Alpha-Synuclein Antibody Therapeutics (MDS)

Alpha-synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. They have also been detected in several other neurodegenerative diseases, known as synucleopathies. Here is the latest research on alpha-synuclein antibody therapeutics.

September 15, 2021
Preprint
Open Access

Epitope scaffolding using alpha-synuclein cyclic peptides to generate oligomer-selective antibodies for Parkinson's disease

BioRxiv : the Preprint Server for Biology
S. C. C. HsuehSteven S Plotkin
September 6, 2021

SARS-CoV-2 infection of the central nervous system in a 14-month-old child: A case report of a complete autopsy.

Lancet Regional Health. Americas
Ismael GomesStevens Rehen
August 30, 2021
Review
Open Access

Wnt signaling activation: targets and therapeutic opportunities for stem cell therapy and regenerative medicine.

RSC Chemical Biology
Clémence BonnetJie J Zheng
August 30, 2021
Review

Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis.

World Journal of Gastrointestinal Oncology
Lumir KunovskyJan Trna
August 30, 2021
Open Access

Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies.

Acta Neuropathologica Communications
Ethan W HassBenoit I Giasson
August 28, 2021
Review
Open Access

Current Therapies in Clinical Trials of Parkinson's Disease: A 2021 Update.

Pharmaceuticals
E Maruthi Prasad, Shih-Ya Hung
August 27, 2021
Review

Significance of Oligomeric and Fibrillar Species in Amyloidosis: Insights into Pathophysiology and Treatment.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Haruki KoikeMasahisa Katsuno
August 16, 2021
Review
Open Access

Current Nosology of Neural Autoantibody-Associated Dementia.

Frontiers in Aging Neuroscience
Niels Hansen
August 12, 2021
Review

Anti-CD20 therapies for multiple sclerosis: current status and future perspectives.

Journal of Neurology
Monica MargoniMaria A Rocca
August 9, 2021
Review
Open Access

Tweaking Progranulin Expression: Therapeutic Avenues and Opportunities.

Frontiers in Molecular Neuroscience
Joke TerrynPhilip Van Damme
August 6, 2021
Open Access

Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study.

Acta Neuropathologica Communications
Megan A IidaJohn F Crary
August 6, 2021

Recent progress towards vaccines and antibody-based therapies against Alzheimer's disease.

Mini Reviews in Medicinal Chemistry
Wenbo JiYou Yin
August 6, 2021
Review
Open Access

View Point: Disease Modification and Cell Secretome Based Approaches in Parkinson's Disease: Are We on the Right Track?

Biologics : Targets & Therapy
Thomas Müller
August 2, 2021

DNAJB6b is Downregulated in Synucleinopathies.

Journal of Parkinson's Disease
Jonas FolkeChristian Hansen
July 29, 2021
Preprint
Open Access

Systemic antibody-oligonucleotide delivery to the central nervous system ameliorates mouse models of spinal muscular atrophy

BioRxiv : the Preprint Server for Biology
Suzan M HammondC. Webster
July 29, 2021
Case Report

The hot cross bun sign in corticobasal degeneration.

Neuropathology : Official Journal of the Japanese Society of Neuropathology
Takashi AndoYasushi Iwasaki

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