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Alpha-Synuclein Structure and Function

Alpha-Synuclein Structure and Function diagram by StudioMolekuul, Shutterstock
StudioMolekuul, Shutterstock

α-Synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. Here is the latest research on α-Synuclein structure and function.

Top 20 most recent papers
May 7, 2020
ReviewOpen Access

Glucocerebrosidase Defects as a Major Risk Factor for Parkinson's Disease

Frontiers in Aging Neuroscience
Micol AvenaliSilvia Cerri
March 27, 2020
Open Access

The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi

Scientific Reports
Hea-Jong ChungSeong-Tshool Hong
May 7, 2020
Open Access

Long-range Regulation of Partially Folded Amyloidogenic Peptides

Scientific Reports
Shayon BhattacharyaDamien Thompson
April 8, 2020
Open Access

Hsp27 reduces glycation-induced toxicity and aggregation of alpha-synuclein

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Hugo Vicente MirandaTiago F Outeiro
February 13, 2020

A new MAP-Rasagiline conjugate reduces α-synuclein inclusion formation in a cell model

Pharmacological Reports : PR
Nuno ValeTiago F Outeiro
April 30, 2020
Open Access

Immunotherapies for Aging-Related Neurodegenerative Diseases-Emerging Perspectives and New Targets

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Somin KwonEliezer Masliah
March 21, 2020
Open Access

Neurodegeneration-Associated Proteins in Human Olfactory Neurons Collected by Nasal Brushing

Frontiers in Neuroscience
Lorenzo BrozzettiGianluigi Zanusso
March 27, 2020
ReviewOpen Access

Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson's Disease

Frontiers in Cellular Neuroscience
Deqiang HanZhiguo Chen
May 14, 2020
ReviewOpen Access

Protein trapping leads to altered synaptic proteostasis in synucleinopathies

The FEBS Journal
Patrícia I Santos, Tiago F Outeiro
April 16, 2020
Open Access

SARS-CoV-2: at the crossroad between aging and neurodegeneration

Movement Disorders : Official Journal of the Movement Disorder Society
Alice LippiAnita Krisko
May 24, 2020

Increased alpha-synuclein tear fluid levels in patients with Parkinson's disease

Scientific Reports
Fabian MaassPaul Lingor
March 1, 2020

Protein structural changes characterized by high-pressure, pulsed field gradient diffusion NMR spectroscopy

Journal of Magnetic Resonance
Venkatraman RamanujamAd Bax
April 3, 2020
Open Access

Freezing and piercing of in vitro asymmetric plasma membrane by α-synuclein

Communications Biology
Paul Heo, Frederic Pincet
April 10, 2020
Open Access

Inhibition of HDAC6 activity protects dopaminergic neurons from alpha-synuclein toxicity

Scientific Reports
Laetitia FrancelleGudrun A Rappold

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