Feed Preview

Fast Growing

ALS - Pathogenic Mechanisms

ALS - Pathogenic Mechanisms diagram by Kasper Kepp, PLOS One
Kasper Kepp, PLOS One

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

Top 20 most recent papers
Neurology

ALS phenotype is influenced by age, sex, and genetics: A population-based study

NeurologyJanuary 8, 2020
Adriano ChiòAndrea Calvo
12
1
Scientific Reports

Microendoscopy detects altered muscular contractile dynamics in a mouse model of amyotrophic lateral sclerosis

Scientific ReportsJanuary 18, 2020
Xuefeng ChenScott L Delp
Journal of Neurology, Neurosurgery, and Psychiatry

Cross-sectional and longitudinal measures of chitinase proteins in amyotrophic lateral sclerosis and expression of CHI3L1 in activated astrocytes

Journal of Neurology, Neurosurgery, and PsychiatryJanuary 16, 2020
Lucas VuRobert Bowser
3
1
Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Analyzing progression of motor and speech impairment in ALS

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology SocietyJanuary 18, 2020
Carla AgurtoNicholas J Maragakis
bioRxiv

Genetic ablation of SOD1G37R selectively from corticofugal projection neurons protects corticospinal neurons from degeneration without affecting ALS onset and progression

bioRxivJanuary 10, 2020
Jelena Scekic-ZahirovicCaroline Rouaux
3
Journal of Neuropathology and Experimental Neurology

Neuropathology of Speech Network Distinguishes Bulbar From Nonbulbar Amyotrophic Lateral Sclerosis

Journal of Neuropathology and Experimental NeurologyJanuary 18, 2020
Sanjana ShellikeriYana Yunusova
Revue neurologique

Pre-symptomatic diagnosis in ALS

Revue neurologiqueJanuary 15, 2020
P Corciaon Behalf the FILSLAN network
1
The European Journal of Neuroscience

The influence of metallothionein treatment and treadmill running exercise on disease onset and survival in SOD1G93A amyotrophic lateral sclerosis mice

The European Journal of NeuroscienceJanuary 19, 2020
Katherine Ea LewisMeng Inn Chuah
Journal of Neurology

ALS-derived fibroblasts exhibit reduced proliferation rate, cytoplasmic TDP-43 aggregation and a higher susceptibility to DNA damage

Journal of NeurologyJanuary 16, 2020
Javier RianchoMiguel Lafarga
1
Journal of Neurology, Neurosurgery, and Psychiatry

Chitinases, neuroinflammation and biomarkers in ALS

Journal of Neurology, Neurosurgery, and PsychiatryJanuary 16, 2020
Michael Swash
1
Journal of Neuroinflammation

The progress of gut microbiome research related to brain disorders

Journal of NeuroinflammationJanuary 19, 2020
Sibo ZhuXingdong Chen
European Journal of Radiology

Toward a marker of upper motor neuron impairment in amyotrophic lateral sclerosis: A fully automatic investigation of the magnetic susceptibility in the precentral cortex

European Journal of RadiologyJanuary 17, 2020
Valeria Elisa ContarinoFabio Triulzi
2
International Journal of Biological Sciences

Nicotinamide Riboside Enhances Mitochondrial Proteostasis and Adult Neurogenesis through Activation of Mitochondrial Unfolded Protein Response Signaling in the Brain of ALS SOD1G93A Mice

International Journal of Biological SciencesJanuary 14, 2020
Qi ZhouRenshi Xu
1
Expert Review of Neurotherapeutics

Advanced neuroimaging approaches in amyotrophic lateral sclerosis: refining the clinical diagnosis

Expert Review of NeurotherapeuticsJanuary 16, 2020
Jan Kassubek, Hans-Peter Müller
Bioorganic & Medicinal Chemistry Letters

Development of novel small molecules for the treatment of ALS

Bioorganic & Medicinal Chemistry LettersJanuary 14, 2020
Bini MathewMark J Suto
1
Cells

Splicing Players Are Differently Expressed in Sporadic Amyotrophic Lateral Sclerosis Molecular Clusters and Brain Regions

CellsJanuary 16, 2020
Valentina La CognataSebastiano Cavallaro
1
1
Journal of Biomolecular Structure & Dynamics

Effect of Tetracycline family of antibiotics on actin aggregation, resulting in the formation of Hirano bodies responsible for neuropathological disorders

Journal of Biomolecular Structure & DynamicsJanuary 18, 2020
Samridhi PathakAvinash Kale
2
International Journal of Molecular Sciences

PIP2 Mediated Inhibition of TREK Potassium Currents by Bradykinin in Mouse Sympathetic Neurons

International Journal of Molecular SciencesJanuary 16, 2020
Paula Rivas-RamírezJ Antonio Lamas
6
Behavioral Sciences

Associations of Patient Mood, Modulators of Quality of Life, and Pharmaceuticals with Amyotrophic Lateral Sclerosis Survival Duration

Behavioral SciencesJanuary 16, 2020
Leila BondCassie S Mitchell
5
The Medical Journal of Australia

Expanding the availability of medications for amyotrophic lateral sclerosis in Australia

The Medical Journal of AustraliaJanuary 17, 2020
Colin J Mahoney, Matthew C Kiernan

See more papers from this feed

Related Feeds

ALS

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

ALS & FTD: TDP-43

ALS shares with a considerable proportion of FTD cases the same neuropathological substrate, namely, inclusions of abnormally phosphorylated protein tdp-43 (ptdp-43). Here are the latest discoveries pertaining to ptdp-43 and these diseases.

ALS - Phenotypes

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating phenotypes associated with this genetically heterogeneous disorder.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here are the latest discoveries pertaining to this disease.

ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS therapies here.

ALS: Transposon de-silencing

Transposon silencing is a form of transcriptional gene silencing. These gene silencing mechanisms are impaired in Amyotrophic lateral sclerosis (ALS). Here are the latest discoveries pertaining to transposon silencing and this disease.

Age-related Dementia

Age-related dementia (Alzheimer's disease) results from the destructive impact of the pulse on cerebral vasculature. Evidence is reviewed that the neuropathology of the dementia is caused by the breakdown of small cerebral vessels (silent microbleeds), that the microbleeds result from pulse-induced damage to the cerebral vessels, and that pulse becomes increasingly destructive with age, because of the age-related stiffening of the aorta and great arteries, which causes an increase in the intensity of the pressure pulse. Discover the latest research on age-related dementia here.

Aging Epidemiology

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

© 2020 Meta ULC. All rights reserved
/feed-previews/als---pathogenic-mechanisms/1e2f6567-a7ae-4de0-a163-383117313513