ALS - Pathogenic Mechanisms

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

June 20, 2020

Evidence Linking Protein Misfolding to Quality Control in Progressive Neurodegenerative Diseases

Current Topics in Medicinal Chemistry
Md Tanvir KabirMohamed M Abdel-Daim
July 8, 2020

Neuropathological profile of long duration amyotrophic lateral sclerosis in military Veterans

Brain Pathology
Keith R SpencerThor D Stein
July 4, 2020
Open Access

Quantitative patterns of motor cortex proteinopathy across ALS genotypes

Acta Neuropathologica Communications
Matthew NolanOlaf Ansorge
July 1, 2020
Review
Open Access

P2X7 Receptor Antagonism as a Potential Therapy in Amyotrophic Lateral Sclerosis

Frontiers in Molecular Neuroscience
Cristina Ruiz-RuizAntonio G García
July 1, 2020

Central motor conduction time reveals upper motor neuron involvement masked by lower motor neuron impairment in a significant portion of patients with amyotrophic lateral sclerosis

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Ryo TokimuraYoshikazu Ugawa
July 9, 2020
Review

Modern approaches in gene therapy of motor neuron diseases

Medicinal Research Reviews
Maria Zakharova
July 6, 2020
Review

Poly adenosine diphosphate-ribosylation and neurodegenerative diseases

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
Yi Wang, Yunbi Lu
June 25, 2020
Comment / Editorial

Prognostic value of weight loss in patients with amyotrophic lateral sclerosis

Journal of Neurology, Neurosurgery, and Psychiatry
Frederik J Steyn, Shyuan T Ngo
June 21, 2020

Application of yeast to studying amyloid and prion diseases

Advances in Genetics
Yury O ChernoffTatiana A Chernova
June 27, 2020
Review
Open Access

MAP/ERK Signaling in Developing Cognitive and Emotional Function and Its Effect on Pathological and Neurodegenerative Processes

International Journal of Molecular Sciences
Héctor Albert-GascóFrancisco E Olucha-Bordonau
June 26, 2020
Review
Open Access

Therapeutic Approaches Targeting Protein Aggregation in Amyotrophic Lateral Sclerosis

Frontiers in Molecular Neuroscience
Ravinder Malik, Martina Wiedau
June 28, 2020

Peptide variability and signatures associated with disease progression in CSF collected longitudinally from ALS patients

Analytical and Bioanalytical Chemistry
Allyson L MellingerMichael S Bereman
July 7, 2020
Review

ALS, a cellular whodunit on motor neuron degeneration

Molecular and Cellular Neurosciences
Peter Karagiannis, Haruhisa Inoue
July 2, 2020

The role of arterial blood gas analysis (ABG) in amyotrophic lateral sclerosis respiratory monitoring

Journal of Neurology, Neurosurgery, and Psychiatry
Umberto ManeraAdriano Chio
July 2, 2020
Open Access

Neuronal RNA-binding protein dysfunction in multiple sclerosis cortex

Annals of Clinical and Translational Neurology
Hannah E SalapaMichael C Levin

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