ALS & FTD: TDP-43

ALS shares with a considerable proportion of FTD cases the same neuropathological substrate, namely, inclusions of abnormally phosphorylated protein tdp-43 (ptdp-43). Here are the latest discoveries pertaining to ptdp-43 and these diseases.

May 30, 2020
Review
Open Access

Over-expressed MST1 impaired spatial memory via disturbing neural oscillation patterns in mice

Genes, Brain, and Behavior
Yingchun ShangTao Zhang
May 28, 2020
Open Access

ASC-Exosomes Ameliorate the Disease Progression in SOD1(G93A) Murine Model Underlining Their Potential Therapeutic Use in Human ALS

International Journal of Molecular Sciences
Roberta BonafedeRaffaella Mariotti
June 28, 2020
Preprint
Open Access

Caudal-rostral progression of alpha motoneurone degeneration in the SOD1G93A mouse model of amyotrophic lateral sclerosis

BioRxiv : the Preprint Server for Biology
A. J. KirbySamit Chakrabarty
May 22, 2020

DCTN1-related Parkinson-plus disorder (Perry syndrome)

Practical Neurology
Daniel RichardsonJeremy D Isaacs
May 30, 2020

Tetrodotoxin-Sensitive Neuronal-Type Na+ Channels: A Novel and Druggable Target for Prevention of Atrial Fibrillation

Journal of the American Heart Association
Mark A MungerPrzemysław B Radwański
June 7, 2020

Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies

Brain : a Journal of Neurology
Xiaolai ZhouRosa Rademakers
June 3, 2020

C9orf72 suppresses systemic and neural inflammation induced by gut bacteria

Nature
Aaron BurberryKevin Eggan
June 9, 2020
Open Access

The Electrophysiological Determinants of Corticospinal Motor Neuron Vulnerability in ALS

Frontiers in Molecular Neuroscience
Javier H JaraP Hande Ozdinler
June 11, 2020

Neuropathy target esterase (NTE/PNPLA6) and organophosphorus compound-induced delayed neurotoxicity (OPIDN)

Advances in Neurotoxicology
Rudy J RichardsonSanjeeva J Wijeyesakere
May 30, 2020

Overexpression of NDRG2 in skeletal muscle does not ameliorate the effects of stress in vivo

Experimental Physiology
B A MirV C Foletta
May 31, 2020
Review
Open Access

CRISPR/Cas9-Mediated Gene Correction to Understand ALS

International Journal of Molecular Sciences
Yeomin Yun, Yoon Ha
June 20, 2020

Angiogenesis-Centered Molecular Cross-Talk in Amyotrophic Lateral Sclerosis Survival: Mechanistic Insights

Critical Reviews in Eukaryotic Gene Expression
Keshav ThakurAkshay Anand
June 11, 2020

Utility of FDG-PET in diagnosis of Alzheimer-related TDP-43 proteinopathy

Neurology
Marina BuciucKeith A Josephs
July 9, 2020
Open Access

Synonymous variants associated with Alzheimer disease in multiplex families

Neurology. Genetics
Min TangChristiane Reitz

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