dependent endocytosis pathway mediates cellular entry of α-synuclein fibrils and polycation-bearing cargos

Proceedings of the National Academy of Sciences of the United States of America
Qi ZhangYihong Ye
April 30, 2020
Open Access

Immunotherapies for Aging-Related Neurodegenerative Diseases-Emerging Perspectives and New Targets

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Somin KwonEliezer Masliah
July 6, 2020

Structures of the intrinsically disordered Aβ, tau and α-synuclein proteins in aqueous solution from computer simulations

Biophysical Chemistry
Phuong H Nguyen, Philippe Derreumaux
May 14, 2020
Review
Open Access

Protein trapping leads to altered synaptic proteostasis in synucleinopathies

The FEBS Journal
Patrícia I Santos, Tiago F Outeiro
June 17, 2020

Effect of benzo(a)pyrene on dopaminergic neurons and α-synuclein in brain and its mechanism involved

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
Y Z QiH Zhou
June 5, 2020
Open Access

Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases

Quarterly Reviews of Biophysics
Tessa SinnigeMichele Vendruscolo
May 30, 2020

NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models

Molecular Psychiatry
Swagata GhatakStuart A Lipton
May 24, 2020
Open Access

Increased alpha-synuclein tear fluid levels in patients with Parkinson's disease

Scientific Reports
Fabian MaassPaul Lingor
June 18, 2020
Open Access

α-Synuclein-112 Impairs Synaptic Vesicle Recycling Consistent With Its Enhanced Membrane Binding Properties

Frontiers in Cell and Developmental Biology
Lindsey G SollJennifer R Morgan
July 29, 2020
Open Access

Unroofing site-specific α-synuclein-lipid interactions at the plasma membrane

Proceedings of the National Academy of Sciences of the United States of America
Upneet Kaur, Jennifer C Lee
June 17, 2020
Open Access

α-synuclein overexpression in the retina leads to vision impairment and degeneration of dopaminergic amacrine cells

Scientific Reports
Elena MarroccoElvira De Leonibus
May 21, 2020
Open Access

Interaction of the chaperones alpha B-crystallin and CHIP with fibrillar alpha-synuclein: Effects on internalization by cells and identification of interacting interfaces

Biochemical and Biophysical Research Communications
Maya BendifallahRonald Melki
May 8, 2020
Open Access

Understanding Creutzfeldt-Jackob disease from a viewpoint of amyloidogenic evolvability

Prion
Makoto HashimotoTakato Takenouchi

Sign up to follow this feed and discover related papers.

Related Feeds

ALS

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

ALS & FTD: TDP-43

ALS shares with a considerable proportion of FTD cases the same neuropathological substrate, namely, inclusions of abnormally phosphorylated protein tdp-43 (ptdp-43). Here are the latest discoveries pertaining to ptdp-43 and these diseases.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here are the latest discoveries pertaining to this disease.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS therapies here.

ALS: Transposon de-silencing

Transposon silencing is a form of transcriptional gene silencing. These gene silencing mechanisms are impaired in Amyotrophic lateral sclerosis (ALS). Here are the latest discoveries pertaining to transposon silencing and this disease.

Alpha-Synuclein Structure and Function

α-Synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. Here is the latest research on α-Synuclein structure and function.

Antisense Oligonucleotide - Therapies For ALS

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Bacterial Protein Structures

Bacterial protein structures can expedite the development of novel antibiotics. Here is the latest research on bacterial proteins and the resolution of their structures.

© 2020 Meta ULC. All rights reserved
/feed-previews/-synuclein-structure-and-function/6e04a8d7-607d-41cc-a7b5-87f705708984