Alpha-Synuclein Structure & Function

α-Synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. Here is the latest research on α-synuclein structure and function.

November 13, 2020
Review
Open Access

Neuroimaging Advances in Parkinson's Disease and Atypical Parkinsonian Syndromes

Frontiers in Neurology
Usman SaeedMario Masellis
December 3, 2020
Open Access

TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson's Disease

Cell Reports
Guixin ZhuXiaolu Yang
September 5, 2020
Open Access

Molecular basis for N-terminal alpha-synuclein acetylation by human NatB

ELife
Sunbin DengRonen Marmorstein
December 29, 2020

Molecular Dynamics Study of the Interaction between the N-terminal of α-Synuclein and a Lipid Bilayer Mimicking Synaptic Vesicles

The Journal of Physical Chemistry. B
Christopher Kang, Rui Sun
December 18, 2020
Open Access

β-Turn exchanges in the α-synuclein segment 44-TKEG-47 reveal high sequence fidelity requirements of amyloid fibril elongation

Biophysical Chemistry
Emil Dandanell AgerschouWolfgang Hoyer
October 11, 2020
Preprint
Open Access

Structure Specific Neuro-toxicity of α-Synuclein Oligomer

BioRxiv : the Preprint Server for Biology
A. MondalNakul Chandra Maiti
November 29, 2020
Open Access

Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war

Nature Communications
Filippo FavrettoMarkus Zweckstetter
September 8, 2020

Wedelolactone Mitigates Parkinsonism Via Alleviating Oxidative Stress and Mitochondrial Dysfunction Through NRF2/SKN-1

Molecular Neurobiology
Shruti SharmaRakesh Pandey
October 30, 2020
Open Access

Effects of Detergent on α-Synuclein Structure. A Native MS-Ion Mobility Study

International Journal of Molecular Sciences
Rani MoonsFrank Sobott
November 24, 2020
Open Access

The MHC class II transactivator modulates seeded alpha-synuclein pathology and dopaminergic neurodegeneration in an in vivo rat model of Parkinson's disease

Brain, Behavior, and Immunity
Itzia Jimenez-FerrerMaria Swanberg
October 20, 2020

Remodeling of the Conformational Dynamics of Noncanonical DNA Structures by Monomeric and Aggregated α-Synuclein

Journal of the American Chemical Society
Jim-Marcel KnopRoland Winter
August 14, 2020
Open Access

Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding

ACS Chemical Biology
Robert W NewberryMartin Kampmann
November 3, 2020
Preprint
Open Access

The Hsc70 Disaggregation Machinery RemovesMonomer Units Directly from α-Synuclein FibrilEnds

BioRxiv : the Preprint Server for Biology
M. M. SchneiderTuomas Knowles
July 6, 2020

Structures of the intrinsically disordered Aβ, tau and α-synuclein proteins in aqueous solution from computer simulations

Biophysical Chemistry
Phuong H Nguyen, Philippe Derreumaux
June 17, 2020

Effect of benzo(a)pyrene on dopaminergic neurons and α-synuclein in brain and its mechanism involved

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
Y Z QiH Zhou
June 5, 2020
Open Access

Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases

Quarterly Reviews of Biophysics
Tessa SinnigeMichele Vendruscolo
January 9, 2021

Membrane Interactions of α-Synuclein Probed by Neutrons and Photons

Accounts of Chemical Research
Upneet Kaur, Jennifer C Lee

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