Alpha-Synuclein Antibody Therapeutics (MDS)

Alpha-synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. They have also been detected in several other neurodegenerative diseases, known as synucleopathies. Here is the latest research on alpha-synuclein antibody therapeutics.

September 15, 2021
Open Access

Epitope scaffolding using alpha-synuclein cyclic peptides to generate oligomer-selective antibodies for Parkinson's disease

BioRxiv : the Preprint Server for Biology
S. C. C. HsuehSteven S Plotkin
September 6, 2021

SARS-CoV-2 infection of the central nervous system in a 14-month-old child: A case report of a complete autopsy.

Lancet Regional Health. Americas
Ismael GomesStevens Rehen
August 30, 2021
Open Access

Wnt signaling activation: targets and therapeutic opportunities for stem cell therapy and regenerative medicine.

RSC Chemical Biology
Clémence BonnetJie J Zheng
August 30, 2021

Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis.

World Journal of Gastrointestinal Oncology
Lumir KunovskyJan Trna
August 30, 2021
Open Access

Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies.

Acta Neuropathologica Communications
Ethan W HassBenoit I Giasson
August 28, 2021
Open Access

Current Therapies in Clinical Trials of Parkinson's Disease: A 2021 Update.

E Maruthi Prasad, Shih-Ya Hung
August 27, 2021

Significance of Oligomeric and Fibrillar Species in Amyloidosis: Insights into Pathophysiology and Treatment.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Haruki KoikeMasahisa Katsuno
August 16, 2021
Open Access

Current Nosology of Neural Autoantibody-Associated Dementia.

Frontiers in Aging Neuroscience
Niels Hansen
August 12, 2021

Anti-CD20 therapies for multiple sclerosis: current status and future perspectives.

Journal of Neurology
Monica MargoniMaria A Rocca
August 9, 2021
Open Access

Tweaking Progranulin Expression: Therapeutic Avenues and Opportunities.

Frontiers in Molecular Neuroscience
Joke TerrynPhilip Van Damme
August 6, 2021
Open Access

Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study.

Acta Neuropathologica Communications
Megan A IidaJohn F Crary
August 6, 2021

Recent progress towards vaccines and antibody-based therapies against Alzheimer's disease.

Mini Reviews in Medicinal Chemistry
Wenbo JiYou Yin
August 6, 2021
Open Access

View Point: Disease Modification and Cell Secretome Based Approaches in Parkinson's Disease: Are We on the Right Track?

Biologics : Targets & Therapy
Thomas Müller
August 2, 2021

DNAJB6b is Downregulated in Synucleinopathies.

Journal of Parkinson's Disease
Jonas FolkeChristian Hansen
July 29, 2021
Open Access

Systemic antibody-oligonucleotide delivery to the central nervous system ameliorates mouse models of spinal muscular atrophy

BioRxiv : the Preprint Server for Biology
Suzan M HammondC. Webster
July 29, 2021
Case Report

The hot cross bun sign in corticobasal degeneration.

Neuropathology : Official Journal of the Japanese Society of Neuropathology
Takashi AndoYasushi Iwasaki

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