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α-Synuclein Structure and Function

α-Synuclein Structure and Function diagram by StudioMolekuul, Shutterstock
StudioMolekuul, Shutterstock

α-Synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. Here is the latest research on α-Synuclein structure and function.

Top 20 most recent papers
bioRxiv

The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure

bioRxivDecember 8, 2019
David R. BoyerDavid S Eisenberg
14
bioRxiv

Molecular dynamics simulation of local structural models of PrPSc reveals how codon 129 polymorphism affects propagation of PrPSc.

bioRxivDecember 27, 2019
Hiroki OtakiNoriyuki Nishida
2
Angewandte Chemie

Molecular basis of the interaction of cyclophilin A with alpha-synuclein

Angewandte ChemieDecember 13, 2019
Filippo FavrettoMarkus Zweckstetter
7
1
Scientific Reports

Parkinson's disease recovery by GM1 oligosaccharide treatment in the B4galnt1+/- mouse model

Scientific ReportsDecember 20, 2019
Elena ChiricozziSandro Sonnino
1
1
Acta Neuropathologica

PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins

Acta NeuropathologicaDecember 20, 2019
Grant T CorbettDominic M Walsh
34
1
bioRxiv

Physical mechanisms of amyloid nucleation on fluid membranes

bioRxivDecember 27, 2019
Johannes KrausserAndela Saric
12
Scientific Reports

The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State

Scientific ReportsJanuary 16, 2020
Matteo RunfolaGiuliana Fusco
3
1
Nature

Strain engineering and epitaxial stabilization of halide perovskites

NatureJanuary 10, 2020
Yimu ChenSheng Xu
6
8
2
2
Neurology

Proteinopathy and longitudinal changes in functional connectivity networks in Parkinson disease

NeurologyDecember 20, 2019
Meghan C CampbellJoel S Perlmutter
22
1
1
Neurobiology of Disease

Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease

Neurobiology of DiseaseDecember 15, 2019
Michael X HendersonKelvin Luk
15
1
1
bioRxiv

C subunit of the ATP synthase is an amyloidogenic channel-forming peptide: possible implications in mitochondrial pathogenesis

bioRxivJanuary 16, 2020
Giuseppe Federico AmodeoEvgeny V Pavlov
4
ELife

Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

ELifeDecember 10, 2019
Ricardo Guerrero-FerreiraHenning Stahlberg
60
1
Aging

Plasma ubiquitin C-terminal hydrolase L1 levels reflect disease stage and motor severity in Parkinson's disease

AgingJanuary 15, 2020
Adeline Su Lyn NgEng-King Tan
2
1
Molecular Neurodegeneration

Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

Molecular NeurodegenerationJanuary 15, 2020
Jae-Hyeon ParkPamela J McLean
7
1
Biochimie

Naturally occurring cinnamic acid derivatives prevent amyloid transformation of alpha-synuclein

BiochimieJanuary 17, 2020
Maria MedvedevaVladimir Muronetz
The Biochemical Journal

Scutellarin Inhibits the Uninduced and Metal-Induced Aggregation of ɑ-Synuclein and Disaggregates Preformed Fibrils: Implications for Parkinson's disease

The Biochemical JournalJanuary 16, 2020
Fatima Kamal Zaidi, Shashank Deep
3
1
Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry

The Amyloid as a Ribbon-Like Micelle in Contrast to Spherical Micelles Represented by Globular Proteins

Molecules : a Journal of Synthetic Chemistry and Natural Product ChemistryDecember 11, 2019
Mateusz BanachIrena Roterman
1
Journal of Dentistry

Enamel remineralization via poly(amido amine) and adhesive resin containing calcium phosphate nanoparticles

Journal of DentistryDecember 15, 2019
Yuan GaoHockin H K Xu
ELife

Inhibition of synucleinopathic seeding by rationally designed inhibitors

ELifeJanuary 3, 2020
Smriti SangwanDavid S Eisenberg
13
1
Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society

The gut in Parkinson's disease: Bottom-up, top-down, or neither?

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility SocietyDecember 20, 2019
Laurène Leclair-VisonneauThibaud Lebouvier
4
1

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