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α-Synuclein Structure and Function
StudioMolekuul, Shutterstockα-Synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. Here is the latest research on α-Synuclein structure and function.
Top 20 most recent papers
The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure
bioRxivDecember 8, 2019
David R. BoyerDavid S Eisenberg
14
Molecular dynamics simulation of local structural models of PrPSc reveals how codon 129 polymorphism affects propagation of PrPSc.
bioRxivDecember 27, 2019
Hiroki OtakiNoriyuki Nishida
2
Molecular basis of the interaction of cyclophilin A with alpha-synuclein
Angewandte ChemieDecember 13, 2019
Filippo FavrettoMarkus Zweckstetter
7
1
Parkinson's disease recovery by GM1 oligosaccharide treatment in the B4galnt1+/- mouse model
Scientific ReportsDecember 20, 2019
Elena ChiricozziSandro Sonnino
1
1
PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins
Acta NeuropathologicaDecember 20, 2019
Grant T CorbettDominic M Walsh
34
1
Physical mechanisms of amyloid nucleation on fluid membranes
bioRxivDecember 27, 2019
Johannes KrausserAndela Saric
12
The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State
Scientific ReportsJanuary 16, 2020
Matteo RunfolaGiuliana Fusco
3
1
Strain engineering and epitaxial stabilization of halide perovskites
NatureJanuary 10, 2020
Yimu ChenSheng Xu
6
8
2
2
Proteinopathy and longitudinal changes in functional connectivity networks in Parkinson disease
NeurologyDecember 20, 2019
Meghan C CampbellJoel S Perlmutter
22
1
1
Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease
Neurobiology of DiseaseDecember 15, 2019
Michael X HendersonKelvin Luk
15
1
1
C subunit of the ATP synthase is an amyloidogenic channel-forming peptide: possible implications in mitochondrial pathogenesis
bioRxivJanuary 16, 2020
Giuseppe Federico AmodeoEvgeny V Pavlov
4
Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy
ELifeDecember 10, 2019
Ricardo Guerrero-FerreiraHenning Stahlberg
60
1
Plasma ubiquitin C-terminal hydrolase L1 levels reflect disease stage and motor severity in Parkinson's disease
AgingJanuary 15, 2020
Adeline Su Lyn NgEng-King Tan
2
1
Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway
Molecular NeurodegenerationJanuary 15, 2020
Jae-Hyeon ParkPamela J McLean
7
1
Naturally occurring cinnamic acid derivatives prevent amyloid transformation of alpha-synuclein
BiochimieJanuary 17, 2020
Maria MedvedevaVladimir Muronetz
Scutellarin Inhibits the Uninduced and Metal-Induced Aggregation of ɑ-Synuclein and Disaggregates Preformed Fibrils: Implications for Parkinson's disease
The Biochemical JournalJanuary 16, 2020
Fatima Kamal Zaidi, Shashank Deep
3
1
The Amyloid as a Ribbon-Like Micelle in Contrast to Spherical Micelles Represented by Globular Proteins
Molecules : a Journal of Synthetic Chemistry and Natural Product ChemistryDecember 11, 2019
Mateusz BanachIrena Roterman
1
Enamel remineralization via poly(amido amine) and adhesive resin containing calcium phosphate nanoparticles
Journal of DentistryDecember 15, 2019
Yuan GaoHockin H K Xu
Inhibition of synucleinopathic seeding by rationally designed inhibitors
ELifeJanuary 3, 2020
Smriti SangwanDavid S Eisenberg
13
1
The gut in Parkinson's disease: Bottom-up, top-down, or neither?
Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility SocietyDecember 20, 2019
Laurène Leclair-VisonneauThibaud Lebouvier
4
1