ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

January 16, 2021
Review

FUS and TDP-43 Phases in Health and Disease

Trends in Biochemical Sciences
Bede PortzJames Shorter
December 18, 2020
Open Access

Alzheimer's, Parkinson's Disease and Amyotrophic Lateral Sclerosis Gene Expression Patterns Divergence Reveals Different Grade of RNA Metabolism Involvement

International Journal of Molecular Sciences
Maria GarofaloStella Gagliardi
January 17, 2021

Interplay between tau and α-synuclein LLPS

Protein Science : a Publication of the Protein Society
Anna SiegertMarkus Zweckstetter
January 9, 2021
Open Access

Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration

ACS Chemical Neuroscience
Debasis PatnaikStephen J Haggarty
December 23, 2020

Effects of Dissolved Gases on the Amyloid Fibril Morphology.

Langmuir : the ACS Journal of Surfaces and Colloids
Ya-Ling ChiangIng-Shouh Hwang
January 13, 2021
Open Access

Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases

Neural Regeneration Research
Isaac G OnyangoGorazd B Stokin
January 16, 2021

Direct Observation of β-Barrel Intermediates in the Self-Assembly of Toxic SOD128-38 and Absence in Nontoxic Glycine Mutants

Journal of Chemical Information and Modeling
Yunxiang SunFeng Ding
January 5, 2021
Open Access

Protective Effect of Edaravone against Cationic Lipid-Mediated Oxidative Stress and Apoptosis

Biological & Pharmaceutical Bulletin
Takeshi TeradaPieter Cullis
January 13, 2021

Trends in Understanding the Pathological Roles of TDP-43 and FUS Proteins

Advances in Experimental Medicine and Biology
Emanuele Buratti
December 17, 2020

Exposure of β6/β7-Loop in Zn/Cu Superoxide Dismutase (SOD1) Is Coupled to Metal Loss and Is Transiently Reversible During Misfolding

ACS Chemical Neuroscience
Shamchal BakavayevStanislav Engel
December 31, 2020
Review
Open Access

Paraoxonase Role in Human Neurodegenerative Diseases

Antioxidants
Cadiele Oliana ReichertSergio P Bydlowski
January 23, 2021
Open Access

Serum naturally occurring anti-TDP-43 auto-antibodies are increased in amyotrophic lateral sclerosis.

Scientific Reports
Elisa ContiLucio Tremolizzo
December 18, 2020
Open Access

Amyotrophic Lateral Sclerosis: Proteins, Proteostasis, Prions, and Promises

Frontiers in Cellular Neuroscience
Luke McAlaryNeil R Cashman
December 16, 2020
Open Access

Suicide transport blockade of motor neuron survival generates a focal graded injury and functional deficit

Neural Regeneration Research
Allison S LiangRandall D McKinnon
January 6, 2021
Review

Formaldehyde and Brain Disorders: A Meta-Analysis and Bioinformatics Approach

Neurotoxicity Research
Iemaan RanaLuoping Zhang
December 16, 2020
Preprint
Open Access

Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation.

BioRxiv : the Preprint Server for Biology
I. Sanjuan-RuizLuc Dupuis
December 29, 2020
Review

Molecular imaging for mitochondrial metabolism and oxidative stress in mitochondrial diseases and neurodegenerative disorders

Biochimica Et Biophysica Acta. General Subjects
Masamichi IkawaMakoto Yoneda

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