3D Cellular Models of Brain and Neurodegeneration

Brain organoids are three-dimensional in vitro cellular models of the brain that can recapitulate many processes such as the neurodevelopment. In addition, these organoids can be combined with other cell types, such as neurons and astrocytes to study their interactions in assembloids. Disease processes can also be modeled by induced pluripotent stem cell-derived organoids and assembloids from patients with neurodegenerative disorders. Discover the latest research on the models here.

January 12, 2022
Open Access

Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids.

Ilkka FagerlundTarja Malm
January 12, 2022

Hydrogel Mechanics Influence the Growth and Development of Embedded Brain Organoids.

ACS Applied Bio Materials
Camille Cassel de CampsChristopher Moraes
January 12, 2022

Hypes and Hopes of Stem Cell Therapies in Dentistry: a Review.

Stem Cell Reviews and Reports
Alessandra Rodriguez Y BaenaManuela Monti
January 10, 2022
Open Access

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects.

Acta Neuropathologica Communications
Erwan LambertPierre Dourlen
January 9, 2022

FASN-dependent de novo lipogenesis is required for brain development.

Proceedings of the National Academy of Sciences of the United States of America
Daniel Gonzalez-BohorquezSebastian Jessberger
January 8, 2022

Engineering brain assembloids to interrogate human neural circuits.

Nature Protocols
Yuki MiuraSergiu P Pașca
January 6, 2022

ID2 controls differentiation of enteroendocrine cells in mouse small intestine.

Acta Physiologica
Valeriya V ZininaNatalia Soshnikova
January 6, 2022

Challenges of Organoid Research.

Annual Review of Neuroscience
Madeline G Andrews, Arnold R Kriegstein
January 5, 2022

Modeling human neurodevelopmental diseases with brain organoids.

Cell Regeneration
Xiaoxiang LuYangfei Xiang
January 4, 2022
Open Access

Generation of Vascularized Brain Organoids to Study Neurovascular Interactions

BioRxiv : the Preprint Server for Biology
Zhen-Ge LuoY. Chen
January 1, 2022
Open Access

A systematic characterization of intrinsically formed microglia-like cells during retinal organoid differentiation.

BioRxiv : the Preprint Server for Biology
K. BartalskaSandra Siegert
December 31, 2021

Mitochondrial phenotypes in iPSC AD models.

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Kaitlin FlannaganHeather M Wilkins
December 31, 2021

Single cell transcriptomic profiling of neurodegeneration mediated by tau in a novel 3D neuron-astrocyte coculture model.

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Hannah RicknerChristine Cheng
December 31, 2021

Effect of duty cycles of tumor‑treating fields on glioblastoma cells and normal brain organoids.

International Journal of Oncology
Eunbi YeSung-Min Park
December 31, 2021
Open Access

Transcriptome Dynamics of Human Neuronal Differentiation From iPSC.

Frontiers in Cell and Developmental Biology
Meltem KuruşGökhan Karakülah
December 31, 2021

Lineage recording in human cerebral organoids.

Nature Methods
Zhisong HeBarbara Treutlein

Sign up to follow this feed and discover related papers.

Related Feeds


TAR DNA-binding protein 43 (TDP-43) is a pathological protein identified in sporadic Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Here are the latest discoveries pertaining to TDP-43 and these diseases.

ALS: Genetics

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

ALS: Phenotypes

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized phenotypically by progressive muscle weakness. Clinical phenotypes of ALS can be classified based on the pattern, level, and area of onset (e.g. bulbar, cervical, lumbar). Here is the latest research investigating phenotypes of ALS.

ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here is the latest research on ALS and prions.

ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research in this field.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS) is associated with the death of neurons that control voluntary muscles. This feed followes the latest research into therapies for this progressive neurodegenerative disease.

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

Alexander Disease

Alexander disease is a rare leukodystrophy caused by mutations in the astrocyte-specific intermediate filament protein glial fibrillary acidic protein (GFAP). Here is the latest research on this disease.

Alpha-Synuclein Aggregation

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

© 2022 Meta ULC. All rights reserved