Alexander Disease

Alexander disease is a rare leukodystrophy caused by mutations in the astrocyte-specific intermediate filament protein glial fibrillary acidic protein (GFAP). Here is the latest research on this disease.

August 23, 2021
Preprint
Open Access

Directed Differentiation of Human Pluripotent Stem Cells into Radial Glia and Astrocytes Bypasses Neurogenesis

BioRxiv : the Preprint Server for Biology
Ilyas SingecA. Simeonov
July 13, 2021
Case Report
Open Access

A Case Report of Adult-Onset Alexander Disease with a Tumor-Like Lesion in the Lateral Ventricle.

Case Reports in Neurology
Tongjia CaiJianjun Wu
July 11, 2021

Clinical and radiological characteristics of older-adult-onset Alexander disease.

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
Tomokatsu YoshidaToshiki Mizuno
July 8, 2021
Open Access

Area Postrema Syndrome as the Initial Presentation of Alexander Disease.

Neurology
Florence RenaldoDiana Rodriguez
July 1, 2021

[Alexander disease: diversity of cell population and interactions between neuron and glia].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
Kozo SaitoSchuichi Koizumi
June 20, 2021

GFAP variants leading to infantile Alexander disease: Phenotype and genotype analysis of 135 cases and report of a de novo variant.

Clinical Neurology and Neurosurgery
Katayoun HeshmatzadBahareh Rabbani
June 10, 2021
Open Access

A report of two cases of bulbospinal form Alexander disease and preliminary exploration of the disease.

Molecular Medicine Reports
Xiaoxuan SongLi Cao
May 28, 2021
Open Access

Does genetic anticipation occur in familial Alexander disease?

Neurogenetics
Camille K HuntJemeen Sreedharan
May 20, 2021
Open Access

Late-Onset Leukodystrophy Mimicking Hereditary Spastic Paraplegia without Diffuse Leukodystrophy on Neuroimaging.

Neuropsychiatric Disease and Treatment
Tongxia ZhangYuying Zhao
April 29, 2021

Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Ni-Hsuan LinMing-Der Perng
April 18, 2021

Adult-onset Alexander disease mimicking multiple system atrophy predominant cerebellar ataxia.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Yuji WatanabeKeisuke Suzuki
January 31, 2021
Preprint
Open Access

Antisense therapy in a new rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment.

BioRxiv : the Preprint Server for Biology
Tracy L HagemannA. Messing
January 29, 2021
Open Access

Waning efficacy in a long-term AAV-mediated gene therapy study in the murine model of Krabbe disease.

Molecular Therapy : the Journal of the American Society of Gene Therapy
Gregory J HellerErnesto R Bongarzone
December 29, 2020
Review
Open Access

Patient-derived iPSC modeling of rare neurodevelopmental disorders: Molecular pathophysiology and prospective therapies.

Neuroscience and Biobehavioral Reviews
K R SabithaDinesh Upadhya
December 18, 2020
Review
Open Access

Astrocyte-Oligodendrocyte-Microglia Crosstalk in Astrocytopathies

Frontiers in Cellular Neuroscience
Dieuwke Maria de Waard, Marianna Bugiani

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