Alpha-Synuclein Antibody Therapeutics

Alpha-synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. They have also been detected in several other neurodegenerative diseases, known as synucleopathies. Here is the latest research on alpha-synuclein antibody therapeutics.

January 12, 2022
Preprint
Open Access

Pathological relevance of post-translationally modified alpha-synuclein (pSer87, pSer129, nTyr39) in idiopathic Parkinson's disease and Multiple System Atrophy.

BioRxiv : the Preprint Server for Biology
B. SonustunRina Bandopadhyay
January 12, 2022
Open Access

Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain.

Molecular Neurodegeneration
Enquan XuAndrew B West
January 12, 2022
Open Access

Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies.

NPJ Vaccines
Changyoun KimMichael G Agadjanyan
January 12, 2022

Simultaneously Detecting Monoamine Oxidase A and B in Disease Cell/Tissue Samples Using Paper-Based Devices.

ACS Applied Bio Materials
Haixiao FangLin Li
December 29, 2021

New Insights into the Biosensing of Parkinson's Disease Biomarkers: A Concise Review.

Current Medicinal Chemistry
Elaheh Sadat HosseiniSoraya Sajadimajd
December 23, 2021
Preprint
Open Access

Distribution of phosphorylated alpha-synuclein in non-diseased brain implicates olfactory bulb mitral cells in synucleinopathy pathogenesis

BioRxiv : the Preprint Server for Biology
Bryan A KillingerY. Chu
December 24, 2021
Review

Multiple Sclerosis in Children: Differential Diagnosis, Prognosis, and Disease-Modifying Treatment.

CNS Drugs
Dejan JakimovskiBianca Weinstock-Guttman
December 22, 2021
Open Access

Alpha-synuclein oligomers and small nerve fiber pathology in skin are potential biomarkers of Parkinson's disease.

NPJ Parkinson's Disease
Elena VacchiGiorgia Melli
December 21, 2021
Open Access

Engineering, Characterization, and Biological Evaluation of an Antibody Targeting the HGF Receptor.

Frontiers in Immunology
Claudia DesoleTiziana Crepaldi
December 17, 2021

Central high mobility group box-1 induces mechanical hypersensitivity with spinal microglial activation in a mouse model of hemi-Parkinson's disease.

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Fumiaki SatoNorimitsu Morioka
December 17, 2021

Mild Chronic Colitis Triggers Parkinsonism in LRRK2 Mutant Mice Through Activating TNF-α Pathway.

Movement Disorders : Official Journal of the Movement Disorder Society
Chin-Hsien LinMing-Shiang Wu
December 16, 2021
Open Access

Antibody-Based Therapeutic Interventions for Amyotrophic Lateral Sclerosis: A Systematic Literature Review.

Frontiers in Neuroscience
Amélie Poulin-BrièreSilvia Pozzi

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