3D Cellular Models of Brain and Neurodegeneration

Brain organoids are three-dimensional in vitro cellular models of the brain that can recapitulate many processes such as the neurodevelopment. In addition, these organoids can be combined with other cell types, such as neurons and astrocytes to study their interactions in assembloids. Disease processes can also be modeled by induced pluripotent stem cell-derived organoids and assembloids from patients with neurodegenerative disorders. Discover the latest research on the models here.

December 30, 2020

Human Brain Surrogates Research: The Onrushing Ethical Dilemma

The American Journal of Bioethics : AJOB
Henry T Greely
January 13, 2021
Open Access

Neuroinvasion of SARS-CoV-2 in human and mouse brain.

The Journal of Experimental Medicine
Eric SongAkiko Iwasaki
January 25, 2021
Preprint
Open Access

Modeling autism-associated SHANK3 deficiency using human cortico-striatal organoids generated from single neural rosettes

BioRxiv : the Preprint Server for Biology
Y. WangAleksandr Shcheglovitov
January 1, 2021
Review
Open Access

Cilia, ciliopathies and hedgehog-related forebrain developmental disorders.

Neurobiology of Disease
Abraham Andreu-CerveraSylvie Schneider-Maunoury
January 21, 2021
Review
Open Access

From Cell Culture to Organoids-Model Systems for Investigating Prion Strain Characteristics.

Biomolecules
Hailey Pineau, Valerie L Sim
January 25, 2021
Preprint
Open Access

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition

ResearchSquare
Caterina Prelli BozzoFrank Kirchhoff
December 29, 2020
Comment / Editorial
Open Access

A screen of brain organoids to study neurodevelopmental disease.

Nature
Adriana Cherskov, Nenad Sestan
January 16, 2021

Advances in CNS organoids: a focus on organoid-based models for motor neuron disease

Tissue Engineering. Part C, Methods
Renata Vieira de SaJeroen Pasterkamp
December 31, 2020
Review
Open Access

Vascularized Organoids: A More Complete Model

International Journal of Stem Cells
Jin Yu
December 29, 2020
Review
Open Access

Retinal organoids: a window into human retinal development

Development
Michelle O'Hara-Wright, Anai Gonzalez-Cordero
January 23, 2021
Review

The genetic basis of inter-individual variation in recovery from traumatic brain injury.

Npj Regenerative Medicine
Daniel Cortes, Martin F Pera
January 2, 2021
Open Access

Broadly Active Antiviral Compounds Disturb Zika Virus Progeny Release Rescuing Virus-Induced Toxicity in Brain Organoids.

Viruses
Aleksandra PettkeMarjo-Riitta Puumalainen
January 5, 2021
Review
Open Access

Great Expectations: Induced pluripotent stem cell technologies in neurodevelopmental impairments

International Journal of Medical Sciences
Xue ZhangZhongtao Gai
December 29, 2020
Open Access

Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids

Frontiers in Cell and Developmental Biology
Ana Rita GomesMaria Margarida Diogo

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