Single-Cell RNA Sequencing: Kidney and Organoids

Single-cell RNA sequencing of the adult human kidney transcriptome can provide molecular information about cell-specific responses to environmental variables and disease states. This information can provide a dataset to benchmark human kidney organoids. Discover the latest research on adult kidney organoids at single cell resolution here.

October 21, 2020
Open Access

Single-cell transcriptomics: a new research technique for precision medicine in nephrology

The Korean Journal of Internal Medicine
Jisoo Kim, Jihwan Park
December 31, 2020

Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk

Cell Stem Cell
Sara E HowdenMelissa H Little
December 12, 2020
Open Access

The miR-199a/214 Cluster Controls Nephrogenesis and Vascularization in a Human Embryonic Stem Cell Model

Stem Cell Reports
Ioannis BantounasSusan J Kimber
December 15, 2020

Dissecting the human kidney allograft transcriptome: single-cell RNA sequencing

Current Opinion in Organ Transplantation
Elly VarmaThangamani Muthukumar
September 26, 2020
Open Access

Human kidney organoids model the tacrolimus nephrotoxicity and elucidate the role of autophagy

The Korean Journal of Internal Medicine
Jin Won KimYong Kyun Kim
November 17, 2020
Open Access

Molecular detection of maturation stages in the developing kidney

Developmental Biology
Hidekazu NaganumaRyuichi Nishinakamura
December 18, 2020

Experimental and computational technologies to dissect the kidney at the single-cell level

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Christoph KuppeRafael Kramann
December 28, 2020
Open Access

SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity

BioRxiv : the Preprint Server for Biology
C. RamirezCarl Herrmann
October 31, 2020

A human tissue screen identifies a regulator of ER secretion as a brain size determinant

Christopher EskJürgen A Knoblich
January 15, 2021

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): a Systemic Infection

Clinical Microbiology Reviews
Aleksandra SynowiecKrzysztof Pyrc
December 20, 2020

Directed Differentiation of Human Pluripotent Stem Cells for the Generation of High-Order Kidney Organoids

Methods in Molecular Biology
Idoia Lucía SelfaElena Garreta
September 20, 2020

Single-Cell Sequencing in Genitourinary Malignancies

Advances in Experimental Medicine and Biology
Neal MurphyAnnette Lee
December 21, 2020

A Rare Kidney Disease To Cure Them All? Towards Mechanism-Based Therapies for Proteinopathies

Trends in Molecular Medicine
Moran Dvela-LevittAnna Greka
November 27, 2020
Open Access

Predicting the impact of sequence motifs on gene regulation using single-cell data

BioRxiv : the Preprint Server for Biology
J. HepkemaMartin Hemberg
December 1, 2020
Open Access

Kidney Organoids as Disease Models: Strengths, Weaknesses and Perspectives

Frontiers in Physiology
Ricardo Romero-GuevaraChristodoulos Xinaris
November 10, 2020
Open Access

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments

BioRxiv : the Preprint Server for Biology
X. ShengKatalin Susztak
November 12, 2020
Open Access

Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu

BioRxiv : the Preprint Server for Biology
B. A. GoodsLauren H Sansing
November 17, 2020
Open Access

Thiol-ene cross-linked alginate hydrogel encapsulation modulates the extracellular matrix of kidney organoids by reducing abnormal type 1a1 collagen deposition

BioRxiv : the Preprint Server for Biology
T. GeuensV. L. S. LaPointe
December 16, 2020
Open Access

3-D Human Renal Tubular Organoids Generated from Urine-Derived Stem Cells for Nephrotoxicity Screening

ACS Biomaterials Science & Engineering
Haibin GuoYuanyuan Zhang

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