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ALS & FTD: TDP-43

ALS & FTD: TDP-43 diagram by undefined

ALS shares with a considerable proportion of FTD cases the same neuropathological substrate, namely, inclusions of abnormally phosphorylated protein tdp-43 (ptdp-43). Here are the latest discoveries pertaining to ptdp-43 and these diseases.

Top 20 most recent papers
Alzheimer's & Dementia : the Journal of the Alzheimer's Association

The longitudinal evaluation of familial frontotemporal dementia subjects protocol: Framework and methodology

Alzheimer's & Dementia : the Journal of the Alzheimer's AssociationOctober 18, 2019
Bradley F. BoeveLEFFTDS Consortium
5
1
1
Lancet Neurology

Clinical and dopamine transporter imaging characteristics of non-manifest LRRK2 and GBA mutation carriers in the Parkinson's Progression Markers Initiative (PPMI): a cross-sectional study

Lancet NeurologyOctober 30, 2019
Tanya SimuniPPMI Investigators
10
bioRxiv

Granulins modulate liquid-liquid phase separation and aggregation of TDP-43 C-terminal domain

bioRxivOctober 20, 2019
Anukool A BhopatkarVijayaraghavan Rangachari
13
bioRxiv

Loss of region-specific glial homeostatic signature in prion diseases

bioRxivOctober 30, 2019
Natallia MakaravaIlia V Baskakov
2
bioRxiv

Staufen 1 amplifies pro-apoptotic activation of the unfolded protein response.

bioRxivOctober 28, 2019
Mandi GandelmanStefan Matthias Pulst
9
bioRxiv

Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression

bioRxivNovember 11, 2019
Júlia Canet-PonsGeorg W J Auburger
3
Nature Communications

Phase separation-deficient TDP43 remains functional in splicing

Nature CommunicationsOctober 25, 2019
Hermann Broder SchmidtRajat Rohatgi
78
1
Acta Neuropathologica Communications

Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants

Acta Neuropathologica CommunicationsOctober 22, 2019
Li-Chun LinWilliam W. Seeley
9
1
Journal of Neurology, Neurosurgery, and Psychiatry

Genetic and immunopathological analysis of CHCHD10 in Australian amyotrophic lateral sclerosis and frontotemporal dementia and transgenic TDP-43 mice

Journal of Neurology, Neurosurgery, and PsychiatryNovember 5, 2019
Emily P. McCannShu Yang
22
1
Frontiers in Molecular Neuroscience

Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

Frontiers in Molecular NeuroscienceNovember 1, 2019
Luke McAlaryNeil R. Cashman
JAMA Neurology

Survival and Prognostic Factors in C9orf72 Repeat Expansion Carriers: A Systematic Review and Meta-analysis

JAMA NeurologyNovember 18, 2019
Stella Andrea GlasmacherSuvankar Pal
Acta Neuropathologica Communications

Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease

Acta Neuropathologica CommunicationsNovember 16, 2019
Michael X HendersonVirginia M Y- Lee
15
Neurobiology of Disease

Wild-type p53-induced phosphatase 1 down-regulation promotes apoptosis by activating the DNA damage-response pathway in amyotrophic lateral sclerosis

Neurobiology of DiseaseOctober 30, 2019
Yue-Qing YangHong-Lin Feng
1
1
Cell Reports

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

Cell ReportsOctober 29, 2019
Oliver H TamMolly Gale Hammell
36
14
1
Hippocampus

Characterization of hippocampal subfields using ex vivo MRI and histology data: Lessons for in vivo segmentation

HippocampusNovember 1, 2019
Robin de FloresLaura E.M. Wisse
48
1
Progress in Molecular Biology and Translational Science

Neuroimmune interactions in Alzheimer's disease-New frontier with old challenges?

Progress in Molecular Biology and Translational ScienceOctober 24, 2019
Stefan ProkopJohn Q. Trojanowski
1
1
Biochemistry. Biokhimii︠a︡

Changes in the Metabolism of Sphingoid Bases in the Brain and Spinal Cord of Transgenic FUS(1-359) Mice, a Model of Amyotrophic Lateral Sclerosis

Biochemistry. Biokhimii︠a︡October 1, 2019
U A GutnerAlice V Alessenko
2
Alzheimer's Research & Therapy

Age-dependent emergence of neurophysiological and behavioral abnormalities in progranulin-deficient mice

Alzheimer's Research & TherapyOctober 22, 2019
Dávid NagyMihaly Hajos
4
2
Acta Neuropathologica Communications

Synergistic toxicity in an in vivo model of neurodegeneration through the co-expression of human TDP-43M337V and tauT175D protein

Acta Neuropathologica CommunicationsNovember 8, 2019
Alexander J MoszczynskiKathryn Volkening
1
Journal of Neuroinflammation

MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology

Journal of NeuroinflammationOctober 30, 2019
Javier H JaraPembe Hande Ozdinler
11
1

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