Alpha-Synuclein Aggregation

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

July 28, 2020
Open Access

Synthesis of α-Aminophosphonic Acid Derivatives Through the Addition of O - and S -Nucleophiles to 2H -Azirines and Their Antiproliferative Effect on A549 Human Lung Adenocarcinoma Cells

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Victor CarramiñanaJesús M de Los Santos
August 5, 2020

Where and how alpha-synuclein pathology spreads in Parkinson's disease

Neuropathology : Official Journal of the Japanese Society of Neuropathology
Koichi Wakabayashi
July 31, 2020

Dopamine promotes the neurodegenerative potential of β-synuclein

Journal of Neurochemistry
Anupam RainaSebastian Kügler
August 2, 2020

Maysin plays a protective role against α-Synuclein oligomers cytotoxicity by triggering autophagy activation

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Manuela LeriDonatella Degl'Innocenti
July 28, 2020
Open Access

Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor

International Journal of Molecular Sciences
Elizabeth Terry-KantorUlf Dettmer
July 30, 2020
Preprint
Open Access

Studies on C. elegans probed with estradiol, elucidate the critical role of Na+/H+ exchanger, nhx-2 in reproductive senescence and neuronal health

BioRxiv : the Preprint Server for Biology
S. ShuklaAamir Nazir
August 3, 2020

Endosomal-lysosomal dysfunction in metabolic diseases and Alzheimer's disease

International Review of Neurobiology
Michael F AlmeidaStephen T Kinsey
July 28, 2020
Review
Open Access

Tau and Alpha Synuclein Synergistic Effect in Neurodegenerative Diseases: When the Periphery Is the Core

International Journal of Molecular Sciences
Elena VacchiGiorgia Melli
July 28, 2020
Review

Animal Models of Parkinson's Disease: Are They Useful or Not?

Journal of Parkinson's Disease
Roger A Barker, Anders Björklund
July 31, 2020

Mechanisms by which autophagy regulates memory capacity in ageing

Aging Cell
Maria De RisiElvira De Leonibus
July 30, 2020

Hemiterpene compound, 3,3-dimethylallyl alcohol promotes longevity and neuroprotection in Caenorhabditis elegans

GeroScience
Suresh Chandra PhularaVirendra Shukla
August 5, 2020
Open Access

Defining and predicting transdiagnostic categories of neurodegenerative disease

Nature Biomedical Engineering
Eli J CornblathDanielle S Bassett
July 28, 2020
Review
Open Access

Endosomal-Lysosomal Processing of Neurodegeneration-Associated Proteins in Astrocytes

International Journal of Molecular Sciences
Ching-On Wong
July 28, 2020

Modeling α-Synucleinopathy in Organotypic Brain Slice Culture with Preformed α-Synuclein Amyloid Fibrils

Journal of Parkinson's Disease
Amandine RouxJiyan Ma
July 29, 2020
Open Access

Unroofing site-specific α-synuclein-lipid interactions at the plasma membrane

Proceedings of the National Academy of Sciences of the United States of America
Upneet Kaur, Jennifer C Lee
July 30, 2020
Open Access

The Inhibition of miR-873 Provides Therapeutic Benefit in a Lipopolysaccharide-Induced Neuroinflammatory Model of Parkinson's Disease

Oxidative Medicine and Cellular Longevity
Jinhua WuJiang Yue
July 31, 2020

α-Synuclein in Parkinson's Disease: Does a Prion-Like Mechanism of Propagation from Periphery to the Brain Play a Role?

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
Huimin ZhengYuming Xu

Sign up to follow this feed and discover related papers.

Related Feeds

ALS

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

ALS & FTD: TDP-43

ALS shares with a considerable proportion of FTD cases the same neuropathological substrate, namely, inclusions of abnormally phosphorylated protein tdp-43 (ptdp-43). Here are the latest discoveries pertaining to ptdp-43 and these diseases.

ALS - Pathogenic Mechanisms

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

ALS - Phenotypes

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating phenotypes associated with this genetically heterogeneous disorder.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here are the latest discoveries pertaining to this disease.

ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS therapies here.

ALS: Transposon de-silencing

Transposon silencing is a form of transcriptional gene silencing. These gene silencing mechanisms are impaired in Amyotrophic lateral sclerosis (ALS). Here are the latest discoveries pertaining to transposon silencing and this disease.

Age-related Dementia

Age-related dementia (Alzheimer's disease) results from the destructive impact of the pulse on cerebral vasculature. Evidence is reviewed that the neuropathology of the dementia is caused by the breakdown of small cerebral vessels (silent microbleeds), that the microbleeds result from pulse-induced damage to the cerebral vessels, and that pulse becomes increasingly destructive with age, because of the age-related stiffening of the aorta and great arteries, which causes an increase in the intensity of the pressure pulse. Discover the latest research on age-related dementia here.

© 2020 Meta ULC. All rights reserved
/feed-previews/alpha-synuclein-aggregation/cb325b50-e1da-42be-a718-5beab88d57dc