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ALS - Pathogenic Mechanisms

ALS - Pathogenic Mechanisms diagram by Kasper Kepp, PLOS One
Kasper Kepp, PLOS One

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

Top 20 most recent papers
bioRxiv

Connexin 43 hemichannels mediate spatial and temporal disease spread in ALS

bioRxivMarch 15, 2020
Akshata A. AlmadNicholas J. Maragakis
26
Neurology. Neuroimmunology and Neuroinflammation

Inflammatory profiles relate to survival in subtypes of amyotrophic lateral sclerosis

Neurology. Neuroimmunology and NeuroinflammationMarch 4, 2020
Mads Nikolaj OlesenNasrin Asgari
1
Journal of Molecular Biology

Liquid-Liquid Phase Separation and its Mechanistic Role in Pathological Protein Aggregation

Journal of Molecular BiologyMarch 15, 2020
W Michael Babinchak, Witold K Surewicz
22
1
Nature Reviews. Neurology

Protein transmission in neurodegenerative disease

Nature Reviews. NeurologyMarch 24, 2020
Chao PengVirginia M-Y Lee
95
1
4
1
Acta neurologica Belgica

Amyotrophic lateral sclerosis with coexisting cancer: a single-center study

Acta neurologica BelgicaMarch 30, 2020
Onur Akan, Leyla Baysal-Kirac
Expert Opinion on Therapeutic Targets

Silence superoxide dismutase 1 (SOD1): a promising therapeutic target for amyotrophic lateral sclerosis (ALS)

Expert Opinion on Therapeutic TargetsMarch 4, 2020
Elena AbatiStefania Corti
1
Disease Models & Mechanisms

The transcription factor Nurr1 is up-regulated in amyotrophic lateral sclerosis patients and SOD1-G93A mice

Disease Models & MechanismsMarch 20, 2020
Valeria ValsecchiAlessandro Vercelli
2
1
Journal of Pain and Symptom Management

Dyspnea as a fatigue-promoting factor in ALS and the role of objective indicators of respiratory impairment

Journal of Pain and Symptom ManagementMarch 8, 2020
Susanne VogtMichael Brinkers
4
Frontiers in Molecular Neuroscience

Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation

Frontiers in Molecular NeuroscienceMarch 6, 2020
Fernando OrmeñoMauricio Budini
3
1
Communications Biology

Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy

Communications BiologyMarch 7, 2020
Varunya ChantadulS Samar Hasnain
3
The EMBO Journal

Cell-to-cell transmission of C9orf72 poly-(Gly-Ala) triggers key features of ALS/FTD

The EMBO JournalMarch 17, 2020
Bahram KhosraviDieter Edbauer
18
1

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