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African Trypanosomiasis
ggw, ShutterstockAfrican trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.
Top 20 most recent papers
Unconventional kinetochore kinases KKT2 and KKT3 have a unique zinc finger that promotes their kinetochore localization
bioRxivDecember 13, 2019
Gabriele MarcianòBungo Akiyoshi
13
Tools for the genetic manipulation of Herpetomonas muscarum
bioRxivJanuary 3, 2020
Megan A Sloan, Petros Ligoxygakis
6
Control of assembly of extra-axonemal structures: the paraflagellar rod of trypanosomes
bioRxivDecember 17, 2019
Aline A. AlvesJack D. Sunter
8
Discovery of new mitochondrial DNA segregation machinery components in Trypanosoma brucei: a comparison of three approaches
bioRxivDecember 28, 2019
Hélène Clémentine Margareta BaudouinTorsten Ochsenreiter
5
Modelling optimal timing and frequency of insecticide sprays for eradication or knockdown of closed populations of tsetse flies Glossina spp. (Diptera: Glossinidae)
Medical and Veterinary EntomologyJanuary 18, 2020
H J BarclayP van den Driessche
Evolutionary Divergence of Enzymatic Mechanisms for Tubulin Detyrosination
Cell ReportsDecember 19, 2019
Siem van der LaanKrzysztof Rogowski
11
Gambiense Human African Trypanosomiasis Sequelae after Treatment: A Follow-Up Study 12 Years after Treatment
Tropical Medicine and Infectious DiseaseJanuary 17, 2020
Junior MudjiJohannes Blum
Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy
bioRxivJanuary 9, 2020
Renee C GeckAlex Toker
3
Steric constraints control processing of glycosylphosphatidylinositol anchors in Trypanosoma brucei
The Journal of Biological ChemistryJanuary 15, 2020
Carolina M KoellerJames D Bangs
Whose Elimination? Frontline Workers' Perspectives on the Elimination of the Human African Trypanosomiasis and Its Anticipated Consequences
Tropical Medicine and Infectious DiseaseJanuary 8, 2020
Jean-Benoît FalisseAlain Mpanya
Structure-activity relationship in pyrazolo[4,3-c]pyridines, first inhibitors of PEX14-PEX5 Protein-Protein Interaction (PPI) with trypanocidal activity
Journal of Medicinal ChemistryDecember 21, 2019
Maciej DawidowskiGrzegorz M Popowicz
2
Design, synthesis, and antiprotozoal evaluation of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives
Journal of Enzyme Inhibition and Medicinal ChemistryJanuary 5, 2020
Jean GuillonBertrand Courtioux
1
Synthesis and biological evaluation of bis-N2 ,N2 '-(4-hydroxycoumarin-3-yl)ethylidene]-2,3-dihydroxysuccinodihydrazides
Bioorganic & Medicinal Chemistry LettersJanuary 19, 2020
Meloddy H ManyerukePerry T Kaye
Wing length of tsetse caught by stationary and mobile sampling methods
Acta TropicaJanuary 14, 2020
Cornelius MweempwaReginald De Deken
3
Repurposing a polymer precursor: Synthesis and in vitro medicinal potential of ferrocenyl 1,3-benzoxazine derivatives
European Journal of Medicinal ChemistryDecember 20, 2019
Mziyanda MbabaSetshaba D Khanye
1
Product Development Partnerships: Delivering Innovation for the Elimination of African Trypanosomiasis?
Tropical Medicine and Infectious DiseaseJanuary 19, 2020
Emma Michelle Taylor, James Smith
Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-b]pyridazines for the Treatment of Human African Trypanosomiasis
Journal of Medicinal ChemistryDecember 18, 2019
Westley TearMichael P Pollastri
1
Mapping the RNA Chaperone Activity of the T. brucei Editosome Using SHAPE Chemical Probing
Methods in Molecular BiologyJanuary 1, 2020
W-Matthias Leeder, H Ulrich Göringer
One Hundred Years of Suramin
Antimicrobial Agents and ChemotherapyDecember 18, 2019
Natalie WiedemarPascal Mäser
2
Prevalence of Trypanosoma evansi in livestock in Palestine
Parasites & VectorsJanuary 15, 2020
Suheir EreqatZiad Abdeen
2