Alpha-Synuclein Antibody Therapeutics (MDS)

Alpha-synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. They have also been detected in several other neurodegenerative diseases, known as synucleopathies. Here is the latest research on alpha-synuclein antibody therapeutics.

December 13, 2018
Open Access

Emerging Immunotherapies for Parkinson Disease

Neurology and Therapy
Samis M A ZellaLars Tönges
June 20, 2019
Open Access

The Role of Antibodies and Their Receptors in Protection Against Ordered Protein Assembly in Neurodegeneration

Frontiers in Immunology
Taxiarchis KatsinelosWilliam A McEwan
June 25, 2020
Open Access

Parkinson's disease: etiopathogenesis and treatment

Journal of Neurology, Neurosurgery, and Psychiatry
Joseph Jankovic, Eng King Tan
June 25, 2020

The Effect of (-)-Epigallocatechin-3-Gallate on the Amyloid-β Secondary Structure

Biophysical Journal
Atanu AcharyaVictor S Batista
July 11, 2018
Open Access

Angiotensin Type 1 Receptor Antagonists Protect Against Alpha-Synuclein-Induced Neuroinflammation and Dopaminergic Neuron Death

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Ana I Rodriguez-PerezJose L Labandeira-Garcia
May 21, 2019
Open Access

Anti-HMGB1 monoclonal antibody therapy for a wide range of CNS and PNS diseases

Journal of Pharmacological Sciences
Masahiro NishiboriHideo K Takahashi
September 12, 2019
Open Access

Encoding the Sequence of Specific Autoantibodies Against beta-Amyloid and alpha-Synuclein in Neurodegenerative Diseases

Frontiers in Immunology
Alexandra AlbusRichard Dodel
January 8, 2020

Current Status and Future Prospects of Therapeutic Development of Parkinson's Disease

Brain and nerve = Shinkei kenkyū no shinpo
Hideki Mochizuki
February 10, 2020

Emerging Disease-modifying Strategies Targeting α-synuclein in Parkinson's Disease

Brain and nerve = Shinkei kenkyū no shinpo
Takafumi HasegawaShun Ishiyama
August 11, 2020
Open Access

Recent Preclinical Insights Into the Treatment of Chronic Traumatic Encephalopathy

Frontiers in Neuroscience
Patrick W Breen, Vaishnav Krishnan
March 8, 2018
Case Report
Open Access

Secondary antibody deficiency: a complication of anti-CD20 therapy for neuroinflammation

Journal of Neurology
E C TallantyreA Jacob
August 30, 2018
Open Access

Proteasome-targeted nanobodies alleviate pathology and functional decline in an α-synuclein-based Parkinson's disease model

NPJ Parkinson's Disease
Diptaman ChatterjeeJeffrey H Kordower
April 22, 2017
Open Access

Identification of a novel PD-L1 positive solid tumor transplantable in HLA-A*0201/DRB1*0101 transgenic mice

Laurie RanganOlivier Adotévi
September 11, 2020
Open Access

Immunotherapies Targeting α-Synuclein in Parkinson Disease

Federal Practitioner : for the Health Care Professionals of the VA, DoD, and PHS
Fariha Jamal
April 18, 2020
Open Access

Applying Antibodies Inside Cells: Principles and Recent Advances in Neurobiology, Virology and Oncology

BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
Congcong ZhangAndrea L J Marschall
April 8, 2018

Biophysical Properties and Heating-Induced Aggregation of Lysine-Conjugated Antibody-Drug Conjugates

Journal of Pharmaceutical Sciences
Aditya V GandhiJohn F Carpenter
May 6, 2019
Open Access

Antibodies against alpha-synuclein: tools and therapies

Journal of Neurochemistry
Nishant N VaikathOmar M A El-Agnaf

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Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

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Bovine Spongiform Encephalopathy (MDS)

Bovine spongiform encephalopathy is a neurodegenerative disease belonging to the transmissible spongiform encephalopathies, a group of diseases including sheep scrapie and human Creutzfeldt-Jakob disease. Here is the latest research.

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Cerebral Palsy & Spasticity (MDS)

Spactic cereberal palsy is one of the most common types of cerebral palsy that stems from an upper motor neuron lesion in the brain. Discover the latest research on cerebral palsy and spasticity here.

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