α-Synuclein Structure and Function

α-Synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. Here is the latest research on α-Synuclein structure and function.

November 13, 2020
Review
Open Access

Neuroimaging Advances in Parkinson's Disease and Atypical Parkinsonian Syndromes

Frontiers in Neurology
Usman SaeedMario Masellis
December 3, 2020
Open Access

TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson's Disease

Cell Reports
Guixin ZhuXiaolu Yang
January 8, 2021
Review
Open Access

Alpha-Synuclein Antibody Characterization: Why Semantics Matters

Molecular Neurobiology
Tiago Fleming Outeiro
December 29, 2020

Molecular Dynamics Study of the Interaction between the N-terminal of α-Synuclein and a Lipid Bilayer Mimicking Synaptic Vesicles

The Journal of Physical Chemistry. B
Christopher Kang, Rui Sun
December 18, 2020
Open Access

β-Turn exchanges in the α-synuclein segment 44-TKEG-47 reveal high sequence fidelity requirements of amyloid fibril elongation

Biophysical Chemistry
Emil Dandanell AgerschouWolfgang Hoyer
November 29, 2020
Open Access

Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war

Nature Communications
Filippo FavrettoMarkus Zweckstetter
October 30, 2020
Open Access

Effects of Detergent on α-Synuclein Structure. A Native MS-Ion Mobility Study

International Journal of Molecular Sciences
Rani MoonsFrank Sobott
December 16, 2020
Open Access

ANA Webinars: Clinical and basic research resilience during COVID-19

Annals of Clinical and Translational Neurology
Michelle C JohansenJustin C McArthur
November 18, 2020

From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease

Movement Disorders : Official Journal of the Movement Disorder Society
Tiago Fleming OuteiroAngela M Cenci
October 22, 2020
Open Access

Toxic oligomers of the amyloidogenic HypF-N protein form pores in mitochondrial membranes

Scientific Reports
Maria Ylenia FarrugiaNeville Vassallo
November 24, 2020
Open Access

The MHC class II transactivator modulates seeded alpha-synuclein pathology and dopaminergic neurodegeneration in an in vivo rat model of Parkinson's disease

Brain, Behavior, and Immunity
Itzia Jimenez-FerrerMaria Swanberg
October 20, 2020

Remodeling of the Conformational Dynamics of Noncanonical DNA Structures by Monomeric and Aggregated α-Synuclein

Journal of the American Chemical Society
Jim-Marcel KnopRoland Winter
November 3, 2020
Preprint
Open Access

The Hsc70 Disaggregation Machinery RemovesMonomer Units Directly from α-Synuclein FibrilEnds

BioRxiv : the Preprint Server for Biology
M. M. SchneiderTuomas Knowles
October 29, 2020
Preprint
Open Access

Protein kinase CK2 alpha prime and alpha-synuclein constitute a key regulatory pathway in Huntington's disease

BioRxiv : the Preprint Server for Biology
D. YuRocio Gomez-Pastor
January 12, 2021
Open Access

Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo

Neurobiology of Disease
Antonio Dominguez-MeijideTiago Fleming Outeiro
November 25, 2020

JM-20 protects against 6-hydroxydopamine-induced neurotoxicity in models of Parkinson's disease: mitochondrial protection and antioxidant properties

Neurotoxicology
Luis Arturo Fonseca-FonsecaYanier Núñez-Figueredo
November 17, 2020
Open Access

Connecting Alzheimer's Disease With Diabetes Mellitus Through Amyloidogenic Evolvability

Frontiers in Aging Neuroscience
Gilbert HoMakoto Hashimoto

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Alpha-Synuclein Structure & Function

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