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Alpha-Synuclein Structure and Function

Alpha-Synuclein Structure and Function diagram by undefined

α-Synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. Here is the latest research on α-Synuclein structure and function.

Top 20 most recent papers
Brain : a Journal of Neurology

Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes

Brain : a Journal of NeurologyOctober 4, 2019
Yaping ChuJeffrey H Kordower
45
1
bioRxiv

HSP110 dependent HSP70 disaggregation machinery mediates prion-like propagation of amyloidogenic proteins in metazoa

bioRxivOctober 9, 2019
Jessica TittelmeierCarmen I Nussbaum-Krammer
16
Scientific Reports

Amyloid fibrils prepared using an acetylated and methyl amidated peptide model of the α-Synuclein NAC 71-82 amino acid stretch contain an additional cross-β structure also found in prion proteins

Scientific ReportsNovember 4, 2019
Thomas NäsströmBjorn C G Karlsson
Scientific Reports

α-Synuclein oligomers mediate the aberrant form of spike-induced calcium release from IP3 receptor

Scientific ReportsNovember 4, 2019
Kenji YamamotoHideyuki Sawada
1
1
bioRxiv

Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in non-human primates

bioRxivOctober 31, 2019
Mathieu BourdenxErwan Bezard
10
bioRxiv

Selective K-ATP channel-dependent loss of pacemaking in vulnerable nigrostriatal dopamine neurons by α-synuclein aggregates

bioRxivNovember 15, 2019
Poonam ThakurJochen Roeper
Chemical Science

An unusual [4 + 2] fusion strategy to forge meso-N /O -heteroarene-fused (quinoidal) porphyrins with intense near-infrared Q-bands

Chemical ScienceAugust 14, 2019
Chengming LiJing-Song You
Brain and nerve = Shinkei kenkyū no shinpo

The Propagation Hypothesis of Prion-like Protein Agregates in Neurodegenerative Diseases

Brain and nerve = Shinkei kenkyū no shinpoNovember 1, 2019
Takashi Nonaka
Brain : a Journal of Neurology

Lower nucleus accumbens α-synuclein load and D3 receptor levels in Parkinson's disease with impulsive compulsive behaviours

Brain : a Journal of NeurologyOctober 12, 2019
Pedro Melo BarbosaThomas T Warner
73
1
1
Scientific Reports

Plant poisoning leads to alpha-synucleinopathy and neuromelanopathy in kangaroos

Scientific ReportsNovember 13, 2019
Mourad TayebiBrian Alan Summers
International Journal of Molecular Sciences

Examination of Adsorption Orientation of Amyloidogenic Peptides Over Nano-Gold Colloidal Particle Surfaces

International Journal of Molecular SciencesOctober 28, 2019
Kazushige YokoyamaAkane Ichiki
1
1
2
Cell Death & Disease

A split-GFP tool reveals differences in the sub-mitochondrial distribution of wt and mutant alpha-synuclein

Cell Death & DiseaseNovember 12, 2019
Mattia VicarioTito Calì
The FEBS Journal

Characterization of α-synuclein N-terminal domain as a novel cellular phosphatidic acid sensor

The FEBS JournalNovember 13, 2019
Haruka YamadaFumio Sakane
International Journal of Molecular Sciences

Therapeutic Evaluation of Synthetic Peucedanocoumarin III in an Animal Model of Parkinson's Disease

International Journal of Molecular SciencesNovember 4, 2019
Sangwoo HamByoung Dae Lee
1
Scientific Reports

Contribution of syndecans to cellular uptake and fibrillation of α-synuclein and tau

Scientific ReportsNovember 12, 2019
Anett HudákTamás Letoha
Proceedings of the National Academy of Sciences of the United States of America

Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons

Proceedings of the National Academy of Sciences of the United States of AmericaOctober 24, 2019
Michael A MetrickByron W Caughey
16
1
Clinical Proteomics

iTRAQ-based quantitative proteomic analysis provides insight for molecular mechanism of neuroticism

Clinical ProteomicsNovember 8, 2019
Lei TianXingang Hu
International Journal of Molecular Sciences

Depicting Conformational Ensembles of α-Synuclein by Single Molecule Force Spectroscopy and Native Mass Spectroscopy

International Journal of Molecular SciencesOctober 19, 2019
Roberta CortiValeria Cassina
1
Movement Disorders : Official Journal of the Movement Disorder Society

Structurally distinct α-synuclein fibrils induce robust parkinsonian pathology

Movement Disorders : Official Journal of the Movement Disorder SocietyOctober 23, 2019
Hideki HayakawaKousuke Baba
10
2
Cell Research

Initiation of Parkinson's disease from gut to brain by δ-secretase

Cell ResearchOctober 24, 2019
Eun Hee AhnKeqiang Ye
13
1
1

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