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ALS - Pathogenic Mechanisms

ALS - Pathogenic Mechanisms diagram by undefined

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

Top 20 most recent papers
Nature Neuroscience

Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein

Nature NeuroscienceNovember 27, 2019
Sali M.K. FarhanBenjamin M. Neale
395
2
3
bioRxiv

RBM45 associates with nuclear stress bodies and forms nuclear inclusions during chronic cellular stress and in neurodegenerative diseases

bioRxivNovember 27, 2019
Mahlon A CollinsRobert P Bowser
8
bioRxiv

Absence of subcerebral projection neurons delays disease onset and extends survival in a mouse model of ALS

bioRxivNovember 21, 2019
Thibaut BurgCaroline Rouaux
6
bioRxiv

An ALS-associated mutation in human FUS reduces neurotransmission from C. elegans motor neurons to muscles

bioRxivNovember 30, 2019
Sebastian Matthias MarkertChristian Stigloher
5
bioRxiv

Comprehensive identification of HSP70/HSC70 Chaperone Clients in Human Cells

bioRxivDecember 4, 2019
Seung W RyuTanya T. Paull
8
bioRxiv

G-Quadruplexes Act as Sequence Dependent Chaperones via Protein Oligomerization

bioRxivNovember 21, 2019
Adam BegemanScott Horowitz
12
bioRxiv

Serial assessment of iron in the motor cortex in limb-onset Amyotrophic Lateral Sclerosis using Quantitative Susceptibility Mapping

bioRxivDecember 6, 2019
Anjan BhattaraiPhyllis Chua
7
ACS Chemical Neuroscience

A native mass spectrometry-based method for studying stilbenoid effects on the stabilities and aggregation of Cu, Zn-superoxide dismutase

ACS Chemical NeuroscienceDecember 10, 2019
Xiaoyu ZhuangJian-Zhong Lu
BMJ Open

Induced pluripotent stem cell-based Drug Repurposing for Amyotrophic lateral sclerosis Medicine (iDReAM) study: protocol for a phase I dose escalation study of bosutinib for amyotrophic lateral sclerosis patients

BMJ OpenDecember 2, 2019
Keiko ImamuraHaruhisa Inoue
1
Molecular Brain

RT2 PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease

Molecular BrainDecember 4, 2019
Hai-Bo WangMuralidhar L Hegde
5
International Journal of Molecular Sciences

In Human and Mouse Spino-Cerebellar Tissue, Ataxin-2 Expansion Affects Ceramide-Sphingomyelin Metabolism

International Journal of Molecular SciencesNovember 21, 2019
Nesli-Ece SenGeorg Auburger
3
Stem Cells Translational Medicine

Spinal parenchymal occupation by neural stem cells after subpial delivery in adult immunodeficient rats

Stem Cells Translational MedicineDecember 4, 2019
Martin MarsalaJoseph D Ciacci
11
2
European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies

Respiratory function and cognitive profile in amyotrophic lateral sclerosis

European Journal of Neurology : the Official Journal of the European Federation of Neurological SocietiesNovember 21, 2019
William HuynhMatthew Colm Kiernan
1
1
Cells

JNK Signaling Pathway Involvement in Spinal Cord Neuron Development and Death

CellsDecember 5, 2019
Roberta SchellinoAlessandro Vercelli
Cells

The Impact of Kinases in Amyotrophic Lateral Sclerosis at the Neuromuscular Synapse: Insights into BDNF/TrkB and PKC Signaling

CellsDecember 5, 2019
Maria Angel LanuzaJosep Maria Tomàs
Nature Communications

Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization

Nature CommunicationsDecember 6, 2019
Ian CasciUdai Bhan Pandey
25
Current Pharmaceutical Design

Neurofilament proteins as prognostic biomarkers in neurological disorders

Current Pharmaceutical DesignDecember 10, 2019
Yi-Chen LeeBak-Sau Yip
EBioMedicine

Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity

EBioMedicineNovember 28, 2019
Anastasya BirgerBenjamin E Reubinoff
3
1
BioMed Research International

Review on Cross Talk between Neurotransmitters and Neuroinflammation in Striatum and Cerebellum in the Mediation of Motor Behaviour

BioMed Research InternationalNovember 14, 2019
Dayang Yasmin Abg Abd WahabSangu Muthuraju
International Journal of Molecular Sciences

Interplay between MicroRNAs and Oxidative Stress in Neurodegenerative Diseases

International Journal of Molecular SciencesNovember 30, 2019
Julia KonovalovaAndrii Domanskyi
2

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