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ALS & FTD: TDP-43

ALS & FTD: TDP-43 diagram by Atthapon Raksthaput, Shutterstock
Atthapon Raksthaput, Shutterstock

ALS shares with a considerable proportion of FTD cases the same neuropathological substrate, namely, inclusions of abnormally phosphorylated protein tdp-43 (ptdp-43). Here are the latest discoveries pertaining to ptdp-43 and these diseases.

Top 20 most recent papers
Acta Neuropathologica

Synaptotagmin 13 is neuroprotective across motor neuron diseases

Acta NeuropathologicaFebruary 18, 2020
M NizzardoS Corti
23
5
2
Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics

Pharmacological BACE Inhibition Improves Axonal Regeneration in Nerve Injury and Disease Models

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeuticsApril 3, 2020
Carolyn TallonMohamed H Farah
1
Nature Reviews. Neuroscience

Programmed axon degeneration: from mouse to mechanism to medicine

Nature Reviews. NeuroscienceMarch 11, 2020
Michael P Coleman, Ahmet Höke
36
1
International Journal of Molecular Sciences

Abnormal Upregulation of GPR17 Receptor Contributes to Oligodendrocyte Dysfunction in SOD1 G93A Mice

International Journal of Molecular SciencesApril 5, 2020
Elisabetta BonfantiMarta Fumagalli
1
Journal of Alzheimer's Disease : JAD

Apolipoprotein E Facilitates Amyloid-β Oligomer-Induced Tau Phosphorylation

Journal of Alzheimer's Disease : JADFebruary 18, 2020
Ting-Ting HouYi-Feng Du
2
1
bioRxiv

A conserved role for SFPQ in repression of pathogenic cryptic last exons

bioRxivMarch 18, 2020
Patricia GordonCorinne Houart
8
Brain : a Journal of Neurology

CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis

Brain : a Journal of NeurologyMarch 19, 2020
Carol Dobson-StoneJohn B Kwok
62
1
Revue neurologique

Cognitive deficit, and neuropathological correlates, in the oldest-old

Revue neurologiqueMarch 18, 2020
M Verny, C Duyckaerts
1
Chemical Communications : Chem Comm

Synthesis and characterization of high affinity fluorogenic α-synuclein probes

Chemical Communications : Chem CommFebruary 28, 2020
Zsofia Lengyel-ZhandRobert H Mach
12
1
Nature Reviews. Neurology

Protein transmission in neurodegenerative disease

Nature Reviews. NeurologyMarch 24, 2020
Chao PengVirginia M-Y Lee
95
1
Brain : a Journal of Neurology

Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis

Brain : a Journal of NeurologyFebruary 11, 2020
Phillip SmethurstRickie Patani
49
8
Clinical Chemistry

Analytical and Clinical Performance of Amyloid-Beta Peptides Measurements in CSF of ADNIGO/2 Participants by an LC-MS/MS Reference Method

Clinical ChemistryFebruary 23, 2020
Magdalena KoreckaAlzheimer’s Disease Neuroimaging Initiative
4
1
International Journal of Molecular Sciences

Insights into the Therapeutic Potential of Glucocorticoid Receptor Modulators for Neurodegenerative Diseases

International Journal of Molecular SciencesApril 5, 2020
Alejandro F De NicolaMaria Claudia Gonzalez Deniselle
Neurology. Genetics

Neuropathologic description of CHCHD10 mutated amyotrophic lateral sclerosis

Neurology. GeneticsFebruary 12, 2020
Julia KeithLorne Zinman
11
1
1

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