African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.

January 13, 2022
Preprint
Open Access

Livestock, pathogens, vectors, and their environment: a causal inference-based approach to estimating the pathway-specific effect of livestock on human African trypanosomiasis risk

MedRxiv : the Preprint Server for Health Sciences
Julianne MeisnerP. Rabinowitz
January 12, 2022

Sesquiterpene Lactones with Dual Inhibitory Activity against the Trypanosoma brucei Pteridine Reductase 1 and Dihydrofolate Reductase.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Katharina PossartThomas J Schmidt
January 12, 2022

An assembly of nuclear bodies associates with the active VSG expression site in African trypanosomes.

Nature Communications
James BudzakGloria Rudenko
January 11, 2022
Preprint
Open Access

Genomic occupancy of the bromodomain protein Bdf3 is dynamic during differentiation of African trypanosomes from bloodstream to procyclic forms

BioRxiv : the Preprint Server for Biology
E. AshbyDanae Schulz
January 11, 2022
Review

Promising antiparasitic agents from marine sponges.

Saudi Journal of Biological Sciences
Osama MostafaMahmoud Moustafa
January 11, 2022

Evaluating Release Kinetics from Alginate Beads Coated with Polyelectrolyte Layers for Sustained Drug Delivery.

ACS Applied Bio Materials
Markus WitzlerMargit Schulze
January 7, 2022
Open Access

Novel Trypanocidal Inhibitors that Block Glycosome Biogenesis by Targeting PEX3-PEX19 Interaction.

Frontiers in Cell and Developmental Biology
Mengqiao LiVishal C Kalel
January 4, 2022

The role of TRPC6 calcium channels and P2 purinergic receptors in podocyte mechanical and metabolic sensing.

Physiology International
Georgina GyarmatiJános Peti-Peterdi
December 31, 2021

Synthesis and evaluation of antibacterial and trypanocidal activity of derivatives of monensin A.

Bioorganic & Medicinal Chemistry Letters
Marta JędrzejczykAdam Huczyński
December 31, 2021

Antitrypanosomal activity of new semi-synthetic bergenin derivatives.

Chemical Biology & Drug Design
Seham S El-HawaryHeba A H Elshemy
December 30, 2021

Benzophenone Glucosides and B-Type Proanthocyanidins Dimer from Zambian Cassia abbreviata and Their Trypanocidal Activities.

Journal of Natural Products
Linous MunsimbweToshihiro Murata
December 30, 2021

Ku80 is involved in telomere maintenance but dispensable for genomic stability in Leishmania mexicana.

PLoS Neglected Tropical Diseases
Ester PolákováVyacheslav Yurchenko

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