Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

September 5, 2020
Open Access

Molecular basis for N-terminal alpha-synuclein acetylation by human NatB

ELife
Sunbin DengRonen Marmorstein
September 15, 2020

Perturbation of in vivo Neural Activity Following α-Synuclein Seeding in the Olfactory Bulb

Journal of Parkinson's Disease
Aishwarya S KulkarniDaniel W Wesson
September 16, 2020
Open Access

Norepinephrine depleting toxin DSP-4 and LPS alter gut microbiota and induce neurotoxicity in α-synuclein mutant mice

Scientific Reports
Sheng SongJau-Shyong Hong
September 6, 2020

Reduction of Lewy Body Pathology by Oral Cinnamon

Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology
Sumita RahaKalipada Pahan
September 15, 2020

Squalamine Restores the Function of the Enteric Nervous System in Mouse Models of Parkinson's Disease

Journal of Parkinson's Disease
Christine L WestWolfgang A Kunze
September 15, 2020
Open Access

Rational design of small molecules able to inhibit α-synuclein amyloid aggregation for the treatment of Parkinson's disease

Journal of Enzyme Inhibition and Medicinal Chemistry
Serena VittorioLaura De Luca
September 8, 2020

Wedelolactone Mitigates Parkinsonism Via Alleviating Oxidative Stress and Mitochondrial Dysfunction Through NRF2/SKN-1

Molecular Neurobiology
Shruti SharmaRakesh Pandey
September 16, 2020

Changes in the cellular fatty acid profile drive the proteasomal degradation of α-synuclein and enhance neuronal survival

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Mary XylakiEvangelia Emmanouilidou
September 6, 2020

Combining valproate and bipyridyl ligands to construct a 0D core-shell Zn5 (μ3 -OH)2 cluster and a 2D layered coordination network with a [Zn3 (μ3 -OH)]2 SBU

Acta Crystallographica. Section C, Structural Chemistry
Hijazi Abu Ali, Mohanad Darawsheh
September 15, 2020

Alpha-Synuclein Aggregates Associated with Mitochondria in Tunnelling Nanotubes

Neurotoxicity Research
Dario ValdinocciDean L Pountney
September 5, 2020

Effects of Subthalamic Deep Brain Stimulation With Different Frequencies in a Parkinsonian Rat Model

Neuromodulation : Journal of the International Neuromodulation Society
Zhimin LiRenzhi Wang
September 18, 2020

Gut microbiota dynamics in Parkinsonian mice

ACS Chemical Neuroscience
Emily KlannVinata Vedam-Mai
September 15, 2020

A Comparative Photophysical Study of Structural Modifications of Thioflavin T-Inspired Fluorophores

The Journal of Physical Chemistry Letters
Lisa-Maria NeedhamSteven F Lee
September 12, 2020
Review
Open Access

Fluid Biomarkers for Synaptic Dysfunction and Loss

Biomarker Insights
Elena CamporesiHenrik Zetterberg
September 11, 2020
Open Access

Immunotherapies Targeting α-Synuclein in Parkinson Disease

Federal Practitioner : for the Health Care Professionals of the VA, DoD, and PHS
Fariha Jamal
September 15, 2020

Phosphorylated Alpha-Synuclein Within Cutaneous Autonomic Nerves of Patients With Parkinson's Disease: The Implications of Sample Thickness on Results

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Ningshan WangChristopher H Gibbons

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