3D Cellular Models of Brain and Neurodegeneration

Brain organoids are three-dimensional in vitro cellular models of the brain that can recapitulate many processes such as the microenvironment and neurodevelopment. In addition, these organoids can be combined with other cell types, such as neurons and astrocytes to study their interactions in assembloids. Disease processes can also be modelled by induced pluripotent stem cell derived organoids and assembloids from patients with neurodegenerative disorders. Discover the latest research here.

June 13, 2020

Human CNS barrier-forming organoids with cerebrospinal fluid production

Science
Laura PellegriniM. A. Lancaster
July 6, 2020
Review

Genetic pathways involved in human speech disorders

Current Opinion in Genetics & Development
Joery den Hoed, Simon E Fisher
July 17, 2020
Open Access

Brainstem Organoids From Human Pluripotent Stem Cells

Frontiers in Neuroscience
Nobuyuki EuraEiichiro Mori
July 14, 2020
Review

PsychENCODE and beyond: transcriptomics and epigenomics of brain development and organoids

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Alexandre JourdonFlora M Vaccarino
July 10, 2020

3D Brain Organoids: Studying Brain Development and Disease Outside the Embryo

Annual Review of Neuroscience
Silvia VelascoPaola Arlotta
July 1, 2020

Neural In Vitro Models for Studying Substances Acting on the Central Nervous System

Handbook of Experimental Pharmacology
Ellen FritscheBarbara Viviani
July 28, 2020
Preprint

Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism

BioRxiv : the Preprint Server for Biology
Fadi JacobG.-l. Ming
June 27, 2020

Single-cell genomic analysis of human cerebral organoids

Methods in Cell Biology
Sabina KantonJ. G. Camp
June 21, 2020
Review

Modeling neurological disorders using brain organoids

Seminars in Cell & Developmental Biology
Daniel Y ZhangGuo-Li Ming
June 20, 2020
Preprint
Open Access

Lineage recording reveals dynamics of cerebral organoid regionalization

BioRxiv : the Preprint Server for Biology
Z. HeBarbara Treutlein
July 1, 2020
Preprint
Open Access

Single-cell sequencing of human iPSC-derived cerebellar organoids shows recapitulation of cerebellar development

BioRxiv : the Preprint Server for Biology
S. NaylerEsther Becker
June 20, 2020
Review

Deconstructing and reconstructing the human brain with regionally specified brain organoids

Seminars in Cell & Developmental Biology
Yangfei XiangIn-Hyun Park
June 14, 2020

Machine learning-assisted neurotoxicity prediction in human midbrain organoids

Parkinsonism & Related Disorders
Anna Sophia MonzelJens Christian Schwamborn
July 4, 2020
Preprint
Open Access

An early cell shape transition drives evolutionary expansion of the human forebrain

BioRxiv : the Preprint Server for Biology
S. Benito-KwiecinskiM. A. Lancaster
July 5, 2020
Preprint
Open Access

A model of traumatic brain injury using human iPSC-derived cortical brain organoids

BioRxiv : the Preprint Server for Biology
J. D. LaiJustin Ichida
July 28, 2020

In vitro models for ASD-patient-derived iPSCs and cerebral organoids

Progress in Molecular Biology and Translational Science
Sonja Simone HohmannTanja Maria Michel
July 23, 2020
Preprint
Open Access

The supramolecular landscape of growing human axons

BioRxiv : the Preprint Server for Biology
P. C. HoffmannM. A. Lancaster
June 17, 2020
Open Access

Commentary: A Primer on Human Brain Organoids for the Neurosurgeon

Neurosurgery
Ahmed HabibPascal O Zinn

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