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African Trypanosomiasis

African Trypanosomiasis diagram by undefined

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.

Top 20 most recent papers

Phylobioactive hotspots identified through multidimensional profiling of botanical drugs used to treat Chagas disease in Bolivia and Dioscorides' De Materia Medica

bioRxivDecember 2, 2019
Andrea SalmJürg Gertsch
American Journal of Human Genetics

Mutations in TTC29, Encoding an Evolutionarily Conserved Axonemal Protein, Result in Asthenozoospermia and Male Infertility

American Journal of Human GeneticsNovember 19, 2019
Patrick LorèsAminata Touré

A Trypanosoma brucei ORFeome-based Gain-of-Function Library reveals novel genes associated with melarsoprol resistance

bioRxivNovember 20, 2019
McKenzie CarterGaladriel A Hovel-Miner
Scientific Reports

Transcription activity contributes to the firing of non-constitutive origins in African trypanosomes helping to maintain robustness in S-phase duration

Scientific ReportsDecember 6, 2019
Marcelo Santos Da SilvaMaria Carolina Elias
Nature Communications

Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

Nature CommunicationsDecember 5, 2019
Fabian HulpiaSerge Van Calenbergh
Angewandte Chemie

A Unified Total Synthesis of the Actinoallolides, a Family of Potent Anti-trypanosomal Macrolides

Angewandte ChemieNovember 19, 2019
Matthew J AnketellIan Paterson
Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry

Antiprotozoal Activity of Turkish Origanum onites Essential Oil and Its Components

Molecules : a Journal of Synthetic Chemistry and Natural Product ChemistryDecember 3, 2019
Deniz TasdemirKemal Husnu Can Baser
International Journal of Molecular Sciences

Trypanosoma brucei J-Protein 2 Functionally Co-Operates with the Cytosolic Hsp70 and Hsp70.4 Proteins

International Journal of Molecular SciencesNovember 21, 2019
Stephen John Bentley, Aileen Boshoff
The Journal of Biological Chemistry

Regulated protein stabilization underpins the functional interplay among basal body components in Trypanosoma brucei

The Journal of Biological ChemistryDecember 9, 2019
Kieu Thuy Pham, Ziyin Li
PLoS Neglected Tropical Diseases

The impact of vector migration on the effectiveness of strategies to control gambiense human African trypanosomiasis

PLoS Neglected Tropical DiseasesDecember 1, 2019
Martial L Ndeffo-MbahAlison P Galvani

An integrated microfluidic device for studying controllable gas embolism induced cellular responses

TalantaDecember 11, 2019
Peng Yi MaBi-Feng Liu
PLoS Neglected Tropical Diseases

Thermal stress responses of Sodalis glossinidius, an indigenous bacterial symbiont of hematophagous tsetse flies

PLoS Neglected Tropical DiseasesNovember 18, 2019
Jose Santinni RomaBrian L. Weiss
Parasite : Journal De La Société Française De Parasitologie

Immune trypanolysis test as a promising bioassay to monitor the elimination of gambiense human African trypanosomiasis

Parasite : Journal De La Société Française De ParasitologieNovember 22, 2019
Emilie T H DamaVincent Jamonneau

Frontiers in Microfluidics, a Teaching Resource Review

BioengineeringDecember 3, 2019
Jack Merrin
Journal of Medicinal Chemistry

Optimization Strategy of Novel Peptide-Based Michael Acceptors for the Treatment of Human African Trypanosomiasis

Journal of Medicinal ChemistryNovember 13, 2019
Roberta EttariMaria Zappalá
BMC Public Health

Associations of mental disorders and neurotropic parasitic diseases: a meta-analysis in developing and emerging countries

BMC Public HealthDecember 5, 2019
Labanté Outcha DaréPierre-Marie Preux
European Journal of Medicinal Chemistry

Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y2 and GPR17

European Journal of Medicinal ChemistryOctober 18, 2019
Thanigaimalai PillaiyarChrista E Müller
Open Biology

Escaping the immune system by DNA repair and recombination in African trypanosomes

Open BiologyNovember 14, 2019
Núria SimaLucy Glover

Popillia biguttata (Wiedemann in Wiedemann amp; Germar, 1821) (Coleoptera: Scarabaeidae: Rutelinae) established on New Guinea? With an illustrated key to Sundaland Popillia Dejean species

ZootaxaOctober 10, 2019
Dmitry Telnov, Carsten Zorn
Journal of Medicinal Chemistry

Unforeseen possibilities to investigate the regulation of polyamine metabolism revealed by novel C-methylated spermine derivatives

Journal of Medicinal ChemistryNovember 25, 2019
Maxim A KhomutovAlex R Khomutov

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