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African Trypanosomiasis

African Trypanosomiasis diagram by ggw, Shutterstock
ggw, Shutterstock

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.

Top 20 most recent papers

Unconventional kinetochore kinases KKT2 and KKT3 have a unique zinc finger that promotes their kinetochore localization

bioRxivDecember 13, 2019
Gabriele MarcianòBungo Akiyoshi

Tools for the genetic manipulation of Herpetomonas muscarum

bioRxivJanuary 3, 2020
Megan A Sloan, Petros Ligoxygakis

Control of assembly of extra-axonemal structures: the paraflagellar rod of trypanosomes

bioRxivDecember 17, 2019
Aline A. AlvesJack D. Sunter

Discovery of new mitochondrial DNA segregation machinery components in Trypanosoma brucei: a comparison of three approaches

bioRxivDecember 28, 2019
Hélène Clémentine Margareta BaudouinTorsten Ochsenreiter
Medical and Veterinary Entomology

Modelling optimal timing and frequency of insecticide sprays for eradication or knockdown of closed populations of tsetse flies Glossina spp. (Diptera: Glossinidae)

Medical and Veterinary EntomologyJanuary 18, 2020
H J BarclayP van den Driessche
Cell Reports

Evolutionary Divergence of Enzymatic Mechanisms for Tubulin Detyrosination

Cell ReportsDecember 19, 2019
Siem van der LaanKrzysztof Rogowski
Tropical Medicine and Infectious Disease

Gambiense Human African Trypanosomiasis Sequelae after Treatment: A Follow-Up Study 12 Years after Treatment

Tropical Medicine and Infectious DiseaseJanuary 17, 2020
Junior MudjiJohannes Blum

Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy

bioRxivJanuary 9, 2020
Renee C GeckAlex Toker
The Journal of Biological Chemistry

Steric constraints control processing of glycosylphosphatidylinositol anchors in Trypanosoma brucei

The Journal of Biological ChemistryJanuary 15, 2020
Carolina M KoellerJames D Bangs
Tropical Medicine and Infectious Disease

Whose Elimination? Frontline Workers' Perspectives on the Elimination of the Human African Trypanosomiasis and Its Anticipated Consequences

Tropical Medicine and Infectious DiseaseJanuary 8, 2020
Jean-Benoît FalisseAlain Mpanya
Journal of Medicinal Chemistry

Structure-activity relationship in pyrazolo[4,3-c]pyridines, first inhibitors of PEX14-PEX5 Protein-Protein Interaction (PPI) with trypanocidal activity

Journal of Medicinal ChemistryDecember 21, 2019
Maciej DawidowskiGrzegorz M Popowicz
Journal of Enzyme Inhibition and Medicinal Chemistry

Design, synthesis, and antiprotozoal evaluation of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives

Journal of Enzyme Inhibition and Medicinal ChemistryJanuary 5, 2020
Jean GuillonBertrand Courtioux
Bioorganic & Medicinal Chemistry Letters

Synthesis and biological evaluation of bis-N2 ,N2 '-(4-hydroxycoumarin-3-yl)ethylidene]-2,3-dihydroxysuccinodihydrazides

Bioorganic & Medicinal Chemistry LettersJanuary 19, 2020
Meloddy H ManyerukePerry T Kaye
Acta Tropica

Wing length of tsetse caught by stationary and mobile sampling methods

Acta TropicaJanuary 14, 2020
Cornelius MweempwaReginald De Deken
European Journal of Medicinal Chemistry

Repurposing a polymer precursor: Synthesis and in vitro medicinal potential of ferrocenyl 1,3-benzoxazine derivatives

European Journal of Medicinal ChemistryDecember 20, 2019
Mziyanda MbabaSetshaba D Khanye
Tropical Medicine and Infectious Disease

Product Development Partnerships: Delivering Innovation for the Elimination of African Trypanosomiasis?

Tropical Medicine and Infectious DiseaseJanuary 19, 2020
Emma Michelle Taylor, James Smith
Journal of Medicinal Chemistry

Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-b]pyridazines for the Treatment of Human African Trypanosomiasis

Journal of Medicinal ChemistryDecember 18, 2019
Westley TearMichael P Pollastri
Methods in Molecular Biology

Mapping the RNA Chaperone Activity of the T. brucei Editosome Using SHAPE Chemical Probing

Methods in Molecular BiologyJanuary 1, 2020
W-Matthias Leeder, H Ulrich Göringer
Antimicrobial Agents and Chemotherapy

One Hundred Years of Suramin

Antimicrobial Agents and ChemotherapyDecember 18, 2019
Natalie WiedemarPascal Mäser
Parasites & Vectors

Prevalence of Trypanosoma evansi in livestock in Palestine

Parasites & VectorsJanuary 15, 2020
Suheir EreqatZiad Abdeen

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